Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0442 | 0.0744 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.003 | 0.0442 | 0.0442 |
Echinococcus multilocularis | geminin | 0.0368 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0016 | 0.0047 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.4627 | 0.7787 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.0442 | 0.0744 |
Onchocerca volvulus | 0.003 | 0.0442 | 0.0692 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.003 | 0.0442 | 0.0744 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0016 | 0.0047 | 0.008 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.003 | 0.0442 | 0.0442 |
Brugia malayi | ecdysteroid receptor | 0.003 | 0.0442 | 0.0744 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1152 | 0.1152 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.0442 | 0.0744 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.0442 | 0.0442 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.003 | 0.0442 | 0.0744 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1152 | 0.1152 |
Brugia malayi | nuclear hormone receptor | 0.003 | 0.0442 | 0.0744 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0127 | 0.3201 | 0.3201 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.003 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0442 | 0.0744 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.003 | 0.0442 | 0.0442 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.0047 | 0.008 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.003 | 0.0442 | 0.0744 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.003 | 0.0442 | 0.0744 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0047 | 0.008 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.003 | 0.0442 | 0.0442 |
Brugia malayi | nuclear hormone receptor | 0.0224 | 0.5942 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.003 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0442 | 0.0744 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.0442 | 0.0744 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.0442 | 0.0442 |
Onchocerca volvulus | Bile acid receptor homolog | 0.003 | 0.0442 | 0.0692 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.003 | 0.0442 | 0.0442 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0016 | 0.0047 | 0.0047 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.003 | 0.0442 | 0.0692 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.003 | 0.0442 | 0.0744 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0112 | 0.2759 | 0.2759 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0442 | 0.0744 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.003 | 0.0442 | 0.0744 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1152 | 0.1152 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.003 | 0.0442 | 0.0442 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.0442 | 0.0442 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.003 | 0.0442 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0442 | 0.0744 |
Brugia malayi | nuclear receptor NHR-88 | 0.003 | 0.0442 | 0.0744 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.003 | 0.0442 | 0.0442 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.0442 | 0.0442 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0.0442 | 0.0442 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1152 | 0.1152 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0442 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0442 | 0.0744 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.003 | 0.0442 | 0.0744 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.003 | 0.0442 | 0.0744 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.003 | 0.0442 | 0.0442 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0047 | 0.008 |
Schistosoma mansoni | coup transcription factor | 0.003 | 0.0442 | 0.0442 |
Echinococcus multilocularis | FTZ F1 alpha | 0.003 | 0.0442 | 0.0442 |
Schistosoma mansoni | nuclear hormone receptor | 0.003 | 0.0442 | 0.0442 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.003 | 0.0442 | 0.0442 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.003 | 0.0442 | 0.0744 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.0047 | 0.008 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.003 | 0.0442 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0047 | 0.008 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.0442 | 0.0442 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.003 | 0.0442 | 0.0442 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.0442 | 0.0442 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0127 | 0.3201 | 0.3201 |
Echinococcus granulosus | FTZ F1 alpha | 0.003 | 0.0442 | 0.0442 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0016 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.003 | 0.0442 | 0.0744 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.003 | 0.0442 | 0.0442 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0178 | 0.4627 | 0.7248 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.5547 | 0.9336 |
Brugia malayi | N-terminal motif family protein | 0.0178 | 0.4627 | 0.7787 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0224 | 0.5942 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.024 | 0.6384 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.0442 | 0.0744 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.003 | 0.0442 | 0.0744 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0047 | 0.008 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1152 | 0.1152 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.003 | 0.0442 | 0.0744 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.0442 | 0.0442 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0016 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0047 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0047 | 0.008 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.0442 | 0.0442 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0016 | 0.0047 | 0.0047 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.003 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0047 | 0.008 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.003 | 0.0442 | 0.0744 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.003 | 0.0442 | 0.0744 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.003 | 0.0442 | 0.0744 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.0442 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0442 | 0.0744 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.003 | 0.0442 | 0.0744 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1152 | 0.1939 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.0442 | 0.0744 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1152 | 0.1939 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1152 | 0.1152 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.003 | 0.0442 | 0.0442 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1152 | 0.1152 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0.0442 | 0.0442 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.003 | 0.0442 | 0.0744 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 5.65 % | Analgesic activity in ICR mouse assessed as pain threshold variation at 25 umol/kg, po administered as single dose measured after 180 mins by tail flick test relative to control | ChEMBL. | 19679482 |
Activity (functional) | = 21.08 % | Analgesic activity in ICR mouse assessed as pain threshold variation at 25 umol/kg, po administered as single dose measured after 150 mins by tail flick test relative to control | ChEMBL. | 19679482 |
Activity (functional) | = 21.83 % | Analgesic activity in ICR mouse assessed as pain threshold variation at 25 umol/kg, po administered as single dose measured after 30 mins by tail flick test relative to control | ChEMBL. | 19679482 |
Activity (functional) | = 25.79 % | Analgesic activity in ICR mouse assessed as pain threshold variation at 25 umol/kg, po administered as single dose measured after 120 mins by tail flick test relative to control | ChEMBL. | 19679482 |
Activity (functional) | = 30.14 % | Analgesic activity in ICR mouse assessed as pain threshold variation at 25 umol/kg, po administered as single dose measured after 90 mins by tail flick test relative to control | ChEMBL. | 19679482 |
Activity (functional) | = 34.85 % | Analgesic activity in ICR mouse assessed as pain threshold variation at 25 umol/kg, po administered as single dose measured after 60 mins by tail flick test relative to control | ChEMBL. | 19679482 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.