Detailed information for compound 1095968

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.875 | Formula: C20H22ClN5O
  • H donors: 3 H acceptors: 2 LogP: 2.31 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CNC(=O)C1(N)CCN(CC1)c1ccnc2c1cc[nH]2
  • InChi: 1S/C20H22ClN5O/c21-15-3-1-14(2-4-15)13-25-19(27)20(22)7-11-26(12-8-20)17-6-10-24-18-16(17)5-9-23-18/h1-6,9-10H,7-8,11-13,22H2,(H,23,24)(H,25,27)
  • InChiKey: WPDHASUWSYKMLT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References
Homo sapiens v-akt murine thymoma viral oncogene homolog 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.003 0.296 0.2907
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0787 0.0716
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0787 0.0774
Echinococcus multilocularis serine threonine protein kinase 0.003 0.296 0.3143
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0058 0.6267 0.6746
Loa Loa (eye worm) hypothetical protein 0.003 0.296 0.2907
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0152 0.0077
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0787 0.0774
Loa Loa (eye worm) hypothetical protein 0.0029 0.2806 0.2751
Trichomonas vaginalis AGC family protein kinase 0.003 0.296 0.2725
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0152 0.0164
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.003 0.296 0.2907
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0787 0.0716
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0787 0.0774
Echinococcus multilocularis Protein kinase C, brain isozyme 0.003 0.296 0.3143
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.003 0.296 0.2907
Brugia malayi nuclear hormone receptor 0.0012 0.0787 0.0716
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0787 0.0774
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0058 0.6267 0.5
Echinococcus multilocularis nervana 2 0.0058 0.6191 0.6663
Loa Loa (eye worm) histone methyltransferase 0.001 0.0646 0.0575
Schistosoma mansoni serine/threonine protein kinase 0.003 0.296 0.3199
Echinococcus multilocularis lamin 0.0062 0.6689 0.7205
Onchocerca volvulus 0.0012 0.0787 0.1075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0787 0.0774
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0076 0.0082
Onchocerca volvulus 0.0062 0.6689 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.003 0.296 0.2907
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.003 0.296 0.3143
Echinococcus granulosus serine/threonine protein kinase 0.0061 0.6557 0.7061
Entamoeba histolytica protein kinase, putative 0.009 1 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.009 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.0152 0.0077
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0076 0.0082
Echinococcus multilocularis rac serine:threonine kinase 0.0061 0.6557 0.7061
Schistosoma mansoni cpg binding protein 0.0035 0.3559 0.3845
Schistosoma mansoni atypical protein kinase C 0.003 0.296 0.3199
Brugia malayi CXXC zinc finger family protein 0.0033 0.3336 0.3285
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.003 0.296 0.3143
Echinococcus granulosus serine threonine protein kinase nrc 0.0058 0.6267 0.6746
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.6557 0.5109
Trichomonas vaginalis AGC family protein kinase 0.003 0.296 0.2725
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0787 0.0716
Loa Loa (eye worm) hypothetical protein 0.0012 0.0787 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0787 0.0716
Brugia malayi intermediate filament protein 0.0062 0.6689 0.6664
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0029 0.2885 0.2646
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0787 0.0774
Brugia malayi nuclear receptor NHR-88 0.0012 0.0787 0.0716
Trichomonas vaginalis AGC family protein kinase 0.009 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.2939 0.2885
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0061 0.6557 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0409 0.0363
Schistosoma mansoni nuclear receptor 0.0005 0.0076 0.0082
Echinococcus granulosus Glutaredoxin protein 5 0.0058 0.6191 0.6663
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0152 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0787 0.0716
Loa Loa (eye worm) hypothetical protein 0.0006 0.0152 0.0077
Brugia malayi Protein kinase domain containing protein 0.003 0.296 0.2907
Schistosoma mansoni serine/threonine-protein kinase 0.0061 0.6557 0.7086
Loa Loa (eye worm) hypothetical protein 0.0006 0.0152 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0787 0.0774
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0084 0.9254 1
Echinococcus granulosus intermediate filament protein 0.0062 0.6689 0.7205
Brugia malayi nuclear receptor RXR 0.0006 0.0152 0.0077
Onchocerca volvulus 0.0033 0.3336 0.493
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0058 0.6191 0.6663
Loa Loa (eye worm) intermediate filament protein 0.0062 0.6689 0.6664
Trichomonas vaginalis AGC family protein kinase 0.009 1 1
Schistosoma mansoni cpg binding protein 0.0033 0.3336 0.3605
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0787 0.0716
