Detailed information for compound 1097804

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.7 | Formula: C11H15ClN2O6
  • H donors: 4 H acceptors: 5 LogP: -1.44 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCc1cn(c(=O)[nH]c1=O)C1O[C@@H]([C@H]([C@@H]1O)O)CO
  • InChi: 1S/C11H15ClN2O6/c12-2-1-5-3-14(11(19)13-9(5)18)10-8(17)7(16)6(4-15)20-10/h3,6-8,10,15-17H,1-2,4H2,(H,13,18,19)/t6-,7-,8+,10?/m1/s1
  • InChiKey: VSWBKXJDWJNKJN-UUBZBTQISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis p2X purinoceptor 4 0.0463 0.5687 0.5661
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0795 1 1
Trypanosoma brucei ribokinase, putative 0.003 0.0059 0.0059
Onchocerca volvulus 0.0231 0.2677 1
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0083 0.0746 0.0746
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.006 0.0449 0.0449
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.018 0.2072
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0083 0.0746 0.2623
Echinococcus multilocularis adenosine kinase 0.0261 0.3063 0.3022
Echinococcus multilocularis programmed cell death protein 4 0.006 0.0449 0.0392
Schistosoma mansoni peptidase 0.0083 0.0746 0.0847
Echinococcus granulosus xaa Pro dipeptidase 0.0083 0.0746 0.0691
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0577 0.0577
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Trypanosoma brucei adenosine kinase, putative 0.0261 0.3063 0.3063
Chlamydia trachomatis methionine aminopeptidase 0.0654 0.8166 1
Schistosoma mansoni P2X receptor subunit 0.0463 0.5687 0.6942
Trypanosoma cruzi ribokinase, putative 0.003 0.0059 0.0059
Brugia malayi chromobox protein homolog 3 0.0039 0.018 0.018
Onchocerca volvulus 0.0031 0.007 0.0042
Giardia lamblia Methionine aminopeptidase 0.0083 0.0746 1
Toxoplasma gondii peptidase D, putative 0.0083 0.0746 0.0746
Plasmodium vivax peptidase, putative 0.0083 0.0746 0.0746
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.032 0.032
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.01 0.01
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0795 1 1
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0654 0.8166 0.8166
Brugia malayi photoreceptor-specific nuclear receptor 0.0276 0.3259 0.3259
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.032 0.032
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.01 0.01
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0083 0.0746 0.0847
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0795 1 1
Echinococcus granulosus methionine aminopeptidase type I 0.0083 0.0746 0.0691
Schistosoma mansoni chromobox protein 0.007 0.0577 0.0638
Trypanosoma brucei methionine aminopeptidase, putative 0.0795 1 1
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0654 0.8166 1
Echinococcus granulosus methionyl aminopeptidase 2 0.0083 0.0746 0.0691
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Brugia malayi hypothetical protein 0.003 0.0059 0.0059
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0083 0.0746 0.0847
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Echinococcus granulosus chromobox protein 1 0.007 0.0577 0.0521
Loa Loa (eye worm) hypothetical protein 0.0083 0.0746 0.0746
Treponema pallidum methionine aminopeptidase (map) 0.0654 0.8166 1
Mycobacterium tuberculosis Dipeptidase PepE 0.0083 0.0746 0.0847
Schistosoma mansoni hypothetical protein 0.0034 0.0115 0.0069
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.01 0.0041
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0083 0.0746 0.0847
Toxoplasma gondii MA3 domain-containing protein 0.006 0.0449 0.0449
Plasmodium vivax hypothetical protein, conserved 0.006 0.0449 0.0449
Brugia malayi metallopeptidase family M24 containing protein 0.0083 0.0746 0.0746
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.0959 1
Mycobacterium ulcerans methionine aminopeptidase 0.0654 0.8166 1
Echinococcus granulosus p2X purinoceptor 4 0.0463 0.5687 0.5661
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0795 1 1
Echinococcus multilocularis Proliferation associated protein 2G4 0.0083 0.0746 0.0691
Trypanosoma brucei adenosine kinase, putative 0.0261 0.3063 0.3063
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Entamoeba histolytica hypothetical protein 0.0075 0.0645 0.6504
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0795 1 1
