Detailed information for compound 1095923

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 402.232 | Formula: C15H11BrF3N3S
  • H donors: 2 H acceptors: 0 LogP: 4.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)N/N=C(/c1cccc(c1)Br)\c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C15H11BrF3N3S/c16-12-3-1-2-10(8-12)13(21-22-14(20)23)9-4-6-11(7-5-9)15(17,18)19/h1-8H,(H3,20,22,23)/b21-13+
  • InChiKey: AXNLLLBHXXPCHL-FYJGNVAPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0151 0.0091
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0178 0.0178
Mycobacterium ulcerans lipase LipD 0.0035 0.0465 0.9367
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0465 0.1091
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0493 0.1165
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0076 0.0043
Onchocerca volvulus 0.0029 0.0335 0.016
Mycobacterium tuberculosis Conserved protein 0.0035 0.0465 0.0814
Trichomonas vaginalis esterase, putative 0.0035 0.0465 0.4013
Brugia malayi Cathepsin L-like precursor 0.0032 0.0394 0.0394
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0076 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0394 0.3308
Loa Loa (eye worm) cysteine protease 0.0032 0.0394 0.0336
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0117 0.0117
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0076 0.0369
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0465 0.0814
Onchocerca volvulus 0.0032 0.0394 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0076 0.0158
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0168 0.1067
Loa Loa (eye worm) hypothetical protein 0.0097 0.1982 0.1933
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.1069 1
Giardia lamblia Cathepsin B precursor 0.006 0.1069 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0335 0.0335
Plasmodium falciparum cysteine proteinase falcipain 1 0.0019 0.0076 0.0477
Brugia malayi Cation transporter family protein 0.0064 0.1173 0.1173
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0366 0.0307
Loa Loa (eye worm) ACC-1 protein 0.0064 0.1173 0.1119
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0465 0.0814
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Schistosoma mansoni nAChR subunit 0.0029 0.0335 0.0404
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0394 0.3308
Loa Loa (eye worm) hypothetical protein 0.0034 0.0455 0.0397
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0394 0.09
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0366 0.0307
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0019 0.0076 0.0043
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0465 0.4013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0394 0.3308
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0034 0.0455 0.0455
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0172 0.5
Leishmania major importin beta-1 subunit, putative 0.0023 0.0168 0.1067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0394 0.3308
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.1173 0.1173
Onchocerca volvulus 0.0064 0.1173 0.1013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0168 0.1067
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Schistosoma mansoni importin beta-1 0.0028 0.0297 0.0347
Loa Loa (eye worm) hypothetical protein 0.0034 0.0455 0.0397
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0076 0.0369
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0401 0.7809
Echinococcus multilocularis cathepsin b 0.0171 0.3771 0.3733
Onchocerca volvulus 0.0032 0.0394 0.0221
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0076 0.0043
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0029 0.0335 0.0276
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0366 0.0307
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0117 0.1703
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0076 0.0023
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0394 0.0336
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.3771 0.5454
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0493 0.4284
Onchocerca volvulus 0.0032 0.0394 0.0221
Onchocerca volvulus Putative nachr subunit 0.0427 1 1
Echinococcus multilocularis snurportin 1 0.0298 0.6864 0.6844
Loa Loa (eye worm) hypothetical protein 0.0035 0.0465 0.0407
Brugia malayi Cathepsin L-like precursor 0.0032 0.0394 0.0394
Brugia malayi Cathepsin L-like precursor 0.0032 0.0394 0.0394
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0172 0.2573
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0117 0.0563
Mycobacterium ulcerans beta-lactamase 0.0035 0.0465 0.9367
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.1173 0.1173
Schistosoma mansoni ran 0.0021 0.0117 0.0084
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.1069 1
Loa Loa (eye worm) cathepsin B 0.006 0.1069 0.1015
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0493 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0034 0.0455 0.0455
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0493 0.4284
Brugia malayi hypothetical protein 0.0029 0.0335 0.0335
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0697 0.064
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Echinococcus granulosus cathepsin L cysteine protease 0.0019 0.0076 0.0016
Brugia malayi beta-lactamase family protein 0.0035 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.0035 0.0465 0.0407
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0076 0.0076
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.1587 0.2244
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0034 0.0455 0.0581
Plasmodium vivax vivapain-2 0.0032 0.0394 0.8245
Schistosoma mansoni nAChR subunit 0.0029 0.0335 0.0404
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.021 0.369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0394 0.3308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0394 0.3308
Echinococcus granulosus snurportin 1 0.0298 0.6864 0.6844
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0172 0.1102
