Detailed information for compound 1098116

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.311 | Formula: C19H14O6
  • H donors: 0 H acceptors: 2 LogP: 3.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Oc1ccc2c(c1C)occ(c2=O)c1ccc2c(c1)OCO2
  • InChi: 1S/C19H14O6/c1-10-15(25-11(2)20)6-4-13-18(21)14(8-22-19(10)13)12-3-5-16-17(7-12)24-9-23-16/h3-8H,9H2,1-2H3
  • InChiKey: WBXJDWATEDHTCT-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax serine-repeat antigen (SERA) 0.0065 0.0184 0.0911
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0086 0.0033
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0595 0.26 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.117 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.0626 0.0892
Loa Loa (eye worm) transcription factor SMAD2 0.0141 0.053 0.0743
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0351 0.0351
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0162 0.0626 0.5024
Schistosoma mansoni peptidylglycine monooxygenase 0.0125 0.0458 0.0458
Echinococcus granulosus Mastin 0.0042 0.0078 0.0078
Echinococcus multilocularis cathepsin L 0.0065 0.0184 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0282 0.117 1
Giardia lamblia Hypothetical protein 0.0065 0.0184 0.1168
Trypanosoma cruzi cysteine peptidase, putative 0.0282 0.117 0.4332
Schistosoma mansoni importin beta-1 0.0059 0.0157 0.0157
Echinococcus granulosus integrin alpha ps 0.0035 0.0048 0.0048
Leishmania major cathepsin L-like protease 0.0282 0.117 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0162 0.0626 0.0626
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0239 0.0841
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.0746 0.0746
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0239 0.0841
Loa Loa (eye worm) hypothetical protein 0.0162 0.0626 0.0892
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0143 0.054 0.2291
Loa Loa (eye worm) hypothetical protein 0.0077 0.0239 0.0295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.117 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.117 1
Plasmodium vivax vivapain-1 0.0153 0.0584 0.4596
Plasmodium vivax heterochromatin protein 1, putative 0.0162 0.0626 0.4986
Loa Loa (eye worm) hypothetical protein 0.0282 0.117 0.1731
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0086 0.0076
Giardia lamblia Cysteine protease 0.0065 0.0184 0.1168
Brugia malayi Cathepsin L-like precursor 0.0282 0.117 0.1729
Schistosoma mansoni hypothetical protein 0.0363 0.154 0.154
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.02 0.0652
Brugia malayi cathepsin B-like cysteine proteinase 0.0595 0.26 0.3935
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0494 0.2137 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0282 0.117 1
Loa Loa (eye worm) cathepsin B 0.0229 0.0932 0.1363
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0162 0.0626 0.0626
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0144 0.0144
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0239 0.1479
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0064 0.0178 0.0398
Brugia malayi cathepsin F-like cysteine proteinase 0.0065 0.0184 0.0208
Loa Loa (eye worm) hypothetical protein 0.0162 0.0626 0.0892
Leishmania major hypothetical protein, conserved 0.0077 0.0239 0.1479
Plasmodium falciparum glutathione reductase 0.0056 0.0144 0.054
Brugia malayi Cathepsin L-like precursor 0.0282 0.117 0.1729
Mycobacterium tuberculosis Conserved protein 0.0077 0.0239 0.0841
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0125 0.0458 0.063
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0162 0.0626 0.5024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.02 0.652
Echinococcus multilocularis Chromo domain 0.0162 0.0626 0.0626
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.117 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0162 0.0626 0.4986
Treponema pallidum exodeoxyribonuclease (exoA) 0.0064 0.0178 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0064 0.0178 0.0178
Onchocerca volvulus 0.0282 0.117 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0065 0.0184 0.0211
Echinococcus granulosus cathepsin l cysteine peptidase 0.0282 0.117 0.117
Loa Loa (eye worm) hypothetical protein 0.0194 0.0771 0.1115
Trypanosoma cruzi cysteine peptidase, putative 0.0282 0.117 0.4332
Schistosoma mansoni ap endonuclease 0.0064 0.0178 0.0178
Brugia malayi Kelch motif family protein 0.0092 0.0306 0.0395
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0065 0.0184 0.0911
Trypanosoma cruzi major cysteine proteinase, putative 0.0065 0.0184 0.0425
Loa Loa (eye worm) hypothetical protein 0.0088 0.0286 0.0368
Entamoeba histolytica cysteine protease, putative 0.0065 0.0184 0.098
Leishmania major cathepsin L-like protease 0.0282 0.117 1
Giardia lamblia Cathepsin B precursor 0.0229 0.0932 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0086 0.0086
Schistosoma mansoni ran 0.0044 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0035 0.0048 0.0048
