Detailed information for compound 109587

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 393.358 | Formula: C21H29BrO2
  • H donors: 2 H acceptors: 2 LogP: 5.28 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrCCC[C@@H]1CC2[C@@]([C@@H]1O)(C)CCC1C2CCc2c1ccc(c2)O
  • InChi: 1S/C21H29BrO2/c1-21-9-8-17-16-7-5-15(23)11-13(16)4-6-18(17)19(21)12-14(20(21)24)3-2-10-22/h5,7,11,14,17-20,23-24H,2-4,6,8-10,12H2,1H3/t14-,17?,18?,19?,20+,21+/m1/s1
  • InChiKey: NKYWUIDJPNFZAP-FSFDJYKXSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni peroxidasin 0.0026 0.0119 0.088
Brugia malayi glutathione reductase 0.0039 0.0218 0.0985
Schistosoma mansoni cpg binding protein 0.0031 0.016 0.1213
Echinococcus multilocularis tumor protein p63 0.0326 0.2387 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.2168 1
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0119 0.0227
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0232 0.096
Brugia malayi steroid hormone receptor 0.0041 0.0232 0.1047
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0211 0.0283
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0123 0.0114
Brugia malayi isocitrate dehydrogenase 0.0015 0.0041 0.0184
Echinococcus granulosus peroxidasin 0.0026 0.0119 0.0486
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0211 0.0202
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0073 0.0225
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0444 0.2014
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0009 0.0002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0232 0.1787
Onchocerca volvulus Peroxidase homolog 0.0026 0.0119 0.0227
Onchocerca volvulus 0.0026 0.0119 0.0227
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.007 0.0282
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0119 0.0536
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0087 0.0629
Echinococcus multilocularis geminin 0.0176 0.1255 0.5252
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0027 0.0083
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0073 0.0225
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Brugia malayi hypothetical protein 0.0019 0.007 0.0316
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.004 0.0158
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0027 0.0083
Brugia malayi ecdysteroid receptor 0.0041 0.0232 0.1047
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0119 0.0227
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0119 0.0536
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0444 0.2014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0087 0.0355
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0816 0.3684
Plasmodium falciparum glutathione reductase 0.0039 0.0218 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0241 0.1074
Onchocerca volvulus 0.0048 0.0286 0.1008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2095 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0189 0.0783
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0009 0.0002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1607 0.2236
Onchocerca volvulus 0.0035 0.0189 0.0555
Onchocerca volvulus 0.0047 0.0279 0.0978
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0171
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0218 0.0968
Loa Loa (eye worm) hypothetical protein 0.0021 0.0087 0.0383
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0232 0.1047
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.011 0.0143
Brugia malayi nuclear receptor NHR-88 0.0041 0.0232 0.1047
Mycobacterium ulcerans lipase LipD 0.0035 0.0189 0.018
Loa Loa (eye worm) hypothetical protein 0.0033 0.0174 0.0775
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0226 0.0934
Schistosoma mansoni cpg binding protein 0.0029 0.0147 0.1112
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0592 0.0816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0232 0.1036
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.007 0.0304
Onchocerca volvulus 0.0029 0.0147 0.0362
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.007 0.0282
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0232 0.096
Onchocerca volvulus 0.0041 0.0232 0.0755
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0041 0.0159
Schistosoma mansoni hypothetical protein 0.0176 0.1255 1
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.007 0.0304
Schistosoma mansoni nuclear hormone receptor 0.0019 0.007 0.049
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0116 0.0151
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.012 0.0404
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0592 0.0817
Mycobacterium ulcerans hypothetical protein 0.0035 0.0189 0.018
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0015 0.0041 0.0045
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.007 0.049
Schistosoma mansoni zinc finger protein 0.0019 0.007 0.049
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Brugia malayi nuclear receptor NHR-67 0.0019 0.007 0.0316
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0161 0.0552
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.2168 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0072 0.0089
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.007 0.0282
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1336 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0087 0.0629
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0289 0.1306
Echinococcus granulosus GPCR family 2 0.0015 0.004 0.0158
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0009 0.0002
Onchocerca volvulus 0.0035 0.0189 0.0555
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0027 0.0083
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0444 0.1997
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.2095 0.2074
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0189 0.0253
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0232 0.096
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.007 0.0061
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0027 0.0083
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0119 0.0524
Loa Loa (eye worm) hypothetical protein 0.0021 0.0087 0.0383
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.012 0.4894
Mycobacterium tuberculosis Probable reductase 0.0088 0.0592 0.0817
Brugia malayi beta-lactamase family protein 0.0035 0.0189 0.0854
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0232 0.1787
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0232 0.0755
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0057 0.0176
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.0843
Echinococcus granulosus cpg binding protein 0.0031 0.016 0.066
