Detailed information for compound 109557

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 341.401 | Formula: C20H23NO4
  • H donors: 3 H acceptors: 3 LogP: 1.21 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1C=C[C@@]2(C34[C@H]1Oc1c4c(CC2N(CC3)CC2CC2)ccc1O)O
  • InChi: 1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-6,11,14-15,18,22-24H,1-2,7-10H2/t14-,15?,18-,19?,20+/m0/s1
  • InChiKey: VMRNCMCYDMPKHE-SPJVMBNZSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase shark 0.0063 0.0135 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0079 0.45
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Schistosoma mansoni eps8-related protein 0.0048 0.0079 0.008
Loa Loa (eye worm) aminopeptidase N 0.0074 0.0175 0.0345
Echinococcus granulosus adam 17 protease 0.045 0.1567 0.1567
Onchocerca volvulus 0.0078 0.019 0.5375
Loa Loa (eye worm) TK protein kinase 0.0063 0.0135 0.0266
Brugia malayi SH2 domain containing protein 0.005 0.0083 0.0366
Schistosoma mansoni adapter molecule crk 0.0098 0.0262 0.0267
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0048 0.0079 0.0079
Echinococcus granulosus epidermal growth factor receptor kinase 0.0048 0.0079 0.0079
Echinococcus granulosus hypothetical protein 0.005 0.0083 0.0083
Onchocerca volvulus Matrilysin homolog 0.0123 0.0354 1
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0135 0.0266
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0048 0.0079 0.0079
Schistosoma mansoni tyrosine-protein kinase zap-70 0.005 0.0083 0.0085
Schistosoma mansoni tyrosine kinase 0.0112 0.0314 0.0319
Toxoplasma gondii aminopeptidase N, putative 0.0074 0.0175 1
Echinococcus granulosus nostrin 0.0048 0.0079 0.0079
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.0083 0.0164
Schistosoma mansoni hypothetical protein 0.0048 0.0079 0.008
Schistosoma mansoni tensin-related 0.005 0.0083 0.0085
Schistosoma mansoni tyrosine kinase 0.0112 0.0314 0.0319
Toxoplasma gondii aminopeptidase n, putative 0.0074 0.0175 1
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0213 0.0687 0.0687
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0063 0.0135 0.0135
Echinococcus granulosus aminopeptidase N 0.0074 0.0175 0.0175
Echinococcus multilocularis SH2 domain containing adapter protein F 0.005 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0048 0.0079 0.441
Entamoeba histolytica unconventional myosin IB 0.0048 0.0079 0.441
Loa Loa (eye worm) hypothetical protein 0.0067 0.0149 0.0294
Brugia malayi SH2 domain containing protein 0.005 0.0083 0.0366
Loa Loa (eye worm) hypothetical protein 0.0048 0.0079 0.0155
Onchocerca volvulus 0.0074 0.0175 0.4948
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Brugia malayi SH2 domain containing protein 0.0063 0.0135 0.0591
Loa Loa (eye worm) p53BP2 0.0048 0.0079 0.0155
Brugia malayi Guanylate kinase family protein 0.0048 0.0079 0.0346
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.292 0.292
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0168 0.0522 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0112 0.0314 0.0314
Echinococcus multilocularis 0.005 0.0083 0.0083
Loa Loa (eye worm) protein-tyrosine phosphatase 0.005 0.0083 0.0164
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0063 0.0135 0.0135
Echinococcus granulosus tyrosine protein kinase shark 0.0063 0.0135 0.0135
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0112 0.0314 0.0314
Brugia malayi Protein-tyrosine phosphatase containing protein 0.005 0.0083 0.0366
Echinococcus granulosus fch and double sh3 domains protein 2 0.0048 0.0079 0.0079
Brugia malayi SH2 domain containing protein 0.005 0.0083 0.0366
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.0079 0.0155
Echinococcus granulosus tyrosine protein kinase Src64B 0.0112 0.0314 0.0314
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0175 0.0175
Schistosoma mansoni SH2A 0.005 0.0083 0.0085
Echinococcus granulosus Spectrin alpha actinin 0.0048 0.0079 0.0079
Trypanosoma brucei Aminopeptidase M1, putative 0.0074 0.0175 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.005 0.0083 0.0085
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0112 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Brugia malayi Matrixin family protein 0.0055 0.0105 0.0459
Loa Loa (eye worm) hypothetical protein 0.0074 0.0175 0.0345
Schistosoma mansoni aminopeptidase A (M01 family) 0.0074 0.0175 0.0178
Echinococcus multilocularis endophilin A3 0.0048 0.0079 0.0079
Onchocerca volvulus 0.0063 0.0135 0.3809
Brugia malayi Variant SH3 domain containing protein 0.0077 0.0183 0.0804
