Detailed information for compound 1097386

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 307.393 | Formula: C18H21N5
  • H donors: 1 H acceptors: 2 LogP: 3.51 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc2nn(c(c2c(n1)N1CCCCC1)N)c1ccccc1
  • InChi: 1S/C18H21N5/c1-13-12-15-16(18(20-13)22-10-6-3-7-11-22)17(19)23(21-15)14-8-4-2-5-9-14/h2,4-5,8-9,12H,3,6-7,10-11,19H2,1H3
  • InChiKey: YXWDVJZRUIZIFU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.03 0.3141 0.7451
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0599 0.6437 0.7677
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.164 0.1922
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0231 0.0879
Loa Loa (eye worm) PHD-finger family protein 0.0109 0.1027 0.2538
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0231 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0172 0.1726 0.4053
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0116 0.1112 0.1344
Leishmania major hypothetical protein, conserved 0.0081 0.0717 0.6327
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0156 0.0118
Brugia malayi beta-lactamase family protein 0.0116 0.1112 0.2577
Plasmodium vivax hypothetical protein, conserved 0.0092 0.0841 0.7474
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0121 0.1158 0.1124
Echinococcus multilocularis neuropeptide receptor A26 0.0469 0.4994 0.5585
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0037 0.0141
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0504 0.0468
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.1112 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0023 0.0088 0.0056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0123 0.1184 0.115
Brugia malayi hypothetical protein 0.0036 0.0229 0.0458
Schistosoma mansoni zinc finger protein 0.0105 0.0986 0.0951
Toxoplasma gondii histone lysine methyltransferase SET1 0.0074 0.0649 0.5688
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0256 0.2652 0.6277
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0229 0.0215
Brugia malayi Flap endonuclease-1 0.0026 0.0116 0.0186
Echinococcus multilocularis zinc finger protein 0.0105 0.0986 0.1068
Brugia malayi jmjC domain containing protein 0.003 0.0156 0.0282
Echinococcus multilocularis GPCR, family 2 0.0081 0.0723 0.0771
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0156 0.0301
Brugia malayi PHD-finger family protein 0.0042 0.0291 0.0606
Onchocerca volvulus 0.0116 0.1112 0.3824
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.1759 0.4132
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0116 0.0721
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0172 0.1726 0.1902
Trichomonas vaginalis chromobox protein, putative 0.0071 0.061 0.232
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0114 0.109 0.1185
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0156 0.0132
Schistosoma mansoni hypothetical protein 0.0051 0.0388 0.0351
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1374 0.3207
Schistosoma mansoni alpha-glucosidase 0.0141 0.1388 0.1355
Schistosoma mansoni hypothetical protein 0.0515 0.5508 0.5491
Toxoplasma gondii PHD-finger domain-containing protein 0.0092 0.0841 0.7474
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0608 0.1463
Loa Loa (eye worm) hypothetical protein 0.0157 0.1563 0.3913
Loa Loa (eye worm) jmjC domain-containing protein 0.0189 0.1917 0.4823
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0038 0.5
Onchocerca volvulus 0.0151 0.1495 0.5386
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0122 0.1179 0.1285
Brugia malayi chromobox protein homolog 3 0.004 0.0267 0.0549
Loa Loa (eye worm) hypothetical protein 0.0042 0.0291 0.0648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1374 0.1341
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0504 0.434
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0032 0.0181 0.1783
Echinococcus granulosus lysine specific demethylase 5A 0.0123 0.1184 0.1375
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0038 0.0146
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0608 0.1463
Echinococcus granulosus microtubule associated protein 2 0.0775 0.8374 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.016 0.1132
Loa Loa (eye worm) MBCTL1 0.0172 0.1726 0.4332
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0231 0.1796
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.1112 0.4228
Brugia malayi hypothetical protein 0.0248 0.2566 0.6071
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0116 0.0199
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.003 0.016 0.1132
Trichomonas vaginalis chromobox protein, putative 0.0043 0.03 0.1141
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1374 0.3428
Brugia malayi beta-lactamase family protein 0.0116 0.1112 0.2577
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0038 0.5
Echinococcus granulosus PHD finger protein rhinoceros 0.0092 0.0841 0.0962
Loa Loa (eye worm) bromodomain containing protein 0.0093 0.0855 0.2095
Schistosoma mansoni phd/f-box containing protein 0.003 0.0156 0.0118
Echinococcus multilocularis polycomb protein SCMH1 0.0151 0.1495 0.1642
Echinococcus multilocularis cpg binding protein 0.0044 0.0314 0.031
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0107 0.1005 0.2482
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0037 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0231 0.1796
