Detailed information for compound 1095126

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 261.32 | Formula: C14H19N3O2
  • H donors: 1 H acceptors: 2 LogP: 0.85 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N1CCN(CC1)C(=O)Nc1ccccc1
  • InChi: 1S/C14H19N3O2/c1-2-13(18)16-8-10-17(11-9-16)14(19)15-12-6-4-3-5-7-12/h3-7H,2,8-11H2,1H3,(H,15,19)
  • InChiKey: WKADJLQAKWQJKI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.5792 0.7651
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.7555 1
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.212 0.3615
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0159 0.015
Brugia malayi Thioredoxin reductase 0.0049 0.2837 0.3716
Onchocerca volvulus 0.0025 0.1205 0.8045
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0698 0.2337
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0698 0.1142
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.7862 1
Loa Loa (eye worm) inositol-1 0.0038 0.212 0.2762
Schistosoma mansoni Smad4 0.0008 0.0109 0.0067
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0159 0.0204
Trypanosoma brucei ISWI complex protein 0.0016 0.0614 0.2036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.5792 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.1205 0.1543
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0698 0.2337
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.2837 0.3716
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.212 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0698 0.2337
Schistosoma mansoni hypothetical protein 0.0016 0.0656 0.0617
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0698 0.3144
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0283 0.0315
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.1221 0.2051
Schistosoma mansoni cpg binding protein 0.0032 0.1727 0.1693
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0723 0.0867
Brugia malayi MH2 domain containing protein 0.0008 0.0109 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.5792 0.5774
Schistosoma mansoni bromodomain containing protein 0.0066 0.4016 0.3991
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0046 0.0004
Brugia malayi Bromodomain containing protein 0.0079 0.4821 0.6358
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0698 0.2337
Brugia malayi MH1 domain containing protein 0.0008 0.0109 0.0084
Schistosoma mansoni zinc finger protein 0.0022 0.1017 0.098
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.2837 0.4861
Echinococcus granulosus Smad4 0.0008 0.0109 0.0116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0723 0.0867
Loa Loa (eye worm) hypothetical protein 0.0039 0.2197 0.2865
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0109 0.0116
Schistosoma mansoni smad1 5 8 and 0.0008 0.0109 0.0067
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.7029 0.8934
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0656 0.1068
Loa Loa (eye worm) hypothetical protein 0.0018 0.079 0.0991
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0723 0.0867
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.5792 0.7651
Schistosoma mansoni cpg binding protein 0.0029 0.1487 0.1451
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.079 0.2667
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.1205 0.5587
Schistosoma mansoni hypothetical protein 0.0016 0.0656 0.0617
Loa Loa (eye worm) hypothetical protein 0.0035 0.1923 0.2499
Mycobacterium tuberculosis Probable reductase 0.0111 0.7029 0.8934
Toxoplasma gondii thioredoxin reductase 0.0049 0.2837 0.8399
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.212 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.212 0.7433
Schistosoma mansoni smad1 5 8 and 0.0008 0.0109 0.0067
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.1221 0.2051
Plasmodium falciparum glutathione reductase 0.0049 0.2837 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0109 0.0116
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.212 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.1205 0.1543
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.1853 0.2311
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.1487 0.1918
Echinococcus multilocularis Smad4 0.0008 0.0109 0.0116
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.212 0.3615
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.2837 0.4861
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.7029 0.8934
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0109 0.0084
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.7862 1
Leishmania major trypanothione reductase 0.0049 0.2837 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.1205 0.4153
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0397 0.0468
Loa Loa (eye worm) hypothetical protein 0.0045 0.2601 0.3402
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.1205 0.1483
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.7029 0.8934
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0777 0.0738
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0698 0.2337
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0698 0.0834
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.3369 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0698 0.1963
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0656 0.0812
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0656 0.1068
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0698 0.0869
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0698 0.2337
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.1853 0.2311
Brugia malayi AMP-binding enzyme family protein 0.0025 0.1205 0.1543
Brugia malayi MH1 domain containing protein 0.0008 0.0109 0.0084
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.079 1
Plasmodium falciparum glutathione reductase 0.0017 0.0698 0.2337
Brugia malayi MH2 domain containing protein 0.0008 0.0109 0.0084
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.1205 0.1483
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.212 0.7433
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.1205 0.5587
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0698 0.3294
Mycobacterium ulcerans hypothetical protein 0.0025 0.1205 0.5587
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0698 0.2337
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.1205 0.5587
Brugia malayi glutathione reductase 0.0049 0.2837 0.3716
Brugia malayi Smad1 0.0008 0.0109 0.0084
Trypanosoma brucei trypanothione reductase 0.0049 0.2837 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0698 0.2337
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.079 0.3588
Echinococcus multilocularis cpg binding protein 0.0032 0.1727 0.2931
Loa Loa (eye worm) hypothetical protein 0.0016 0.0656 0.0812
Brugia malayi Bromodomain containing protein 0.0039 0.2193 0.2858
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.212 0.6243
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0698 0.3294
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0698 0.2337
Brugia malayi CXXC zinc finger family protein 0.0029 0.1487 0.1918
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.1205 0.1483
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.1205 0.5587
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0698 0.2337
Echinococcus multilocularis GPCR, family 2 0.0016 0.0656 0.1068
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.1923 0.2499
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.3771 0.6485
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.7029 0.8934
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.5792 0.5774
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0698 0.3144