Brugia malayi hypothetical protein 0.0074 0.0175 0.0768
Brugia malayi Spectrin alpha chain 0.0048 0.0079 0.0346
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0063 0.0135 0.0135
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0135 0.0266
Echinococcus multilocularis growth factor receptor bound protein 2 0.0098 0.0262 0.0262
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0079 0.45
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Brugia malayi SH2 domain containing protein 0.005 0.0083 0.0366
Loa Loa (eye worm) hypothetical protein 0.0048 0.0079 0.0155
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0135 0.0266
Echinococcus granulosus tyrosine protein kinase Lyn 0.0112 0.0314 0.0314
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0048 0.0079 0.45
Echinococcus multilocularis tensin 0.005 0.0083 0.0083
Trichomonas vaginalis p67phox protein, putative 0.0048 0.0079 0.45
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0112 0.0314 0.0314
Brugia malayi Src substrate cortactin 0.0048 0.0079 0.0346
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0074 0.0175 1
Schistosoma mansoni sorting nexin 0.0048 0.0079 0.008
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0048 0.0079 0.0079
Echinococcus multilocularis SHC transforming protein 3 0.005 0.0083 0.0083
Brugia malayi Variant SH3 domain containing protein 0.0098 0.0262 0.1149
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0112 0.0314 0.0314
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0079 0.0346
Entamoeba histolytica SH2 domain containing protein 0.005 0.0083 0.4665
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0074 0.0175 0.0178
Loa Loa (eye worm) TATA binding protein associated factor 0.0074 0.0175 0.0345
Brugia malayi hypothetical protein 0.005 0.0083 0.0366
Onchocerca volvulus 0.0048 0.0079 0.2227
Loa Loa (eye worm) hypothetical protein 0.0048 0.0079 0.0155
Onchocerca volvulus 0.0074 0.0175 0.4948
Brugia malayi Tensin 0.005 0.0083 0.0366
Echinococcus granulosus leukotriene A 4 hydrolase 0.1399 0.5077 0.5077
Echinococcus granulosus expressed conserved protein 0.005 0.0083 0.0083
Entamoeba histolytica protein kinase, putative 0.0048 0.0079 0.441
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0135 0.0266
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0135 0.0266
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0135 0.0266
Echinococcus granulosus suppressor of cytokine signaling 6 0.005 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0063 0.0135 0.0591
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1399 0.5077 0.5077
Echinococcus multilocularis tyrosine protein kinase Blk 0.0063 0.0135 0.0135
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0175 0.0768
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0048 0.0079 0.0079
Brugia malayi Protein kinase domain containing protein 0.0063 0.0135 0.0591
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0048 0.0079 0.0079
Schistosoma mansoni nck2/grb4 0.0098 0.0262 0.0267
Brugia malayi protein-tyrosine kinase 0.0063 0.0135 0.0591
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0074 0.0175 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0079 0.45
Entamoeba histolytica hypothetical protein 0.0048 0.0079 0.441
Echinococcus granulosus signal transduction protein lnk realted 0.005 0.0083 0.0083
Echinococcus granulosus intersectin 2 0.0048 0.0079 0.0079
Entamoeba histolytica hypothetical protein 0.0075 0.0179 1
Schistosoma mansoni suppressor of cytokine signaling 0.005 0.0083 0.0085
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0175 1
Schistosoma mansoni shc transforming protein 0.005 0.0083 0.0085
Loa Loa (eye worm) SRC-1 0.0112 0.0314 0.0618
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0175 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0112 0.0314 0.1375
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0175 1
Trypanosoma cruzi aminopeptidase, putative 0.0074 0.0175 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0112 0.0314 0.0314
Onchocerca volvulus 0.005 0.0083 0.2355
Brugia malayi Myosin tail family protein 0.0048 0.0079 0.0346
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0075 0.0179 0.0179
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0098 0.0262 0.0516
Echinococcus granulosus SH2 domain containing adapter protein F 0.005 0.0083 0.0083
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0075 0.0179 0.0182
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0074 0.0175 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.005 0.0083 0.0083
Echinococcus granulosus N chimaerin 0.005 0.0083 0.0083