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0493 0.1165
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0465 0.0814
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0465 0.4013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0697 0.0935
Brugia malayi Cation transporter family protein 0.0064 0.1173 0.1173
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0172 0.1102
Plasmodium vivax unspecified product 0.0019 0.0076 0.0394
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0335 0.0404
Brugia malayi Cytochrome P450 family protein 0.0022 0.0151 0.0151
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0465 0.4013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0064 0.1173 0.1119
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0076 0.0369
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.1069 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Brugia malayi hypothetical protein 0.0024 0.021 0.021
Entamoeba histolytica Ran family GTPase 0.0021 0.0117 0.1315
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0465 0.4013
Loa Loa (eye worm) acetylcholine receptor protein 0.0029 0.0335 0.0276
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0297 0.234
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0029 0.0335 0.0335
Schistosoma mansoni hypothetical protein 0.0031 0.0366 0.0449
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0493 0.0435
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0401 0.0685
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0427 1 1
Echinococcus multilocularis cathepsin L 0.0019 0.0076 0.0016
Brugia malayi RNA, U transporter 1 0.0079 0.1548 0.1548
Entamoeba histolytica hypothetical protein 0.0023 0.0172 0.2573
Echinococcus granulosus cathepsin l cysteine peptidase 0.0032 0.0394 0.0336
Echinococcus multilocularis geminin 0.0171 0.3764 0.3726
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0064 0.1173 0.1119
Onchocerca volvulus 0.0064 0.1173 0.1013
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.1587 0.1536
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.1173 0.1119
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0394 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0178 0.116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0172 0.3331
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.021 0.4475
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0064 0.1173 0.1119
Loa Loa (eye worm) hypothetical protein 0.0034 0.0455 0.0397
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0178 0.2709
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0465 0.4013
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0394 0.0336
Brugia malayi hypothetical protein 0.0029 0.0335 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.1173 0.1635
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0427 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.1587 0.1587
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0064 0.1173 0.1119
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0064 0.1173 0.1119
Echinococcus multilocularis glycine receptor subunit beta 0.0064 0.1173 0.1119
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0427 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.1173 0.1119
Leishmania major cathepsin L-like protease 0.0032 0.0394 0.3308
Entamoeba histolytica cysteine proteinase 2 0.0019 0.0076 0.0369
Loa Loa (eye worm) ACC-1 protein 0.0064 0.1173 0.1119
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0032 0.0394 0.0336
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.1173 0.1119
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.1173 0.1119
Loa Loa (eye worm) LGC-31 protein 0.0064 0.1173 0.1119
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0076 0.0043
Loa Loa (eye worm) hypothetical protein 0.0034 0.0455 0.0397
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0076 0.0158
Echinococcus multilocularis GPCR, family 2 0.0031 0.0366 0.0307
Mycobacterium ulcerans hypothetical protein 0.0035 0.0465 0.9367
Loa Loa (eye worm) hypothetical protein 0.0023 0.0178 0.0118
Leishmania major cathepsin L-like protease 0.0032 0.0394 0.3308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0394 0.3308
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0117 0.0563
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0168 0.1067
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1982 0.1982
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0493 0.0435
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0064 0.1173 0.1173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0697 0.0935
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Leishmania major GTP-binding protein, putative 0.0021 0.0117 0.0563
Loa Loa (eye worm) hypothetical protein 0.0034 0.0455 0.0397
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Giardia lamblia Cathepsin B precursor 0.006 0.1069 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0465 0.9367
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0465 0.0814
Schistosoma mansoni nAChR subunit 0.0064 0.1173 0.1635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0394 0.3308
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0029 0.0335 0.0276
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0465 0.0465
Echinococcus granulosus cathepsin b 0.0171 0.3771 0.3733
Loa Loa (eye worm) hypothetical protein 0.0031 0.0366 0.0307
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0394 0.0491
Brugia malayi cathepsin B-like cysteine proteinase 0.0171 0.3771 0.3771
Echinococcus multilocularis cysteine protease 0.0032 0.0394 0.0336
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0151 0.0893
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0029 0.0335 0.0276
Onchocerca volvulus 0.0064 0.1173 0.1013
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.021 0.1481
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.1173 0.1173
Echinococcus granulosus nAChR subunit 0.0064 0.1173 0.1119
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0465 0.0407
