Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0087 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0097 | 0.7738 | 1 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 0.1307 | 0.1027 |
Mycobacterium tuberculosis | Probable reductase | 0.0087 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0087 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0087 | 0.6874 | 0.8837 |
Treponema pallidum | NADH oxidase | 0.0013 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0097 | 0.7738 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0087 | 0.6874 | 0.8837 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0024 | 0.1307 | 0.44 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0024 | 0.1307 | 0.449 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0038 | 0.2529 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0097 | 0.7738 | 1 |
Trypanosoma brucei | T-complex protein 1, beta subunit, putative | 0.0024 | 0.1307 | 0.449 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0087 | 0.6874 | 0.8837 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0024 | 0.1307 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0312 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0039 | 0.2574 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0013 | 0.0312 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0013 | 0.0312 | 0.1234 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0024 | 0.1307 | 0.449 |
Plasmodium vivax | glutathione reductase, putative | 0.0038 | 0.2529 | 1 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0024 | 0.1307 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0038 | 0.2529 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0039 | 0.2574 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0097 | 0.7738 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0038 | 0.2529 | 1 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 0.1307 | 0.1027 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0024 | 0.1307 | 0.517 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0024 | 0.1307 | 1 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 0.1307 | 0.1027 |
Plasmodium falciparum | thioredoxin reductase | 0.0038 | 0.2529 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0312 | 0.5 |
Brugia malayi | glutathione reductase | 0.0038 | 0.2529 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0038 | 0.2529 | 0.2985 |
Brugia malayi | Thioredoxin reductase | 0.0038 | 0.2529 | 1 |
Trypanosoma cruzi | T-complex protein 1, beta subunit, putative | 0.0024 | 0.1307 | 0.449 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0024 | 0.1307 | 0.517 |
Trypanosoma brucei | trypanothione reductase | 0.0038 | 0.2529 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0038 | 0.2529 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0013 | 0.0312 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0038 | 0.2529 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0.0312 | 0.5 |
Leishmania major | T-complex protein 1, beta subunit, putative | 0.0024 | 0.1307 | 0.449 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0013 | 0.0312 | 0.5 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0024 | 0.1307 | 0.449 |
Leishmania major | trypanothione reductase | 0.0038 | 0.2529 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0038 | 0.2529 | 1 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0024 | 0.1307 | 0.44 |
Trichomonas vaginalis | chaperonin, putative | 0.0024 | 0.1307 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.49 nM | Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat cerebellar membrane | ChEMBL. | 20045337 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.