Detailed information for compound 1094737

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 424.534 | Formula: C28H28N2O2
  • H donors: 1 H acceptors: 2 LogP: 6.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1CC1CC1)c(nc(=O)n2Cc1ccccc1)c1ccc(cc1)C(C)C
  • InChi: 1S/C28H28N2O2/c1-18(2)21-10-12-22(13-11-21)27-26-23(16-19-8-9-19)25(31)15-14-24(26)30(28(32)29-27)17-20-6-4-3-5-7-20/h3-7,10-15,18-19,31H,8-9,16-17H2,1-2H3
  • InChiKey: SECAOYYCZNJQAN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium-sensing receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127276 All targets in OG5_127276
Schistosoma japonicum Metabotropic glutamate receptor 7 precursor, putative Get druggable targets OG5_127276 All targets in OG5_127276
Schistosoma japonicum Metabotropic glutamate receptor 7 precursor, putative Get druggable targets OG5_127276 All targets in OG5_127276
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase kappa 0.0207 0.2168 0.2168
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0164 0.0535
Schistosoma mansoni cpg binding protein 0.0032 0.0285 0.0617
Mycobacterium ulcerans DNA polymerase IV 0.0207 0.2168 1
Mycobacterium tuberculosis Probable lipase LipE 0.0083 0.0828 0.143
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0011 0.0053 0.0115
Echinococcus multilocularis 0.0014 0.0084 0.0084
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0283 0.0283
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0164 0.0187
Mycobacterium tuberculosis Probable esterase LipL 0.0083 0.0828 0.143
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0011 0.0053 0.0146
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0028 0.01
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0084 0.03
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0008 0.0028 0.006
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0053 0.019
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0006 0.0003 0.001
Mycobacterium ulcerans hypothetical protein 0.0083 0.0828 0.3051
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0049 0.0464 0.0464
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0057 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0044
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0011 0.0053 0.019
Plasmodium vivax DNA repair protein REV1, putative 0.0064 0.063 0.5674
Onchocerca volvulus 0.003 0.0266 0.0864
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0028 0.0091
Trypanosoma brucei DNA damage repair protein, putative 0.0064 0.063 0.2053
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0011 0.0053 0.0053
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0028 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0164 0.0535
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0008 0.0028 0.0091
Brugia malayi G-protein alpha subunit 0.0011 0.0053 0.0172
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0207 0.2168 0.2471
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0044
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0244 0.0672
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0007
Brugia malayi hypothetical protein 0.0018 0.0127 0.0414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.2617 0.5677
Onchocerca volvulus 0.001 0.0045 0.0061
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0008 0.0028 0.025
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0028 0.0091
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0028 0.0091
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0011 0.0053 0.006
Echinococcus multilocularis GPCR, family 3, C terminal 0.001 0.0045 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0164 0.0453
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.461 0.461
Leishmania major RNA-editing complex protein MP100, putative 0.0008 0.0028 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0044
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0011 0.0053 0.0053
Brugia malayi Metabotropic glutamate receptor precursor. 0.0016 0.0106 0.0347
Trichomonas vaginalis hypothetical protein 0.0006 0.0003 0.0011
Echinococcus granulosus importin subunit beta 1 0.0032 0.0283 0.0323
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0028 0.0128
Echinococcus granulosus geminin 0.0381 0.4042 0.4606
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0028 0.0091
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0014 0.0084 0.0385
Giardia lamblia DINP protein human, muc B family 0.0207 0.2168 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0077
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.024 0.216
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0164 0.0535
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Loa Loa (eye worm) DR-78 0.001 0.0045 0.0123
Trypanosoma cruzi DNA damage repair protein, putative 0.0064 0.063 0.2053
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0128
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0164 0.0187
Brugia malayi hypothetical protein 0.001 0.0045 0.0145
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0164 0.0535
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0028 0.0091
Brugia malayi CUB domain containing protein 0.0006 0.0003 0.0009
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0207 0.2168 0.4703
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0028 0.0091
Trichomonas vaginalis Phospholipase C precursor, putative 0.0008 0.0028 0.01
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0182
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0182
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0438 0.1576
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0164 0.0356
Schistosoma mansoni importin beta-1 0.0032 0.0283 0.0614
Onchocerca volvulus 0.0083 0.0828 0.2906
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0011 0.0053 0.0053
