Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.026 | 0.0205 | 0.5 |
Onchocerca volvulus | 0.0237 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1401 | 1 | 1 |
Onchocerca volvulus | 0.0237 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1401 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.026 | 0.0205 | 0.0205 |
Onchocerca volvulus | 0.0237 | 0 | 0.5 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.026 | 0.0205 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.0218 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.026 | 0.0205 | 0.0205 |
Echinococcus granulosus | dihydrofolate reductase | 0.026 | 0.0205 | 0.0205 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.026 | 0.0205 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1401 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.0218 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0237 | 0 | 0.5 |
Onchocerca volvulus | 0.0237 | 0 | 0.5 | |
Brugia malayi | Dihydrofolate reductase | 0.026 | 0.0205 | 0.0205 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1401 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.026 | 0.0205 | 0.0205 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0262 | 0.0218 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1401 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.0218 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0237 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1401 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.026 | 0.0205 | 0.0205 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.0218 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1401 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1401 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1401 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1401 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.0218 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1401 | 1 | 1 |
Onchocerca volvulus | 0.0237 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.1401 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.026 | 0.0205 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.52 | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 6.09 | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 0.81 uM | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 3 uM | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.