Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0065 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 6 % | Cytotoxicity against human Jurkat T cells assessed as cell death at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 20034801 |
Activity (functional) | = 7 % | Induction of apoptosis in human Jurkat T cells at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 20034801 |
Activity (functional) | = 21 % | Cytotoxicity against human Jurkat T cells assessed as cell death at 100 uM after 24 hrs by flow cytometry | ChEMBL. | 20034801 |
Activity (functional) | = 22 % | Induction of apoptosis in human Jurkat T cells at 100 uM after 24 hrs by flow cytometry | ChEMBL. | 20034801 |
Activity (functional) | = 89 % | Cytotoxicity against human Jurkat T cells assessed as viable cells at 10 uM after 24 hrs by flow cytometry | ChEMBL. | 20034801 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.