Brugia malayi protein-tyrosine kinase 0.0048 0.0079 0.0346
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0175 0.0175
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0175 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0175 0.0175
Echinococcus multilocularis tensin 0.005 0.0083 0.0083
Echinococcus granulosus tyrosine protein kinase Blk 0.0063 0.0135 0.0135
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0135 0.0266
Echinococcus multilocularis adam 17 protease 0.045 0.1567 0.1567
Echinococcus granulosus tyrosine protein kinase Fyn 0.0112 0.0314 0.0314
Onchocerca volvulus 0.0055 0.0105 0.2959
Schistosoma mansoni vav2 0.0077 0.0183 0.0187
Brugia malayi SH2 domain containing protein 0.0063 0.0135 0.0591
Entamoeba histolytica hypothetical protein 0.0048 0.0079 0.441
Loa Loa (eye worm) matrixin family protein 0.0134 0.0395 0.0778
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.0083 0.0164
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.0135 0.0135
Brugia malayi Matrixin family protein 0.0055 0.0105 0.0459
Echinococcus multilocularis c src tyrosine kinase 0.0112 0.0314 0.0314
Brugia malayi Protein kinase domain containing protein 0.0063 0.0135 0.0591
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0074 0.0175 1
Echinococcus granulosus SHC transforming protein 3 0.005 0.0083 0.0083
Brugia malayi Hemopexin family protein 0.0078 0.019 0.0834
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1399 0.5077 1
Trypanosoma brucei conserved protein 0.0048 0.0079 0.45
Loa Loa (eye worm) hypothetical protein 0.0048 0.0079 0.0155
Onchocerca volvulus 0.0063 0.0135 0.3809
Leishmania major hypothetical protein, conserved 0.0048 0.0079 0.45
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0238 0.078 0.078
Brugia malayi SH2 domain containing protein 0.005 0.0083 0.0366
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0175 0.0768
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Trypanosoma cruzi Aminopeptidase M1, putative 0.0074 0.0175 1
Onchocerca volvulus 0.0063 0.0135 0.3809
Echinococcus multilocularis transfer RNA-Ala 0.0048 0.0079 0.0079
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0175 0.0175
Onchocerca volvulus 0.0048 0.0079 0.2227
Onchocerca volvulus 0.005 0.0083 0.2355
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0201 0.0644 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0079 0.45
Entamoeba histolytica hypothetical protein 0.0048 0.0079 0.441
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.0083 0.0164
Brugia malayi Peptidase family M1 containing protein 0.0074 0.0175 0.0768
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2729 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0206
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.005 0.0083 0.0083
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0048 0.0079 0.0079
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0201 0.0644 0.0644
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.013 0.0133
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0079 0.0346
Loa Loa (eye worm) hypothetical protein 0.0048 0.0079 0.0155
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0074 0.0175 1
Brugia malayi SRC-1 0.0112 0.0314 0.1375
Mycobacterium ulcerans aminopeptidase N PepN 0.0074 0.0175 0.0693
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0074 0.0175 1
Echinococcus granulosus src region 0.0048 0.0079 0.0079
Onchocerca volvulus 0.005 0.0083 0.2355
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Schistosoma mansoni hypothetical protein 0.005 0.0083 0.0085
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.005 0.0083 0.2355
Brugia malayi hypothetical protein 0.0063 0.0135 0.0591
Entamoeba histolytica SH2-protein kinase domain containing protein 0.005 0.0083 0.4665
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0078 0.019 0.0194
Brugia malayi Fes/CIP4 homology domain containing protein 0.0048 0.0079 0.0346
Echinococcus multilocularis NCK adaptor protein 0.0098 0.0262 0.0262
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0048 0.0079 0.0079
Echinococcus multilocularis suppressor of cytokine signaling 7 0.005 0.0083 0.0083
Brugia malayi TATA binding protein associated factor 0.0074 0.0175 0.0768
Onchocerca volvulus Matrix metalloproteinase homolog 0.0123 0.0354 1
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0135 0.0266
Schistosoma mansoni hypothetical protein 0.005 0.0083 0.0085
Brugia malayi SH3 domain containing protein 0.0048 0.0079 0.0346
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0135 0.0266
Onchocerca volvulus 0.005 0.0083 0.2355