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0086 0.0033
Loa Loa (eye worm) hypothetical protein 0.0194 0.0771 0.1115
Brugia malayi Cathepsin L-like precursor 0.0282 0.117 0.1729
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0184 0.098
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.0746 0.0746
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0229 0.0932 0.7816
Trypanosoma brucei cysteine peptidase C (CPC) 0.0229 0.0932 0.7816
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0157 0.0729
Plasmodium falciparum serine repeat antigen 6 0.0065 0.0184 0.0911
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.0746 0.1074
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0162 0.0626 0.5024
Echinococcus granulosus geminin 0.0363 0.154 0.154
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0626 0.5024
Echinococcus multilocularis snurportin 1 0.0633 0.2773 0.2773
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0144 0.0149
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0139 0.0569
Leishmania major GTP-binding protein, putative 0.0044 0.0086 0.0076
Giardia lamblia Hypothetical protein 0.0065 0.0184 0.1168
Schistosoma mansoni ran 0.0044 0.0086 0.0086
Toxoplasma gondii cathepsin CPC2 0.0065 0.0184 0.098
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0106 0.0261
Plasmodium vivax vivapain-2 0.0282 0.117 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0064 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0229 0.0932 0.7816
Entamoeba histolytica cysteine protease, putative 0.0065 0.0184 0.098
Schistosoma mansoni cathepsin C 0.0065 0.0184 0.0184
Loa Loa (eye worm) beta-lactamase 0.0077 0.0239 0.0295
Brugia malayi Cathepsin L-like precursor 0.0194 0.0771 0.1112
Leishmania major cathepsin L-like protease 0.0282 0.117 1
Giardia lamblia Cathepsin B precursor 0.0065 0.0184 0.1168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.117 1
Trypanosoma cruzi cysteine protease, putative 0.0153 0.0584 0.2009
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0088 0.0286 0.0365
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0153 0.0584 0.2009
Brugia malayi beta-lactamase 0.0077 0.0239 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0626 0.5024
Entamoeba histolytica hypothetical protein 0.0065 0.0184 0.098
Leishmania major importin beta-1 subunit, putative 0.0048 0.0106 0.0261
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0239 0.0292
Plasmodium falciparum serine repeat antigen 1 0.0065 0.0184 0.0911
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0086 0.0058
Echinococcus granulosus cysteine protease 0.0153 0.0584 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0626 0.5024
Plasmodium falciparum serine repeat antigen 8 0.0065 0.0184 0.0911
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0239 0.0295
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0065 0.0184 0.0208
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0162 0.0626 0.5024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0162 0.0626 0.5024
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0162 0.0626 0.0626
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0065 0.0184 0.0911
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0162 0.0626 0.0626
Schistosoma mansoni integrin alpha-ps 0.0038 0.0062 0.0062
Schistosoma mansoni chromobox protein 0.0162 0.0626 0.0626
Loa Loa (eye worm) cysteine protease 0.0282 0.117 0.1731
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0229 0.0932 0.3386
Onchocerca volvulus 0.0077 0.0239 0.0553
Plasmodium vivax vivapain-2 0.0282 0.117 1
Trypanosoma cruzi cysteine peptidase, putative 0.0088 0.0286 0.0828
Giardia lamblia Cathepsin B precursor 0.0229 0.0932 1
Brugia malayi Heterochromatin protein 1 0.0162 0.0626 0.089
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0236 0.0963 0.0963
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0184 0.098
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0139 0.0497
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0065 0.0184 0.0911
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0153 0.0584 0.4637
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0092 0.0306 0.0398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0584 0.4637
Loa Loa (eye worm) hypothetical protein 0.0162 0.0626 0.0892
Loa Loa (eye worm) hypothetical protein 0.0162 0.0626 0.0892
Plasmodium falciparum serine repeat antigen 4 0.0065 0.0184 0.0911
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0077 0.0045
Giardia lamblia Cysteine protease 0.0065 0.0184 0.1168
Trichomonas vaginalis ap endonuclease, putative 0.0064 0.0178 0.0919
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0239 0.1479
Giardia lamblia Cathepsin B precursor 0.0065 0.0184 0.1168
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0085 0.0075
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.0584 0.4637
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0129 0.0474 0.1975
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0595 0.26 0.26