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0083 0.0746 0.0847
Echinococcus granulosus Proliferation associated protein 2G4 0.0083 0.0746 0.0691
Trypanosoma cruzi aminopeptidase P, putative 0.0083 0.0746 0.0746
Toxoplasma gondii kinase, pfkB family protein 0.0261 0.3063 0.3063
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0083 0.0746 0.0691
Leishmania major tagatose-6-phosphate kinase-like protein 0.003 0.0059 0.0059
Schistosoma mansoni P2X receptor subunit 0.0463 0.5687 0.6942
Trichomonas vaginalis ribokinase, putative 0.003 0.0059 0.0386
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.01 0.01
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.018 0.2072
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0795 1 1
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0654 0.8166 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.01 0.005
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0083 0.0746 0.0847
Mycobacterium ulcerans dipeptidase 0.0083 0.0746 0.0847
Giardia lamblia Xaa-Pro dipeptidase 0.0083 0.0746 1
Echinococcus granulosus xaa Pro dipeptidase 0.0083 0.0746 0.0691
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0083 0.0746 0.0847
Entamoeba histolytica hypothetical protein 0.0075 0.0645 0.6504
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.01 0.0041
Leishmania major adenosine kinase, putative 0.0261 0.3063 0.3063
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.01 0.01
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.01 0.0041
Giardia lamblia Xaa-Pro dipeptidase 0.0083 0.0746 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.01 0.01
Plasmodium vivax FACT complex subunit SPT16, putative 0.0083 0.0746 0.0746
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0645 0.0589
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0083 0.0746 0.0746
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0083 0.0746 0.0847
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.01 0.005
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0083 0.0746 0.0746
Echinococcus granulosus programmed cell death protein 4 0.006 0.0449 0.0392
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0083 0.0746 0.0746
Trypanosoma brucei ribokinase, putative 0.003 0.0059 0.0059
Brugia malayi initiation factor 2-associated protein. 0.0083 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0099 0.0959 0.0959
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.01 0.0041
Echinococcus multilocularis methionine aminopeptidase, type I 0.0083 0.0746 0.0691
Toxoplasma gondii methionine aminopeptidase 0.0795 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.01 0.01
Entamoeba histolytica aminopeptidase, putative 0.0083 0.0746 0.7628
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0218 0.0607
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Schistosoma mansoni hypothetical protein 0.0352 0.425 0.5169
Loa Loa (eye worm) hypothetical protein 0.0039 0.018 0.018
Echinococcus granulosus adenosine kinase 0.0261 0.3063 0.3022
Echinococcus granulosus xaa pro aminopeptidase 0.0083 0.0746 0.0691
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.2618 0.2618
Entamoeba histolytica hypothetical protein, conserved 0.0083 0.0746 0.7628
Echinococcus multilocularis xaa Pro dipeptidase 0.0083 0.0746 0.0691
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.01 0.01
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0099 0.0959 0.3438
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0083 0.0746 0.0746
Trichomonas vaginalis chromobox protein, putative 0.007 0.0577 0.7634
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0083 0.0746 0.0746
Schistosoma mansoni hypothetical protein 0.0352 0.425 0.5169
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.0959 1
Echinococcus granulosus p2X purinoceptor 4 0.0463 0.5687 0.5661
Trypanosoma cruzi adenosine kinase, putative 0.003 0.0059 0.0059
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Echinococcus multilocularis p2X purinoceptor 4 0.0463 0.5687 0.5661
Schistosoma mansoni chromobox protein 0.007 0.0577 0.0638
Leishmania major hypothetical protein, conserved 0.0083 0.0746 0.0746
Echinococcus multilocularis methionyl aminopeptidase 2 0.0083 0.0746 0.0691
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0083 0.0746 0.0746
Mycobacterium ulcerans aminopeptidase 0.0083 0.0746 0.0847