Loa Loa (eye worm) hypothetical protein 0.0226 0.2325 0.5869
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0608 0.0572
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.1179 0.1145
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0231 0.0495
Schistosoma mansoni flap endonuclease-1 0.0023 0.0088 0.005
Loa Loa (eye worm) hypothetical protein 0.0202 0.2056 0.518
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0388 0.0839
Mycobacterium tuberculosis Conserved protein 0.0116 0.1112 0.1344
Schistosoma mansoni hypothetical protein 0.0081 0.0723 0.0687
Onchocerca volvulus 0.0044 0.0317 0.0587
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.0156 0.1094
Brugia malayi PHD-finger family protein 0.0133 0.1295 0.3019
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1156 0.2869
Mycobacterium leprae conserved hypothetical protein 0.0116 0.1112 0.5
Trichomonas vaginalis set domain proteins, putative 0.0254 0.2629 1
Schistosoma mansoni hypothetical protein 0.0515 0.5508 0.5491
Echinococcus multilocularis lysine specific demethylase 5A 0.0111 0.1053 0.1144
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0723 0.1756
Schistosoma mansoni alpha-glucosidase 0.0141 0.1388 0.1355
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.03 0.3141 0.3496
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0114 0.109 0.2526
Echinococcus multilocularis chromobox protein 1 0.0071 0.061 0.0644
Echinococcus multilocularis histone acetyltransferase MYST2 0.0172 0.1726 0.1902
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0723 0.1643
Brugia malayi mbt repeat family protein 0.0151 0.1495 0.3499
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0599 0.6437 0.721
Echinococcus granulosus tar DNA binding protein 0.0071 0.0608 0.0684
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0723 0.0771
Plasmodium vivax hypothetical protein, conserved 0.0116 0.1112 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.009 0.0819 0.0784
Schistosoma mansoni hypothetical protein 0.003 0.016 0.0122
Echinococcus granulosus neuropeptide receptor A26 0.0469 0.4994 0.5946
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0156 0.0118
Entamoeba histolytica hypothetical protein 0.0036 0.0229 0.9899
Echinococcus multilocularis phd:f box containing protein 0.003 0.0156 0.0132
Echinococcus granulosus histone lysine methyltransferase setb 0.0122 0.1179 0.1368
Mycobacterium tuberculosis Conserved protein 0.0116 0.1112 0.1344
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.1184 0.2941
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.1112 1
Schistosoma mansoni hypothetical protein 0.0109 0.1027 0.0992
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0041 0.0287 0.028
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0231 0.0879
Brugia malayi AF-10 protein 0.003 0.016 0.0292
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1374 0.1602
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0301
Mycobacterium tuberculosis Probable esterase LipL 0.0116 0.1112 0.1344
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0608 0.0572
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0504 0.434
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.229 0.5779
Loa Loa (eye worm) hypothetical protein 0.0116 0.1112 0.2755
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.2566 0.3033
Echinococcus granulosus beta LACTamase domain containing family member 0.0116 0.1112 0.1288
Loa Loa (eye worm) hypothetical protein 0.0116 0.1112 0.2755
Brugia malayi jmjC domain containing protein 0.003 0.0156 0.0282
Plasmodium vivax SET domain protein, putative 0.0033 0.0189 0.1403
Onchocerca volvulus 0.0254 0.2629 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0231 0.0879
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1374 0.1505
Echinococcus multilocularis SAM and MBT domain containing protein 0.0151 0.1495 0.1642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1374 0.1341
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0116 0.1112 0.2755
Echinococcus multilocularis PHD finger protein rhinoceros 0.0092 0.0841 0.0904
Trypanosoma brucei glucosidase, putative 0.0036 0.0231 0.1796
Echinococcus granulosus zinc finger protein 0.0105 0.0986 0.1137
Brugia malayi PHD-finger family protein 0.0092 0.0841 0.1926
Echinococcus granulosus methyl CpG binding domain protein 2 0.009 0.0819 0.0937
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0156 0.0141
Schistosoma mansoni microtubule-associated protein tau 0.0775 0.8374 0.8368
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0116 0.1112 0.2755
Loa Loa (eye worm) PHD-finger family protein 0.0092 0.0841 0.2059
Giardia lamblia PHD finger protein 15 0.0092 0.0841 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0151 0.1495 0.1748
Brugia malayi Bromodomain containing protein 0.0104 0.0978 0.2256
Loa Loa (eye worm) CHromoDomain protein family member 0.0023 0.0088 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.1179 0.1145
Trichomonas vaginalis chromobox protein, putative 0.0043 0.03 0.1141
Brugia malayi Calcitonin receptor-like protein seb-1 0.0256 0.2652 0.6277
Loa Loa (eye worm) hypothetical protein 0.0092 0.0841 0.2059
Onchocerca volvulus Alhambra homolog 0.0092 0.0841 0.272
Echinococcus multilocularis chromobox protein 1 0.0071 0.061 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0267 0.1015
Onchocerca volvulus 0.0032 0.0183 0.0042
Schistosoma mansoni jumonji domain containing protein 0.0239 0.246 0.2431