Trichomonas vaginalis esterase, putative 0.0035 0.0189 0.0783
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0123 0.0161
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0009 0.0002
Schistosoma mansoni nuclear receptor 0.0019 0.007 0.049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0232 0.096
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0444 0.349
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.096 0.716 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0119 0.0536
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0073 0.0225
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0148 0.0608
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0009 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1106 0.1536
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0041 0.0115
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.0843
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0286 0.2223
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0027 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0189 0.0783
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.031 0.1394
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0161 0.0664
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0211 0.0283
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0232 0.096
Trypanosoma brucei cytochrome P450, putative 0.002 0.0078 0.0319
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0087 0.0383
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0119 0.0536
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1336 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Brugia malayi beta-lactamase family protein 0.0035 0.0189 0.0854
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0027 0.0083
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0405 0.3176
Loa Loa (eye worm) hypothetical protein 0.0021 0.0087 0.0383
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0289 0.1306
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.011 0.0101
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.004 0.0183
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0009 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.007 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0232 0.1047
Mycobacterium ulcerans thioesterase TesA 0.0022 0.0095 0.0086
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0211 0.0282
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0189 0.018
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0041 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0232 0.1047
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0027 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0232 0.1047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0161 0.0664
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0377 0.2766 0.2759
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.002 0.0074 0.0236
Brugia malayi CXXC zinc finger family protein 0.0029 0.0147 0.0667
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0232 0.1036
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.007 0.0282
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0027 0.0018
Brugia malayi MH2 domain containing protein 0.0118 0.0816 0.3692
Schistosoma mansoni cpg binding protein 0.0031 0.016 0.1213
Brugia malayi beta-lactamase 0.0035 0.0189 0.0854
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0241 0.1074
Brugia malayi nuclear receptor RXR 0.0021 0.0087 0.0395
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2095 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0232 0.1036
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1036
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0041 0.0147
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0189 0.0253
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0189 0.0783
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0667 0.0921
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0027 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0189 0.0833
Onchocerca volvulus 0.0031 0.0161 0.0425
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.012 0.4894
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0189 0.1444
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0232 0.1787
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.007 0.0316
Loa Loa (eye worm) hypothetical protein 0.0048 0.0286 0.1282
Leishmania major hypothetical protein, conserved 0.0026 0.012 0.0516
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0147 0.0655
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0232 0.096
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.007 0.0086
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0123 0.0159
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0009 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0232 0.096
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0027 0.0083
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.007 0.0304
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.004 0.0171
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0232 0.096
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0009 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0009 0.0002
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0073 0.0225
Echinococcus granulosus geminin 0.0176 0.1255 0.5252
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0126 0.0559
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0232 0.1787
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0232 0.1036
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0189 0.018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0027 0.0083
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.0843
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.007 0.0316
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0074 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2095 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0087 0.0395
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.007 0.0223
Echinococcus granulosus tumor protein p63 0.0326 0.2387 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1036
Toxoplasma gondii thioredoxin reductase 0.0039 0.0218 0.0758
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0189 0.0253
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0985 0.1366
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.007 0.0282
Brugia malayi nuclear hormone receptor 0.0041 0.0232 0.1047
Schistosoma mansoni hypothetical protein 0.0176 0.1255 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.0095 0.012
Loa Loa (eye worm) DR-78 0.0019 0.007 0.0304
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0189 0.0781