Onchocerca volvulus 0.0018 0.0127 0.036
Leishmania major DNA damage repair protein, putative 0.0064 0.063 0.2053
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0127 0.035
Echinococcus multilocularis dna polymerase eta 0.0291 0.3068 0.3068
Schistosoma mansoni GTP-binding protein alpha subunit 0.0011 0.0053 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Schistosoma mansoni zinc finger protein 0.001 0.0045 0.0097
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0011 0.0053 0.0115
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0011 0.0053 0.0172
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0011 0.0053 0.0053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0164 0.0187
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0011 0.0053 0.0146
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0057 0.0124
Trichomonas vaginalis penicillin-binding protein, putative 0.0083 0.0828 0.2977
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0053 0.019
Brugia malayi beta-lactamase family protein 0.0083 0.0828 0.2699
Schistosoma mansoni neutral sphingomyelinase 0.0008 0.0028 0.006
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0128
Loa Loa (eye worm) hypothetical protein 0.0291 0.3068 0.8465
Schistosoma mansoni coup transcription factor 0.0021 0.0164 0.0356
Brugia malayi Nuclear hormone receptor E75 0.001 0.0045 0.0145
Schistosoma mansoni cpg binding protein 0.0032 0.0285 0.0617
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0077
Schistosoma mansoni carbon catabolite repressor protein 0.0008 0.0028 0.006
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0383 0.1768
Echinococcus granulosus dna polymerase eta 0.0291 0.3068 0.3496
Brugia malayi Protein kinase domain containing protein 0.0018 0.0127 0.0414
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0011 0.0053 0.0115
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0008 0.0028 0.0091
Onchocerca volvulus 0.0016 0.0114 0.0312
Brugia malayi hypothetical protein 0.0011 0.0057 0.0187
Leishmania major hypothetical protein, conserved 0.0083 0.0828 0.2699
Brugia malayi hypothetical protein 0.001 0.0045 0.0145
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0158
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0008 0.0028 0.0128
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.024 0.216
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0003 0.0009
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0372 0.1213
Trypanosoma brucei DNA damage repair protein, putative 0.0064 0.063 0.2053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0158
Trichomonas vaginalis ran, putative 0.0024 0.0192 0.069
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0011 0.0053 0.0172
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0283 0.185
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0011 0.0053 0.0172
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0006 0.0003 0.001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0028 0.0091
Loa Loa (eye worm) glutamate receptor 0.0024 0.0197 0.0542
Trypanosoma brucei DNA polymerase IV, putative 0.0207 0.2168 0.7066
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0057 0.0187
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0045 0.0061
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0128
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0397 0.3573
Loa Loa (eye worm) G protein alpha subunit 3 0.0011 0.0053 0.0146
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0192 0.1255
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0011 0.0053 0.0172
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0049 0.0464 0.0528
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.063 0.2053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0383 0.125
Mycobacterium ulcerans esterase/lipase LipP 0.0083 0.0828 0.3051
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0207 0.2168 0.5981
Schistosoma mansoni hypothetical protein 0.0049 0.0464 0.1006
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0044
Onchocerca volvulus 0.0021 0.0164 0.0495
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0057 0.0158
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0158
Trypanosoma cruzi mitochondrial protein 99, putative 0.0008 0.0028 0.0091
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0244 0.1124
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0164 0.0535
Trypanosoma brucei DNA polymerase kappa, putative 0.0143 0.1476 0.481
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0453
Echinococcus multilocularis beta LACTamase domain containing family member 0.0083 0.0828 0.0828
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0303 0.0656
Trypanosoma cruzi DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Brugia malayi Pre-SET motif family protein 0.0232 0.2438 0.7944
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0083 0.0828 0.143
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0828 0.2699
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0028 0.0091
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0045 0.0145
Trypanosoma brucei hypothetical protein, conserved 0.0083 0.0828 0.2699
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0164 0.0453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.2617 0.5677
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0024 0.0197 0.0426
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0244 0.1592
Echinococcus granulosus CTD small phosphatase protein like 0.0014 0.0084 0.0095
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0244 0.0794
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0008 0.0028 0.0032
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0053 0.019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0453