Schistosoma mansoni hypothetical protein 0.0092 0.0841 0.0805
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1112 0.4228
Onchocerca volvulus 0.0095 0.0877 0.2867
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0189 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0317 0.0279
Onchocerca volvulus 0.0116 0.1112 0.3824
Loa Loa (eye worm) hypothetical protein 0.0151 0.1495 0.374
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0231 0.0879
Schistosoma mansoni sex comb on midleg homolog 0.0151 0.1495 0.1463
Brugia malayi CHD4 protein 0.0023 0.0088 0.0119
Leishmania major hypothetical protein, conserved 0.0116 0.1112 1
Echinococcus granulosus GPCR family 2 0.0081 0.0723 0.0821
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0316 0.3315 0.3931
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0231 0.0879
Loa Loa (eye worm) hypothetical protein 0.0248 0.2566 0.6489
Mycobacterium ulcerans esterase/lipase LipP 0.0116 0.1112 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.1112 0.4228
Onchocerca volvulus 0.0116 0.1112 0.3824
Entamoeba histolytica hypothetical protein 0.0036 0.0229 0.9899
Brugia malayi jmjC domain containing protein 0.003 0.0156 0.0282
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0504 0.434
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.061 0.1467
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0231 0.0879
Schistosoma mansoni survival motor neuron protein 0.0051 0.0388 0.0351
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0116 0.1112 0.1344
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1112 0.4228
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0231 0.0231
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.1112 0.1077
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0168 0.0156
Echinococcus multilocularis methyl CpG binding domain protein 2 0.009 0.0819 0.088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0504 0.434
Schistosoma mansoni protein phosphatase 2C 0.003 0.0156 0.0118
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0316 0.3315 0.3692
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0088 0.005
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0156 0.0141
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0504 0.0559
Trypanosoma brucei ISWI complex protein 0.0081 0.0717 0.6327
Schistosoma mansoni cpg binding protein 0.0044 0.0314 0.0276
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0824 0.8913 1
Mycobacterium ulcerans lipase LipD 0.0116 0.1112 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0023 0.0088 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0152
Schistosoma mansoni hypothetical protein 0.0081 0.0723 0.0687
Brugia malayi jmjC domain containing protein 0.0123 0.1184 0.2752
Echinococcus multilocularis microtubule associated protein 2 0.0775 0.8374 0.9392
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.164 0.3846
Echinococcus granulosus chromobox protein 1 0.0071 0.061 0.0686
Schistosoma mansoni methyl-cpg binding protein mbd 0.009 0.0819 0.0784
Schistosoma mansoni hypothetical protein 0.0081 0.0717 0.0682
Mycobacterium tuberculosis Conserved protein 0.0116 0.1112 0.1344
Loa Loa (eye worm) hypothetical protein 0.0172 0.1726 0.4332
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0151 0.1495 0.5386
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0037 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0139 0.0529
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1374 0.1505
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0189 0.017
Schistosoma mansoni bromodomain containing protein 0.0024 0.0098 0.006
Loa Loa (eye worm) hypothetical protein 0.0372 0.3934 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0504 0.0468
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0256 0.2652 0.671
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0139 0.0529
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0608 0.0572
Brugia malayi jmjC domain containing protein 0.003 0.0156 0.0282
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0037 0.0141
Schistosoma mansoni cpg binding protein 0.0032 0.0183 0.0145
Brugia malayi TAR-binding protein 0.0071 0.0608 0.1369
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0114 0.109 0.1318
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.03 0.052
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0231 0.0879
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0156 0.0132
Echinococcus granulosus chromobox protein 1 0.0071 0.061 0.0686
Echinococcus granulosus neuropeptide s receptor 0.0469 0.4994 0.5946
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0723 0.0821
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0116 0.1112 0.2577
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.1112 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.03 0.3141 0.3722
Entamoeba histolytica hypothetical protein 0.0036 0.0229 0.9899
Trichomonas vaginalis esterase, putative 0.0116 0.1112 0.4228
Brugia malayi Pre-SET motif family protein 0.0033 0.0189 0.0361
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0231 0.0879
Brugia malayi mbt repeat family protein 0.0151 0.1495 0.3499
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0156 0.0132
Loa Loa (eye worm) hypothetical protein 0.0215 0.2194 0.5533
Schistosoma mansoni chromobox protein 0.0071 0.061 0.0574
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0038 0.0146
