Detailed information for compound 109734

Basic information

Technical information
  • TDR Targets ID: 109734
  • Name: 4-(2,4-dichloro-5-methoxyanilino)-7-(2-pyridi n-3-ylethynyl)quinoline-3-carbonitrile
  • MW: 445.3 | Formula: C24H14Cl2N4O
  • H donors: 1 H acceptors: 3 LogP: 6.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cnc2c(c1Nc1cc(OC)c(cc1Cl)Cl)ccc(c2)C#Cc1cccnc1
  • InChi: 1S/C24H14Cl2N4O/c1-31-23-11-22(19(25)10-20(23)26)30-24-17(12-27)14-29-21-9-15(6-7-18(21)24)4-5-16-3-2-8-28-13-16/h2-3,6-11,13-14H,1H3,(H,29,30)
  • InChiKey: SQKNEXBFHCJKNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2,4-dichloro-5-methoxy-anilino)-7-[2-(3-pyridyl)ethynyl]quinoline-3-carbonitrile
  • 4-(2,4-dichloro-5-methoxyanilino)-7-[2-(3-pyridyl)ethynyl]-3-quinolinecarbonitrile
  • 4-[(2,4-dichloro-5-methoxy-phenyl)amino]-7-(2-pyridin-3-ylethynyl)quinoline-3-carbonitrile
  • 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-(2-pyridin-3-ylethynyl)quinoline-3-carbonitrile
  • 4-[(2,4-dichloro-5-methoxy-phenyl)amino]-7-[2-(3-pyridyl)ethynyl]quinoline-3-carbonitrile
  • 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[2-(3-pyridyl)ethynyl]-3-quinolinecarbonitrile
  • ethynyl-4-phenylamino-3-quinolinecarbonitrile 3b

