Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0906 | 0.2915 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0.3108 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0906 | 0.2915 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0906 | 0.0906 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0.3108 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0906 | 0.2915 |
Schistosoma mansoni | histone deacetylase | 0.0062 | 0.3108 | 0.3108 |
Brugia malayi | histone deacetylase 11 | 0.0018 | 0.0723 | 0.2294 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1604 | 0.1604 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3108 | 0.9864 |
Plasmodium falciparum | histone deacetylase 1 | 0.0062 | 0.3108 | 1 |
Onchocerca volvulus | 0.0032 | 0.1504 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0164 | 0.0526 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0019 | 0.0019 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0164 | 0.0526 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3151 | 0.3151 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0906 | 0.2915 |
Trypanosoma brucei | histone deacetylase 3 | 0.0018 | 0.0723 | 0.2326 |
Schistosoma mansoni | histone deacetylase | 0.0062 | 0.3108 | 0.3108 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.03 | 0.0953 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0164 | 0.0526 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0164 | 0.0526 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0018 | 0.0723 | 0.2294 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0164 | 0.0526 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0062 | 0.3108 | 0.3108 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0018 | 0.0723 | 0.2326 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2453 | 0.7785 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0062 | 0.3108 | 0.9864 |
Brugia malayi | RNA binding protein | 0.0063 | 0.3151 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0164 | 0.0526 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2453 | 0.7785 |
Trypanosoma brucei | histone deacetylase 1 | 0.0062 | 0.3108 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.1603 | 0.1603 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3151 | 0.3151 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3151 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0018 | 0.0723 | 0.2326 |
Trypanosoma brucei | histone deacetylase 4 | 0.0018 | 0.0723 | 0.2326 |
Trypanosoma brucei | histone deacetylase 2 | 0.0018 | 0.0723 | 0.2326 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0906 | 0.0906 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3151 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0307 | 0.0975 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0906 | 0.0906 |
Echinococcus granulosus | histone deacetylase 3 | 0.0062 | 0.3108 | 0.3108 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1604 | 0.5092 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3151 | 0.3151 |
Schistosoma mansoni | hypothetical protein | 0.019 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0201 | 0.0201 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0062 | 0.3108 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0906 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0619 | 0.0619 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0201 | 0.0201 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.1504 | 0.1504 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0018 | 0.0723 | 0.0723 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0062 | 0.3108 | 1 |
Leishmania major | histone deacetylase, putative | 0.0018 | 0.0723 | 0.2326 |
Leishmania major | histone deacetylase, putative | 0.0018 | 0.0723 | 0.2326 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0062 | 0.3108 | 0.3108 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0062 | 0.3108 | 0.9864 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0062 | 0.3108 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0164 | 0.0526 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0062 | 0.3108 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0619 | 0.1966 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0164 | 0.0526 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0906 | 0.2915 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0018 | 0.0723 | 0.2326 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0201 | 0.0201 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0906 | 0.2915 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0619 | 0.0619 |
Echinococcus granulosus | histone deacetylase 7 | 0.0018 | 0.0723 | 0.0723 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0018 | 0.0723 | 0.0723 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0062 | 0.3108 | 0.9864 |
Trypanosoma brucei | histone deacetylase, putative | 0.0018 | 0.0723 | 0.2326 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0018 | 0.0723 | 0.2326 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0906 | 0.2915 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0068 | 0.3448 | 0.3448 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3151 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3151 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3151 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0164 | 0.0526 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0906 | 0.2876 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0018 | 0.0723 | 0.0723 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.3151 | 0.3151 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.1504 | 0.4775 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0201 | 0.0201 |
Echinococcus granulosus | histone deacetylase 8 | 0.0018 | 0.0723 | 0.0723 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0906 | 0.2915 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0906 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0062 | 0.3108 | 0.9864 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0018 | 0.0723 | 0.2326 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0018 | 0.0723 | 0.0723 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.1603 | 0.1603 |