Loa Loa (eye worm) hypothetical protein 0.0109 0.111 0.3063
Loa Loa (eye worm) hypothetical protein 0.0083 0.0828 0.2285
Plasmodium vivax transportin, putative 0.0006 0.0003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0083 0.0828 0.2285
Brugia malayi metabotropic glutamate receptor type 2 0.003 0.0258 0.0842
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0249 0.2617 0.2982
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0028 0.0032
Leishmania major hypothetical protein, conserved 0.0008 0.0028 0.0091
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0383 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.0294
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0372 0.1213
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0084 0.03
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0383 0.125
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0372 0.1213
Mycobacterium leprae conserved hypothetical protein 0.0083 0.0828 1
Schistosoma mansoni hypothetical protein 0.0018 0.0127 0.0275
Brugia malayi nuclear hormone receptor 0.0021 0.0164 0.0535
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0032 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0453
Giardia lamblia Inositol 5-phosphatase 4 0.0008 0.0028 0.0128
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0084 0.03
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0207 0.2168 0.3823
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0084 0.0272
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0057 0.0065
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0052 0.0052
Onchocerca volvulus 0.001 0.0045 0.0061
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0164 0.0187
Brugia malayi RNA, U transporter 1 0.0091 0.092 0.2998
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0028 0.0091
Trichomonas vaginalis penicillin-binding protein, putative 0.0083 0.0828 0.2977
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0045 0.0145
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0453
Leishmania major hypothetical protein, conserved 0.0008 0.0028 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0164 0.0535
Plasmodium falciparum importin beta, putative 0.0032 0.0283 0.255
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0231
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0453
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0011 0.0053 0.006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0052 0.006
Giardia lamblia DNA damage repair protein 0.0064 0.063 0.2906
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.063 0.2053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0453
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0028 0.0091
Brugia malayi hypothetical protein 0.0109 0.111 0.3619
Schistosoma mansoni hypothetical protein 0.0381 0.4042 0.8768
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0164 0.0164
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0045 0.0123
Loa Loa (eye worm) hypothetical protein 0.0083 0.0828 0.2285
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0192 0.1729
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0438 0.1576
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0084 0.0181
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0303 0.0345
Echinococcus granulosus cpg binding protein 0.0032 0.0285 0.0324
Trypanosoma cruzi DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0372 0.1717
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0164 0.0535
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.1012 0.1153
Echinococcus granulosus histone acetyltransferase KAT2B 0.0154 0.1592 0.1815
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0008 0.0028 0.01
Trypanosoma cruzi DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Plasmodium falciparum flap endonuclease 1 0.0028 0.0244 0.2195
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.024 0.1568
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0028 0.0077
Schistosoma mansoni hypothetical protein 0.0343 0.3624 0.7863
Onchocerca volvulus 0.0083 0.0828 0.2906
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0014 0.0084 0.0753
Trichomonas vaginalis esterase, putative 0.0083 0.0828 0.2977
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0051 0.0167
Onchocerca volvulus 0.0011 0.0053 0.0091
Echinococcus multilocularis neutral sphingomyelinase 0.0008 0.0028 0.0028
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0218 0.0783
Brugia malayi ecdysone receptor 0.001 0.0045 0.0145
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0032 0.0032
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0192 0.0886
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0077
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0164 0.0356
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0008 0.0028 0.01
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0011 0.0053 0.0115
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0207 0.2168 0.2168
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0249 0.2617 0.8529
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0011 0.0053 0.0146
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0303 0.0656
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0164 0.0535
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0164 0.0495
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0372 0.0424
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.063 0.2053
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0266 0.0734
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0244 0.1124
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0164 0.0535
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0008 0.0028 0.0128
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0045 0.0097
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0397 0.183