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Schistosoma mansoni ap endonuclease 0.0064 0.0178 0.0178
Mycobacterium tuberculosis Conserved protein 0.0077 0.0239 0.0841
Giardia lamblia Cathepsin B precursor 0.0065 0.0184 0.1168
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.0584 0.0824
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0184 0.0184
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.0771 0.6343
Schistosoma mansoni inositol monophosphatase 0.0044 0.0085 0.0085
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0129 0.0474 0.1975
Brugia malayi POT family protein 0.0048 0.0106 0.0087
Brugia malayi chromobox protein homolog 3 0.0162 0.0626 0.089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0771 0.6343
Schistosoma mansoni cathepsin F (C01 family) 0.0282 0.117 0.117
Giardia lamblia Cathepsin L precursor 0.0065 0.0184 0.1168
Plasmodium falciparum importin beta, putative 0.0059 0.0157 0.0658
Trichomonas vaginalis ap endonuclease, putative 0.0064 0.0178 0.0919
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.117 1
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Plasmodium vivax unspecified product 0.0153 0.0584 0.4596
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Entamoeba histolytica hypothetical protein 0.0162 0.0626 0.5024
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0626 0.5024
Loa Loa (eye worm) hypothetical protein 0.0124 0.0454 0.0627
Trichomonas vaginalis chromobox protein, putative 0.0162 0.0626 0.5024
Trypanosoma cruzi cysteine peptidase, putative 0.0282 0.117 0.4332
Brugia malayi hypothetical protein 0.0092 0.0306 0.0395
Giardia lamblia Cathepsin L precursor 0.0065 0.0184 0.1168
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.02 0.1121
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0065 0.0184 0.0911
Echinococcus granulosus cathepsin L cysteine protease 0.0153 0.0584 0.0584
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0162 0.0626 0.5024
Mycobacterium leprae Probable lipase LipE 0.0077 0.0239 0.3669
Echinococcus multilocularis Chromobox protein 3 0.0162 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0038 0.0062 0.0021
Giardia lamblia Cathepsin L precursor 0.0065 0.0184 0.1168
Brugia malayi beta-lactamase family protein 0.0077 0.0239 0.0292
Brugia malayi cathepsin L-like cysteine proteinase 0.0065 0.0184 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0065 0.0184 0.098
Echinococcus multilocularis Mastin 0.0042 0.0078 0.0078
Trichomonas vaginalis Heterochromatin protein, putative 0.0162 0.0626 0.5024
Brugia malayi Associated with TFs and helicases family protein 0.0162 0.0626 0.089
Brugia malayi Integrin beta pat-3 precursor 0.0605 0.2646 0.4006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0088 0.0286 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0626 0.5024
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0162 0.0626 0.5024
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.053 0.0743
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0236 0.0963 0.0963
Brugia malayi exodeoxyribonuclease III family protein 0.0064 0.0178 0.0197
Entamoeba histolytica cysteine proteinase, putative 0.0282 0.117 1
Onchocerca volvulus 0.0282 0.117 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0129 0.0474 0.862
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0184 0.098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0184 0.098
Echinococcus multilocularis glycoprotein Antigen 5 0.0042 0.0078 0.0078
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0085 0.0085
Echinococcus granulosus cathepsin L 0.0153 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0059 0.0157 0.0168
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.0351 0.0467
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0065 0.0184 0.0911
Onchocerca volvulus 0.0282 0.117 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0139 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0065 0.0184 0.098
Echinococcus granulosus glycoprotein Antigen 5 0.0042 0.0078 0.0078
Onchocerca volvulus 0.0194 0.0771 0.5946
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.0584 0.4637
Brugia malayi glutathione reductase 0.0056 0.0144 0.0145
Brugia malayi fibroinase precursor 0.0065 0.0184 0.0208
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.02 0.02
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.117 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0065 0.0184 0.0184
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.117 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0236 0.0963 0.1409
Toxoplasma gondii preprocathepsin c precursor, putative 0.0065 0.0184 0.098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Trichomonas vaginalis chromobox protein, putative 0.0162 0.0626 0.5024
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1457 0.653 1
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0626 0.5024
Toxoplasma gondii exonuclease III APE 0.0064 0.0178 0.0919
Echinococcus granulosus chromobox protein 1 0.0162 0.0626 0.0626