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.003 0.296 0.3143
Schistosoma mansoni serine/threonine protein kinase 0.003 0.296 0.3199
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.2939 0.3119
Entamoeba histolytica hypothetical protein 0.0084 0.9254 0.894
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0787 0.0716
Brugia malayi ecdysteroid receptor 0.0012 0.0787 0.0716
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0631 0.0559
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0088 0.971 0.9708
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0152 0.0164
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0076 0.0082
Trichomonas vaginalis AGC family protein kinase 0.009 1 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0058 0.6267 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0787 0.0716
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0787 0.0774
Schistosoma mansoni serine/threonine-protein kinase 0.0061 0.6557 0.7086
Schistosoma mansoni serine/threonine kinase 0.003 0.296 0.3199
Loa Loa (eye worm) hypothetical protein 0.0006 0.0152 0.0077
Echinococcus granulosus nervana 2 0.0058 0.6191 0.6663
Trichomonas vaginalis AGC family protein kinase 0.009 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0084 0.9254 1
Entamoeba histolytica hypothetical protein 0.0084 0.9254 0.894
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0787 0.0774
Brugia malayi hypothetical protein 0.0006 0.0152 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.003 0.296 0.3199
Schistosoma mansoni serine/threonine protein kinase 0.003 0.296 0.3199
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0409 0.0442
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0787 0.085
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0787 0.085
Schistosoma mansoni cpg binding protein 0.0035 0.3559 0.3845
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0787 0.0716
Trypanosoma cruzi Protein kinase B 0.0061 0.6557 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0787 0.1075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0787 0.0716
Toxoplasma gondii AGC kinase 0.0088 0.971 1
Trichomonas vaginalis AGC family protein kinase 0.003 0.296 0.2725
Loa Loa (eye worm) hypothetical protein 0.0006 0.0152 0.0077
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.6689 0.6664
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0787 0.085
Schistosoma mansoni lamin 0.0062 0.6689 0.7228
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0787 0.0774
Loa Loa (eye worm) hypothetical protein 0.0012 0.0787 0.0716
Schistosoma mansoni serine/threonine protein kinase 0.003 0.296 0.3199
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.003 0.296 0.3143
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0076 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0787 0.0716
Schistosoma mansoni hypothetical protein 0.0084 0.9254 1
Echinococcus multilocularis protein kinase c iota type 0.003 0.296 0.3143
Trichomonas vaginalis AGC family protein kinase 0.009 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2806 0.2751
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0409 0.0363
Onchocerca volvulus 0.0062 0.6689 1
Entamoeba histolytica hypothetical protein 0.0084 0.9254 0.894
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.003 0.296 0.3143
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0787 0.0716
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0787 0.085
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.003 0.296 0.3143
Loa Loa (eye worm) hypothetical protein 0.0061 0.6556 0.653
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.2939 0.3119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0787 0.0716
Echinococcus granulosus protein kinase c epsilon type 0.003 0.296 0.3143
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0787 0.085
Echinococcus multilocularis musashi 0.0062 0.6689 0.7205
Echinococcus granulosus protein kinase c iota type 0.003 0.296 0.3143
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.3336 0.3285
Schistosoma mansoni zinc finger protein 0.0005 0.0076 0.0082
Echinococcus granulosus lamin 0.0062 0.6689 0.7205
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0787 0.085
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0787 0.0716
Brugia malayi protein kinase C II. 0.003 0.296 0.2907
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0787 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0787 0.0716
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0787 0.1075
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.3324 0.3273
Entamoeba histolytica protein kinase 2, putative 0.0058 0.6267 0.4697
Echinococcus multilocularis nervana 2 0.0058 0.6191 0.6663
Brugia malayi hypothetical protein 0.0006 0.0152 0.0077
Echinococcus granulosus Protein kinase C brain isozyme 0.003 0.296 0.3143
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0787 0.0774
Schistosoma mansoni serine/threonine protein kinase 0.003 0.296 0.3199
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0787 0.0774
Schistosoma mansoni coup transcription factor 0.0012 0.0787 0.085
Echinococcus granulosus NDR protein kinase 0.003 0.296 0.3143