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.005 0.0083 0.0083
Echinococcus multilocularis nostrin 0.0048 0.0079 0.0079
Schistosoma mansoni tyrosine kinase 0.0063 0.0135 0.0137
Echinococcus granulosus tyrosine protein kinase Fyn 0.0112 0.0314 0.0314
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0175 0.0175
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0074 0.0175 1
Onchocerca volvulus Matrilysin homolog 0.0055 0.0105 0.2959
Loa Loa (eye worm) hypothetical protein 0.0238 0.078 0.1536
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0175 0.0175
Loa Loa (eye worm) STAT protein 0.005 0.0083 0.0164
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0175 1
Mycobacterium ulcerans epoxide hydrolase EphA 0.0168 0.0522 1
Echinococcus granulosus tensin 0.005 0.0083 0.0083
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.005 0.0083 0.0164
Echinococcus multilocularis Spectrin alpha actinin 0.0048 0.0079 0.0079
Onchocerca volvulus 0.0048 0.0079 0.2227
Brugia malayi Sex muscle abnormal protein 5 0.0098 0.0262 0.1149
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0112 0.0314 0.0314
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0079 0.441
Brugia malayi Matrixin family protein 0.0134 0.0395 0.1732
Echinococcus multilocularis tyrosine protein kinase Src42A 0.005 0.0083 0.0083
Brugia malayi Peripheral plasma membrane protein CASK 0.0048 0.0079 0.0346
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0079 0.441
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0048 0.0079 0.0079
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.005 0.0083 0.0083
Schistosoma mansoni tensin 0.005 0.0083 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0079 0.45
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.005 0.0083 0.2355
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0079 0.45
Echinococcus multilocularis suppressor of cytokine signaling 7 0.005 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0079 0.45
Echinococcus multilocularis N chimaerin 0.005 0.0083 0.0083
Echinococcus granulosus tyrosine protein kinase ABL1 0.0063 0.0135 0.0135
Trypanosoma brucei Aminopeptidase M1, putative 0.0074 0.0175 1
Brugia malayi Matrixin family protein 0.0055 0.0105 0.0459
Loa Loa (eye worm) hypothetical protein 0.0063 0.0135 0.0266
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0048 0.0079 0.0155
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0098 0.0262 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0079 0.45
Schistosoma mansoni tyrosine kinase 0.0112 0.0314 0.0319
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0075 0.0179 0.0179
Entamoeba histolytica BAR/SH3 domain containing protein 0.0048 0.0079 0.441
Echinococcus multilocularis SH2 domain containing protein 7 0.005 0.0083 0.0083
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0213 0.0687 0.3014
Schistosoma mansoni dynamin-associated protein 0.0048 0.0079 0.008
Brugia malayi SH2 domain containing protein 0.005 0.0083 0.0366
Schistosoma mansoni apoptosis stimulating of P53 0.0048 0.0079 0.008
Entamoeba histolytica hypothetical protein 0.0048 0.0079 0.441
Schistosoma mansoni Dab2-interacting protein-like 0.0048 0.0079 0.008
Onchocerca volvulus 0.0074 0.0175 0.4948
Schistosoma mansoni GTPase activating protein 0.005 0.0083 0.0085
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.005 0.0083 0.0083
Schistosoma mansoni tyrosine kinase 0.2681 0.9821 1
Schistosoma mansoni growth factor receptor-bound protein 0.0098 0.0262 0.0267
Loa Loa (eye worm) hypothetical protein 0.0077 0.0183 0.0361
Loa Loa (eye worm) RhoGAP domain-containing protein 0.005 0.0083 0.0164
Trypanosoma cruzi aminopeptidase, putative 0.0074 0.0175 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0063 0.0135 0.0135
Schistosoma mansoni growth factor receptor-bound protein 0.0098 0.0262 0.0267
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0112 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Mycobacterium ulcerans aminopeptidase N PepN 0.0074 0.0175 0.0693
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0048 0.0079 0.0079
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0074 0.0175 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0175 0.0345
Loa Loa (eye worm) hypothetical protein 0.0048 0.0079 0.0155
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.005 0.0083 0.0085
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0074 0.0175 1
Schistosoma mansoni C-fyn 0.0048 0.0079 0.008
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0175 0.0175
Onchocerca volvulus 0.005 0.0083 0.2355