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0083 0.0746 0.0746
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0083 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0276 0.3259 0.3259
Loa Loa (eye worm) methionine aminopeptidase type I 0.0795 1 1
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0083 0.0746 0.0746
Trypanosoma brucei hypothetical protein, conserved 0.0141 0.1507 0.1507
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0654 0.8166 0.8155
Schistosoma mansoni P2X receptor subunit 0.0463 0.5687 0.6942
Leishmania major adenosine kinase-like protein 0.003 0.0059 0.0059
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0083 0.0746 0.7628
Mycobacterium ulcerans dipeptidase PepE 0.0083 0.0746 0.0847
Plasmodium falciparum methionine aminopeptidase 2 0.0083 0.0746 0.0746
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Brugia malayi MH2 domain containing protein 0.0248 0.2897 0.2897
Trypanosoma brucei Metallopeptidase family M24, putative 0.0083 0.0746 0.0746
Brugia malayi hypothetical protein 0.0075 0.0645 0.0645
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Trichomonas vaginalis ribokinase, putative 0.003 0.0059 0.0386
Entamoeba histolytica hypothetical protein 0.0075 0.0645 0.6504
Trypanosoma cruzi adenosine kinase, putative 0.003 0.0059 0.0059
Brugia malayi follicle stimulating hormone receptor 0.0227 0.2618 0.2618
Schistosoma mansoni programmed cell death protein 0.006 0.0449 0.0481
Trichomonas vaginalis chromobox protein, putative 0.007 0.0577 0.7634
Leishmania major hypothetical protein, conserved 0.0141 0.1507 0.1507
Trypanosoma cruzi hypothetical protein, conserved 0.0141 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0059
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0083 0.0746 0.0847
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Schistosoma mansoni programmed cell death protein 0.006 0.0449 0.0481
Brugia malayi Adenosine kinase-like 0.0261 0.3063 0.3063
Brugia malayi metallopeptidase family M24 containing protein 0.0083 0.0746 0.0746
Plasmodium vivax hypothetical protein, conserved 0.0141 0.1507 0.1507
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0654 0.8166 0.8166
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0654 0.8166 1
Onchocerca volvulus 0.0083 0.0746 0.2623
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0083 0.0746 0.0746
Leishmania major tagatose-6-phosphate kinase-like protein 0.003 0.0059 0.0059
Schistosoma mansoni adenosine kinase 0.0261 0.3063 0.3705
Echinococcus multilocularis geminin 0.0352 0.425 0.4215
Trypanosoma cruzi adenosine kinase, putative 0.0261 0.3063 0.3063
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0654 0.8166 1
Entamoeba histolytica peptidase, putative 0.0083 0.0746 0.7628
Brugia malayi HSF-type DNA-binding domain containing protein 0.0099 0.0959 0.0959
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0083 0.0746 0.2623
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0654 0.8166 1
Loa Loa (eye worm) initiation factor 2-associated protein 0.0083 0.0746 0.0746
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0654 0.8166 1
Trypanosoma cruzi hypothetical protein, conserved 0.0141 0.1507 0.1507
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0795 1 1
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0083 0.0746 0.0746
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Entamoeba histolytica methionine aminopeptidase, putative 0.0083 0.0746 0.7628
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0218 0.261
Plasmodium falciparum HP12 protein homolog, putative 0.0141 0.1507 0.1507
Trichomonas vaginalis ribokinase, putative 0.003 0.0059 0.0386
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0083 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0059
Echinococcus multilocularis chromobox protein 1 0.007 0.0577 0.0521
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0083 0.0746 0.0691
Echinococcus granulosus chromobox protein 1 0.007 0.0577 0.0521
Toxoplasma gondii transcriptional elongation factor FACT140 0.0083 0.0746 0.0746
Toxoplasma gondii methionine aminopeptidase 0.0654 0.8166 0.8166
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0083 0.0746 0.0746
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0218 0.261
Leishmania major adenosine kinase-like protein 0.003 0.0059 0.0059
Trypanosoma cruzi adenosine kinase, putative 0.0261 0.3063 0.3063