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0109 0.0116
Loa Loa (eye worm) hypothetical protein 0.0072 0.4417 0.5821
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0656 0.1068
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.7555 1
Schistosoma mansoni hypothetical protein 0.0035 0.1923 0.1889
Brugia malayi PHD-finger family protein 0.0027 0.1383 0.1781
Schistosoma mansoni smad1 5 8 and 0.0008 0.0109 0.0067
Trypanosoma cruzi ISWI complex protein 0.0016 0.0614 0.2036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0698 0.2337
Loa Loa (eye worm) hypothetical protein 0.0042 0.236 0.3081
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0109 0.0067
Leishmania major hypothetical protein, conserved 0.0016 0.0614 0.2036
Schistosoma mansoni inositol monophosphatase 0.0038 0.212 0.2087
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.7029 0.8934
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0698 0.2337
Schistosoma mansoni hypothetical protein 0.0016 0.0656 0.0617
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0698 0.1963
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.1205 0.4153
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.1205 0.1483
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.1205 0.5587
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.3014 0.3953
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0698 0.2337
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0698 0.2337
Schistosoma mansoni hypothetical protein 0.0016 0.0614 0.0575
Echinococcus granulosus GPCR family 2 0.0016 0.0656 0.1068
Echinococcus granulosus cpg binding protein 0.0032 0.1727 0.2931
Loa Loa (eye worm) Smad1 0.0008 0.0109 0.0084
Brugia malayi MH2 domain containing protein 0.0119 0.7555 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.5792 0.5774
Loa Loa (eye worm) glutathione reductase 0.0049 0.2837 0.3716
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.2837 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0777 0.1278
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0698 0.2337
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0656 0.1068
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.7029 0.8934
Loa Loa (eye worm) hypothetical protein 0.0052 0.3014 0.3953
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0109 0.0084
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.1205 0.4153
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0159 0.0204
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.3642 0.3615
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0777 0.1278
Loa Loa (eye worm) hypothetical protein 0.0018 0.0777 0.0973
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0698 0.3144
Loa Loa (eye worm) hypothetical protein 0.0018 0.079 0.0991
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.212 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.079 0.2667
Schistosoma mansoni cpg binding protein 0.0032 0.1727 0.1693
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.212 1
Onchocerca volvulus 0.0029 0.1487 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0735 0.1205
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0698 0.2337
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.5792 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0698 0.2337
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0698 0.2337
Trypanosoma cruzi ISWI complex protein 0.0016 0.0614 0.2036
Plasmodium vivax glutathione reductase, putative 0.0049 0.2837 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.212 0.7433
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0735 0.0696
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0735 0.1205
Treponema pallidum NADH oxidase 0.0017 0.0698 0.5
Brugia malayi Inositol-1 0.0038 0.212 0.2762
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0698 0.1142
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.7862 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0777 0.0738
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.1205 0.5587
Loa Loa (eye worm) hypothetical protein 0.0025 0.1205 0.1543
Schistosoma mansoni inositol monophosphatase 0.0038 0.212 0.2087
Brugia malayi AMP-binding enzyme family protein 0.0025 0.1205 0.1543
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0046 0.0218
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0698 0.0659
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.3771 0.6485
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0656 0.0812
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.203 0.3458
Echinococcus granulosus smad 0.0008 0.0109 0.0116
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.1205 0.5587
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.3014 0.3953
Plasmodium falciparum thioredoxin reductase 0.0017 0.0698 0.2337
Brugia malayi AMP-binding enzyme family protein 0.0025 0.1205 0.1543
Schistosoma mansoni hypothetical protein 0.0016 0.0656 0.0617
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0698 0.5
Echinococcus multilocularis zinc finger protein 0.0022 0.1017 0.1696
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0698 0.2337
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.1221 0.1184
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0046 0.0218
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0109 0.0116
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.212 0.7433
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.212 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.203 0.3458
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0698 0.2337
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.079 0.0952
Loa Loa (eye worm) hypothetical protein 0.0018 0.079 0.0991
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.5792 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0656 0.0812
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.098 0.1244
Echinococcus multilocularis smad 0.0008 0.0109 0.0116
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.1205 0.5587
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0777 0.0973
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0698 0.2337
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.3014 0.3953
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0735 0.0696
Plasmodium falciparum thioredoxin reductase 0.0049 0.2837 1
Schistosoma mansoni smad 0.0008 0.0109 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0723 0.0867
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.1205 0.5587
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.2837 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.1205 0.5587
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0046 0.0007
Schistosoma mansoni zinc finger protein 0.0016 0.0614 0.0575
Loa Loa (eye worm) hypothetical protein 0.0018 0.079 0.0991
Schistosoma mansoni hypothetical protein 0.0021 0.098 0.0942
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0046 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.5792 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.2837 0.357
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.7862 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0397 0.0468
Loa Loa (eye worm) hypothetical protein 0.0018 0.079 0.0991
Echinococcus granulosus zinc finger protein 0.0022 0.1017 0.1696

Activities

Activity type Activity value Assay description Source Reference
MED (functional) > 10 mg kg-1 Antiamnesic activity against scopolamine-induced amnesia in ip dosed mouse by passive-avoidance test ChEMBL. 19786353

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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