Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitochondrial DNA topoisomerase II | 0.0083 | 0.2217 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0083 | 0.2217 | 0.1706 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.268 | 0.22 |
Brugia malayi | RNA binding protein | 0.0128 | 0.4415 | 0.4049 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.015 | 0.5442 | 0.5185 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.268 | 0.0595 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.268 | 0.0595 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.4415 | 0.4049 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0083 | 0.2217 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.4415 | 0.2825 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.268 | 0.5432 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0083 | 0.2217 | 0.1706 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.4415 | 0.2825 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.4415 | 0.4415 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.268 | 0.268 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4415 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4415 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0083 | 0.2217 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0244 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4415 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.268 | 0.0595 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0083 | 0.2217 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0096 | 0.287 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0083 | 0.2217 | 0.1867 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0083 | 0.2217 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.4415 | 0.4415 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.268 | 0.5432 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4415 | 1 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.4415 | 0.4049 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4415 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.015 | 0.5442 | 0.5185 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.287 | 0.5932 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0212 | 0.8437 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.268 | 0.5432 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0063 | 0.1238 | 0.5 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0083 | 0.2217 | 0.1706 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0083 | 0.2217 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0083 | 0.2217 | 0.5469 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0212 | 0.8437 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0212 | 0.8437 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0083 | 0.2217 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.268 | 0.0595 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0083 | 0.2217 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.4415 | 0.4415 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0212 | 0.8437 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0212 | 0.8437 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0083 | 0.2217 | 0.2217 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0212 | 0.8437 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0212 | 0.8437 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0212 | 0.8437 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0083 | 0.2217 | 0.4213 |
Giardia lamblia | DNA topoisomerase II | 0.0076 | 0.1871 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0244 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.13 uM | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay | ChEMBL. | 20199865 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20199865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.