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.3437 0.3437
Schistosoma mansoni biogenic amine receptor 0.01 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.3437 0.3437
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus g protein coupled receptor 0.01 1 1
Loa Loa (eye worm) TK protein kinase 0.0036 0.293 0.2899
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Echinococcus granulosus G protein coupled receptor 139 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0044 0.5
Schistosoma mansoni amine GPCR 0.01 1 1
Brugia malayi G protein-coupled receptor 0.01 1 1
Brugia malayi Serotonin receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.01 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi neuropeptide F receptor 0.01 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.01 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.01 1 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.3932 0.3932
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni hypothetical protein 0.01 1 1
Brugia malayi SRC-1 0.0045 0.3932 0.3932
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.3932 0.3932
Echinococcus granulosus peptide allatostatin:somatostatin 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi ORL1-like opioid receptor 0.01 1 1
Brugia malayi G-protein coupled receptor 0.01 1 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0044 0.5
Echinococcus granulosus serotonin receptor 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.01 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.01 1 1
Echinococcus granulosus neuropeptide receptor A26 0.01 1 1
Schistosoma mansoni histamine h1 receptor 0.01 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 1 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0044 0.5
Echinococcus multilocularis fmrfamide receptor 0.01 1 1
Echinococcus granulosus neuropeptide s receptor 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0044 0.5
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0044 0.0044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.01 1 1
Brugia malayi follicle stimulating hormone receptor 0.01 1 1
Echinococcus granulosus hypothetical protein 0.01 1 1
Schistosoma mansoni amine GPCR 0.01 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.3932 0.3932
Brugia malayi Cytochrome P450 family protein 0.0011 0.0044 0.0044
Brugia malayi Serotonin/octopamine receptor family protein 7 0.01 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.01 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.01 1 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0044 0.5
Echinococcus granulosus neuropeptide receptor 0.01 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.01 1 1
Echinococcus granulosus neuropeptides capa receptor 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.01 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.01 1 0.5
Trypanosoma brucei cytochrome P450, putative 0.0037 0.2986 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0044 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.293 0.293
Echinococcus multilocularis g protein coupled receptor 0.01 1 1
Brugia malayi GnHR receptor homolog 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.2986 0.2956
Loa Loa (eye worm) neuropeptide F receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.293 0.293
Entamoeba histolytica protein kinase, putative 0.0036 0.293 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.01 1 1
Schistosoma mansoni cytochrome P450 0.0011 0.0044 0.0044
Echinococcus granulosus alpha 1A adrenergic receptor 0.01 1 1
Echinococcus granulosus g-protein coupled receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus sex peptide receptor 0.01 1 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0044 0.5
Brugia malayi Cytochrome P450 family protein 0.0011 0.0044 0.0044
Echinococcus granulosus tachykinin peptides receptor 99D 0.01 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.01 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.3932 0.3932
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.3932 0.3932
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.01 1 1
Echinococcus granulosus somatostatin receptor 0.01 1 1
Brugia malayi Dopamine receptor protein 2 0.01 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0044 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.01 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi larval opioid receptor 0.01 1 1
Echinococcus multilocularis neuropeptide receptor 0.01 1 1
Schistosoma mansoni adenoreceptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.01 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.2986 1
Echinococcus multilocularis orexin receptor type 2 0.01 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.01 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.01 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.01 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.01 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0044 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.01 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.3437 0.3437
Echinococcus multilocularis neuropeptides capa receptor 0.01 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.01 1 1
Schistosoma mansoni opsin-like receptor 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0044 0.5
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0044 0.5
Schistosoma mansoni opsin-like receptor 0.01 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.01 1 1
Brugia malayi protein-tyrosine kinase 0.0041 0.3437 0.3437
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.01 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.01 1 1
Brugia malayi RE15519p 0.01 1 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0044 0.5
Brugia malayi Cytochrome P450 family protein 0.0037 0.2986 0.2986
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus neuropeptides capa receptor 0.01 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.01 1 1
Echinococcus granulosus neuropeptide receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) SRC-1 0.0045 0.3932 0.3906
Schistosoma mansoni tyrosine kinase 0.0045 0.3932 0.3932
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Brugia malayi Melatonin receptor type 1A 0.01 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.2986 1
Brugia malayi hypothetical protein 0.01 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.01 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.01 1 1
Schistosoma mansoni amine GPCR 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.01 1 1
Schistosoma mansoni myosin xvIII 0.01 1 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0044 0.5
Onchocerca volvulus 0.01 1 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.01 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.3932 0.3932
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.01 1 1
Echinococcus granulosus g protein coupled receptor 0.01 1 1
Echinococcus multilocularis g protein coupled receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.1798 0.1762
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.01 1 1
Loa Loa (eye worm) TK protein kinase 0.0041 0.3437 0.3409
Echinococcus multilocularis somatostatin receptor 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.01 1 1
Echinococcus multilocularis sex peptide receptor 0.01 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.3932 0.3932
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.3295 0.3295
Onchocerca volvulus 0.01 1 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Mycobacterium leprae putative cytochrome p450 0.0011 0.0044 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.3932 0.3932
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.01 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.01 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.01 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus g protein coupled receptor 0.01 1 1
Brugia malayi Serotonin receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.01 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Brugia malayi Dopamine receptor 0.01 1 1
Echinococcus granulosus neuropeptide Y receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0044 0.5
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0044 0.5
Brugia malayi hypothetical protein 0.01 1 1
Echinococcus multilocularis g protein coupled receptor 0.01 1 1
Echinococcus granulosus fmrfamide receptor 0.01 1 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.2986 1
Brugia malayi hypothetical protein 0.01 1 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0044 0.5
Onchocerca volvulus 0.01 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Leishmania major cytochrome p450-like protein 0.0037 0.2986 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni hypothetical protein 0.01 1 1
Brugia malayi cytochrome P450 0.0011 0.0044 0.0044
Brugia malayi Tachykinin-like peptides receptor 99D 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis allatostatin A receptor 0.01 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.01 1 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0044 0.5
Schistosoma mansoni amine GPCR 0.01 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.2986 0.2956
Brugia malayi G-protein coupled receptor 0.01 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.01 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 1 1
Echinococcus multilocularis fmrfamide receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis neuropeptide s receptor 0.01 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.3437 0.3437
Schistosoma mansoni hypothetical protein 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0044 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.01 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi Cytochrome P450 family protein 0.0037 0.2986 0.2986
Echinococcus granulosus orexin receptor type 2 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Brugia malayi AKH receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.3932 0.3932
Brugia malayi neuropeptide F receptor 0.01 1 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0044 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.3932 0.3932
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.01 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.01 1 1
Echinococcus multilocularis serotonin receptor 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 1 1
Schistosoma mansoni amine GPCR 0.01 1 1
Brugia malayi putative neuropeptide receptor 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.3932 0.3932
Loa Loa (eye worm) TYRA-2 protein 0.01 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.01 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.01 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.3932 0.3932
Brugia malayi hypothetical protein 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.01 1 1
Schistosoma mansoni biogenic amine receptor 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.3932 0.3932
Onchocerca volvulus 0.01 1 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.01 1 1
Brugia malayi sulfakinin receptor protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Schistosoma mansoni tyrosine kinase 0.0045 0.3932 0.3932
Echinococcus granulosus neuropeptide Y receptor 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Echinococcus granulosus allatostatin A receptor 0.01 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.3295 0.3295
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.01 1 1
Brugia malayi hypothetical protein 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Loa Loa (eye worm) CYP4Cod1 0.0037 0.2986 0.2956
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Echinococcus multilocularis neuropeptide receptor 0.01 1 1
Schistosoma mansoni opsin-like receptor 0.01 1 1
Brugia malayi Dopamine receptor protein 1 0.01 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 1 1
Echinococcus multilocularis g-protein coupled receptor 0.01 1 1
Onchocerca volvulus 0.01 1 0.5
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0044 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.01 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.01 1 1
Schistosoma mansoni hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0044 0.5
Schistosoma mansoni biogenic amine receptor 0.01 1 1
Echinococcus granulosus tyrosine kinase 0.0041 0.3437 0.3437
Schistosoma mansoni neuropeptide receptor 0.01 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.3932 0.3932
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.3437 0.3437
Echinococcus granulosus biogenic amine 5HT receptor 0.01 1 1
Echinococcus multilocularis 0.0011 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0011 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.3932 0.3932
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.3932 0.3932
Onchocerca volvulus 0.01 1 0.5
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.01 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.01 1 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.3932 0.3932
Loa Loa (eye worm) G-protein coupled receptor 0.01 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 1 1
Echinococcus multilocularis serotonin receptor 0.01 1 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0044 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 47 nM Enzyme inhibitory activity against recombinant human Src protein tryrosine kinase ChEMBL. 15080999
IC50 (binding) = 47 nM Inhibition of human Src kinase ChEMBL. 15745832
IC50 (binding) = 47 nM Enzyme inhibitory activity against recombinant human Src protein tryrosine kinase ChEMBL. 15080999
IC50 (binding) = 47 nM Inhibition of human Src kinase ChEMBL. 15745832
IC50 (functional) = 0.65 uM Inhibitory activity against Src-dependent cell proliferation assay using rat fibroblasts ChEMBL. 15080999

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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