Giardia lamblia Kinase, AGC PKA 0.0058 0.6267 0.5
Echinococcus multilocularis protein kinase c epsilon type 0.003 0.296 0.3143
Echinococcus multilocularis Glutaredoxin protein 5 0.0058 0.6191 0.6663
Loa Loa (eye worm) hypothetical protein 0.0012 0.0787 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0787 0.0716
Echinococcus granulosus protein kinase C gamma type 0.003 0.296 0.3143
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0787 0.0716
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0787 0.1075
Echinococcus granulosus lamin dm0 0.0062 0.6689 0.7205
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0409 0.0363
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0152 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.003 0.296 0.3199
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.6557 0.5109
Schistosoma mansoni intermediate filament proteins 0.0062 0.6689 0.7228
Entamoeba histolytica protein kinase, putative 0.0088 0.971 0.9589
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0787 0.0716
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0787 0.0774
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0646 0.0622
Brugia malayi hypothetical protein 0.0084 0.9254 0.9248
Trichomonas vaginalis AGC family protein kinase 0.009 1 1
Echinococcus multilocularis lamin dm0 0.0062 0.6689 0.7205
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0152 0.0083
Echinococcus multilocularis serine:threonine protein kinase N2 0.003 0.296 0.3143
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0058 0.6191 0.6663
Echinococcus multilocularis serine:threonine protein kinase 38 0.003 0.296 0.3143
Loa Loa (eye worm) AGC/PKN protein kinase 0.003 0.296 0.2907
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0787 0.085
Loa Loa (eye worm) AGC/AKT protein kinase 0.009 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0787 0.0716
Echinococcus granulosus cpg binding protein 0.0035 0.3559 0.3794
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0787 0.085
Echinococcus multilocularis cpg binding protein 0.0035 0.3559 0.3794
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0787 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0787 0.0716
Loa Loa (eye worm) hypothetical protein 0.0062 0.6689 0.6664
Loa Loa (eye worm) hypothetical protein 0.0012 0.0787 0.0716
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0787 0.0774
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0787 0.0716
Entamoeba histolytica hypothetical protein 0.0084 0.9254 0.894
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0787 0.0716
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0787 0.085
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0787 0.085
Brugia malayi p70 ribosomal S6 kinase beta 0.0088 0.971 0.9708
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0787 0.0774
Echinococcus granulosus nervana 2 0.0058 0.6191 0.6663
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0409 0.0363
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0152 0.0077
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0058 0.6267 0.6746
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0787 0.0774
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0787 0.0774
Trichomonas vaginalis AGC family protein kinase 0.009 1 1
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0076 0.0082
Trichomonas vaginalis AGC family protein kinase 0.0033 0.325 0.3024
Brugia malayi Hr1 repeat family protein 0.003 0.296 0.2907
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0646 0.0622
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.7703 0.8324
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0787 0.085
Schistosoma mansoni nuclear receptor 0.0005 0.0076 0.0082
Schistosoma mansoni transcription factor LCR-F1 0.0084 0.9254 1
Entamoeba histolytica protein kinase, putative 0.009 1 1
Schistosoma mansoni lamin 0.0062 0.6689 0.7228
Loa Loa (eye worm) hypothetical protein 0.0012 0.0787 0.0716
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.3324 0.3273
Echinococcus granulosus serine:threonine protein kinase N2 0.003 0.296 0.3143
Brugia malayi steroid hormone receptor 0.0012 0.0787 0.0716
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0787 0.0716
Loa Loa (eye worm) hypothetical protein 0.0012 0.0787 0.0716
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0787 0.0774
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0787 0.0716
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.6689 0.6664
Echinococcus multilocularis serine:threonine protein kinase N2 0.003 0.296 0.3143
Loa Loa (eye worm) AGC/NDR protein kinase 0.003 0.296 0.2907
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.003 0.296 0.2907
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0787 0.085

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) Inhibition of PKB in human PC3M cells assessed as GSK3-beta phosphorylation by ELISA ChEMBL. 20151677
IC50 (functional) = 7.2 nM Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISA ChEMBL. 20151677
IC50 (binding) = 12 nM Inhibition of PKBbeta by radiometric filter binding assay ChEMBL. 20151677

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.