Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.75 | Antitrypanosomal activity against Trypanosoma cruzi epimastigote Y strain after 24 hrs by trypan blue exclusion assay | ChEMBL. | 19683450 |
IC50 (functional) | = 17.9 uM | Antitrypanosomal activity against Trypanosoma cruzi epimastigote Y strain after 24 hrs by trypan blue exclusion assay | ChEMBL. | 19683450 |
IC50 (functional) | = 47.8 uM | Antitrypanosomal activity against Trypanosoma cruzi trypomastigote Y strain after 24 hrs by trypan blue exclusion assay | ChEMBL. | 19683450 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 19683450 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.