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0074 0.0175 0.0175
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0048 0.0079 0.2227
Loa Loa (eye worm) matrix metalloproteinase 0.0055 0.0105 0.0206
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0048 0.0079 0.0079
Onchocerca volvulus 0.0063 0.0135 0.3809
Brugia malayi Protein kinase domain containing protein 0.0063 0.0135 0.0591
Brugia malayi hypothetical protein 0.0643 0.228 1
Entamoeba histolytica BAR/SH3 domain containing protein 0.0048 0.0079 0.441
Entamoeba histolytica aminopeptidase, putative 0.0074 0.0175 0.9801
Onchocerca volvulus 0.0063 0.0135 0.3809
Brugia malayi Variant SH3 domain containing protein 0.005 0.0083 0.0366
Brugia malayi hypothetical protein 0.0074 0.0175 0.0768
Echinococcus granulosus suppressor of cytokine signaling 7 0.005 0.0083 0.0083
Onchocerca volvulus 0.0048 0.0079 0.2227
Echinococcus granulosus tyrosine protein kinase Srms 0.0063 0.0135 0.0135
Loa Loa (eye worm) thyroid receptor interactor 0.0048 0.0079 0.0155
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Schistosoma mansoni tensin 0.005 0.0083 0.0085
Schistosoma mansoni cell polarity protein 0.0048 0.0079 0.008
Schistosoma mansoni formin binding protein and related proteins 0.0048 0.0079 0.008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0112 0.0314 0.0314
Echinococcus granulosus SH2 motif 0.005 0.0083 0.0083
Brugia malayi Variant SH3 domain containing protein 0.0098 0.0262 0.1149
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0077 0.0183 0.0361
Echinococcus multilocularis aminopeptidase N 0.0074 0.0175 0.0175
Schistosoma mansoni tyrosine kinase 0.0112 0.0314 0.0319
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.045 0.1567 0.1595
Echinococcus multilocularis SH2 motif 0.005 0.0083 0.0083
Brugia malayi SH2 domain containing protein 0.005 0.0083 0.0366
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0079 0.0346
Loa Loa (eye worm) TK/ABL protein kinase 0.0063 0.0135 0.0266
Brugia malayi STAT protein, DNA binding domain containing protein 0.005 0.0083 0.0366
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0213 0.0687 0.0687
Entamoeba histolytica protein kinase, putative 0.005 0.0083 0.4665
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0112 0.0314 0.0314
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0048 0.0079 0.45
Loa Loa (eye worm) hypothetical protein 0.0098 0.0262 0.0516
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Echinococcus multilocularis SH2 motif 0.005 0.0083 0.0083
Echinococcus granulosus tyrosine kinase 0.0063 0.0135 0.0135
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0098 0.0262 0.0267
Schistosoma mansoni sorbin 0.0048 0.0079 0.008
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0175 0.0175
Onchocerca volvulus 0.005 0.0083 0.2355
Loa Loa (eye worm) guanylate kinase 0.0048 0.0079 0.0155
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0079 0.0346
Echinococcus granulosus SH2 motif 0.005 0.0083 0.0083
Brugia malayi Matrixin family protein 0.0055 0.0105 0.0459
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0112 0.0314 0.0319
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0238 0.078 0.078
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0063 0.0135 0.7544
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0206
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1399 0.5077 0.5169
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0213 0.0687 0.07
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0067 0.0149 0.0655
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0074 0.0175 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0098 0.0262 0.0262
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.005 0.0083 0.0083
Echinococcus granulosus tensin C1 domain containing phosphatase 0.005 0.0083 0.0083
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.005 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0063 0.0135 0.0591
Schistosoma mansoni tensin 0.005 0.0083 0.0085
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0079 0.0346
Echinococcus granulosus c src tyrosine kinase 0.0112 0.0314 0.0314
Echinococcus multilocularis tyrosine kinase 0.0063 0.0135 0.0135
Schistosoma mansoni run and tbc1 domain containing 0.0048 0.0079 0.008
Onchocerca volvulus 0.0063 0.0135 0.3809
Schistosoma mansoni dreadlocks/dock 0.0048 0.0079 0.008
Echinococcus multilocularis intersectin 2 0.0048 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0074 0.0175 0.0345
Schistosoma mansoni tensin-related 0.005 0.0083 0.0085
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0055 0.0105 0.0107