Onchocerca volvulus 0.0032 0.0394 0.0221
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0029 0.0335 0.0276
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0493 1
Onchocerca volvulus 0.0064 0.1173 0.1013
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0335 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0394 0.3308
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.1234 0.1234
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.1587 0.1536
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.021 0.0403
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0493 0.4284
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0394 0.3308
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0394 0.3308
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0172 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0032 0.0394 0.0336
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0076 0.0076
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0064 0.1173 0.1173
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0697 0.064
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0394 0.7723
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0029 0.0335 0.0335
Schistosoma mansoni nAChR subunit 0.0064 0.1173 0.1635
Onchocerca volvulus 0.0032 0.0394 0.0221
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0117 0.0057
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0465 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0064 0.1173 0.1119
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.5032 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0394 0.3308
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0394 0.0491
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0117 0.0563
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0076 0.0023
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0029 0.0335 0.0335
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0171 0.3771 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Brugia malayi hypothetical protein 0.0029 0.0335 0.0335
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0697 0.0697
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.6864 0.6844
Schistosoma mansoni ran 0.0021 0.0117 0.0084
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.1069 0.2719
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0366 0.0366
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0465 0.0407
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.3771 0.5454
Schistosoma mansoni nAChR subunit 0.0064 0.1173 0.1635
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.021 0.0403
Brugia malayi MH2 domain containing protein 0.0118 0.2475 0.2475
Loa Loa (eye worm) hypothetical protein 0.0066 0.1234 0.118
Entamoeba histolytica cysteine protease, putative 0.0032 0.0394 0.7723
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0029 0.0335 0.0276
Echinococcus multilocularis glycine receptor subunit beta 0.0064 0.1173 0.1119
Schistosoma mansoni neurotransmitter gated ion channel 0.0034 0.0455 0.0581
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.021 0.1481
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0465 0.9367
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0064 0.1173 0.1635
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0465 0.1091
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0297 0.0237
Loa Loa (eye worm) hypothetical protein 0.0035 0.0465 0.0407
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0151 0.0091
Brugia malayi Inositol-1 0.0036 0.0493 0.0493
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0029 0.0335 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0427 1 1
Trypanosoma cruzi cysteine protease, putative 0.0019 0.0076 0.0043
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.1173 0.1635
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0297 0.234
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0168 0.029
Echinococcus granulosus GPCR family 2 0.0031 0.0366 0.0307
Mycobacterium tuberculosis Conserved protein 0.0035 0.0465 0.0814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0178 0.116
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0394 0.09
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0064 0.1173 0.1119
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.3771 0.5454
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0064 0.1173 0.1119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0493 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0465 1
Schistosoma mansoni hypothetical protein 0.0171 0.3764 0.5443
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0064 0.1173 0.1119
Loa Loa (eye worm) GABA receptor subunit 0.0034 0.0455 0.0397
Leishmania major hypothetical protein, conserved 0.0024 0.021 0.1481
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0064 0.1173 0.1119
Brugia malayi Cathepsin L-like precursor 0.0032 0.0394 0.0394
Schistosoma mansoni nAChR subunit 0.0064 0.1173 0.1635
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0697 0.0935
Onchocerca volvulus 0.0032 0.0394 0.0221
Schistosoma mansoni acetylcholine receptor-related 0.0029 0.0335 0.0404
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0394 0.09
Loa Loa (eye worm) beta-lactamase 0.0035 0.0465 0.0407
Plasmodium vivax vivapain-2 0.0032 0.0394 0.8245
Onchocerca volvulus 0.0035 0.0465 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Loa Loa (eye worm) hypothetical protein 0.0081 0.1587 0.1536
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.1173 0.1173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0394 0.3308
Echinococcus multilocularis nAChR subunit 0.0034 0.0455 0.0397
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0465 0.4013
Schistosoma mansoni hypothetical protein 0.0031 0.0366 0.0449
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0465 0.0407
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Loa Loa (eye worm) hypothetical protein 0.0034 0.0455 0.0397