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.117 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.0184 0.098
Loa Loa (eye worm) hypothetical protein 0.0236 0.0963 0.1411
Giardia lamblia Cathepsin B precursor 0.0229 0.0932 1
Giardia lamblia Cathepsin B precursor 0.0065 0.0184 0.1168
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0162 0.0626 0.0626
Leishmania major cysteine peptidase A (CPA) 0.0282 0.117 1
Echinococcus multilocularis integrin alpha 3 0.0126 0.0462 0.0462
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0239 0.0841
Echinococcus granulosus snurportin 1 0.0633 0.2773 0.2773
Brugia malayi Thioredoxin reductase 0.0056 0.0144 0.0145
Echinococcus multilocularis integrin alpha ps 0.0074 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0141
Trypanosoma cruzi cysteine proteinase, putative 0.0153 0.0584 0.2009
Leishmania major cathepsin L-like protease 0.0282 0.117 1
Leishmania major cathepsin L-like protease 0.0282 0.117 1
Brugia malayi MH2 domain containing protein 0.0141 0.053 0.074
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0139 0.0497
Loa Loa (eye worm) hypothetical protein 0.0065 0.0184 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.117 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0162 0.0626 0.0626
Schistosoma mansoni hypothetical protein 0.0633 0.2773 0.2773
Brugia malayi cathepsin Z-like cysteine proteinase 0.0065 0.0184 0.0208
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0064 0.0178 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0282 0.117 0.117
Echinococcus granulosus integrin alpha 3 0.0126 0.0462 0.0462
Echinococcus granulosus enteropeptidase 0.0042 0.0078 0.0078
Mycobacterium ulcerans beta-lactamase 0.0077 0.0239 0.8749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0351 0.0351
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0239 0.0239
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0162 0.0626 0.5024
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Toxoplasma gondii ABC1 family protein 0.0077 0.0239 0.1479
Brugia malayi CHD4 protein 0.0162 0.0626 0.089
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0239 0.0641
Brugia malayi Papain family cysteine protease containing protein 0.0282 0.117 0.1729
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0184 0.0184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0351 0.0351
Schistosoma mansoni chromobox protein 0.0162 0.0626 0.0626
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0239 0.1479
Brugia malayi Cathepsin L-like precursor 0.0282 0.117 0.1729
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0282 0.117 0.117
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0086 0.0086
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0064 0.0178 0.0849
Trichomonas vaginalis chromobox protein, putative 0.0162 0.0626 0.5024
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0065 0.0184 0.0211
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0239 0.3669
Echinococcus granulosus importin subunit beta 1 0.0059 0.0157 0.0157
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.0261 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1007 0.4478 0.4478
Echinococcus granulosus Chromobox protein 3 0.0162 0.0626 0.0626
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0085 0.0075
Brugia malayi RNA, U transporter 1 0.0169 0.0655 0.0934
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0065 0.0184 0.0184
Onchocerca volvulus Cathepsin F homolog 0.0282 0.117 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0184 0.098
Entamoeba histolytica cysteine protease, putative 0.0065 0.0184 0.098
Entamoeba histolytica hypothetical protein 0.0162 0.0626 0.5024
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0106 0.0113
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0144 0.054
Schistosoma mansoni integrin alpha 0.0165 0.0637 0.0637
Loa Loa (eye worm) hypothetical protein 0.0595 0.26 0.3937
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0085 0.0085
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0162 0.0626 0.0626
Schistosoma mansoni cathepsin s 0.0088 0.0286 0.0286
Trypanosoma cruzi cruzipain precursor, putative 0.0282 0.117 0.4332
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0162 0.0626 0.4483
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0124 0.0454 0.0624
Echinococcus multilocularis cysteine protease 0.0282 0.117 0.117
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0162 0.0626 0.5024
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0153 0.0584 0.0584
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0064 0.0178 0.0919
Brugia malayi Cathepsin L-like precursor 0.0194 0.0771 0.1112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0351 0.0351
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0239 0.0239
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0086 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0584 0.4637
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0239 0.1414
Schistosoma mansoni dopamine-beta-monooxygenase 0.0125 0.0458 0.0458
