Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Mus musculus | fructose bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Toxoplasma gondii | fructose-bisphospatase I | fructose bisphosphatase 1 | 338 aa | 326 aa | 29.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.0134 | 0.0354 |
Loa Loa (eye worm) | thioredoxin reductase | 0.005 | 0.0134 | 0.0354 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0126 | 0.0981 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.0134 | 0.0354 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0114 | 0.0841 | 0.8342 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.0134 | 0.0354 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0141 | 0.114 | 0.2766 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0378 | 0.3772 | 1 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0114 | 0.0841 | 0.8342 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0141 | 0.114 | 0.2766 |
Schistosoma mansoni | gabp alpha | 0.0076 | 0.0427 | 0.0427 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0141 | 0.114 | 0.3022 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0126 | 0.0981 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0126 | 0.0981 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0304 | 0.0807 |
Mycobacterium tuberculosis | Probable reductase | 0.0114 | 0.0841 | 0.8342 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Brugia malayi | Ets-domain containing protein | 0.0076 | 0.0427 | 0.1132 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0076 | 0.0427 | 0.1132 |
Brugia malayi | Ets-domain containing protein | 0.0076 | 0.0427 | 0.1132 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0114 | 0.0841 | 0.8342 |
Schistosoma mansoni | ets-related | 0.0232 | 0.2148 | 0.2148 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.0134 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0378 | 0.3772 | 1 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0.0134 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0378 | 0.3772 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.005 | 0.0134 | 0.0354 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0378 | 0.3772 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0378 | 0.3772 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0378 | 0.3772 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0378 | 0.3772 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0.0134 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0126 | 0.0981 | 1 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.0134 | 0.0354 |
Leishmania major | 0.0378 | 0.3772 | 1 | |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.0134 | 1 |
Brugia malayi | Fli-1 protein | 0.0232 | 0.2148 | 0.5695 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0076 | 0.0427 | 0.1132 |
Brugia malayi | glutathione reductase | 0.005 | 0.0134 | 0.0354 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0378 | 0.3772 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0378 | 0.3772 | 0.3772 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0114 | 0.0841 | 0.8342 |
Loa Loa (eye worm) | fli-1 protein | 0.0232 | 0.2148 | 0.5695 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0141 | 0.114 | 0.2766 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0114 | 0.0841 | 0.8342 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0141 | 0.114 | 0.3022 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0076 | 0.0427 | 0.1132 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 9 uM | Inhibition of FBPase in mouse liver | ChEMBL. | 19969452 |
IC50 (binding) | = 0.05 uM | Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrate | ChEMBL. | 19969452 |
IC50 (binding) | = 0.06 uM | Inhibition of FBPase in human liver | ChEMBL. | 19969452 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.