TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.421 | Formula: C24H32Cl2FNO2
H donors: 1 H acceptors: 1 LogP: 6.17 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCC(C(c1ccc(cc1)Cl)CN1CCOCC1)(c1ccc(cc1)F)O.Cl
InChi: 1S/C24H31ClFNO2.ClH/c1-2-3-4-13-24(28,20-7-11-22(26)12-8-20)23(18-27-14-16-29-17-15-27)19-5-9-21(25)10-6-19;/h5-12,23,28H,2-4,13-18H2,1H3;1H
InChiKey: AVWUVHAZCJEJLJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0088	0.2033
Brugia malayi	Carboxylesterase family protein	0.0129	0.1299	0.1558
Schistosoma mansoni	gliotactin	0.0129	0.1299	0.1299
Schistosoma mansoni	hypothetical protein	0.0911	1	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0053	0.0053
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0129	0.1299	0.1299
Echinococcus granulosus	acetylcholinesterase	0.0762	0.834	0.834
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0016	0.0045	0.0045
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0088	0.0679
Echinococcus granulosus	inositol monophosphatase 1	0.0042	0.034	0.034
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0088	0.1559
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0129	0.1299	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1592	0.1909
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.1559
Echinococcus granulosus	GPCR family 2	0.0017	0.0053	0.0053
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0029	0.0225
Schistosoma mansoni	hypothetical protein	0.0036	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0761699	1	1
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0053	0.0063
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0129	0.1299	1
Brugia malayi	Muscleblind-like protein	0.0314	0.3362	0.4031
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.034	0.262
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0088	0.1559
Brugia malayi	Carboxylesterase family protein	0.0762	0.834	1
Schistosoma mansoni	cpg binding protein	0.0068	0.062	0.062
Brugia malayi	Importin beta-1 subunit	0.0063	0.0566	0.0679
Echinococcus multilocularis	acetylcholinesterase	0.0761699	1	1
Schistosoma mansoni	hypothetical protein	0.0183	0.1898	0.1898
Echinococcus multilocularis	acetylcholinesterase	0.0762	0.834	0.834
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0053	0.0053
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0029	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1299	0.1558
Echinococcus multilocularis	geminin	0.0183	0.1898	0.1898
Schistosoma mansoni	hypothetical protein	0.0017	0.0053	0.0053
Onchocerca volvulus		0.0129	0.1299	0.7109
Trichomonas vaginalis	spcc417.12 protein, putative	0.0128701	0	0.5
Brugia malayi	F/Y-rich N-terminus family protein	0.002	0.0085	0.0102
Schistosoma mansoni	inositol monophosphatase	0.0042	0.034	0.034
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0088	0.0088
Leishmania major	DNA polymerase eta, putative	0.002	0.0088	0.2033
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0267	0.032
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0267	0.032
Loa Loa (eye worm)	hypothetical protein	0.0762	0.834	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.1298	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1299	0.1558
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.002	0.0351
Trypanosoma brucei	importin beta-1 subunit, putative	0.0063	0.0566	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.1559
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0128701	0	0.5
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0042	0.034	0.5
Mycobacterium ulcerans	carboxylesterase, LipT	0.0128701	0	0.5
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0088	0.0088
Schistosoma mansoni	importin beta-1	0.0063	0.0566	0.0566
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0024	0.0139	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.0129	0.1299	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0129	0.1299	0.1299
Onchocerca volvulus		0.0129	0.1299	0.7109
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0452	0.0542
Schistosoma mansoni	acetylcholinesterase	0.0129	0.1299	0.1299
Leishmania major	DNA polymerase kappa, putative	0.002	0.0088	0.2033
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.002	0.0351
Brugia malayi	Carboxylesterase family protein	0.0129	0.1299	0.1558
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0038	0.0291	0.1674
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0121	0.1216	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0016	0.0045	0.0045
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.1559
Brugia malayi	Carboxylesterase family protein	0.0761699	1	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.067	0.7318	0.8775
Loa Loa (eye worm)	hypothetical protein	0.002	0.0088	0.0106
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.1559
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0029	0.0225
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0139	0.1483
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0029	0.0225
Echinococcus multilocularis	inositol monophosphatase 1	0.0042	0.034	0.034
Entamoeba histolytica	hypothetical protein	0.0051	0.0434	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0003	0.0003
Loa Loa (eye worm)	carboxylesterase	0.0129	0.1299	0.1558
Trypanosoma brucei	unspecified product	0.002	0.0088	0.1559
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.1559
Echinococcus granulosus	geminin	0.0183	0.1898	0.1898
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.017	0.1398
Loa Loa (eye worm)	carboxylesterase	0.0762	0.834	1
Loa Loa (eye worm)	histone methyltransferase	0.002	0.0088	0.0106
Loa Loa (eye worm)	acetylcholinesterase 1	0.0762	0.834	1
Echinococcus granulosus	microtubule associated protein 2	0.0794	0.8695	0.8695