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0085 0.0075
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.02 0.02
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0065 0.0184 0.1168
Toxoplasma gondii thioredoxin reductase 0.0056 0.0144 0.0611
Loa Loa (eye worm) hypothetical protein 0.0091 0.0301 0.039
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0144 0.0144
Echinococcus multilocularis geminin 0.0363 0.154 0.154
Entamoeba histolytica cysteine protease, putative 0.0065 0.0184 0.098
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0239 0.0841
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.117 1
Trypanosoma cruzi cruzipain precursor, putative 0.0088 0.0286 0.0828
Plasmodium falciparum thioredoxin reductase 0.0056 0.0144 0.054
Giardia lamblia Cysteine protease 0.0065 0.0184 0.1168
Loa Loa (eye worm) hypothetical protein 0.0129 0.0476 0.066
Onchocerca volvulus 0.0162 0.0626 0.4483
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0239 0.1479
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0064 0.0178 0.0849
Trypanosoma brucei trypanothione reductase 0.0056 0.0144 0.0611
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0162 0.0626 0.5024
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.02 0.1121
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0085 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0143 0.054 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0162 0.0626 0.5024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.117 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0239 0.0295
Echinococcus multilocularis cathepsin b 0.0595 0.26 0.26
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0184 0.0184
Leishmania major trypanothione reductase 0.0056 0.0144 0.0611
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0077 0.0042
Brugia malayi Importin beta-1 subunit 0.0059 0.0157 0.0165
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0065 0.0184 0.0911
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0351 0.0351
Brugia malayi cathepsin L-like precursor 0.0194 0.0771 0.1112
Loa Loa (eye worm) hypothetical protein 0.0077 0.0239 0.0295
Plasmodium falciparum serine repeat antigen 2 0.0065 0.0184 0.0911
Brugia malayi Cathepsin L-like precursor 0.0088 0.0286 0.0365
Brugia malayi Cathepsin L-like cysteine proteinase 0.0194 0.0771 0.1112
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0064 0.0178 0.0919
Echinococcus multilocularis integrin beta 2 0.0448 0.1931 0.1931
Plasmodium vivax glutathione reductase, putative 0.0056 0.0144 0.054
Echinococcus multilocularis fibrillin 1 0.0033 0.0035 0.0035
Brugia malayi Angiotensin-converting enzyme family protein 0.1457 0.653 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0282 0.117 1
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0065 0.0184 0.0211
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0065 0.0184 0.0184
Schistosoma mansoni alpha glucosidase 0.0042 0.0077 0.0077
Leishmania major cathepsin L-like protease 0.0282 0.117 1
Schistosoma mansoni alpha-glucosidase 0.0162 0.0626 0.0626
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.0184 0.098
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.0584 0.4637
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0106 0.0261
Onchocerca volvulus 0.0282 0.117 1
Onchocerca volvulus Cathepsin L homolog 0.0282 0.117 1
Giardia lamblia Cathepsin L precursor 0.0065 0.0184 0.1168
Onchocerca volvulus 0.0109 0.0384 0.2021
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0085 0.0075
Echinococcus multilocularis enteropeptidase 0.0042 0.0078 0.0078
Echinococcus granulosus tm gpcr rhodopsin 0.1007 0.4478 0.4478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.117 1
Entamoeba histolytica cysteine protease, putative 0.0065 0.0184 0.098
Trichomonas vaginalis chromobox protein, putative 0.0162 0.0626 0.5024
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0184 0.0184
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.0184 0.098
Loa Loa (eye worm) POT family protein 0.0048 0.0106 0.009
Echinococcus multilocularis chromobox protein 1 0.0162 0.0626 0.0626
Echinococcus multilocularis cysteine protease 0.0282 0.117 0.117
Echinococcus multilocularis integrin alpha ps 0.0035 0.0048 0.0048
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0065 0.0184 0.1168
Trichomonas vaginalis ran, putative 0.0044 0.0086 0.0076
Loa Loa (eye worm) heterochromatin protein 1 0.0162 0.0626 0.0892
Brugia malayi Valyl-tRNA synthetase 0.0162 0.0626 0.089
Toxoplasma gondii cathepsin B 0.0229 0.0932 0.7816
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0065 0.0184 0.0911
Echinococcus granulosus cathepsin l1 0.0194 0.0771 0.0771
Giardia lamblia Cathepsin L precursor 0.0065 0.0184 0.1168
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0239 0.0841
Trichomonas vaginalis chromobox protein, putative 0.0162 0.0626 0.5024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0184 0.098
Loa Loa (eye worm) hypothetical protein 0.0065 0.0184 0.0211