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2095 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0078 0.0319
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0667 0.092
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0041 0.0147
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.0843
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0078 0.0069
Trichomonas vaginalis set domain proteins, putative 0.0243 0.176 0.838
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0232 0.1047
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0444 0.185
Mycobacterium tuberculosis Conserved protein 0.0035 0.0189 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0232 0.1047
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0019 0.0074
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0159 0.0706
Mycobacterium tuberculosis Conserved protein 0.0035 0.0189 0.0253
Echinococcus multilocularis peroxidasin 0.0026 0.0119 0.0486
Plasmodium vivax SET domain protein, putative 0.0031 0.0161 0.7027
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0027 0.0065
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.004 0.0158
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0232 0.1047
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0041 0.0047
Brugia malayi Peroxidasin 0.0026 0.0119 0.0536
Brugia malayi hypothetical protein 0.0026 0.012 0.0544
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0028 0.007
Brugia malayi Pre-SET motif family protein 0.0031 0.0161 0.0728
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0377 0.2766 1
Brugia malayi Blistered cuticle protein 3 0.0026 0.0119 0.0536
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Schistosoma mansoni coup transcription factor 0.0041 0.0232 0.1787
Loa Loa (eye worm) glutathione reductase 0.0039 0.0218 0.0974
Loa Loa (eye worm) hypothetical protein 0.0031 0.0161 0.0717
Loa Loa (eye worm) hypothetical protein 0.0043 0.0248 0.1112
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0073 0.0091
Onchocerca volvulus 0.0026 0.0119 0.0227
Schistosoma mansoni nuclear hormone receptor 0.0019 0.007 0.049
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0232 0.1787
Schistosoma mansoni hypothetical protein 0.0015 0.004 0.0253
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0123 0.0161
Schistosoma mansoni nuclear receptor 0.0019 0.007 0.049
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.011 0.0498
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2095 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.011 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2095 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.012 0.4894
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0189 0.0854
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0009 0.0002
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0985 0.1367
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0009 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0161 0.1221
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0123 0.0413
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0009 0.0002
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0009 0.0026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.004 0.0158
Mycobacterium ulcerans polyketide synthase 0.0024 0.011 0.0101
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0444 0.2014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0041 0.0159
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0222 0.0919
Echinococcus multilocularis 0.0011 0.0009 0.0026
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0078 0.0339
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0041 0.0255
Loa Loa (eye worm) hypothetical protein 0.0021 0.0087 0.0383
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0232 0.0755
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0073 0.0225
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0041 0.0147
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.011 0.0143
Brugia malayi Pax transcription factor protein 2 0.0233 0.1678 0.759
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1036
Schistosoma mansoni peroxidasin 0.0026 0.0119 0.088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Loa Loa (eye worm) beta-lactamase 0.0035 0.0189 0.0843
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0027 0.0065
Trichomonas vaginalis C-MYB, putative 0.002 0.0073 0.0225
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0174 0.0786
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0073 0.0225
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0027 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.012 0.0532
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.004 0.0158
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.007 0.0282
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0027 0.0083
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0027 0.0027
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0232 0.1787
Brugia malayi conserved hypotetical protein 0.0019 0.007 0.0316
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0041 0.0046
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0222 0.0919
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0087 0.0355
Mycobacterium ulcerans polyketide synthase 0.0026 0.0123 0.0114
Mycobacterium ulcerans hypothetical protein 0.0157 0.1106 0.1099
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0189 0.0833
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0009 0.0002
Brugia malayi Cytochrome P450 family protein 0.002 0.0078 0.0351
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.007 0.049
Schistosoma mansoni hypothetical protein 0.0015 0.004 0.0253
Leishmania major trypanothione reductase 0.0039 0.0218 0.0968
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Toxoplasma gondii hypothetical protein 0.0048 0.0287 0.1009
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0987 0.4529
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.007 0.049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0027 0.0083
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0073 0.0225
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0232 0.1787
Onchocerca volvulus 0.0026 0.0119 0.0227
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0027 0.0083
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0218 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1036
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0241 0.1074
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0241 0.1074
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0667 0.0921
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0027 0.0083
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0232 0.0755