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0383 0.0744
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0083 0.0828 0.1797
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0011 0.0053 0.0115
Onchocerca volvulus 0.0016 0.0114 0.0312
Leishmania major GTP-binding protein, putative 0.0024 0.0192 0.0626
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0303 0.0303
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0164 0.0356
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0011 0.0053 0.0115
Schistosoma mansoni nuclear receptor 0.001 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.1027
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0207 0.2168 0.7793
Echinococcus granulosus beta LACTamase domain containing family member 0.0083 0.0828 0.0944
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0084 0.03
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0182
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0207 0.2168 0.7066
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0303 0.0303
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0303 0.0656
Toxoplasma gondii ABC1 family protein 0.0083 0.0828 0.5412
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0045 0.0051
Leishmania major hypothetical protein, conserved 0.0006 0.0003 0.001
Brugia malayi metabotropic GABA-B receptor subtype 2 0.001 0.0045 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.063 0.2053
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0008 0.0028 0.0032
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0028 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0453
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0244 0.0876
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0045 0.0123
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0028 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0164 0.0453
Plasmodium vivax SET domain protein, putative 0.0034 0.0303 0.2725
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0164 0.0535
Schistosoma mansoni hypothetical protein 0.001 0.0045 0.0097
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0164 0.0164
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0008 0.0028 0.0028
Mycobacterium ulcerans lipase LipD 0.0083 0.0828 0.3051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0083 0.0828 0.1797
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0014 0.0084 0.0272
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0044
Schistosoma mansoni flap endonuclease-1 0.0026 0.0214 0.0465
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0028 0.025
Loa Loa (eye worm) hypothetical protein 0.01 0.1012 0.2791
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0303 0.1977
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0192 0.0626
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0164 0.0535
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0045 0.0051
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0008 0.0028 0.0091
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0244 0.0244
Schistosoma mansoni nuclear hormone receptor 0.001 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0244 0.0794
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0008 0.0028 0.0091
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0045 0.0123
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0028 0.025
Schistosoma mansoni importin-beta 2 0.0006 0.0003 0.0007
Schistosoma mansoni ran 0.0024 0.0192 0.0417
Trichomonas vaginalis DNA polymerase eta, putative 0.0207 0.2168 0.7793
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0164 0.0535
Trypanosoma cruzi mitochondrial protein 99, putative 0.0008 0.0028 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0044
Echinococcus granulosus MAM 0.0018 0.0127 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0372 0.1338
Schistosoma mansoni ran 0.0024 0.0192 0.0417
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0045 0.0097
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0057 0.0057
Echinococcus granulosus dnaJ subfamily B 0.0434 0.461 0.5253
Trypanosoma brucei DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0383 0.1378
Loa Loa (eye worm) hypothetical protein 0.0064 0.063 0.1738
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0008 0.0028 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0828 0.2699
Echinococcus multilocularis expressed protein 0.0011 0.0053 0.0053
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.024 0.0782
Brugia malayi ImpB/MucB/SamB family protein 0.0207 0.2168 0.7066
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.024 0.5964
Brugia malayi polk-prov protein 0.0064 0.063 0.2053
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0011 0.0053 0.019
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0164 0.0187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0249 0.2617 0.2617
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0028 0.0028
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0383 0.0437
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0383 0.125
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0023 0.005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0164 0.0356
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0083 0.0828 0.143
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0383 0.3453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.2617 0.5677
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0014 0.0084 0.0546
Brugia malayi nuclear receptor RXR 0.001 0.0045 0.0145
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Trypanosoma brucei DNA polymerase IV, putative 0.0207 0.2168 0.7066
Giardia lamblia hypothetical protein 0.0008 0.0028 0.0128
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0164 0.0356
