Detailed information for compound 1095479

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.939 | Formula: C26H23ClN4O3
  • H donors: 2 H acceptors: 3 LogP: 3.74 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)NC(=O)[C@@H](NC(=O)Cn1c(=O)c(C)nc2c1cccc2)Cc1ccccc1
  • InChi: 1S/C26H23ClN4O3/c1-17-26(34)31(23-10-6-5-9-21(23)28-17)16-24(32)30-22(15-18-7-3-2-4-8-18)25(33)29-20-13-11-19(27)12-14-20/h2-14,22H,15-16H2,1H3,(H,29,33)(H,30,32)/t22-/m0/s1
  • InChiKey: NPEMIVWBFYPYFR-QFIPXVFZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0031 0.0175
Schistosoma mansoni hypothetical protein 0.0049 0.0137 0.0579
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0245 0.1035
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.011 0.4469
Loa Loa (eye worm) oxidoreductase 0.0054 0.0156 0.0659
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0021 0.0033 0.0137
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.0078 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0137
Loa Loa (eye worm) hypothetical protein 0.0078 0.0245 0.1035
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0805 0.2948 1
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Onchocerca volvulus 0.0061 0.018 0.0966
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0054 0.0156 0.0524
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0054 0.0156 0.053
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0488
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0012 0.0041
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0805 0.2948 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0016
Brugia malayi glutathione reductase 0.0038 0.0094 0.0521
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0012 0.0012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0182 0.0182
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0002 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0495 0.1795 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0002 0.0081
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0495 0.1795 0.7572
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0002 0.0081
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0021 0.0033 0.011
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0021 0.0033 0.0181
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0054 0.0156 0.6365
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0063 0.0265
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.012 0.0407
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0093 0.0317
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.0284 0.0958
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.018 0.7328
Mycobacterium tuberculosis Possible oxidoreductase 0.0054 0.0156 0.053
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0012 0.0012
Trichomonas vaginalis helicase, putative 0.0014 0.0005 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0062 0.0184 0.7502
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0182 0.0618
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0245 0.0833
Trichomonas vaginalis esterase, putative 0.0078 0.0245 0.0833
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0021 0.0033 0.0137
Brugia malayi Thioredoxin reductase 0.0038 0.0094 0.0521
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0021 0.0033 0.011
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.012 0.0669
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0184 0.0625
Onchocerca volvulus 0.0053 0.0149 0.0802
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0062 0.0184 0.7502
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0309 0.1048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0002 0.0081
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0054 0.0156 0.6365
Echinococcus multilocularis expressed protein 0.0021 0.0033 0.0033
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.011 0.0372
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0002 0.0081
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0021 0.0033 0.011
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0184 0.0625
Onchocerca volvulus 0.0054 0.0156 0.084
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0137 0.0465
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0043 0.0043
Echinococcus granulosus importin subunit beta 1 0.0061 0.018 0.0759
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0054 0.0156 0.053
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0021 0.0033 0.0137
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.012 0.0407
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0021 0.0033 0.0033
Schistosoma mansoni inositol monophosphatase 0.0042 0.011 0.0463
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.011 0.4469
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0021 0.0033 0.0137
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0156 0.0524
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0078 0.0245 0.1035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0005 0.0016
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0062 0.0184 0.0625
Schistosoma mansoni cpg binding protein 0.0061 0.018 0.0758
Entamoeba histolytica G protein alpha subunit, putative 0.0021 0.0033 0.1767
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0002 0.0081
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0002 0.0081
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0488
Onchocerca volvulus 0.0029 0.0063 0.0338
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0198 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0016
Brugia malayi beta-lactamase family protein 0.0078 0.0245 0.1367
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0021 0.0033 0.0033
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0156 0.0524
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.011 0.0372
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0006 0.0026
Mycobacterium ulcerans oxidoreductase 0.0054 0.0156 0.0524
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0154 0.6267
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0002 0.0081
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0054 0.0156 0.6365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0495 0.1795 0.1795
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0284 0.0958
Loa Loa (eye worm) hypothetical protein 0.0078 0.0245 0.1035
Brugia malayi CXXC zinc finger family protein 0.0061 0.018 0.1001
Echinococcus multilocularis cpg binding protein 0.0064 0.0192 0.0192
Mycobacterium leprae Probable lipase LipE 0.0078 0.0245 0.0618
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0005 0.0016