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0013 0.0043
Schistosoma mansoni hypothetical protein 0.0015 0.004 0.0253
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.012 0.0516
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0119 0.0524
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0123 0.0114
Brugia malayi Pre-SET motif family protein 0.0214 0.1538 0.6955
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1336 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0041 0.0159
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0189 0.0253
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0119 0.0524
Brugia malayi ecdysone receptor 0.0019 0.007 0.0316
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0123 0.0159
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0041 0.0159
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.0843
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.1678 0.7587
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0232 0.1787
Brugia malayi Thioredoxin reductase 0.0039 0.0218 0.0985
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0078 0.0319
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.011 0.0141
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0041 0.0147
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0041 0.0147
Brugia malayi Cytochrome P450 family protein 0.0011 0.0009 0.004
Trichomonas vaginalis MYB, putative 0.002 0.0074 0.0228
Brugia malayi hypothetical protein 0.0026 0.0119 0.0536
Onchocerca volvulus Peroxidase homolog 0.0026 0.0119 0.0227
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0119 0.0524
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0027 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0232 0.1047
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0218 0.0294
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.007 0.0282
Mycobacterium ulcerans polyketide synthase Pks9 0.0015 0.0041 0.0032
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0232 0.096
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0667 0.0921
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0189 0.0252
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0027 0.0122
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0987 0.4529
Brugia malayi Cytochrome P450 family protein 0.0031 0.0159 0.0718
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0009 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0087 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0232 0.1047
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0015 0.0041 0.0032
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0123 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2095 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0592 0.0817
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2168 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0289 0.1295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0232 0.1036
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.007 0.0282
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0116 0.0511
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.007 0.0282
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0041 0.0723
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0041 0.0159
Echinococcus granulosus transcription factor Dp 1 0.004 0.0226 0.0934
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0232 0.1787
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.011 0.0101
Mycobacterium tuberculosis Conserved protein 0.0035 0.0189 0.0253
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0232 0.096
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0377 0.2766 0.2746
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0232 0.1787
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0189 0.8482
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0116 0.0522
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0816 0.3684
Leishmania major cytochrome p450-like protein 0.002 0.0078 0.0319
Onchocerca volvulus Fatty acid synthase homolog 0.0049 0.0292 0.1037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1538 0.6952
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Onchocerca volvulus 0.0035 0.0189 0.0555
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0123 0.0161
Onchocerca volvulus 0.0243 0.176 0.7893
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0041 0.0723
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0232 0.096
Echinococcus multilocularis GPCR, family 2 0.0015 0.004 0.0158
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0074 0.0228
Trichomonas vaginalis C-MYB, putative 0.002 0.0073 0.0225
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0078 0.0339
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.2095 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0985 0.0977
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0081
Leishmania major hypothetical protein, conserved 0.0035 0.0189 0.0833
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1036
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0232 0.1787
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0119 0.0227
Loa Loa (eye worm) hypothetical protein 0.0303 0.2211 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0027 0.0083
Brugia malayi tailless protein 0.0019 0.007 0.0316
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.007 0.0061
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0009 0.0002
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0013 0.0043
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0232 0.1047
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0189 0.0253
Brugia malayi hypothetical protein 0.0019 0.007 0.0316
Loa Loa (eye worm) cytochrome P450 0.0011 0.0009 0.0028
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0592 0.0817
Mycobacterium ulcerans beta-lactamase 0.0035 0.0189 0.018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2095 1
Brugia malayi Latrophilin receptor protein 2 0.0015 0.004 0.0183
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0218 0.0974
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0161 0.1221
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0289 0.1295
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0041 0.0159
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0027 0.0144
Plasmodium vivax glutathione reductase, putative 0.0039 0.0218 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2095 1
Brugia malayi hypothetical protein 0.0303 0.2211 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0189 0.0783
Brugia malayi Nuclear hormone receptor E75 0.0019 0.007 0.0316
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0161 0.1221
