Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0619 | 0.5 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0172 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0619 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.8296 | 0.6813 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.7596 | 0.5502 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0172 | 1 | 1 |
Schistosoma mansoni | alkaline phosphatase | 0.0172 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0619 | 0.5 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0619 | 0.5 |
Echinococcus granulosus | alkaline phosphatase | 0.0172 | 1 | 1 |
Echinococcus multilocularis | alkaline phosphatase | 0.0172 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0619 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0619 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.8296 | 0.6813 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0619 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0619 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0619 | 0.5 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0172 | 1 | 1 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0172 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0619 | 0.5 |
Schistosoma mansoni | alkaline phosphatase | 0.0172 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0146 | 0.8296 | 0.2913 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 100 uM | Cytotoxicity against human HeLa cells by MTT assay | ChEMBL. | 21650157 |
IC50 (functional) | = 100 uM | Cytotoxicity against human Jurkat cells by MTT assay | ChEMBL. | 21650157 |
IC50 (functional) | = 100 uM | Cytotoxicity against human MCF7 cells by MTT assay | ChEMBL. | 21650157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.