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0028 0.0077
Brugia malayi hypothetical protein 0.007 0.0695 0.2264
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0146
Loa Loa (eye worm) hypothetical protein 0.0016 0.0114 0.0313
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0372 0.1213
Brugia malayi kap beta 3 protein 0.0006 0.0003 0.001
Entamoeba histolytica Ran family GTPase 0.0024 0.0192 0.0886
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.1012 0.3297
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0011 0.0053 0.0172
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0182
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0383 0.1058
Leishmania major hypothetical protein, conserved 0.0109 0.111 0.3619
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0647 0.1403
Leishmania major DNA polymerase eta, putative 0.0148 0.153 0.4988
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0164 0.0356
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0028 0.0077
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0011 0.0053 0.0146
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0164 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Echinococcus granulosus flap endonuclease 1 0.0028 0.0244 0.0278
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0453
Onchocerca volvulus 0.0016 0.0114 0.0312
Mycobacterium tuberculosis Conserved protein 0.0083 0.0828 0.143
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0008 0.0028 0.025
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0008 0.0028 0.0091
Brugia malayi steroid hormone receptor 0.0021 0.0164 0.0535
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0164 0.0187
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0226
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0045 0.0051
Echinococcus multilocularis metabotropic glutamate receptor 5 0.003 0.0258 0.0258
Echinococcus granulosus expressed protein 0.0011 0.0053 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0164 0.0453
Trypanosoma brucei DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Trypanosoma brucei DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.1012 0.1012
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0244 0.0794
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0128
Brugia malayi CXXC zinc finger family protein 0.003 0.0266 0.0867
Trypanosoma brucei DNA polymerase kappa, putative 0.0143 0.1476 0.481
Onchocerca volvulus 0.0034 0.0303 0.0998
Schistosoma mansoni synaptojanin 0.0008 0.0028 0.006
Plasmodium falciparum ataxin-2 like protein, putative 0.0109 0.111 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0192 0.1729
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0372 0.1338
Trichomonas vaginalis dullard protein, putative 0.0014 0.0084 0.03
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0014 0.0084 0.0272
Schistosoma mansoni nuclear hormone receptor 0.001 0.0045 0.0097
Schistosoma mansoni DNA polymerase IV / kappa 0.0064 0.063 0.1367
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0164 0.0164
Trypanosoma brucei unspecified product 0.0143 0.1476 0.481
Schistosoma mansoni nocturnin 0.0008 0.0028 0.006
Brugia malayi acetyltransferase, GNAT family protein 0.0158 0.164 0.5345
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0045 0.0045
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.001 0.0045 0.0145
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0438 0.2865
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0372 0.0807
Echinococcus granulosus traf and tnf receptor associated protein 0.0008 0.0028 0.0032
Schistosoma mansoni hypothetical protein 0.0018 0.0127 0.0275
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0128
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0008 0.0028 0.01
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0249 0.2617 0.722
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0028 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0164 0.0187
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0383 0.125
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0158
Echinococcus granulosus metabotropic glutamate receptor 5 0.003 0.0258 0.0294
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0083 0.0828 0.2699
Schistosoma mansoni terminal deoxycytidyl transferase 0.0207 0.2168 0.4703
Schistosoma mansoni nuclear receptor 0.001 0.0045 0.0097
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0372 0.0372
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0182
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0008 0.0028 0.025
Loa Loa (eye worm) hypothetical protein 0.0083 0.0828 0.2285
Onchocerca volvulus 0.01 0.1012 0.3573
Trypanosoma cruzi DNA polymerase eta, putative 0.0291 0.3068 1
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0011 0.0053 0.0172
Brugia malayi ecdysteroid receptor 0.0021 0.0164 0.0535
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0011 0.0053 0.0115
Brugia malayi Muscle positioning protein 4 0.0016 0.0114 0.037
Trypanosoma cruzi PAB1-binding protein , putative 0.0109 0.111 0.3619
Entamoeba histolytica hypothetical protein 0.0028 0.024 0.1106
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0158
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0372 0.0424
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0084 0.0753
Schistosoma mansoni hypothetical protein 0.0381 0.4042 0.8768
Schistosoma mansoni hypothetical protein 0.0008 0.0028 0.006
Schistosoma mansoni synaptojanin 0.0008 0.0028 0.006
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.024 0.1568
Mycobacterium ulcerans hypothetical protein 0.0064 0.063 0.2023
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.024 0.0782
Trypanosoma brucei DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0828 0.2977
Toxoplasma gondii exonuclease III APE 0.0041 0.0383 0.2505