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.01 0.0041
Echinococcus granulosus FACT complex subunit SPT16 0.0083 0.0746 0.0691
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.01 0.01
Toxoplasma gondii hypothetical protein 0.0141 0.1507 0.1507
Echinococcus granulosus geminin 0.0352 0.425 0.4215
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0795 1 1
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.0959 1
Brugia malayi metallopeptidase family M24 containing protein 0.0083 0.0746 0.0746
Echinococcus granulosus p2X purinoceptor 4 0.0463 0.5687 0.5661
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.018 0.046
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Onchocerca volvulus Dipeptidase C homolog 0.0083 0.0746 0.2623
Brugia malayi Ribokinase 0.003 0.0059 0.0059
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0083 0.0746 0.0746
Echinococcus multilocularis FACT complex subunit SPT16 0.0083 0.0746 0.0691
Plasmodium vivax methionine aminopeptidase 2, putative 0.0083 0.0746 0.0746
Leishmania major putative PfkB family sugar kinase 0.003 0.0059 0.0059
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0115 0.0115
Echinococcus multilocularis xaa Pro dipeptidase 0.0083 0.0746 0.0691
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.01 0.01
Toxoplasma gondii creatinase domain-containing protein 0.0083 0.0746 0.0746
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.01 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0059 0.0386
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0645 0.0722
Plasmodium falciparum aminopeptidase P 0.0083 0.0746 0.0746
Schistosoma mansoni P2X receptor subunit 0.0463 0.5687 0.6942
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0654 0.8166 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0795 1 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0034 0.0115 0.0115
Brugia malayi Isocitrate dehydrogenase 0.0033 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0075 0.0645 0.0722
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.01 0.01
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0645 0.0589
Loa Loa (eye worm) hypothetical protein 0.0031 0.007 0.007
Schistosoma mansoni adenosine kinase 0.0261 0.3063 0.3705
Trypanosoma cruzi aminopeptidase P1, putative 0.0083 0.0746 0.0746
Entamoeba histolytica hypothetical protein 0.0075 0.0645 0.6504
Leishmania major ribokinase, putative 0.003 0.0059 0.0059
Echinococcus multilocularis p2X purinoceptor 4 0.0463 0.5687 0.5661
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0083 0.0746 0.0746
Leishmania major methionine aminopeptidase 2, putative 0.0083 0.0746 0.0746
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0654 0.8166 1
Echinococcus multilocularis chromobox protein 1 0.007 0.0577 0.0521
Loa Loa (eye worm) MH2 domain-containing protein 0.0248 0.2897 0.2897
Loa Loa (eye worm) transcription factor SMAD2 0.0248 0.2897 0.2897
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0083 0.0746 0.0746
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.032 0.032
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0083 0.0746 0.0847
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Echinococcus multilocularis xaa pro aminopeptidase 0.0083 0.0746 0.0691
Leishmania major transcription factor-like protein 0.0083 0.0746 0.0746
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0083 0.0746 1
Loa Loa (eye worm) hypothetical protein 0.0261 0.3063 0.3063
Loa Loa (eye worm) DNA-binding protein 0.0083 0.0746 0.0746
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0654 0.8166 0.8166
Brugia malayi Heterochromatin protein 1 0.007 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.005 0.032 0.032
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0083 0.0746 0.0746
Toxoplasma gondii kinase, pfkB family protein 0.003 0.0059 0.0059
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0083 0.0746 0.0847
Brugia malayi isocitrate dehydrogenase 0.0033 0.01 0.01

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 30 ug ml-1 Antiviral activity against HSV-1 (Brand) in human epithelial (Hep-2) cells ChEMBL. 3037079
MIC (functional) = 100 ug ml-1 Antiviral activity against HSV-2 (K979) in human epithelial (Hep-2) cells ChEMBL. 3037079

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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