Schistosoma mansoni cathepsin S (C01 family) 0.0065 0.0184 0.0184
Loa Loa (eye worm) integrin alpha pat-2 0.0254 0.1043 0.1536
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0162 0.0626 0.0626
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0184 0.098
Echinococcus multilocularis chromobox protein 2 0.2218 1 1
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.0584 0.4637
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Loa Loa (eye worm) integrin beta-2 0.0605 0.2646 0.4008
Plasmodium vivax serine-repeat antigen (SERA) 0.0065 0.0184 0.0911
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.02 0.02
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.0584 0.0824
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0162 0.0626 0.5024
Echinococcus multilocularis chromobox protein 1 0.0162 0.0626 0.0626
Brugia malayi beta-lactamase family protein 0.0077 0.0239 0.0292
Trypanosoma cruzi cysteine peptidase, putative 0.0153 0.0584 0.2009
Entamoeba histolytica cysteine protease, putative 0.0065 0.0184 0.098
Entamoeba histolytica Ran family GTPase 0.0044 0.0086 0.0076
Loa Loa (eye worm) helicase 0.0162 0.0626 0.0892
Echinococcus multilocularis cathepsin L cysteine protease 0.0282 0.117 0.117
Schistosoma mansoni hypothetical protein 0.0162 0.0626 0.0626
Plasmodium vivax importin-beta 2, putative 0.0059 0.0157 0.0658
Loa Loa (eye worm) fibroinase 0.0282 0.117 0.1731
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0065 0.0184 0.1168
Onchocerca volvulus 0.0077 0.0239 0.0553
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0162 0.0626 0.4483
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0085 0.0075
Giardia lamblia Cysteine protease 0.0065 0.0184 0.1168
Brugia malayi Papain family cysteine protease containing protein 0.0065 0.0184 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0626 0.5024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0162 0.0626 0.5024
Brugia malayi Integrin alpha pat-2 precursor 0.0165 0.0637 0.0906
Onchocerca volvulus Cathepsin L homolog 0.0282 0.117 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0184 0.0211
Echinococcus multilocularis cathepsin b 0.0595 0.26 0.26
Leishmania major cathepsin L-like protease 0.0282 0.117 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0633 0.2773 0.4203
Schistosoma mansoni cathepsin F (C01 family) 0.0194 0.0771 0.0771
Plasmodium falciparum serine repeat antigen 3 0.0065 0.0184 0.0911
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.02 0.652
Echinococcus granulosus integrin alpha ps 0.0074 0.0223 0.0223
Entamoeba histolytica cysteine proteinase 1, putative 0.0153 0.0584 0.4637
Schistosoma mansoni inositol monophosphatase 0.0044 0.0085 0.0085
Onchocerca volvulus 0.0162 0.0626 0.4483
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0157 0.0729
Brugia malayi cathepsin L precursor 0.0065 0.0184 0.0208
Schistosoma mansoni cathepsin B (C01 family) 0.0065 0.0184 0.0184
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0162 0.0626 0.5024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0239 0.0841
Entamoeba histolytica cysteine proteinase 2 0.0153 0.0584 0.4637
Brugia malayi cathepsin Z-like cysteine proteinase 0.0065 0.0184 0.0208
Trypanosoma cruzi cysteine proteinase, putative 0.0153 0.0584 0.2009
Toxoplasma gondii cathepsin CPC1 0.0065 0.0184 0.098
Loa Loa (eye worm) hypothetical protein 0.0162 0.0626 0.0892
Loa Loa (eye worm) hypothetical protein 0.0065 0.0184 0.0211
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0153 0.0584 0.0584
Brugia malayi Papain family cysteine protease containing protein 0.0065 0.0184 0.0208
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0085 0.0075
Trypanosoma cruzi cysteine peptidase, putative 0.0282 0.117 0.4332
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0064 0.0178 0.5258
Giardia lamblia Cathepsin L precursor 0.0065 0.0184 0.1168
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0184 0.098
Mycobacterium ulcerans hypothetical protein 0.0077 0.0239 0.8749
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0239 0.1479
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0064 0.0177 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0184 0.0211
Leishmania major cathepsin L-like protease 0.0282 0.117 1
Brugia malayi Papain family cysteine protease containing protein 0.0065 0.0184 0.0208
Giardia lamblia Cathepsin B precursor 0.0065 0.0184 0.1168
Brugia malayi cathepsin F-like cysteine proteinase 0.0088 0.0286 0.0365
Brugia malayi hypothetical protein 0.0055 0.0139 0.0138
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0062 0.0168 0.0182
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0078 0.0078
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0139 0.0569
Brugia malayi Cathepsin L-like precursor 0.0282 0.117 0.1729
Schistosoma mansoni chromobox protein 0.0162 0.0626 0.0626
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0771 0.6343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0184 0.098
Entamoeba histolytica hypothetical protein 0.0048 0.0106 0.0261