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0008 0.0028 0.0091
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0218 0.0783
Brugia malayi Importin beta-1 subunit 0.0032 0.0283 0.0923
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0044
Mycobacterium leprae Probable lipase LipE 0.0083 0.0828 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0044
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0218 0.071
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0164 0.0164
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0397 0.183
Echinococcus multilocularis translational activator gcn1 0.0006 0.0003 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0282 0.0322
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0164 0.0453
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0045 0.0097
Schistosoma mansoni hypothetical protein 0.0016 0.0114 0.0246
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0283 0.0923
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0164 0.0535
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0383 0.3453
Echinococcus granulosus FTZ F1 alpha 0.0821 0.8775 1
Mycobacterium tuberculosis Conserved protein 0.0083 0.0828 0.143
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0028 0.025
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0192 0.0219
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0249 0.2617 0.2617
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0014 0.0084 0.0385
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0057 0.0124
Loa Loa (eye worm) hypothetical protein 0.0083 0.0828 0.2285
Plasmodium falciparum DNase I-like protein, putative 0.0008 0.0028 0.025
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0828 0.7459
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0164 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0303 0.0656
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0008 0.0028 0.0091
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0011 0.0053 0.019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0032 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0828 0.2977
Loa Loa (eye worm) TK/ALK protein kinase 0.0018 0.0127 0.035
Loa Loa (eye worm) acetyltransferase 0.0158 0.164 0.4525
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0164 0.0356
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0008 0.0028 0.01
Mycobacterium ulcerans beta-lactamase 0.0083 0.0828 0.3051
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0011 0.0053 0.0115
Onchocerca volvulus 0.0011 0.0053 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0249 0.2617 0.2982
Schistosoma mansoni cpg binding protein 0.003 0.0266 0.0577
Echinococcus multilocularis MAM 0.0018 0.0127 0.0127
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0438 0.3949
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0372 0.0372
Brugia malayi Flap endonuclease-1 0.0028 0.0244 0.0794
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0011 0.0053 0.006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.2438 0.6725
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0614 0.4013
Echinococcus multilocularis importin 5 0.0006 0.0003 0.0003
Brugia malayi Nuclear hormone receptor E75 0.001 0.0045 0.0145
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0028 0.0091
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0083 0.0828 0.143
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0106 0.0347
Leishmania major importin beta-1 subunit, putative 0.0026 0.0218 0.071
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0438 0.2865
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0045 0.0061
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0164 0.0453
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0146
Schistosoma mansoni hypothetical protein 0.0434 0.461 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0064 0.063 0.4117
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0011 0.0053 0.0115
Schistosoma mansoni GTP-binding protein alpha subunit 0.0011 0.0053 0.0115
Leishmania major DNA polymerase kappa, putative 0.0064 0.063 0.2053
Plasmodium vivax ataxin-2 like protein, putative 0.0109 0.111 1
Leishmania major pantothenate kinase subunit, putative 0.0008 0.0028 0.0091
Loa Loa (eye worm) DOMON domain-containing protein 0.0016 0.0114 0.0313
Echinococcus multilocularis traf and tnf receptor associated protein 0.0008 0.0028 0.0028
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0372 0.1213
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0084 0.0181
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Trypanosoma brucei unspecified product 0.0207 0.2168 0.7066
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.024 0.0379
Trypanosoma brucei unspecified product 0.0143 0.1476 0.481
Trypanosoma brucei DNA polymerase kappa, putative 0.0143 0.1476 0.481
Onchocerca volvulus 0.0083 0.0828 0.2906
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0008 0.0028 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0044
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0014 0.0084 0.0084
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0008 0.0028 0.0028
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.1012 0.2195
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0003 0.0021
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0008 0.0028 0.0091
Brugia malayi nuclear receptor RXR 0.0011 0.0057 0.0187
Trypanosoma cruzi DNA damage repair protein, putative 0.0064 0.063 0.2053
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0052 0.0145
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0343 0.3624 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0128
Trypanosoma brucei chrX additional, unordered contigs 0.0064 0.063 0.2053
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0044
