Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0129 | 0.6906 | 0.8837 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.1052 | 0.4143 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.002 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0056 | 0.254 | 0.2985 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.1052 | 0.4143 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.1052 | 0.0763 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0143 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0129 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0129 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0129 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0129 | 0.6906 | 0.8837 |
Trichomonas vaginalis | glutathione reductase, putative | 0.002 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0143 | 0.7773 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.002 | 0.0313 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.1052 | 0.4143 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.002 | 0.0313 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0056 | 0.254 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.1052 | 0.5 |
Brugia malayi | glutathione reductase | 0.0056 | 0.254 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0056 | 0.254 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0032 | 0.1052 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0129 | 0.6906 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0143 | 0.7773 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.1052 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0056 | 0.254 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.1052 | 0.4143 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.002 | 0.0313 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.002 | 0.0313 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0032 | 0.1052 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0032 | 0.1052 | 0.4143 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.1052 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.002 | 0.0313 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.002 | 0.0313 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0056 | 0.254 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0056 | 0.254 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.1052 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0056 | 0.254 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.002 | 0.0313 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0056 | 0.254 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0056 | 0.254 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0056 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0143 | 0.7773 | 1 |
Brugia malayi | hypothetical protein | 0.0032 | 0.1052 | 0.4143 |
Loa Loa (eye worm) | glutathione reductase | 0.0056 | 0.254 | 1 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.1052 | 0.0763 |
Brugia malayi | Peroxidasin | 0.0032 | 0.1052 | 0.4143 |
Echinococcus multilocularis | peroxidasin | 0.0032 | 0.1052 | 0.3318 |
Echinococcus granulosus | peroxidasin | 0.0032 | 0.1052 | 0.3318 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.1052 | 0.4143 |
Treponema pallidum | NADH oxidase | 0.002 | 0.0313 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.1052 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0.1052 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0.1052 | 0.5 | |
Leishmania major | trypanothione reductase | 0.0056 | 0.254 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0056 | 0.254 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0056 | 0.254 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.002 | 0.0313 | 0.1234 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.3 nM | Inhibition of mouse COX2 | ChEMBL. | 20188577 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.