Echinococcus granulosus cathepsin L 0.0065 0.0184 0.0184
Schistosoma mansoni integrin alpha-ps 0.0074 0.0223 0.0223
Mycobacterium ulcerans lipase LipD 0.0077 0.0239 0.8749
Loa Loa (eye worm) hypothetical protein 0.0077 0.0239 0.0295
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0139 0.0247
Entamoeba histolytica cysteine proteinase, putative 0.0282 0.117 1
Trichomonas vaginalis esterase, putative 0.0077 0.0239 0.1479
Echinococcus granulosus Chromo domain 0.0162 0.0626 0.0626
Echinococcus multilocularis cathepsin L cysteine protease 0.0282 0.117 0.117
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.0351 0.0464
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0144 0.0383
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0162 0.0626 0.0626
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.117 1
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0626 0.5024
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.0184 0.0184
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0595 0.26 0.26
Brugia malayi Inositol-1 0.0044 0.0085 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0184 0.098
Loa Loa (eye worm) hypothetical protein 0.0077 0.0239 0.0295
Loa Loa (eye worm) hypothetical protein 0.0092 0.0306 0.0398
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0064 0.0178 0.0919
Trypanosoma cruzi major cysteine proteinase, putative 0.0065 0.0184 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0065 0.0184 0.098
Echinococcus granulosus cathepsin b 0.0595 0.26 0.26
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0236 0.0963 0.0963
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0626 0.5024
Loa Loa (eye worm) CHromoDomain protein family member 0.0162 0.0626 0.0892
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0162 0.0626 0.5024
Loa Loa (eye worm) hypothetical protein 0.0077 0.0239 0.0295
Plasmodium falciparum serine repeat antigen 9 0.0065 0.0184 0.0911
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0065 0.0184 0.0911
Onchocerca volvulus 0.0282 0.117 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.117 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0282 0.117 0.117
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0139 0.0247
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0085 0.0033
Schistosoma mansoni chromobox protein 0.2218 1 1
Giardia lamblia Encystation-specific protease 0.0065 0.0184 0.1168
Brugia malayi Cathepsin L-like precursor 0.0282 0.117 0.1729
Loa Loa (eye worm) hypothetical protein 0.0162 0.0626 0.0892
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0085 0.0033
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0077 0.0077
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0065 0.0184 0.0911
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0229 0.0932 0.0932
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0065 0.0184 0.0911
Schistosoma mansoni integrin beta subunit 0.0356 0.1512 0.1512
Schistosoma mansoni cathepsin F (C01 family) 0.0282 0.117 0.117
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0065 0.0184 0.0911
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0162 0.0626 0.5024
Leishmania major hypothetical protein, conserved 0.0055 0.0139 0.0569
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0065 0.0184 0.0911
Echinococcus granulosus chromobox protein 1 0.0162 0.0626 0.0626
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0162 0.0626 0.089
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0064 0.0178 0.1089
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0194 0.0771 0.2748
Onchocerca volvulus 0.0077 0.0239 0.0553
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0065 0.0184 0.098
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0064 0.0178 0.0545
Entamoeba histolytica cysteine protease, putative 0.0282 0.117 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0153 0.0584 0.0584
Plasmodium vivax unspecified product 0.0065 0.0184 0.0911
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0065 0.0184 0.0184
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0162 0.0626 0.5024
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0088 0.0286 0.0368
Mycobacterium tuberculosis Probable dehydrogenase 0.0129 0.0474 0.1975
Plasmodium vivax hypothetical protein, conserved 0.0162 0.0626 0.4986
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0144 0.0265
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0064 0.0178 0.02
Trichomonas vaginalis hypothetical protein 0.0162 0.0626 0.5024
Brugia malayi M-phase phosphoprotein, mpp8 0.0162 0.0626 0.089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.117 1
Echinococcus granulosus integrin beta 2 0.0448 0.1931 0.1931
Echinococcus multilocularis cathepsin L 0.0153 0.0584 0.0584
Plasmodium falciparum heterochromatin protein 1 0.0162 0.0626 0.4986
Loa Loa (eye worm) ctsf protein 0.0282 0.117 0.1731
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0162 0.0626 0.5024
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0184 0.098