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0129	0.1299	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0029	0.0225
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.017	0.2365
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0129	0.1299	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0128701	0	0.5
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0139	0.1483
Brugia malayi	Carboxylesterase family protein	0.0762	0.834	1
Echinococcus granulosus	muscleblind protein	0.0314	0.3362	0.3362
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0053	0.0063
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0128701	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1299	0.1558
Echinococcus multilocularis	neuroligin	0.0129	0.1299	0.1299
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0129	0.1299	0.1299
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.1559
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0029	0.0225
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.034	0.7847
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0042	0.034	0.28
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.034	0.7298
Plasmodium falciparum	importin beta, putative	0.0063	0.0566	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0088	0.0088
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0053	0.0063
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0024	0.0139	0.0139
Echinococcus multilocularis	muscleblind protein 1	0.0314	0.3362	0.3362
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.017	0.3004
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0314	0.3362	0.4031
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0053	0.0063
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0452	0.0542
Schistosoma mansoni	cpg binding protein	0.0064	0.0579	0.0579
Toxoplasma gondii	HEAT repeat-containing protein	0.0063	0.0566	0.4654
Schistosoma mansoni	hypothetical protein	0.0017	0.0053	0.0053
Brugia malayi	hypothetical protein	0.0155	0.1592	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0027	0.017	0.0204
Loa Loa (eye worm)	inositol-1	0.0042	0.034	0.0408
Onchocerca volvulus		0.0155	0.1592	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.1559
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0762	0.834	0.834
Loa Loa (eye worm)	acetylcholinesterase 1	0.0761699	1	1
Echinococcus granulosus	neuroligin	0.0129	0.1299	0.1299
Brugia malayi	Carboxylesterase family protein	0.0129	0.1299	0.1558
Echinococcus multilocularis	dna polymerase eta	0.002	0.0088	0.0088
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0024	0.0139	0.0167
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.034	0.262
Onchocerca volvulus		0.0128701	0	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0088	0.1559
Echinococcus granulosus	carboxylesterase 5A	0.0762	0.834	0.834
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0029	0.0225
Schistosoma mansoni	inositol monophosphatase	0.0042	0.034	0.034
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.002	0.0088	0.0088
Brugia malayi	RNA, U transporter 1	0.0178	0.1853	0.2221
Echinococcus granulosus	importin subunit beta 1	0.0063	0.0566	0.0566
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0029	0.0225
Schistosoma mansoni	BC026374 protein (S09 family)	0.0129	0.1299	0.1299
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0088	0.1559
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0761699	1	1
Schistosoma mansoni	ran	0.0024	0.0139	0.0139
Echinococcus granulosus	acetylcholinesterase	0.0762	0.834	0.834
Onchocerca volvulus		0.0129	0.1299	0.7109
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0088	0.2033
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0088	0.0106
Echinococcus granulosus	para nitrobenzyl esterase	0.0129	0.1299	0.1299
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.017	0.2365
Trichomonas vaginalis	helicase, putative	0.0014	0.0029	0.0225
Loa Loa (eye worm)	carboxylesterase	0.0129	0.1299	0.1558
Brugia malayi	hypothetical protein	0.0129	0.1299	0.1558
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0016	0.0045	0.0045
Echinococcus multilocularis	microtubule associated protein 2	0.0794	0.8695	0.8695
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1299	0.1558
Schistosoma mansoni	hypothetical protein	0.0183	0.1898	0.1898
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0003	0.0003
Onchocerca volvulus		0.0128701	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1299	0.1558
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0029	0.0225
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0029	0.0225
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0136	0.1377	0.1377
Echinococcus granulosus	carboxylesterase 5A	0.0761699	1	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0452	0.0542
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0024	0.0139	0.2465
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0129	0.1299	0.1299
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0029	0.0225
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.017	0.3004
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0129	0.1299	0.1299
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.034	0.6017
Trichomonas vaginalis	ran, putative	0.0024	0.0139	0.1073
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.002	0.0351
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.1559
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.1298	0.1557
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0128701	0	0.5
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0038	0.0291	0.5
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0053	0.0053
Echinococcus multilocularis	snurportin 1	0.067	0.7318	0.7318
Onchocerca volvulus		0.0128701	0	0.5
Echinococcus multilocularis	muscleblind protein	0.0314	0.3362	0.3362
