TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 337.29 | Formula: C16H11N5O4
H donors: 0 H acceptors: 6 LogP: 1.6 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1ccc(cc1)n1c(=O)c2c(c1=O)c1c(C)nn(c1nc2)C
InChi: 1S/C16H11N5O4/c1-8-12-13-11(7-17-14(12)19(2)18-8)15(22)20(16(13)23)9-3-5-10(6-4-9)21(24)25/h3-7H,1-2H3
InChiKey: HJABVSGNZPQQEY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.078	0.0672
Echinococcus multilocularis	cpg binding protein	0.0033	0.0462	0.035
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.078	0.1759
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0243	0.0294
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.0026	0.0317	0.1198
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0243	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0243	0.0294
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0243	0.0294
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0089	0.1791	0.6776
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0243	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0169	0.3659	0.8249
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0021	0.0192	0.5
Onchocerca volvulus	Fatty acid synthase homolog	0.0152	0.325	0.6206
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0243	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.0548
Schistosoma mansoni	hypothetical protein	0.0039	0.0601	0.0491
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0243	0.0294
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.102	0.2092
Mycobacterium ulcerans	polyketide synthase Pks13	0.0126	0.2643	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.4436	1
Giardia lamblia	Methyltransferase like 2	0.0025	0.0291	0.5
Schistosoma mansoni	hypothetical protein	0.0199	0.4349	0.4283
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0243	0.0294
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.102	0.2299
Loa Loa (eye worm)	hypothetical protein	0.0053	0.093	0.2096
Mycobacterium tuberculosis	Probable polyketide synthase Pks17	0.0021	0.0179	0.0678
Trypanosoma brucei	hypothetical protein, conserved	0.0229	0.5056	1
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0026	0.0315	0.0252
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0243	0.0294
Mycobacterium ulcerans	polyketide synthase	0.0084	0.1668	0.6023
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0243	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.0548
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0082	0.1608	0.6084
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0243	0.0294
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0089	0.1791	0.6522
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0243	0.0129
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0243	0.0129
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0182	0.3963	0.3892
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0243	0.0129
Brugia malayi	ecdysteroid receptor	0.0023	0.0243	0.0294
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.078	0.0672
Loa Loa (eye worm)	acyl carrier protein	0.0039	0.0604	0.1361
Brugia malayi	AMP-binding enzyme family protein	0.0079	0.1539	0.3294
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.1257	0.1154
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0243	0.0129
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0243	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0243	0.0294
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0061	0.1113	0.4212
Schistosoma mansoni	hypothetical protein	0.0281	0.6277	0.6234
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0243	0.0129
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.035	0.0237
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0089	0.1791	0.6776
Trichomonas vaginalis	set domain proteins, putative	0.023	0.5088	1
Echinococcus multilocularis	muscleblind protein 1	0.0169	0.3659	0.3585
Echinococcus multilocularis	geminin	0.0199	0.4349	0.4283
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0391	0.0278
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0089	0.1791	0.6776
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0243	0.0129
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0084	0.1668	0.3593
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0243	0.0129
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0243	0.0129
Echinococcus granulosus	cpg binding protein	0.0033	0.0462	0.035
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.0548
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.093	0.0823
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0243	0.0129
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0079	0.1539	0.5823
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0391	0.0278
Mycobacterium ulcerans	thioesterase TesA	0.007	0.134	0.4682
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.093	0.0823
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.093	0.1884
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0126	0.2643	1
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0029	0.0375	0.1419
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0391	0.0278
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0391	0.0278
Mycobacterium tuberculosis	Polyketide synthetase MbtD (polyketide synthase)	0.0026	0.0304	0.1149
Schistosoma mansoni	cpg binding protein	0.0033	0.0462	0.035
Echinococcus multilocularis	3 oxoacyl (acyl carrier protein) synthase	0.0021	0.0192	0.0077
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0243	0.0294
Schistosoma mansoni	cpg binding protein	0.0031	0.0421	0.0309
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0243	0.0294
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0315	0.05
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0304	0.0434
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0026	0.0315	0.05
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0026	0.0315	0.0252
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0243	0.0548
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0069	0.1309	0.4954
Mycobacterium ulcerans	thioesterase	0.007	0.134	0.4682
Loa Loa (eye worm)	hypothetical protein	0.0057	0.102	0.2299
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0243	0.0548
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.1093	0.6104
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0048	0.0818	0.3095
Onchocerca volvulus		0.0046	0.078	0.1108
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0243	0.0129
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0116	0.0262
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0243	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0142	0.3008	0.6781
Onchocerca volvulus		0.0031	0.0421	0.0367
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0089	0.1791	0.6776
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0243	0.0129
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0601	0.1124
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0084	0.1668	0.6312
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0243	0.0294
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0021	0.0192	0.0177
Echinococcus granulosus	citrate lyase subunit beta protein	0.0026	0.0315	0.0201
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0391	0.0278
Mycobacterium ulcerans	polyketide synthase MbtD	0.0026	0.0304	0.0454
Schistosoma mansoni	cpg binding protein	0.0033	0.0462	0.035
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0243	0.0548
Echinococcus multilocularis	dnaJ subfamily B	0.044	1	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0391	0.2183
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0421	0.0706
Toxoplasma gondii	3-oxoacyl-acyl-carrier protein synthase I/II, putative	0.0021	0.0192	0.1074
Echinococcus multilocularis	muscleblind protein	0.0169	0.3659	0.3585
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0089	0.1791	0.6776
Schistosoma mansoni	3-oxoacyl-[ACP] synthase	0.0021	0.0192	0.0077