Schistosoma mansoni alpha-glucosidase 0.0162 0.0626 0.0626
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0106 0.0261
Mycobacterium tuberculosis Probable reductase 0.0129 0.0474 0.1975
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0129 0.0474 0.1975
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0595 0.26 0.26
Onchocerca volvulus 0.0162 0.0626 0.4483
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0351 0.0351
Echinococcus granulosus cathepsin l1 0.0282 0.117 0.117
Mycobacterium tuberculosis Probable oxidoreductase 0.0143 0.054 0.2291
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Loa Loa (eye worm) hypothetical protein 0.0065 0.0184 0.0211
Loa Loa (eye worm) glutathione reductase 0.0056 0.0144 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0626 0.5024
Plasmodium vivax unspecified product 0.0088 0.0286 0.185
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0282 0.117 1
Toxoplasma gondii cathepsin CPL 0.0282 0.117 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.0746 0.1077
Plasmodium vivax vivapain-3 0.0153 0.0584 0.4596
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0065 0.0184 0.098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.117 1
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0626 0.5024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0282 0.117 1
Echinococcus granulosus cathepsin b 0.0595 0.26 0.26
Trichomonas vaginalis chromobox protein, putative 0.0162 0.0626 0.5024
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0086 0.0076
Brugia malayi SET domain containing protein 0.0162 0.0626 0.089
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0282 0.117 0.1731
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0129 0.0474 0.1975
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0282 0.117 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0153 0.0584 0.4596
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.0184 0.098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.0771 0.1115
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0239 0.1479
Giardia lamblia Cathepsin L-like protease 0.0065 0.0184 0.1168
Brugia malayi hypothetical protein 0.0162 0.0626 0.089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0351 0.0351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.117 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0239 0.0841
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0065 0.0184 0.098
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0239 0.0239
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0595 0.26 0.26
Giardia lamblia Cathepsin L-like protease 0.0065 0.0184 0.1168
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0143 0.054 0.2291
Plasmodium falciparum serine repeat antigen 5 0.0065 0.0184 0.0911
Echinococcus multilocularis integrin alpha ps 0.0074 0.0223 0.0223
Brugia malayi Protein cec-1. 0.0162 0.0626 0.089
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0162 0.0626 0.5024
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0239 0.8749
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0157 0.0729
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.02 0.02
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0239 0.0641
Loa Loa (eye worm) hypothetical protein 0.0162 0.0626 0.0892
Loa Loa (eye worm) hypothetical protein 0.0125 0.0458 0.0633
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0065 0.0184 0.1168
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0065 0.0184 0.0911
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0153 0.0584 0.4637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0282 0.117 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0282 0.117 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0286 0.0368
Plasmodium falciparum serine repeat antigen 7 0.0065 0.0184 0.0911
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0064 0.0178 0.0398
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.02 0.652
Plasmodium vivax hypothetical protein, conserved 0.0162 0.0626 0.4986
Loa Loa (eye worm) inositol-1 0.0044 0.0085 0.0058
Onchocerca volvulus 0.0282 0.117 1
Schistosoma mansoni hypothetical protein 0.0363 0.154 0.154
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0162 0.0626 0.4986
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Mycobacterium tuberculosis Conserved protein 0.0077 0.0239 0.0841
Onchocerca volvulus 0.0282 0.117 1
Entamoeba histolytica hypothetical protein 0.0162 0.0626 0.5024
Entamoeba histolytica cysteine protease, putative 0.0153 0.0584 0.4637
Trichomonas vaginalis chromobox protein, putative 0.0162 0.0626 0.5024
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0282 0.117 0.1731

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM Antiproliferative activity against human MCF7 cells after 72 hrs by MTS/PMS assay ChEMBL. 19932969
IC50 (functional) > 100 uM Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS/PMS assay ChEMBL. 19932969

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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