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.1069 0.1483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0394 0.3308
Onchocerca volvulus 0.0064 0.1173 0.1013
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0172 0.2746
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0172 0.2573
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.1173 0.1173
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Onchocerca volvulus 0.0034 0.0455 0.0283
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0394 0.0336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Onchocerca volvulus Cathepsin F homolog 0.0032 0.0394 0.0221
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0064 0.1173 0.1173
Loa Loa (eye worm) hypothetical protein 0.0427 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0032 0.0394 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.3771 0.3733
Mycobacterium leprae Probable lipase LipE 0.0035 0.0465 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0465 0.0595
Echinococcus granulosus geminin 0.0171 0.3764 0.3726
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0064 0.1173 0.1119
Plasmodium vivax importin-beta 2, putative 0.0028 0.0297 0.5831
Echinococcus multilocularis nAChR subunit 0.0064 0.1173 0.1119
Echinococcus granulosus cathepsin l1 0.0032 0.0394 0.0336
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0151 0.2084
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.1173 0.1173
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0064 0.1173 0.1119
Schistosoma mansoni inositol monophosphatase 0.0036 0.0493 0.0635
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0427 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0335 0.0335
Schistosoma mansoni hypothetical protein 0.0031 0.0366 0.0449
Loa Loa (eye worm) hypothetical protein 0.0034 0.0455 0.0397
Brugia malayi Cation transporter family protein 0.0064 0.1173 0.1173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0394 0.3308
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0493 0.4284
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Plasmodium vivax vivapain-3 0.0019 0.0076 0.0394
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0427 1 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.0178 0.0178
Plasmodium falciparum cysteine proteinase falcipain 3 0.0032 0.0394 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0394 0.3308
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.1173 0.1119
Echinococcus granulosus glycine receptor subunit beta 0.0064 0.1173 0.1119
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0023 0.0178 0.0315
Onchocerca volvulus 0.0064 0.1173 0.1013
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0394 0.0221
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0064 0.1173 0.1173
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0035 0.0465 0.0407
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Loa Loa (eye worm) ctsf protein 0.0032 0.0394 0.0336
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0335 0.0404
Echinococcus granulosus importin subunit beta 1 0.0028 0.0297 0.0237
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0064 0.1173 0.1635
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0117 0.0057
Leishmania major cysteine peptidase A (CPA) 0.0032 0.0394 0.3308
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0151 0.0243
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0394 0.3308
Brugia malayi Importin beta-1 subunit 0.0028 0.0297 0.0297
Leishmania major cathepsin L-like protease 0.0032 0.0394 0.3308
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Leishmania major cathepsin L-like protease 0.0032 0.0394 0.3308
Onchocerca volvulus 0.0029 0.0335 0.016
Entamoeba histolytica cysteine proteinase 1, putative 0.0019 0.0076 0.0369
Echinococcus granulosus cathepsin L 0.0019 0.0076 0.0016
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.1173 0.1635
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0297 0.234
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0171 0.3771 0.5454
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Onchocerca volvulus 0.0034 0.0455 0.0283
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Schistosoma mansoni nAChR subunit 0.0064 0.1173 0.1635
Leishmania major cathepsin L-like protease 0.0032 0.0394 0.3308
Loa Loa (eye worm) hypothetical protein 0.0034 0.0455 0.0397
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0064 0.1173 0.1119
Brugia malayi Cytochrome P450 family protein 0.0034 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Brugia malayi Cathepsin L-like precursor 0.0023 0.0178 0.0178
Schistosoma mansoni nAChR subunit 0.0064 0.1173 0.1635
Loa Loa (eye worm) hypothetical protein 0.0023 0.0178 0.0118
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2475 0.2429
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0366 0.0307
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0032 0.0394 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0465 0.0407
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0465 0.0814
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1982 0.1933
Giardia lamblia Cathepsin B precursor 0.006 0.1069 1
Loa Loa (eye worm) fibroinase 0.0032 0.0394 0.0336
Plasmodium vivax vivapain-1 0.0019 0.0076 0.0394
Loa Loa (eye worm) hypothetical protein 0.0035 0.0465 0.0407
Trichomonas vaginalis ran, putative 0.0021 0.0117 0.0563
Schistosoma mansoni hypothetical protein 0.0298 0.6864 1
Leishmania major cathepsin L-like protease 0.0032 0.0394 0.3308
Brugia malayi Cathepsin L-like precursor 0.0032 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0032 0.0394 0.0336
Leishmania major cytochrome p450-like protein 0.0022 0.0151 0.0893
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0151 0.0243
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0064 0.1173 0.1173
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0434 0.0376
Echinococcus multilocularis cysteine protease 0.0032 0.0394 0.0336
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0172 0.2573
Onchocerca volvulus 0.0029 0.0335 0.016
