Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0095 | 0.6874 | 0.8837 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0014 | 0.0312 | 0.5 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0015 | 0.0361 | 0.1257 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0361 | 0.032 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0551 | 0.1528 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0043 | 0.0119 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0043 | 0.0119 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0015 | 0.0361 | 0.1257 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0043 | 0.0119 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0823 | 0.2189 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0015 | 0.0361 | 0.1257 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0361 | 0.1001 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0551 | 0.2008 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0823 | 0.0688 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0015 | 0.0361 | 0.1001 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0015 | 0.0361 | 0.1257 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.2192 | 0.2159 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0043 | 0.0119 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0361 | 0.032 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0106 | 0.7738 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0361 | 0.032 |
Loa Loa (eye worm) | ACC-1 protein | 0.0015 | 0.0361 | 0.0893 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0015 | 0.0361 | 0.1257 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0823 | 0.0784 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0823 | 0.0784 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0015 | 0.0361 | 0.032 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0042 | 0.2529 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0551 | 0.2008 |
Brugia malayi | glutathione reductase | 0.0042 | 0.2529 | 0.7011 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0043 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0014 | 0.0312 | 0.1063 |
Onchocerca volvulus | 0.0015 | 0.0361 | 1 | |
Onchocerca volvulus | 0.0015 | 0.0361 | 1 | |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0043 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Echinococcus multilocularis | nAChR subunit | 0.0015 | 0.0361 | 0.1257 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0015 | 0.0361 | 0.1257 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0015 | 0.0361 | 0.1257 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0015 | 0.0361 | 0.1257 |
Onchocerca volvulus | 0.0015 | 0.0361 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0043 | 0.0119 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0043 | 0.0119 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0043 | 0.0119 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0015 | 0.0361 | 0.1257 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0015 | 0.0361 | 0.032 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0823 | 0.3082 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0551 | 0.051 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0043 | 0.0119 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0106 | 0.7738 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0015 | 0.0361 | 0.1257 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0043 | 0.0119 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0015 | 0.0361 | 0.0893 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0551 | 0.2008 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0015 | 0.0361 | 0.1257 |
Onchocerca volvulus | 0.0015 | 0.0361 | 1 | |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0823 | 0.3082 |
Onchocerca volvulus | 0.0015 | 0.0361 | 1 | |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0823 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0043 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0015 | 0.0361 | 0.1001 |
Brugia malayi | Cation transporter family protein | 0.0015 | 0.0361 | 0.1001 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0042 | 0.2529 | 0.2985 |
Toxoplasma gondii | thioredoxin reductase | 0.0042 | 0.2529 | 1 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0015 | 0.0361 | 0.1001 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0551 | 0.2008 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0361 | 0.032 |
Brugia malayi | Cation transporter family protein | 0.0015 | 0.0361 | 0.1001 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0015 | 0.0361 | 0.1257 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0361 | 0.1001 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0015 | 0.0361 | 0.1001 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0823 | 0.2305 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0823 | 0.2305 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0551 | 0.051 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0015 | 0.0361 | 0.1257 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0042 | 0.2529 | 1 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0015 | 0.0361 | 0.1001 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0015 | 0.0361 | 0.032 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0015 | 0.0361 | 0.1001 |
Plasmodium falciparum | thioredoxin reductase | 0.0042 | 0.2529 | 1 |
Echinococcus granulosus | nAChR subunit | 0.0015 | 0.0361 | 0.1257 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0823 | 0.2305 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0043 | 0.0119 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0015 | 0.0361 | 0.1257 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0823 | 0.2282 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.2192 | 0.6031 |
Brugia malayi | Cation transporter family protein | 0.0015 | 0.0361 | 0.1001 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0095 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0095 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0095 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0106 | 0.7738 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0015 | 0.0361 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0015 | 0.0361 | 0.1257 |
Brugia malayi | Thioredoxin reductase | 0.0042 | 0.2529 | 0.7011 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0015 | 0.0361 | 0.032 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0361 | 0.1001 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0043 | 0.0119 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0015 | 0.0361 | 0.0893 |
Loa Loa (eye worm) | LGC-31 protein | 0.0015 | 0.0361 | 0.0893 |
Onchocerca volvulus | Putative nachr subunit | 0.0015 | 0.0361 | 1 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0015 | 0.0361 | 0.1001 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0551 | 0.051 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0043 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3607 | 1 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0015 | 0.0361 | 0.1257 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0043 | 0.0119 |
Loa Loa (eye worm) | ACC-1 protein | 0.0015 | 0.0361 | 0.0893 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0.0361 | 0.1257 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0042 | 0.2574 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0015 | 0.0361 | 0.032 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0823 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0361 | 0.032 |
Loa Loa (eye worm) | glutathione reductase | 0.0042 | 0.2529 | 0.6975 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0551 | 0.2008 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0015 | 0.0361 | 0.1001 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0361 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0043 | 0.0119 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0015 | 0.0361 | 0.1001 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0015 | 0.0361 | 0.0893 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0015 | 0.0361 | 0.0893 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0014 | 0.0312 | 0.027 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0042 | 0.2529 | 0.6975 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0015 | 0.0361 | 0.1001 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0015 | 0.0361 | 0.1257 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.2192 | 0.6078 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0551 | 0.051 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0823 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0823 | 0.2305 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0.0361 | 0.1257 |
Mycobacterium tuberculosis | Probable reductase | 0.0095 | 0.6874 | 0.8837 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0823 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0823 | 1 |
Onchocerca volvulus | 0.0015 | 0.0361 | 1 | |
Leishmania major | trypanothione reductase | 0.0042 | 0.2529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0015 | 0.0361 | 0.1257 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0106 | 0.7738 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0095 | 0.6874 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0551 | 0.1426 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0823 | 0.2305 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0042 | 0.2574 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0.0361 | 0.1257 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0551 | 0.1528 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0361 | 0.032 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0015 | 0.0361 | 0.1257 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0361 | 0.032 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.3607 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.3607 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0043 | 0.0119 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0361 | 0.1001 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0551 | 0.1426 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0823 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0042 | 0.2529 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0551 | 0.2008 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0015 | 0.0361 | 0.0893 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0043 | 0.0119 |
Plasmodium vivax | glutathione reductase, putative | 0.0042 | 0.2529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Trypanosoma brucei | trypanothione reductase | 0.0042 | 0.2529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0015 | 0.0361 | 0.0893 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0043 | 0.0119 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0823 | 0.2305 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0361 | 0.1001 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0823 | 0.2305 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0014 | 0.0312 | 0.1063 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0014 | 0.0312 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0823 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0015 | 0.0361 | 0.1257 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0015 | 0.0361 | 0.1257 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0015 | 0.0361 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0361 | 0.0893 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.3607 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0015 | 0.0361 | 0.1257 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 7 % | Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV at 30 uM by two-microelectrode voltage clamp technique relative to GABA | ChEMBL. | 21699169 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.