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0158 0.164 0.3558
Onchocerca volvulus 0.0011 0.0053 0.0091
Entamoeba histolytica G protein alpha subunit, putative 0.0011 0.0053 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.063 0.2053
Trichomonas vaginalis set domain proteins, putative 0.0264 0.2782 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Echinococcus multilocularis geminin 0.0381 0.4042 0.4042
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0158 0.164 0.164
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0383 0.125
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0383 0.1768
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0291 0.3068 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0148 0.153 1
Entamoeba histolytica hypothetical protein 0.0026 0.0218 0.1005
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0011 0.0053 0.0053
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0011 0.0053 0.019
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0083 0.0828 0.3051
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0011 0.0053 0.0172
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0064 0.063 0.4117
Schistosoma mansoni cript-related 0.0008 0.0028 0.006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0207 0.2168 0.3823
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0372 0.1338
Brugia malayi nuclear receptor NHR-67 0.001 0.0045 0.0145
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0372 0.0807
Mycobacterium tuberculosis Probable lipase LipD 0.0083 0.0828 0.143
Echinococcus granulosus GPCR family 3 C terminal 0.001 0.0045 0.0051
Brugia malayi beta-lactamase family protein 0.0083 0.0828 0.2699
Leishmania major hypothetical protein, conserved 0.0008 0.0028 0.0091
Toxoplasma gondii LsmAD domain-containing protein 0.0109 0.111 0.7255
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0007
Trichomonas vaginalis dullard protein, putative 0.0014 0.0084 0.03
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.024 0.5
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0028 0.01
Mycobacterium tuberculosis Conserved protein 0.0083 0.0828 0.143
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0008 0.0028 0.0128
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0053 0.019
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0383 0.0635
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0028 0.0091
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0003 0.0021
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0244 0.2195
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0383 1
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0218 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0044
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0008 0.0028 0.0077
Schistosoma mansoni hypothetical protein 0.0013 0.0082 0.0177
Loa Loa (eye worm) hypothetical protein 0.0018 0.0127 0.035
Trypanosoma brucei DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0164 0.0356
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0045 0.0145
Echinococcus granulosus snurportin 1 0.0343 0.3624 0.413
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0045 0.0045
Loa Loa (eye worm) glutamate receptor 0.0016 0.0106 0.0294
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0383 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0045 0.0045
Onchocerca volvulus 0.0264 0.2782 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0028 0.0077
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0008 0.0028 0.0091
Loa Loa (eye worm) hypothetical protein 0.0083 0.0828 0.2285
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0192 0.053
Onchocerca volvulus 0.0016 0.0114 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Echinococcus multilocularis transportin 1 0.0006 0.0003 0.0003
Brugia malayi nuclear hormone receptor 0.001 0.0045 0.0145
Loa Loa (eye worm) hypothetical protein 0.0018 0.0127 0.035
Brugia malayi nuclear receptor NHR-88 0.001 0.0045 0.0145
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0164 0.0356
Trichomonas vaginalis helicase, putative 0.0007 0.0012 0.0044
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.001 0.0045 0.0061
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0192 0.0626
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0182
Echinococcus multilocularis synaptojanin 1 0.0008 0.0028 0.0028
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0045 0.0045
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0028 0.0091
Onchocerca volvulus 0.0016 0.0114 0.0312
Brugia malayi SEA domain containing protein 0.0016 0.0114 0.037
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0835
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Trypanosoma brucei DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0164 0.0495
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0164 0.0356
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0008 0.0028 0.0091
Trypanosoma cruzi DNA polymerase eta, putative 0.0148 0.153 0.4988
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0164 0.0356
Leishmania major DNA polymerase eta, putative 0.0291 0.3068 1
Trichomonas vaginalis dullard protein, putative 0.0014 0.0084 0.03
Leishmania major hypothetical protein, conserved 0.0014 0.0084 0.0272
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.0044
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0028 0.0182
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.0106 0.0294
Onchocerca volvulus Poor gastrulation protein homolog 0.001 0.0045 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0146
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0164 0.0356
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0045 0.0045
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0383 0.1378