Toxoplasma gondii cathepsin B 0.006 0.1069 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0394 0.3308
Trypanosoma cruzi cruzipain precursor, putative 0.0032 0.0394 0.09
Echinococcus granulosus cysteine protease 0.0019 0.0076 0.0016
Echinococcus granulosus glycine receptor subunit beta 0.0064 0.1173 0.1119
Echinococcus multilocularis cathepsin b 0.0171 0.3771 0.3733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0394 0.3308
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0697 0.064
Leishmania major cathepsin L-like protease 0.0032 0.0394 0.3308
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0172 0.1102
Leishmania major hypothetical protein, conserved 0.0035 0.0465 0.4013
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0064 0.1173 0.1119
Onchocerca volvulus 0.0032 0.0394 0.0221
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0117 0.1404
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0465 0.0595
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0493 0.4284
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0366 0.0307
Loa Loa (eye worm) inositol-1 0.0036 0.0493 0.0435
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0394 0.0336
Brugia malayi excitatory GABA receptor EXP-1A 0.0064 0.1173 0.1173
Brugia malayi Cytochrome P450 family protein 0.0022 0.0151 0.0151
Onchocerca volvulus 0.0081 0.1587 0.1435
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0465 0.0814
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0493 0.4284
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Loa Loa (eye worm) hypothetical protein 0.0024 0.021 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0172 0.0224
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.1173 0.1119
Loa Loa (eye worm) hypothetical protein 0.0028 0.0297 0.0237
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0151 0.0091
Loa Loa (eye worm) hypothetical protein 0.0023 0.0178 0.0118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1982 0.1982
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0394 0.3308
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0697 0.064
Onchocerca volvulus 0.0035 0.0465 0.0293
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.1173 0.1173
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.1173 0.1173
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.006 0.006
Brugia malayi beta-lactamase 0.0035 0.0465 0.0465
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.1173 0.1173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0394 0.3308
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0394 0.7723
Loa Loa (eye worm) hypothetical protein 0.0034 0.0455 0.0397
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0697 0.064
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0064 0.1173 0.1173
Schistosoma mansoni acetylcholine receptor subunit beta 0.0029 0.0335 0.0404
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0394 0.0221
Schistosoma mansoni inositol monophosphatase 0.0036 0.0493 0.0635
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0178 0.0172
Brugia malayi hypothetical protein 0.0029 0.0335 0.0335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0394 0.3308
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Schistosoma mansoni hypothetical protein 0.0171 0.3764 0.5443
Echinococcus granulosus cathepsin l1 0.0023 0.0178 0.0118
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.0455 0.0455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0076 0.0158
Brugia malayi Cathepsin L-like precursor 0.0032 0.0394 0.0394
Mycobacterium tuberculosis Conserved protein 0.0035 0.0465 0.0814
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0029 0.0335 0.0276
Entamoeba histolytica hypothetical protein 0.0023 0.0168 0.2492
Schistosoma mansoni hypothetical protein 0.0066 0.1234 0.1725
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.021 0.4475
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0117 0.0153
Schistosoma mansoni hypothetical protein 0.0031 0.0366 0.0449
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0394 0.0336
Echinococcus granulosus cathepsin b 0.0171 0.3771 0.3733
Toxoplasma gondii ABC1 family protein 0.0035 0.0465 0.4013
Brugia malayi beta-lactamase family protein 0.0035 0.0465 0.0465
Toxoplasma gondii cathepsin CPL 0.0032 0.0394 0.3308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0117 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0394 0.09
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0465 0.0814
Onchocerca volvulus 0.0035 0.0465 0.0293
Echinococcus granulosus nAChR subunit 0.0034 0.0455 0.0397
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2475 0.2429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0394 0.3308
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0427 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0076 0.0158
Brugia malayi cathepsin L-like precursor 0.0023 0.0178 0.0178
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0076 0.0369
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0064 0.1173 0.1635
Schistosoma mansoni nAChR subunit 0.0064 0.1173 0.1635
Entamoeba histolytica cysteine protease, putative 0.0019 0.0076 0.0369
Loa Loa (eye worm) hypothetical protein 0.0064 0.1173 0.1119
Plasmodium falciparum importin beta, putative 0.0028 0.0297 0.7072
Entamoeba histolytica hypothetical protein 0.0034 0.0455 0.9139
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0172 0.1102
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0117 0.0153
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0034 0.0455 0.0581
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0029 0.0335 0.0276
Brugia malayi hypothetical protein 0.0029 0.0335 0.0335
Leishmania major cathepsin L-like protease 0.0032 0.0394 0.3308

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 521 nM Inhibition of human liver cathepsin L ChEMBL. 20089402
IC50 (binding) > 10000 nM Inhibition of human liver cathepsin B ChEMBL. 20089402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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