Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0075 | 0.1117 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0099 | 0.1692 | 0.1956 |
Brugia malayi | Pre-SET motif family protein | 0.0214 | 0.4504 | 0.9486 |
Onchocerca volvulus | Bile acid receptor homolog | 0.021 | 0.4396 | 0.438 |
Schistosoma mansoni | nuclear hormone receptor | 0.0099 | 0.1692 | 0.3527 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0099 | 0.1692 | 0.1956 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0099 | 0.1692 | 0.1956 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1982 | 0.1959 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0093 | 0.1535 | 0.1512 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.021 | 0.4396 | 0.438 |
Schistosoma mansoni | thyroid hormone receptor | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | nuclear receptor NHR-88 | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0075 | 0.1117 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.021 | 0.4396 | 0.9257 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.021 | 0.4396 | 0.5081 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.021 | 0.4396 | 0.5065 |
Brugia malayi | steroid hormone receptor | 0.021 | 0.4396 | 0.9257 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.021 | 0.4396 | 0.5081 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0099 | 0.1692 | 0.193 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0028 | 0.0032 |
Schistosoma mansoni | coup transcription factor | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.021 | 0.4396 | 0.9257 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.021 | 0.4396 | 0.5065 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.3554 | 0.7473 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.021 | 0.4396 | 0.438 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.021 | 0.4396 | 0.5065 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0224 | 0.4746 | 0.5487 |
Echinococcus multilocularis | expressed protein | 0.0384 | 0.8651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.3554 | 0.7473 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.021 | 0.4396 | 0.5065 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0214 | 0.4504 | 0.4489 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | DR-78 | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Onchocerca volvulus | 0.021 | 0.4396 | 0.438 | |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Schistosoma mansoni | zinc finger protein | 0.0099 | 0.1692 | 0.3527 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0099 | 0.1692 | 0.1956 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.021 | 0.4396 | 0.438 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.021 | 0.4396 | 0.9257 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0099 | 0.1692 | 0.193 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.021 | 0.4396 | 0.438 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Trichomonas vaginalis | set domain proteins, putative | 0.0244 | 0.5226 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.021 | 0.4396 | 0.5065 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.021 | 0.4396 | 0.5081 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.021 | 0.4396 | 0.5065 |
Schistosoma mansoni | nuclear hormone receptor | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0075 | 0.1117 | 0.2308 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.021 | 0.4396 | 0.438 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.021 | 0.4396 | 0.9257 |
Onchocerca volvulus | 0.0099 | 0.1692 | 0.1669 | |
Brugia malayi | nuclear receptor NHR-67 | 0.0099 | 0.1692 | 0.3527 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0099 | 0.1692 | 0.1669 |
Brugia malayi | nuclear hormone receptor | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0224 | 0.4746 | 0.4732 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0111 | 0.1982 | 0.4141 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.021 | 0.4396 | 0.9257 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.021 | 0.4396 | 0.9257 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0099 | 0.1692 | 0.1956 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0075 | 0.1117 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.2291 | 0.2269 |
Onchocerca volvulus | 0.0244 | 0.5226 | 0.5213 | |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0224 | 0.4746 | 0.5472 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0224 | 0.4746 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0224 | 0.4746 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0099 | 0.1692 | 0.3527 |
Schistosoma mansoni | nuclear receptor | 0.0099 | 0.1692 | 0.3527 |
Schistosoma mansoni | nuclear hormone receptor | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1982 | 0.1959 |
Onchocerca volvulus | 0.0099 | 0.1692 | 0.1669 | |
Brugia malayi | Steroid receptor seven-up type 2 | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | nuclear hormone receptor | 0.0099 | 0.1692 | 0.3527 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.021 | 0.4396 | 0.9257 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0099 | 0.1692 | 0.1956 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.021 | 0.4396 | 0.5081 |
Brugia malayi | ecdysone receptor | 0.0099 | 0.1692 | 0.3527 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0099 | 0.1692 | 0.3527 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0075 | 0.1117 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.021 | 0.4396 | 0.438 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0099 | 0.1692 | 0.193 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0099 | 0.1692 | 0.1669 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0099 | 0.1692 | 0.3527 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.2291 | 0.4796 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0099 | 0.1692 | 0.3527 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1982 | 0.1959 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.021 | 0.4396 | 0.9257 |