Onchocerca volvulus 0.0051 0.0388 0.0876
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0151 0.1495 0.1463
Schistosoma mansoni hypothetical protein 0.0175 0.1759 0.1727
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0608 0.0642
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0116 0.0721
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0116 0.4012
Echinococcus granulosus fetal alzheimer antigen falz 0.0121 0.1158 0.1343
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1374 0.1602
Echinococcus multilocularis geminin 0.0515 0.5508 0.6164
Loa Loa (eye worm) hypothetical protein 0.0175 0.1759 0.4417
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0231 0.0463
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0267 0.0385
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0156 0.0141
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0723 0.1643
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0114 0.109 0.9801
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0114 0.109 0.1056
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.016 0.1132
Loa Loa (eye worm) hypothetical protein 0.0122 0.1179 0.2927
Echinococcus granulosus geminin 0.0515 0.5508 0.6562
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.016 0.1132
Mycobacterium tuberculosis Probable lipase LipE 0.0116 0.1112 0.1344
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0723 0.0821
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0231 0.0217
Entamoeba histolytica hypothetical protein 0.0036 0.0229 0.9899
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0092 0.0841 0.0805
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0181 0.1333
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.0156 0.1094
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0608 0.1369
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1156 0.2869
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0116 0.1112 0.1344
Loa Loa (eye worm) RNA binding protein 0.0071 0.0608 0.1463
Brugia malayi MH2 domain containing protein 0.012 0.1156 0.2684
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0037 0.0141
Loa Loa (eye worm) hypothetical protein 0.0116 0.1112 0.2755
Echinococcus granulosus jumonji domain containing protein 0.0128 0.1237 0.1437
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0116 0.0721
Schistosoma mansoni hypothetical protein 0.0036 0.0229 0.0192
Schistosoma mansoni cpg binding protein 0.0044 0.0314 0.0276
Mycobacterium tuberculosis Probable lipase LipD 0.0116 0.1112 0.1344
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0229 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1374 0.1341
Loa Loa (eye worm) hypothetical protein 0.0116 0.1112 0.2755
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.164 0.1805
Toxoplasma gondii PHD-finger domain-containing protein 0.0092 0.0841 0.7474
Schistosoma mansoni myelin transcription factor 1 myt1 0.0172 0.1726 0.1694
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0116 0.044
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0504 0.0584
Mycobacterium ulcerans beta-lactamase 0.0116 0.1112 1
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0156 0.0301
Loa Loa (eye worm) hypothetical protein 0.0256 0.2652 0.671
Trypanosoma cruzi ISWI complex protein 0.0081 0.0717 0.6327
Brugia malayi Heterochromatin protein 1 0.0071 0.061 0.1372
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0172 0.1726 0.2025
Echinococcus multilocularis jumonji domain containing protein 0.0128 0.1237 0.135
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0116 0.0087
Brugia malayi F/Y-rich N-terminus family protein 0.0051 0.0392 0.0848
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0183 0.037
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0156 0.0301
Toxoplasma gondii ABC1 family protein 0.0116 0.1112 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0041 0.0287 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0267 0.1015
Echinococcus multilocularis peregrin 0.0104 0.0978 0.1059
Echinococcus granulosus cpg binding protein 0.0044 0.0314 0.033
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0156 0.1094
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.2566 0.2849
Schistosoma mansoni hypothetical protein 0.0081 0.0723 0.0687
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0116 0.0964
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0723 0.0771
Trichomonas vaginalis chromobox protein, putative 0.0071 0.061 0.232
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0189 0.1403
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0156 0.1094
Schistosoma mansoni zinc finger protein 0.0081 0.0717 0.0682
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0743 0.8021 1
Schistosoma mansoni bromodomain containing protein 0.0335 0.3523 0.3498
Loa Loa (eye worm) hypothetical protein 0.0081 0.0723 0.1756
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0189 0.1915 0.2115
Echinococcus multilocularis neuropeptide s receptor 0.0469 0.4994 0.5585
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0114 0.109 0.1262
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.1112 1
Loa Loa (eye worm) beta-lactamase 0.0116 0.1112 0.2755
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.164 0.1805
Loa Loa (eye worm) hypothetical protein 0.004 0.0267 0.0586
Brugia malayi Bromodomain containing protein 0.0397 0.4203 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0231 0.1796