Onchocerca volvulus		0.003	0.0391	0.0305
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0034	0.0495	0.1871
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0243	0.0129
Mycobacterium leprae	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	0.0026	0.0317	0.1198
Mycobacterium leprae	Polyketide synthase Pks13	0.0126	0.2643	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0089	0.1791	0.6522
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0243	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0169	0.3659	0.8249
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0243	0.0294
Schistosoma mansoni	coup transcription factor	0.0023	0.0243	0.0129
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0084	0.1668	0.6312
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0068	0.1283	0.4452
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0026	0.0315	0.05
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0243	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.0548
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0026	0.0315	0.1191
Schistosoma mansoni	hypothetical protein	0.0199	0.4349	0.4283
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0243	0.0129
Brugia malayi	mbt repeat family protein	0.0046	0.078	0.1537
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0026	0.0315	0.05
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0182	0.3963	0.3892
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0243	0.0548
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0243	0.0129
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.078	0.0672
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0055	0.0976	0.5451
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0082	0.1608	0.6084
Brugia malayi	Muscleblind-like protein	0.0169	0.3659	0.8201
Leishmania major	hypothetical protein, conserved	0.0229	0.5056	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0243	0.0129
Schistosoma mansoni	hypothetical protein	0.044	1	1
Onchocerca volvulus		0.0079	0.1539	0.2674
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0046	0.078	0.1759
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.0548
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0084	0.1668	0.6023
Mycobacterium tuberculosis	Conserved protein	0.0026	0.0315	0.1191
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0243	0.0129
Echinococcus granulosus	muscleblind protein	0.0169	0.3659	0.3585
Brugia malayi	Pre-SET motif family protein	0.003	0.0391	0.0636
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.093	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0601	0.1356
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0243	0.0548
Echinococcus granulosus	geminin	0.0199	0.4349	0.4283
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0315	0.05
Mycobacterium tuberculosis	Conserved protein	0.0025	0.0291	0.1102
Toxoplasma gondii	type I fatty acid synthase, putative	0.0089	0.1791	1
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.007	0.134	0.5069
Toxoplasma gondii	type I fatty acid synthase, putative	0.006	0.11	0.6145
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0243	0.0548
Brugia malayi	steroid hormone receptor	0.0023	0.0243	0.0294
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.102	0.2092
Trypanosoma cruzi	hypothetical protein, conserved	0.0229	0.5056	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.0548
Onchocerca volvulus		0.0147	0.3128	0.5953
Echinococcus granulosus	3 oxoacyl acyl carrier protein synthase	0.0021	0.0192	0.0077
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.016	0.3433	0.7678
Mycobacterium tuberculosis	Hypothetical protein	0.0025	0.0291	0.1102
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0243	0.0129
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0084	0.1668	0.6023
Chlamydia trachomatis	3-oxoacyl-ACP synthase	0.0021	0.0192	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0243	0.0548
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0084	0.1668	0.6023
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0391	0.0278
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0243	0.0548
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.078	0.0672
Trypanosoma cruzi	hypothetical protein, conserved	0.0229	0.5056	1
Brugia malayi	Methyltransferase-like protein 4	0.0025	0.0291	0.0406
Plasmodium vivax	SET domain protein, putative	0.003	0.0391	1
Schistosoma mansoni	methyltransferase-related	0.0025	0.0291	0.0177
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0126	0.2643	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.0548
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0084	0.1668	0.6312
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0243	0.0294
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0026	0.0315	0.0201
Brugia malayi	nuclear hormone receptor	0.0023	0.0243	0.0294
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.078	0.0672
Loa Loa (eye worm)	MBCTL1	0.0053	0.093	0.2096
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0056	0.1001	0.3787
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0068	0.1283	0.4856
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0084	0.1668	0.6312
Loa Loa (eye worm)	beta-ketoacyl synthase domain-containing protein	0.0021	0.0192	0.0434
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.078	0.0672
Plasmodium falciparum	3-oxoacyl-acyl-carrier protein synthase I/II	0.0021	0.0192	0.5
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0084	0.1668	0.6023
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0068	0.1283	0.4452
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0243	0.0129
Brugia malayi	Pre-SET motif family protein	0.0203	0.4436	1
Onchocerca volvulus		0.023	0.5088	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0084	0.1668	0.6312
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0116	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0802	0.1807
Mycobacterium ulcerans	polyketide synthase	0.0089	0.1791	0.6522
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0391	0.0278
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0026	0.0315	0.0252
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0056	0.1001	0.3299
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.078	0.0672
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0089	0.1791	0.6776
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0243	0.0129
Leishmania major	hypothetical protein, conserved	0.0025	0.0291	0.0204
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.093	0.0823
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.078	0.1108
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0243	0.0129
Loa Loa (eye worm)	fatty acid synthase	0.0083	0.1642	0.3702
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0079	0.1539	0.3469
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0243	0.0129
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0243	0.0129
Loa Loa (eye worm)	hypothetical protein	0.003	0.0391	0.0881
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0243	0.0129
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0043	0.0694	0.3874
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0026	0.0315	0.0049
Mycobacterium ulcerans	fatty acid synthase Fas	0.0026	0.0317	0.0508
Mycobacterium ulcerans	polyketide synthase Pks9	0.0056	0.1001	0.3299
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0243	0.0129
Brugia malayi	mbt repeat family protein	0.0046	0.078	0.1537
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0421	0.0949
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0243	0.0129
Mycobacterium tuberculosis	Probable thioesterase TesA	0.007	0.134	0.5069
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.093	0.0823
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0243	0.0294

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL604066

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1097176