Echinococcus granulosus | histone deacetylase 1 | 0.0062 | 0.3108 | 0.3108 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2453 | 0.7785 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0619 | 0.0619 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0164 | 0.0526 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0018 | 0.0723 | 0.2326 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0619 | 0.1966 |
Loa Loa (eye worm) | histone deacetylase | 0.0018 | 0.0723 | 0.2294 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0619 | 0.1966 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.1603 | 0.1603 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3151 | 0.3151 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0619 | 0.0619 |
Giardia lamblia | Histone deacetylase | 0.0062 | 0.3108 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0062 | 0.3108 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0619 | 0.0619 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0164 | 0.0526 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0061 | 0.3055 | 0.983 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0307 | 0.0307 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0062 | 0.3108 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0164 | 0.0526 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0018 | 0.0723 | 0.2326 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0018 | 0.0723 | 0.2326 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0906 | 0.2915 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0906 | 0.2876 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0018 | 0.0723 | 0.0723 |
Schistosoma mansoni | hypothetical protein | 0.019 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0.3108 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1604 | 0.5092 |
Plasmodium falciparum | histone deacetylase 2 | 0.0018 | 0.0723 | 0.2326 |
Echinococcus granulosus | histone deacetylase 6 | 0.0018 | 0.0723 | 0.0723 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0062 | 0.3108 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0619 | 0.1966 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0906 | 0.2915 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0906 | 0.0906 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0.3108 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0018 | 0.0723 | 0.0723 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0.3108 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0018 | 0.0723 | 0.0723 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0164 | 0.0526 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0906 | 0.2915 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3151 | 0.3151 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.1504 | 0.4775 |
Brugia malayi | Histone deacetylase 1 | 0.0062 | 0.3108 | 0.9864 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0619 | 0.0619 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0062 | 0.3108 | 1 |
Leishmania major | histone deacetylase, putative | 0.0062 | 0.3108 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0307 | 0.0307 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0906 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0906 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0018 | 0.0723 | 0.2294 |
Echinococcus multilocularis | geminin | 0.019 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0018 | 0.0723 | 0.2326 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0164 | 0.0526 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0619 | 0.0619 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0018 | 0.0723 | 0.0723 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0018 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0018 | 0.0723 | 0.2294 |
Plasmodium vivax | histone deacetylase, putative | 0.0018 | 0.0723 | 0.2326 |
Echinococcus multilocularis | histone deacetylase | 0.0018 | 0.0723 | 0.0723 |
Plasmodium falciparum | histone deacetylase, putative | 0.0018 | 0.0723 | 0.2326 |
Brugia malayi | Histone deacetylase family protein | 0.0018 | 0.0723 | 0.2294 |
Leishmania major | histone deacetylase, putative | 0.0062 | 0.3108 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0164 | 0.0526 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0201 | 0.0201 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0164 | 0.0526 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.1603 | 0.1603 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0018 | 0.0723 | 0.0723 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0164 | 0.0526 |
Echinococcus granulosus | histone deacetylase 6 | 0.0018 | 0.0723 | 0.0723 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.3151 | 0.3151 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0619 | 0.0619 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0018 | 0.0723 | 0.0723 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0164 | 0.0526 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 0.3108 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0018 | 0.0723 | 0.2326 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0619 | 0.0619 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0018 | 0.0723 | 0.4804 |
Entamoeba histolytica | histone deacetylase, putative | 0.0062 | 0.3108 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2453 | 0.7785 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0619 | 0.0619 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0018 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0723 | 0.2294 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 10 % | Inhibition of 17Beta-HSD3 expressed in homogenized HEK293 cells assessed as transformation of [14C]-4-androstene-3,17-dione into [14C]-testosterone in presence of NADPH at 0.01 uM | ChEMBL. | 21741247 |
Inhibition (binding) | = 33 % | Inhibition of 17Beta-HSD3 expressed in homogenized HEK293 cells assessed as transformation of [14C]-4-androstene-3,17-dione into [14C]-testosterone in presence of NADPH at 0.1 uM | ChEMBL. | 21741247 |
Inhibition (binding) | = 63 % | Inhibition of 17Beta-HSD3 expressed in intact HEK293 cells assessed as transformation of [14C]-4-androstene-3,17-dione into [14C]-testosterone in presence of NADPH at 1 uM after 1 hr incubation | ChEMBL. | 21741247 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.