Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | abhydrolase domain containing 6 | Starlite/ChEMBL | References |
Mus musculus | fatty acid amide hydrolase | Starlite/ChEMBL | References |
Mus musculus | monoglyceride lipase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | monoglyceride lipase | 258 aa | 241 aa | 22.0 % |
Trypanosoma cruzi | amidase, putative | fatty acid amide hydrolase | 579 aa | 467 aa | 26.6 % |
Plasmodium falciparum | epoxide hydrolase 2 | abhydrolase domain containing 6 | 336 aa | 295 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0186 | 0.1002 | 0.5 | |
Onchocerca volvulus | 0.0186 | 0.1002 | 0.5 | |
Plasmodium falciparum | esterase, putative | 0.0084 | 0 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0186 | 0.1002 | 0.0644 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1102 | 1 | 1 |
Onchocerca volvulus | 0.0186 | 0.1002 | 0.5 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0186 | 0.1002 | 0.0644 |
Loa Loa (eye worm) | carboxylesterase | 0.0186 | 0.1002 | 0.0644 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0186 | 0.1002 | 0.0644 |
Echinococcus multilocularis | acetylcholinesterase | 0.1102 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1102 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0186 | 0.1002 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1002 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1002 | 0.0644 |
Onchocerca volvulus | 0.0186 | 0.1002 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0186 | 0.1002 | 0.0644 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1002 | 0.0644 |
Brugia malayi | Carboxylesterase family protein | 0.0186 | 0.1002 | 0.0644 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0186 | 0.1002 | 0.0644 |
Schistosoma mansoni | gliotactin | 0.0186 | 0.1002 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1002 | 0.0644 |
Echinococcus multilocularis | acetylcholinesterase | 0.1102 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0186 | 0.1002 | 1 |
Brugia malayi | hypothetical protein | 0.0186 | 0.1002 | 0.0644 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0186 | 0.1002 | 0.0644 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1102 | 1 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.009 | 0.006 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1102 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1102 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0186 | 0.1002 | 0.0644 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.0499 | 0.4077 | 1 |
Echinococcus granulosus | neuroligin | 0.0186 | 0.1002 | 0.0644 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0186 | 0.1002 | 1 |
Plasmodium vivax | PST-A protein | 0.0084 | 0 | 0.5 |
Onchocerca volvulus | 0.0186 | 0.1002 | 0.5 | |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0499 | 0.4077 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0186 | 0.1002 | 0.0644 |
Schistosoma mansoni | acetylcholinesterase | 0.0186 | 0.1002 | 0.0644 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0186 | 0.1002 | 0.0644 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0186 | 0.1002 | 0.2344 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0186 | 0.1002 | 0.2344 |
Loa Loa (eye worm) | hypothetical protein | 0.1102 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0186 | 0.1002 | 0.2344 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1102 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0186 | 0.1002 | 0.0644 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0186 | 0.1002 | 0.0644 |
Loa Loa (eye worm) | carboxylesterase | 0.0186 | 0.1002 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1002 | 0.0644 |
Brugia malayi | Carboxylesterase family protein | 0.0186 | 0.1002 | 0.0644 |
Echinococcus granulosus | carboxylesterase 5A | 0.1102 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0186 | 0.1002 | 0.0644 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0186 | 0.1002 | 0.0644 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0186 | 0.1002 | 0.2457 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1002 | 0.0644 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1002 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.1102 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1102 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 200 nM | Inhibition of MAGL in mouse brain membrane | ChEMBL. | 20099888 |
IC50 (binding) | = 380 nM | Inhibition of ABHD6 in mouse brain membrane | ChEMBL. | 20099888 |
IC50 (binding) | = 5850 nM | Inhibition of FAAH in mouse brain membrane | ChEMBL. | 20099888 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.