Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0066 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.2085 | 0.2085 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2085 | 0.2085 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.2085 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2085 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.2085 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.2085 | 0.2085 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2085 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2085 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.2085 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0007 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.2085 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2085 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.2085 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.2085 | 0.2085 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.2085 | 0.2085 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.2085 | 0.2085 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.2085 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.2085 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.2085 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2085 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2085 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.2085 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 10 nM | Estrogenic activity at ERalpha in human Ishikawa cells assessed as stimulation of alkaline phosphatase activity after 4 days by microplate scanning spectrophotometry | ChEMBL. | 20031420 |
IC50 (binding) | Antiestrogenic activity at ERalpha in human Ishikawa cells assessed as alkaline phosphatase activity after 4 days by microplate scanning spectrophotometry | ChEMBL. | 20031420 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.