Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0028 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0093 | 0.1535 | 0.1512 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0075 | 0.1117 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0683 | 0.0657 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0111 | 0.1982 | 0.2291 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1982 | 0.1959 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.021 | 0.4396 | 0.438 |
Brugia malayi | hypothetical protein | 0.0058 | 0.0683 | 0.1389 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0099 | 0.1692 | 0.1669 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.021 | 0.4396 | 0.9257 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0075 | 0.1117 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.021 | 0.4396 | 0.9257 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0075 | 0.1117 | 1 |
Echinococcus multilocularis | expressed protein | 0.0384 | 0.8651 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0099 | 0.1692 | 0.3527 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Schistosoma mansoni | thyroid hormone receptor | 0.021 | 0.4396 | 0.9257 |
Trichomonas vaginalis | set domain proteins, putative | 0.0244 | 0.5226 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0214 | 0.4504 | 0.4489 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0099 | 0.1692 | 0.1956 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.021 | 0.4396 | 0.438 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | hypothetical protein | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.021 | 0.4396 | 0.9257 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.021 | 0.4396 | 0.5065 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.021 | 0.4396 | 0.9257 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.021 | 0.4396 | 0.5081 |
Brugia malayi | hypothetical protein | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | nuclear hormone receptor | 0.0099 | 0.1692 | 0.3527 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Brugia malayi | tailless protein | 0.0099 | 0.1692 | 0.3527 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0111 | 0.1982 | 0.4141 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1982 | 0.1959 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0099 | 0.1692 | 0.193 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0075 | 0.1117 | 0.5 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0099 | 0.1692 | 0.1956 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.021 | 0.4396 | 0.5081 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0099 | 0.1692 | 0.1956 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.021 | 0.4396 | 0.9257 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.021 | 0.4396 | 0.9257 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0099 | 0.1692 | 0.1956 |
Brugia malayi | hypothetical protein | 0.0111 | 0.1982 | 0.4141 |
Onchocerca volvulus | Bile acid receptor homolog | 0.021 | 0.4396 | 0.438 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.021 | 0.4396 | 0.5065 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0224 | 0.4746 | 0.4732 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.021 | 0.4396 | 0.9257 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0224 | 0.4746 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.3554 | 0.7473 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | nuclear receptor NHR-67 | 0.0099 | 0.1692 | 0.3527 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.021 | 0.4396 | 0.5081 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.021 | 0.4396 | 0.5065 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0099 | 0.1692 | 0.1669 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.021 | 0.4396 | 0.5081 |
Schistosoma mansoni | nuclear receptor | 0.0099 | 0.1692 | 0.3527 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0099 | 0.1692 | 0.193 |
Brugia malayi | nuclear receptor NHR-88 | 0.0099 | 0.1692 | 0.3527 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.044 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0099 | 0.1692 | 0.193 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Schistosoma mansoni | coup transcription factor | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | steroid hormone receptor | 0.021 | 0.4396 | 0.438 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0099 | 0.1692 | 0.193 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0099 | 0.1692 | 0.1669 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.021 | 0.4396 | 0.5081 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0099 | 0.1692 | 0.1956 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0099 | 0.1692 | 0.3527 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.021 | 0.4396 | 0.438 |
Schistosoma mansoni | nuclear hormone receptor | 0.021 | 0.4396 | 0.9257 |
Onchocerca volvulus | 0.0099 | 0.1692 | 0.1669 | |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0075 | 0.1117 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0099 | 0.1692 | 0.193 |
Schistosoma mansoni | zinc finger protein | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0099 | 0.1692 | 0.3527 |
Schistosoma mansoni | nuclear receptor | 0.0099 | 0.1692 | 0.3527 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | nuclear receptor NHR-88 | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.021 | 0.4396 | 0.9257 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.021 | 0.4396 | 0.9257 |
Echinococcus granulosus | geminin | 0.0175 | 0.3554 | 0.4108 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1982 | 0.1959 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0028 | 0.0032 |
Schistosoma mansoni | thyroid hormone receptor | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0075 | 0.1117 | 0.1291 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.021 | 0.4396 | 0.9257 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.021 | 0.4396 | 0.5065 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0111 | 0.1982 | 0.2266 |