Echinococcus multilocularis | FTZ F1 alpha | 0.021 | 0.4396 | 0.5065 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.021 | 0.4396 | 0.5081 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.021 | 0.4396 | 0.438 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0111 | 0.1982 | 0.4141 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1982 | 0.1959 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.021 | 0.4396 | 0.9257 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.021 | 0.4396 | 0.438 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.021 | 0.4396 | 0.9257 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0075 | 0.1117 | 0.1291 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0111 | 0.1982 | 0.4141 |
Echinococcus granulosus | expressed protein | 0.0384 | 0.8651 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.021 | 0.4396 | 0.9257 |
Echinococcus granulosus | FTZ F1 alpha | 0.021 | 0.4396 | 0.5081 |
Brugia malayi | hypothetical protein | 0.0111 | 0.1982 | 0.4141 |
Brugia malayi | hypothetical protein | 0.0099 | 0.1692 | 0.3527 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0075 | 0.1117 | 0.1263 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0028 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0111 | 0.1982 | 0.2266 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.021 | 0.4396 | 0.5065 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1982 | 0.1959 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0099 | 0.1692 | 0.193 |
Brugia malayi | hypothetical protein | 0.0111 | 0.1982 | 0.4141 |
Echinococcus granulosus | geminin | 0.0175 | 0.3554 | 0.4108 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0111 | 0.1982 | 0.1959 |
Brugia malayi | hypothetical protein | 0.0058 | 0.0683 | 0.1389 |
Brugia malayi | nuclear receptor RXR | 0.0111 | 0.1982 | 0.4141 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0111 | 0.1982 | 0.2291 |
Brugia malayi | nuclear receptor RXR | 0.0099 | 0.1692 | 0.3527 |
Schistosoma mansoni | nuclear receptor | 0.0099 | 0.1692 | 0.3527 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.021 | 0.4396 | 0.5081 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | ecdysteroid receptor | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | hypothetical protein | 0.0099 | 0.1692 | 0.3527 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.044 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1535 | 0.1512 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0683 | 0.0657 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.021 | 0.4396 | 0.9257 |
Schistosoma mansoni | thyroid hormone receptor | 0.021 | 0.4396 | 0.9257 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.021 | 0.4396 | 0.5081 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.021 | 0.4396 | 0.5065 |
Brugia malayi | conserved hypotetical protein | 0.0099 | 0.1692 | 0.3527 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0111 | 0.1982 | 0.4141 |
Echinococcus multilocularis | geminin | 0.0175 | 0.3554 | 0.4089 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0099 | 0.1692 | 0.3527 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0075 | 0.1117 | 0.5 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0099 | 0.1692 | 0.1669 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.021 | 0.4396 | 0.5081 |
Brugia malayi | nuclear receptor NHR-88 | 0.0099 | 0.1692 | 0.3527 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0099 | 0.1692 | 0.193 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.2291 | 0.2269 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0075 | 0.1117 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.021 | 0.4396 | 0.438 |
Brugia malayi | tailless protein | 0.0099 | 0.1692 | 0.3527 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0099 | 0.1692 | 0.193 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0224 | 0.4746 | 0.4732 |
Brugia malayi | Phospholipase A2 family protein | 0.0093 | 0.1535 | 0.3195 |
Loa Loa (eye worm) | steroid hormone receptor | 0.021 | 0.4396 | 0.438 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0075 | 0.1117 | 0.2308 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 12.5 ug ml-1 | Tested in vitro for antibacterial activity against Proteus volgaris | ChEMBL. | 7359536 |
MIC (functional) | = 12.5 ug ml-1 | Tested for antifungal activity against Alternaria solani | ChEMBL. | 7359536 |
MIC (functional) | = 25 ug ml-1 | Tested in vitro for antibacterial activity against Staphylococcus aureus | ChEMBL. | 7359536 |
MIC (functional) | = 100 ug ml-1 | Tested in vitro for antibacterial activity against Bordetella bronchiseptica | ChEMBL. | 7359536 |
MIC (functional) | = 100 ug ml-1 | Tested in vitro for antibacterial activity against Klebsiella pneumoniae | ChEMBL. | 7359536 |
MIC (functional) | > 100 ug ml-1 | Tested in vitro for antibacterial activity against Aerobacter aerogenes | ChEMBL. | 7359536 |
MIC (functional) | > 100 ug ml-1 | Tested in vitro for antibacterial activity against Escherichia coli | ChEMBL. | 7359536 |
MIC (functional) | > 100 ug ml-1 | Tested in vitro for antibacterial activity against Pseudomonas aeruginosa | ChEMBL. | 7359536 |
MIC (functional) | > 100 ug ml-1 | Tested for antifungal activity against Aspergillus niger | ChEMBL. | 7359536 |
MIC (functional) | > 100 ug ml-1 | Tested in vitro for antibacterial activity against Escherichia coli | ChEMBL. | 7359536 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.