Loa Loa (eye worm) matrixin family protein 0.0123 0.0354 0.0697
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0112 0.0314 0.0314
Schistosoma mansoni signal transduction protein lnk-related 0.005 0.0083 0.0085
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0074 0.0175 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0079 0.45
Echinococcus multilocularis signal transduction protein lnk realted 0.005 0.0083 0.0083
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0048 0.0079 0.008
Echinococcus granulosus SH2 domain containing protein 7 0.005 0.0083 0.0083
Echinococcus granulosus tyrosine kinase 0.0063 0.0135 0.0135
Entamoeba histolytica hypothetical protein 0.0048 0.0079 0.441
Loa Loa (eye worm) hypothetical protein 0.0048 0.0079 0.0155
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0175 0.0175
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0048 0.0079 0.008
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0074 0.0175 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.005 0.0083 0.0085
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0112 0.0314 0.0314
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0112 0.0314 0.0314
Entamoeba histolytica hypothetical protein 0.0048 0.0079 0.441
Schistosoma mansoni hypothetical protein 0.0048 0.0079 0.008
Brugia malayi RhoGAP domain containing protein 0.005 0.0083 0.0366
Echinococcus multilocularis expressed protein 0.0048 0.0079 0.0079
Toxoplasma gondii aminopeptidase N protein 0.0074 0.0175 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0112 0.0314 0.0314
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0135 0.0266
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0063 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0048 0.0079 0.0155
Schistosoma mansoni suppressor of cytokine signaling 0.005 0.0083 0.0085
Onchocerca volvulus Putative cortactin 0.0048 0.0079 0.2227
Brugia malayi cytokine inducible SH2-containing protein 5 0.005 0.0083 0.0366
Mycobacterium leprae PROBABLE HYDROLASE 0.0067 0.0149 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0074 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0206
Loa Loa (eye worm) protein-tyrosine kinase 0.0048 0.0079 0.0155
Echinococcus multilocularis SH2 motif 0.005 0.0083 0.0083
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0048 0.0079 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0079 0.45
Echinococcus granulosus NCK adaptor protein 0.0098 0.0262 0.0262
Brugia malayi tRNA modification GTPase TrmE family protein 0.005 0.0083 0.0366
Loa Loa (eye worm) hypothetical protein 0.0048 0.0079 0.0155
Trypanosoma brucei aminopeptidase, putative 0.0074 0.0175 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.005 0.0083 0.0083
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0074 0.0175 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0083 0.0164
Echinococcus multilocularis suppressor of cytokine signaling 6 0.005 0.0083 0.0083
Loa Loa (eye worm) peptidase family M1 containing protein 0.0074 0.0175 0.0345
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0074 0.0175 0.0178
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0081 0.0199 0.0203
Onchocerca volvulus 0.0048 0.0079 0.2227
Echinococcus granulosus expressed protein 0.0048 0.0079 0.0079
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0079 0.0346
Echinococcus granulosus endophilin A3 0.0048 0.0079 0.0079
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.005 0.0083 0.0083

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0 nM Opioid agonistic activity was measured in guinea pig ileum; infinite ChEMBL. 7205890
IC50 (functional) = 0 nM Opioid agonistic activity was measured in mouse vas deferens; infinite ChEMBL. 7205890
Ke (binding) = 2.35 nM Opioid receptor antagonist activity as inhibiting binding of normorphine to guinea pig ileum ChEMBL. 7205890
Ke (functional) = 9 nM Opioid antagonist activity of compound was measured as inhibiting the binding of normorphine to mouse vas deferens ChEMBL. 7205890
Ke (functional) = 9 nM Opioid antagonist activity of compound was measured as inhibiting the binding of normorphine to mouse vas deferens ChEMBL. 7205890
Ke (functional) = 10.5 nM Opioid antagonist activity of compound was measured as inhibiting the binding of normorphine to mouse vas deferens ChEMBL. 7205890
Ke (functional) = 10.5 nM Opioid antagonist activity of compound was measured as inhibiting the binding of normorphine to mouse vas deferens ChEMBL. 7205890

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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