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0021 0.0033 0.0033
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0195 0.068 0.379
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0245 0.0833
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0284 0.0958
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.012 0.0407
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0021 0.0033 0.0137
Echinococcus granulosus cpg binding protein 0.0064 0.0192 0.0812
Loa Loa (eye worm) inositol-1 0.0042 0.011 0.0463
Onchocerca volvulus 0.0021 0.0033 0.0175
Loa Loa (eye worm) hypothetical protein 0.0195 0.068 0.287
Onchocerca volvulus 0.0078 0.0245 0.1319
Schistosoma mansoni GTP-binding protein alpha subunit 0.0021 0.0033 0.0137
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0002 0.0081
Schistosoma mansoni lamin 0.0029 0.0063 0.0265
Treponema pallidum NADH oxidase 0.0013 0.0002 0.007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0062 0.0184 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0018 0.0078
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0182 0.0768
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0043 0.0183
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0054 0.0156 0.053
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0054 0.0156 0.053
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0016
Trypanosoma brucei trypanothione reductase 0.0038 0.0094 0.3813
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0137 0.0137
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0032 0.0136
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0495 0.1795 0.7572
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0391 0.1325
Brugia malayi Inositol-1 0.0042 0.011 0.0611
Onchocerca volvulus 0.0078 0.0245 0.1319
Echinococcus granulosus expressed protein 0.0021 0.0033 0.0137
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0245 0.0826
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.012 0.012
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.017 0.0718
Loa Loa (eye worm) hypothetical protein 0.0049 0.0137 0.0579
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0198 0.0198
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0094 0.3813
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0501 0.1819 0.617
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0005 0.0016
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0005 0.0016
Schistosoma mansoni hypothetical protein 0.0053 0.0149 0.0629
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0182 0.742
Echinococcus granulosus intermediate filament protein 0.0029 0.0063 0.0265
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0245 0.0833
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0062 0.0184 0.0777
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0021 0.0033 0.0137
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0012 0.0051
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.011 0.0366
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0021 0.0033 0.0137
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.011 0.4469
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0078 0.0245 0.1035
Plasmodium falciparum enoyl-acyl carrier reductase 0.0805 0.2948 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0495 0.1795 0.7572
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0062 0.0184 0.0618
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.017 0.0578
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0054 0.0156 0.087
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0245 0.0833
Schistosoma mansoni cpg binding protein 0.0064 0.0192 0.0812
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0002 0.0008
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0182 0.0618
Toxoplasma gondii exonuclease III APE 0.0062 0.0184 0.0625
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.012 0.4892
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0245 0.0826
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0054 0.0156 0.0524
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.011 0.5957
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0137 0.0465
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0002 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0062 0.0184 0.0184
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0054 0.0156 0.053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0005 0.0016
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0156 0.0524
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.012 0.6521
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0137 0.0465
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0002 0.0007
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0245 0.0833
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0067 0.0229
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.0913 0.0913
Loa Loa (eye worm) hypothetical protein 0.0134 0.0451 0.1901
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0284 0.0958
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0054 0.0156 0.0308
Brugia malayi isocitrate dehydrogenase 0.0016 0.0012 0.0067
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0273 0.0927
Onchocerca volvulus 0.0066 0.0198 0.1065
Schistosoma mansoni hypothetical protein 0.0024 0.0043 0.0183
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.011 0.0366
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0002 0.0081
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0182 0.0768
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0002 0.0007
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0137 0.5583
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0182 0.0611
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0137
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0137 0.0579
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0137 0.0137
Echinococcus granulosus snurportin 1 0.0649 0.237 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0002 0.0081
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0265
Loa Loa (eye worm) hypothetical protein 0.0078 0.0245 0.1035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0018 0.0078
Plasmodium falciparum thioredoxin reductase 0.0038 0.0094 0.0317
Leishmania major pteridine reductase 1 0.0054 0.0156 0.6365
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0245 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0156 0.0524
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.0534 0.2977
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0021 0.0033 0.0181
Loa Loa (eye worm) hypothetical protein 0.0054 0.0156 0.0659
Schistosoma mansoni hypothetical protein 0.0049 0.0137 0.0579