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0029	0.0225
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0042	0.034	0.2083
Schistosoma mansoni	DNA polymerase eta	0.002	0.0088	0.0088
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0129	0.1299	0.1299
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.002	0.0088	0.0088
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0042	0.034	0.7847
Echinococcus multilocularis	carboxylesterase 5A	0.0762	0.834	0.834
Schistosoma mansoni	hypothetical protein	0.0017	0.0053	0.0053
Echinococcus multilocularis	para nitrobenzyl esterase	0.0129	0.1299	0.1299
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0762	0.834	1
Echinococcus multilocularis	acetylcholinesterase	0.0762	0.834	0.834
Echinococcus granulosus	acetylcholinesterase	0.0761699	1	1
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0088	0.0106
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0129	0.1299	1
Leishmania major	hypothetical protein, conserved	0.0027	0.017	0.3917
Loa Loa (eye worm)	carboxylesterase	0.0761699	1	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0053	0.0053
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.017	0.3004
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0029	0.0225
Brugia malayi	Inositol-1	0.0042	0.034	0.0408
Brugia malayi	hypothetical protein	0.0027	0.017	0.0204
Brugia malayi	MH2 domain containing protein	0.0129	0.1298	0.1557
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0064	0.0579	0.0695
Onchocerca volvulus		0.0128701	0	0.5
Trypanosoma brucei	importin beta-1 subunit, putative	0.0063	0.0566	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0051	0.0434	0.3339
Loa Loa (eye worm)	hypothetical protein	0.0761699	1	1
Brugia malayi	Carboxylesterase family protein	0.0129	0.1299	0.1558
Onchocerca volvulus		0.0129	0.1299	0.7109
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1299	0.1558
Trichomonas vaginalis	importin beta-1, putative	0.0051	0.0434	0.3339
Onchocerca volvulus		0.0129	0.1299	0.7109
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0016	0.0045	0.0045
Brugia malayi	hypothetical protein	0.0018	0.0063	0.0075
Schistosoma mansoni	cpg binding protein	0.0068	0.062	0.062
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0452	0.0542
Schistosoma mansoni	hypothetical protein	0.067	0.7318	0.7318
Loa Loa (eye worm)	hypothetical protein	0.0314	0.3362	0.4031
Schistosoma mansoni	microtubule-associated protein tau	0.0794	0.8695	0.8695
Leishmania major	importin beta-1 subunit, putative	0.0051	0.0434	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0024	0.0139	0.1147
Schistosoma mansoni	ran	0.0024	0.0139	0.0139
Leishmania major	GTP-binding protein, putative	0.0024	0.0139	0.3214
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1299	0.1558
Onchocerca volvulus		0.0128701	0	0.5
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0024	0.0139	0.0167
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0024	0.0139	0.0139
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.017	0.3004
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0088	0.0106
Entamoeba histolytica	Ran family GTPase	0.0024	0.0139	0.3214
Echinococcus granulosus	snurportin 1	0.067	0.7318	0.7318
Echinococcus multilocularis	importin subunit beta 1	0.0063	0.0566	0.0566
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0029	0.0225
Echinococcus granulosus	acetylcholinesterase	0.0761699	1	1
Echinococcus granulosus	dna polymerase kappa	0.002	0.0088	0.0088
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0024	0.0139	0.2465
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0003	0.0003
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0053	0.0053
Mycobacterium ulcerans	carboxylesterase, LipT	0.0129	0.1299	1
Echinococcus granulosus	BC026374 protein S09 family	0.0129	0.1299	0.1299
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.034	0.7298
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0024	0.0139	0.2465
Trypanosoma brucei	unspecified product	0.0014	0.002	0.0351
Brugia malayi	CXXC zinc finger family protein	0.0064	0.0579	0.0695
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.1559
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0016	0.0045	0.0045
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0088	0.0088
Echinococcus multilocularis	carboxylesterase 5A	0.0761699	1	1
Echinococcus multilocularis	acetylcholinesterase	0.0761699	1	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0051	0.0434	1
Echinococcus granulosus	cpg binding protein	0.0068	0.062	0.062
Plasmodium vivax	importin-beta 2, putative	0.0063	0.0566	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0029	0.0225
Brugia malayi	Carboxylesterase family protein	0.0761699	1	1
Trypanosoma brucei	unspecified product	0.0014	0.002	0.0351
Echinococcus multilocularis	dnaJ subfamily B	0.0911	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0566	0.0679
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0088	0.0679
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0029	0.0225
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0029	0.0225
Trichomonas vaginalis	inositol monophosphatase, putative	0.0042	0.034	0.262
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0051	0.0434	0.3339
Echinococcus granulosus	dna polymerase eta	0.002	0.0088	0.0088
Echinococcus multilocularis	cpg binding protein	0.0068	0.062	0.062

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	0.9354 uM	ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye	ChEMBL.	20485428
EC50 (functional)	1.8267 uM	ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye	ChEMBL.	20485428

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	20485428

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL602915

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1098852