Echinococcus granulosus peregrin 0.0104 0.0978 0.1127
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0231 0.1796
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0189 0.1915 0.2251
Schistosoma mansoni sex comb on midleg homolog 0.0151 0.1495 0.1463
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0114 0.109 0.9801
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0504 0.0525
Schistosoma mansoni alpha glucosidase 0.0036 0.0231 0.0194
Mycobacterium ulcerans hypothetical protein 0.0116 0.1112 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.164 0.4111
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0116 0.0721
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0231 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0121 0.1158 0.1262
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0591 0.0555
Loa Loa (eye worm) mbt repeat family protein 0.0151 0.1495 0.374
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0344
Schistosoma mansoni jumonji/arid domain-containing protein 0.0123 0.1184 0.115
Echinococcus granulosus phd:f box containing protein 0.003 0.0156 0.0141
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.0156 0.1094
Echinococcus granulosus flap endonuclease 1 0.0026 0.0116 0.0093
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0231 0.0879
Echinococcus multilocularis beta LACTamase domain containing family member 0.0116 0.1112 0.1209
Mycobacterium leprae Probable lipase LipE 0.0116 0.1112 0.5
Trypanosoma cruzi ISWI complex protein 0.0081 0.0717 0.6327
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0116 0.0721
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0608 0.0572
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0037 0.0141
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0156 0.1463
Echinococcus granulosus polycomb protein SCMH1 0.0151 0.1495 0.1748
Schistosoma mansoni hypothetical protein 0.0081 0.0723 0.0687
Brugia malayi beta-lactamase 0.0116 0.1112 0.2577
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0504 0.434
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.1112 0.1077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0037 0.0141
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0114 0.109 0.9801
Brugia malayi Bromodomain containing protein 0.0202 0.2052 0.4836
Plasmodium falciparum phd finger protein, putative 0.0092 0.0841 1
Brugia malayi RNA binding protein 0.0071 0.0608 0.1369
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0301
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0039 0.0261 0.0223
Plasmodium vivax JmjC domain containing protein 0.003 0.0156 0.1094
Mycobacterium tuberculosis Probable hydrolase 0.0116 0.1112 0.1344
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0037 0.0141
Schistosoma mansoni jumonji domain containing protein 0.003 0.0156 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1112 0.4228
Echinococcus granulosus histone acetyltransferase MYST2 0.0172 0.1726 0.2025
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0608 0.0572
Brugia malayi Pre-SET motif family protein 0.0223 0.229 0.5407
Schistosoma mansoni chromobox protein 0.0071 0.061 0.0574
Plasmodium falciparum flap endonuclease 1 0.0026 0.0116 0.0964
Leishmania major hypothetical protein, conserved 0.003 0.0156 0.1094
Brugia malayi CXXC zinc finger family protein 0.0032 0.0183 0.0346
Loa Loa (eye worm) hypothetical protein 0.0116 0.1112 0.2755

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = -96 % Inhibition of PKCz at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = -7 % Inhibition of AKT2 at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = -2 % Inhibition of INSR at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = -1 % Inhibition of CHK1 at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 1 % Inhibition of MET at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 1 % Inhibition of AKT1 at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 4 % Inhibition of RSK1 at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 4 % Inhibition of ERK1 at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 4 % Inhibition of CHK2 at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 5 % Inhibition of PKD2 at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 6 % Inhibition of ERK2 at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 7 % Inhibition of MAPKAPK2 at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 7 % Inhibition of ABL at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 7 % Inhibition of FYN at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 7 % Inhibition of SRC at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 7 % Inhibition of GSK3B at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 8 % Inhibition of LYN at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 10 % Inhibition of AurA at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 10 % Inhibition of PRAK1 at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 10 % Inhibition of p38alpha at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 10 % Inhibition of MSK1 at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 12 % Inhibition of LCK at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449
Inhibition (binding) = 24 % Inhibition of CK1d at 30 uM by microfluidic mobility shift assay ChEMBL. 21536449

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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