Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | No references |
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0072 | 0 | 0.5 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0426 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0426 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0426 | 1 | 1 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0426 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0072 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0426 | 1 | 1 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0072 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0426 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0426 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0426 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0426 | 1 | 1 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0426 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0072 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.03 uM | Inhibitory activity against human COX-2 expressed in baculovirus infected Sf9 cells | ChEMBL. | No reference |
IC50 (binding) | = 0.03 uM | Inhibitory activity against human COX-2 expressed in baculovirus infected Sf9 cells | ChEMBL. | No reference |
IC50 (binding) | = 1.3 uM | Inhibitory activity against human COX-1 expressed in baculovirus infected Sf9 cells | ChEMBL. | No reference |
IC50 (binding) | = 1.3 uM | Inhibitory activity against human COX-1 expressed in baculovirus infected Sf9 cells | ChEMBL. | No reference |
Ratio (binding) | = 43 | Ratio of IC50 values against human COX-2 and COX-1 | ChEMBL. | No reference |
Ratio (binding) | = 43 | Ratio of IC50 values against human COX-2 and COX-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.