Plasmodium falciparum ataxin-2 like protein, putative 0.0109 0.111 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0011 0.0053 0.0115
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0529 0.5626 1
Onchocerca volvulus 0.0018 0.0127 0.036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0164 0.0164
Mycobacterium tuberculosis Probable hydrolase 0.0083 0.0828 0.143
Brugia malayi conserved hypotetical protein 0.001 0.0045 0.0145
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.0044
Leishmania major DNA polymerase kappa, putative 0.0207 0.2168 0.7066
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0164 0.0535
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0192 0.0626
Echinococcus granulosus dna polymerase kappa 0.0207 0.2168 0.2471
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0438 0.05
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0372 0.1717
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0032 0.0037
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0011 0.0053 0.006
Leishmania major endonuclease/exonuclease protein-like protein 0.0008 0.0028 0.0091
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0011 0.0053 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0164 0.0453
Loa Loa (eye worm) beta-lactamase 0.0083 0.0828 0.2285
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0083 0.0828 0.2285
Entamoeba histolytica HEAT repeat domain containing protein 0.0006 0.0003 0.0015
Schistosoma mansoni ap endonuclease 0.0041 0.0383 0.0832
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0011 0.0053 0.006
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0045 0.0145
Entamoeba histolytica deoxycytidyl transferase, putative 0.0207 0.2168 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0372 0.0424
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0045 0.0051
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0028 0.0091
Brugia malayi hypothetical protein 0.0011 0.0057 0.0187
Loa Loa (eye worm) hypothetical protein 0.0032 0.0283 0.0781
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0164 0.0535
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0146
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Schistosoma mansoni metabotropic glutamate receptor 0.02 0.209 0.4534
Trypanosoma brucei PAB1-binding protein , putative 0.0109 0.111 0.3619
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0164 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0164 0.0535
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0011 0.0053 0.0115
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0008 0.0028 0.0091
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0192 0.0192
Schistosoma mansoni DNA polymerase eta 0.0291 0.3068 0.6656
Echinococcus granulosus importin 5 0.0006 0.0003 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.063 0.2053
Plasmodium vivax exodeoxyribonuclease III, putative 0.0008 0.0028 0.025
Mycobacterium ulcerans DNA polymerase IV 0.0207 0.2168 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0045 0.0051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0114 0.0313
Trypanosoma brucei DNA polymerase IV, putative 0.0207 0.2168 0.7066
Plasmodium falciparum DNA repair protein REV1, putative 0.0064 0.063 0.5674
Trypanosoma brucei RNA editing exonuclease 2 0.0008 0.0028 0.0091
Plasmodium vivax importin-beta 2, putative 0.0032 0.0283 0.255
Brugia malayi beta-lactamase 0.0083 0.0828 0.2699
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0084 0.0753
Echinococcus granulosus neutral sphingomyelinase 0.0008 0.0028 0.0032
Brugia malayi hypothetical protein 0.0011 0.0053 0.0172
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0008 0.0028 0.01
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0014 0.0084 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0164 0.0453
Schistosoma mansoni ap endonuclease 0.0041 0.0383 0.0832
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0123
Trypanosoma brucei DNA polymerase eta, putative 0.0291 0.3068 1
Echinococcus multilocularis snurportin 1 0.0343 0.3624 0.3624
Echinococcus granulosus synaptojanin 1 0.0008 0.0028 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0828 0.2977
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0011 0.0053 0.0172
Echinococcus granulosus transportin 1 0.0006 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0713
Brugia malayi tailless protein 0.001 0.0045 0.0145
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0028 0.0091
Echinococcus multilocularis cpg binding protein 0.0032 0.0285 0.0285
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0045 0.0045
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0045 0.0051
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0164 0.0495
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0028 0.0091
Brugia malayi Pre-SET motif family protein 0.0034 0.0303 0.0986
Brugia malayi nuclear receptor NHR-88 0.0021 0.0164 0.0535
Trypanosoma cruzi PAB1-binding protein , putative 0.0109 0.111 0.3619
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0283 0.0923
Echinococcus multilocularis deoxyribonuclease 1 2 0.0008 0.0028 0.0028
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.0106 0.0294
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0008 0.0028 0.0091
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0192 0.0626
Plasmodium falciparum transportin 0.0006 0.0003 0.0028
Brugia malayi CCR4 0.0008 0.0028 0.0091
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0164 0.0164
Echinococcus granulosus translational activator gcn1 0.0006 0.0003 0.0004

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.5 nM Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by FLIPR assay ChEMBL. 20158186

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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