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0021 0.0033 0.0181
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0054 0.0156 0.6365
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0062 0.0184 0.0618
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0805 0.2948 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0012 0.005
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0093 0.009
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0198 0.0672
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0054 0.0156 0.053
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0245 0.0833
Brugia malayi Probable ClpP-like protease 0.0089 0.0284 0.1584
Brugia malayi Pre-SET motif family protein 0.045 0.1629 0.9077
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0054 0.0156 0.0524
Schistosoma mansoni GTP-binding protein alpha subunit 0.0021 0.0033 0.0137
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.0913 0.3851
Schistosoma mansoni hypothetical protein 0.0574 0.2088 0.881
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0054 0.0156 0.0524
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0154 0.0522
Leishmania major importin beta-1 subunit, putative 0.0049 0.0137 0.5583
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0054 0.0156 0.053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0182 0.0611
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.011 0.4469
Echinococcus multilocularis musashi 0.0029 0.0063 0.0063
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0002 0.0002
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0012 0.0041
Trypanosoma brucei pteridine reductase 1 0.0054 0.0156 0.6365
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.0458 0.1934
Entamoeba histolytica hypothetical protein 0.0049 0.0137 0.7442
Brugia malayi G-protein alpha subunit 0.0021 0.0033 0.0181
Mycobacterium tuberculosis Conserved protein 0.0078 0.0245 0.0833
Plasmodium vivax importin-beta 2, putative 0.0061 0.018 0.061
Leishmania major trypanothione reductase 0.0038 0.0094 0.3813
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0012 0.005
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0021 0.0033 0.0181
Plasmodium vivax glutathione reductase, putative 0.0038 0.0094 0.0317
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.018 0.0758
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0284 0.0964
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0012 0.0488
Echinococcus multilocularis lamin dm0 0.0029 0.0063 0.0063
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0805 0.2948 1
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.018 0.061
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0021 0.0033 0.0137
Schistosoma mansoni hypothetical protein 0.0574 0.2088 0.881
Toxoplasma gondii hypothetical protein 0.0031 0.0067 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0016
Onchocerca volvulus Huntingtin homolog 0.0134 0.0451 0.2422
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0137
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0245 0.0245
Plasmodium falciparum thioredoxin reductase 0.0013 0.0002 0.0007
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0021 0.0033 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0154 0.0522
Trichomonas vaginalis ran, putative 0.0045 0.012 0.0407
Chlamydia trachomatis oxoacy-ACP reductase 0.0054 0.0156 0.0524
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0021 0.0033 0.0181
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.0284 0.1199
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0198 0.0835
Treponema pallidum exodeoxyribonuclease (exoA) 0.0062 0.0184 0.6477
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0012
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0002 0.0008
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0309 0.1048
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.011 0.011
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0245 0.0833
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0021 0.0033 0.0137
Echinococcus multilocularis geminin 0.0574 0.2088 0.2088
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0805 0.2948 1
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0245 0.0833
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.0284 0.0284
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.011 0.0372
Mycobacterium ulcerans beta-lactamase 0.0078 0.0245 0.0826
Plasmodium falciparum glutathione reductase 0.0013 0.0002 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0245 0.1367
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0012 0.0067
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0063 0.035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0198 0.0835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0198 0.0835
Mycobacterium tuberculosis Conserved protein 0.0078 0.0245 0.0833
Brugia malayi beta-lactamase 0.0078 0.0245 0.1367
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0245 0.0833
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0032 0.0136
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0012 0.0488
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0054 0.0156 0.053
Echinococcus multilocularis snurportin 1 0.0649 0.237 0.237
Schistosoma mansoni lamin 0.0029 0.0063 0.0265
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0156 0.0524
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0021 0.0033 0.0137
Schistosoma mansoni ap endonuclease 0.0062 0.0184 0.0777
Echinococcus granulosus lamin 0.0029 0.0063 0.0265
Mycobacterium tuberculosis Probable oxidoreductase 0.0054 0.0156 0.053
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0054 0.0156 0.8485
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0054 0.0156 0.0524
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0649 0.237 1
Echinococcus granulosus geminin 0.0574 0.2088 0.881
Onchocerca volvulus 0.0021 0.0033 0.0175
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0245 0.1035
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0245 1
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0021 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0137
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.045 0.1629 0.6873
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0245 1
Brugia malayi hypothetical protein 0.0021 0.0033 0.0181
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0156 0.0524
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0062 0.0184 1
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0054 0.0156 0.0156
Toxoplasma gondii thioredoxin reductase 0.0038 0.0094 0.0317
Onchocerca volvulus 0.0078 0.0245 0.1319