Brugia malayi | Pre-SET motif family protein | 0.0214 | 0.4504 | 0.9486 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0099 | 0.1692 | 0.3527 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.021 | 0.4396 | 0.438 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.021 | 0.4396 | 0.5065 |
Brugia malayi | steroid hormone receptor | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | ecdysteroid receptor | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0224 | 0.4746 | 1 |
Brugia malayi | Phospholipase A2 family protein | 0.0093 | 0.1535 | 0.3195 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.021 | 0.4396 | 0.9257 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.021 | 0.4396 | 0.5065 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.021 | 0.4396 | 0.438 |
Loa Loa (eye worm) | DR-78 | 0.0099 | 0.1692 | 0.1669 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.021 | 0.4396 | 0.5081 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.021 | 0.4396 | 0.5081 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | conserved hypotetical protein | 0.0099 | 0.1692 | 0.3527 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0111 | 0.1982 | 0.1959 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0075 | 0.1117 | 0.2308 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.2291 | 0.2269 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.021 | 0.4396 | 0.9257 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.021 | 0.4396 | 0.9257 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0224 | 0.4746 | 0.5472 |
Echinococcus granulosus | expressed protein | 0.0384 | 0.8651 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.021 | 0.4396 | 0.5065 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.2291 | 0.2269 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0099 | 0.1692 | 0.1956 |
Schistosoma mansoni | nuclear hormone receptor | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | ecdysone receptor | 0.0099 | 0.1692 | 0.3527 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.021 | 0.4396 | 0.438 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.021 | 0.4396 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1982 | 0.1959 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0099 | 0.1692 | 0.1669 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.3554 | 0.7473 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0111 | 0.1982 | 0.4141 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.021 | 0.4396 | 0.9257 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.021 | 0.4396 | 0.5065 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0075 | 0.1117 | 0.1263 |
Onchocerca volvulus | 0.0099 | 0.1692 | 0.1669 | |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0075 | 0.1117 | 0.5 |
Brugia malayi | nuclear receptor RXR | 0.0111 | 0.1982 | 0.4141 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0099 | 0.1692 | 0.3527 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.021 | 0.4396 | 0.9257 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0111 | 0.1982 | 0.4141 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0099 | 0.1692 | 0.193 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1535 | 0.1512 |
Brugia malayi | nuclear hormone receptor | 0.021 | 0.4396 | 0.9257 |
Echinococcus multilocularis | geminin | 0.0175 | 0.3554 | 0.4089 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0075 | 0.1117 | 0.2308 |
Brugia malayi | hypothetical protein | 0.0111 | 0.1982 | 0.4141 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0224 | 0.4746 | 0.4732 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1692 | 0.1669 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.021 | 0.4396 | 0.5081 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.021 | 0.4396 | 0.438 |
Brugia malayi | nuclear receptor RXR | 0.0099 | 0.1692 | 0.3527 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0111 | 0.1982 | 0.4141 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.021 | 0.4396 | 0.5065 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.021 | 0.4396 | 0.438 |
Onchocerca volvulus | 0.021 | 0.4396 | 0.438 | |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.4396 | 0.438 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1982 | 0.1959 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.021 | 0.4396 | 0.438 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.021 | 0.4396 | 0.9257 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0224 | 0.4746 | 0.5487 |
Echinococcus granulosus | FTZ F1 alpha | 0.021 | 0.4396 | 0.5081 |
Onchocerca volvulus | 0.0244 | 0.5226 | 0.5213 | |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.2291 | 0.4796 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.3 ug ml-1 | Tested for antifungal activity against Alternaria solani | ChEMBL. | 7359536 |
MIC (functional) | = 12.5 ug ml-1 | Tested in vitro for antibacterial activity against Staphylococcus aureus | ChEMBL. | 7359536 |
MIC (functional) | = 12.5 ug ml-1 | Tested in vitro for antibacterial activity against Proteus volgaris | ChEMBL. | 7359536 |
MIC (functional) | = 50 ug ml-1 | Tested in vitro for antibacterial activity against Klebsiella pneumoniae | ChEMBL. | 7359536 |
MIC (functional) | = 100 ug ml-1 | Tested in vitro for antibacterial activity against Bordetella bronchiseptica | ChEMBL. | 7359536 |
MIC (functional) | > 100 ug ml-1 | Tested in vitro for antibacterial activity against Aerobacter aerogenes | ChEMBL. | 7359536 |
MIC (functional) | = 100 ug ml-1 | Tested in vitro for antibacterial activity against Escherichia coli | ChEMBL. | 7359536 |
MIC (functional) | > 100 ug ml-1 | Tested in vitro for antibacterial activity against Pseudomonas aeruginosa | ChEMBL. | 7359536 |
MIC (functional) | > 100 ug ml-1 | Tested for antifungal activity against Aspergillus niger | ChEMBL. | 7359536 |
MIC (functional) | = 100 ug ml-1 | Tested in vitro for antibacterial activity against Escherichia coli | ChEMBL. | 7359536 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.