Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | platelet-derived growth factor receptor, beta polypeptide | References | |
Homo sapiens | platelet-derived growth factor receptor, alpha polypeptide | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0018 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.4038 | 0.4038 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0353 | 0.4038 | 0.4038 |
Schistosoma mansoni | patched 1 | 0.0353 | 0.4038 | 0.4038 |
Echinococcus granulosus | roundabout 2 | 0.0023 | 0.0133 | 0.0133 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0353 | 0.4038 | 0.4038 |
Brugia malayi | CHE-14 protein | 0.0353 | 0.4038 | 0.4038 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0858 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0353 | 0.4038 | 0.4038 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0133 | 0.0133 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0353 | 0.4038 | 0.4038 |
Schistosoma mansoni | tyrosine kinase | 0.0014 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0018 | 0.0074 | 0.0074 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0353 | 0.4038 | 0.4038 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0403 | 0.462 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0019 | 0.0089 | 0.0089 |
Echinococcus multilocularis | neuroglian | 0.0019 | 0.0089 | 0.0089 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0353 | 0.4038 | 0.4038 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0858 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0042 | 0.0042 |
Echinococcus multilocularis | protein patched | 0.0353 | 0.4038 | 0.4038 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0858 | 1 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0042 | 0.0042 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0858 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0858 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0858 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0858 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0858 | 1 | 1 |
Schistosoma mansoni | nephrin | 0.0019 | 0.0089 | 0.0089 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0353 | 0.4038 | 0.4038 |
Echinococcus multilocularis | roundabout 2 | 0.0023 | 0.0133 | 0.0133 |
Echinococcus multilocularis | protein dispatched 1 | 0.0353 | 0.4038 | 0.4038 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0403 | 0.462 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0133 | 0.0133 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0403 | 0.462 | 1 |
Echinococcus granulosus | twitchin | 0.0019 | 0.0089 | 0.0089 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0403 | 0.462 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 uM | Inhibition of human PDGF receptor phosphorylation; 1-2 | ChEMBL. | 8035419 |
IC50 (binding) | = 2 uM | Inhibition of human PDGF receptor phosphorylation; 1-2 | ChEMBL. | 8035419 |
IC50 (binding) | > 20 uM | Concentration required to inhibit phosphorylation of isolated human epidermal growth factor tyrosine kinase receptor by 50% | ChEMBL. | 8035419 |
IC50 (binding) | > 20 uM | Concentration required to inhibit phosphorylation of isolated human epidermal growth factor tyrosine kinase receptor by 50% | ChEMBL. | 8035419 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.