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0137 0.0579
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0018 0.0078
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.0458 0.1934
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0002 0.0081
Loa Loa (eye worm) hypothetical protein 0.0061 0.018 0.0759
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0805 0.2948 1
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0054 0.0156 0.0659
Schistosoma mansoni importin beta-1 0.0061 0.018 0.0759
Brugia malayi MH2 domain containing protein 0.0136 0.0458 0.2554
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0054 0.0156 0.053
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0054 0.0156 0.6365
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0002 0.0081
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0245 0.0833
Toxoplasma gondii ABC1 family protein 0.0078 0.0245 0.0833
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0002 0.0081
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0245 0.0833
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.011 0.0372
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0495 0.1795 0.1795
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0062 0.0184 0.0777
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.0534 0.2254
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0245 0.0833
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0005 0.0016
Onchocerca volvulus Huntingtin homolog 0.0134 0.0451 0.2422
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0002 0.0007
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0021 0.0033 0.0137
Echinococcus granulosus lamin dm0 0.0029 0.0063 0.0265
Loa Loa (eye worm) hypothetical protein 0.0054 0.0154 0.0649
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0184 0.0777
Loa Loa (eye worm) hypothetical protein 0.0078 0.0245 0.1035
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0016
Onchocerca volvulus 0.0512 0.186 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0273 0.0927
Brugia malayi Pre-SET motif family protein 0.0066 0.0198 0.1103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0026
Brugia malayi hypothetical protein 0.0134 0.0451 0.251
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0054 0.0156 0.0524
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0062 0.0184 0.7502
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0284 0.0964
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.017 0.0357
Plasmodium falciparum importin beta, putative 0.0061 0.018 0.061
Schistosoma mansoni hypothetical protein 0.0649 0.237 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0184 0.0625
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0095 0.0095
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0002 0.0081
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0021 0.0033 0.0137
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0137 0.0765
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0012 0.0041
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0137 0.0765
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0184 0.0625
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0284 0.0958
Trichomonas vaginalis hypothetical protein 0.0805 0.2948 1
Brugia malayi Importin beta-1 subunit 0.0061 0.018 0.1002
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0156 0.0524
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0021 0.0033 0.011
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0021 0.0033 0.0137
Schistosoma mansoni dihydropteridine reductase 0.0054 0.0156 0.0659
Echinococcus multilocularis lamin 0.0029 0.0063 0.0063
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0066 0.0198 0.0835
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0067 0.0229
Schistosoma mansoni ran 0.0045 0.012 0.0506
Loa Loa (eye worm) hypothetical protein 0.0134 0.0451 0.1901
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0273 0.0927
Loa Loa (eye worm) hypothetical protein 0.0156 0.0534 0.2254
Brugia malayi beta-lactamase family protein 0.0078 0.0245 0.1367
Mycobacterium ulcerans lipase LipD 0.0078 0.0245 0.0826
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0156 0.0524
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0054 0.0156 0.0524
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0137
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0488
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0021 0.0033 0.0137
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0021 0.0033 0.0181
Schistosoma mansoni inositol monophosphatase 0.0042 0.011 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.019 0.066 0.224
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0054 0.0156 0.053
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0002 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0154 0.0522
Echinococcus multilocularis GPCR, family 2 0.0049 0.0137 0.0137
Plasmodium vivax SET domain protein, putative 0.0066 0.0198 0.0672
Schistosoma mansoni hypothetical protein 0.0107 0.0351 0.1479
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.012 0.4892
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0054 0.0156 0.6365
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0021 0.0033 0.0137
Echinococcus granulosus GPCR family 2 0.0049 0.0137 0.0579
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0054 0.0156 0.0524
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0002 0.0011
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0054 0.0156 0.0524
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0245 0.1035
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0021 0.0033 0.0137
Schistosoma mansoni ran 0.0045 0.012 0.0506
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0002 0.0007
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0012 0.0067
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0002 0.0081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0182 0.0611
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0005 0.0016
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0054 0.0156 0.0524
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0021 0.0033 0.011
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.0284 0.0753
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0021 0.0033 0.011
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0054 0.0156 0.0659
Loa Loa (eye worm) G protein alpha subunit 3 0.0021 0.0033 0.0137
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0002 0.0081
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.0534 0.2977
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0495 0.1795 0.7572