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0232 0.1036
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0592 0.0817
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0161 0.1221
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2168 1
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0232 0.096
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0189 0.0843
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0232 0.096
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Giardia lamblia Myb 1-like protein 0.002 0.0074 0.0228
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.007 0.0282
Mycobacterium leprae Probable lipase LipE 0.0035 0.0189 0.0252
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0354 0.1253
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0027 0.0083
Brugia malayi nuclear receptor RXR 0.0019 0.007 0.0316
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0041 0.0184
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.0095 0.0122
Trypanosoma brucei trypanothione reductase 0.0039 0.0218 0.0968
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.011 0.0101
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0119 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0232 0.1047
Brugia malayi hypothetical protein 0.0021 0.0087 0.0395
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0123 0.0161
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0027 0.0101
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0232 0.096
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.011 0.0143
Onchocerca volvulus 0.0025 0.0116 0.0213
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0444 0.2006
Brugia malayi cytochrome P450 0.0011 0.0009 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0189 0.1444
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0232 0.1047
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0041 0.0172
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0377 0.2766 0.3855
Brugia malayi Cytochrome P450 family protein 0.002 0.0078 0.0351
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0232 0.096
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0123 0.0161
Trichomonas vaginalis MYB72, putative 0.002 0.0073 0.0225
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0189 0.0253
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0009 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0232 0.1047
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0009 0.0002
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0232 0.1047
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.012 0.0516
Onchocerca volvulus 0.0233 0.1678 0.7512
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0189 0.0833
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.012 0.0516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0232 0.1036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0444 0.185
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0232 0.1047
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0027 0.0083
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1036
Plasmodium falciparum thioredoxin reductase 0.0039 0.0218 1
Echinococcus multilocularis cpg binding protein 0.0031 0.016 0.066
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0189 0.0781
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0119 0.0227
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0232 0.096
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0232 0.1787
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0119 0.0524
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0027 0.0083
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0049 0.0292 0.1321
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0161 0.0664
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0189 0.0783
Schistosoma mansoni hypothetical protein 0.0033 0.0174 0.1323
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.0843
Loa Loa (eye worm) CYP4Cod1 0.002 0.0078 0.0339
Schistosoma mansoni hypothetical protein 0.0015 0.004 0.0253
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0009 0.0002
Brugia malayi Nuclear hormone receptor E75 0.0019 0.007 0.0316
Brugia malayi hypothetical protein 0.0017 0.0051 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0232 0.1047
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0073 0.0225
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0232 0.096
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0987 0.4529
Loa Loa (eye worm) hypothetical protein 0.0021 0.0087 0.0383
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.007 0.0316
Onchocerca volvulus 0.0303 0.2211 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0304
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0444 0.2014
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0009 0.0002
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0232 0.096
Trichomonas vaginalis MYB3r3, putative 0.002 0.0073 0.0225
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.007 0.0282
Brugia malayi nuclear receptor NHR-88 0.0019 0.007 0.0316
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2095 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0592 0.0817
Mycobacterium ulcerans thioesterase 0.0022 0.0095 0.0086
Brugia malayi nuclear hormone receptor 0.0019 0.007 0.0316
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0444 0.1832
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0232 0.1036
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.007 0.0316
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1036
Brugia malayi hypothetical protein 0.0021 0.0087 0.0395
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0524
Toxoplasma gondii ABC1 family protein 0.0035 0.0189 0.0653
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.011 0.0141
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0189 0.0253
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.096 0.716 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.46 uM Compound was tested for the inhibition of 17-beta-hydroxysteroid dehydrogenase type 1(17-beta-HSD type 1) ChEMBL. No reference
IC50 (binding) = 0.46 uM Inhibition of 17-beta-hydroxysteroid dehydrogenase type 1 expressed in T47D human breast cancer cells using 2 nM [3H]-Estrone ChEMBL. 16134943
Inhibition (binding) = 70 % Compound was tested for the inhibition of 17-beta-hydroxysteroid dehydrogenase type 1(17-beta-HSD type 1) at 1 microM concentration ChEMBL. No reference
Inhibition (binding) = 94 % Compound was tested for the inhibition of 17-beta-hydroxysteroid dehydrogenase type 1(17-beta-HSD type 1) at 10 microM concentration ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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