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0032 0.0032
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0095 0.0403
Brugia malayi hypothetical protein 0.0054 0.0154 0.0857
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0351 0.1953
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0021 0.0033 0.0137
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.012 0.0506
Leishmania major oxidoreductase-like protein 0.0054 0.0156 0.6365
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0284 1
Brugia malayi hypothetical protein 0.0035 0.0083 0.0461
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0021 0.0033 0.0137
Loa Loa (eye worm) glutathione reductase 0.0038 0.0094 0.0395
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0273 0.0927
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0021 0.0033 0.011
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0012 0.0041
Trichomonas vaginalis set domain proteins, putative 0.0512 0.186 0.631
Loa Loa (eye worm) hypothetical protein 0.0089 0.0284 0.1199
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.017 0.0578
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0137 0.0579
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0021 0.0033 0.0181
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0067 0.2371
Onchocerca volvulus 0.0021 0.0033 0.0175
Entamoeba histolytica Ran family GTPase 0.0045 0.012 0.6521
Schistosoma mansoni ap endonuclease 0.0062 0.0184 0.0777
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0273 0.0714
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0198 0.0835
Schistosoma mansoni intermediate filament proteins 0.0029 0.0063 0.0265
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0309 0.0838
Loa Loa (eye worm) hypothetical protein 0.0258 0.0913 0.3851
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0442 0.1865
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0016
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0002 0.0007
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0094 0.0317
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0094 0.0395
Loa Loa (eye worm) beta-lactamase 0.0078 0.0245 0.1035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0054 0.0156 0.087
Schistosoma mansoni hypothetical protein 0.0049 0.0137 0.0579
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Loa Loa (eye worm) retinol dehydrogenase 12 0.0054 0.0156 0.0659
Loa Loa (eye worm) hypothetical protein 0.0029 0.0061 0.0257
Brugia malayi RNA, U transporter 1 0.0173 0.0597 0.3327
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.012 0.0506
Schistosoma mansoni hypothetical protein 0.0049 0.0137 0.0579
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0198 0.0835
Mycobacterium tuberculosis Conserved protein 0.0078 0.0245 0.0833
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0054 0.0156 0.053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0002 0.0081
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0094 0.0317
Onchocerca volvulus 0.0054 0.0156 0.084
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0156 0.0659
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.005
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0021 0.0033 0.0137
Mycobacterium tuberculosis Possible oxidoreductase 0.0054 0.0156 0.053
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.012 0.4892
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0805 0.2948 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0245 0.1035
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.0107 0.0351 0.1479
Plasmodium falciparum glutathione reductase 0.0038 0.0094 0.0317
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0273 0.0927
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.018 0.7328
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0054 0.0156 0.0308
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0021 0.0033 0.0181
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0154 0.6267
Brugia malayi intermediate filament protein 0.0029 0.0063 0.035
Schistosoma mansoni survival motor neuron protein 0.0053 0.0149 0.0629
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0062 0.0184 0.7502
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0309 0.1048
Trypanosoma brucei oxidoreductase-like protein 0.0054 0.0156 0.6365
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0021 0.0033 0.0181
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0002 0.0108
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.0284 0.1199
Leishmania major GTP-binding protein, putative 0.0045 0.012 0.4892
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0495 0.1795 0.7572
Brugia malayi hypothetical protein 0.0258 0.0913 0.5086
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0284 0.0964
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0005 0.0016
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0021 0.0033 0.0137
Brugia malayi exodeoxyribonuclease III family protein 0.0062 0.0184 0.1026
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.011 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0016
Schistosoma mansoni cpg binding protein 0.0064 0.0192 0.0812
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0154 0.0522
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0156 0.0524
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0182 0.0768
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0245 0.0618
Leishmania major hypothetical protein, conserved 0.0054 0.0154 0.6267
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0021 0.0033 0.011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0245 0.0833
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0002 0.0007
Echinococcus multilocularis importin subunit beta 1 0.0061 0.018 0.018
Onchocerca volvulus 0.0029 0.0063 0.0338
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0063 0.0265
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0154 0.6267
Mycobacterium tuberculosis Probable reductase 0.0086 0.0273 0.0927
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.0284 0.0964
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0054 0.0156 0.6365
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0495 0.1795 0.7572
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0149 0.0831
Mycobacterium ulcerans hypothetical protein 0.0078 0.0245 0.0826

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of APN assessed as substrate hydrolysis by UV/vis spectrophotometer ChEMBL. 20097082
IC50 (binding) = 624.48 uM Inhibition of MMP2 ChEMBL. 20097082

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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