Detailed information for compound 1099493

Basic information

Technical information
  • TDR Targets ID: 1099493
  • Name: 2-acetyl-3-(2-methylphenyl)imino-7-nitroinden -1-one
  • MW: 322.315 | Formula: C18H14N2O4
  • H donors: 0 H acceptors: 4 LogP: 3.36 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)C1C(=Nc2ccccc2C)c2c(C1=O)c(ccc2)[N+](=O)[O-]
  • InChi: 1S/C18H14N2O4/c1-10-6-3-4-8-13(10)19-17-12-7-5-9-14(20(23)24)16(12)18(22)15(17)11(2)21/h3-9,15H,1-2H3
  • InChiKey: YNLHRTJHAJJWDB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-acetyl-3-(2-methylphenyl)imino-7-nitro-indan-1-one
  • 2-acetyl-3-(2-methylphenyl)imino-7-nitro-1-indanone
  • 2-ethanoyl-3-(2-methylphenyl)imino-7-nitro-inden-1-one
  • SMR000137234
  • CBDivE_015372
  • 2-acetyl-3-[(2-methylphenyl)imino]-7-nitro-1-indanone
  • MLS000532295

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus carbonic anhydrase 0.0362977 0.129568 0.370998
Leishmania major mitochondrial DNA topoisomerase II 0.149601 0.644805 1
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.22771 1 1
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0781949 0.320092 0.404109
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.00880877 0.00456391 0.0130681
Schistosoma mansoni heat shock protein 0.0137161 0.0268797 0.0769661
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0846047 0.349241 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.0721886 0.292779 1
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0162372 0.0383441 0.109793
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbB 0.18051 0.785363 0.784379
Giardia lamblia DNA topoisomerase III 0.0162372 0.0383441 0.151724
Trichomonas vaginalis receptor histidine kinase, putative 0.00880877 0.00456391 0.0155882
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.113633 0.481245 0.478867
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0162372 0.0383441 0.0432636
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0162372 0.0383441 0.109793
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0162372 0.0383441 0.0339351
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Brugia malayi DNA topoisomerase III 0.0162372 0.0383441 0.109793
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0486714 0.185837 0.232163
Loa Loa (eye worm) carbonic anhydrase 3 0.0475929 0.180932 0.518073
Schistosoma mansoni carbonic anhydrase 0.0362977 0.129568 0.370998
Schistosoma mansoni carbonic anhydrase-related 0.0362977 0.129568 0.370998
Trypanosoma brucei heat shock protein, putative 0.0137161 0.0268797 0.0416866
Toxoplasma gondii heat shock protein 90, putative 0.0137161 0.0268797 0.0393229
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.18051 0.785363 0.784379
Trypanosoma brucei heat shock protein, putative 0.0137161 0.0268797 0.0416866
Trypanosoma brucei heat shock protein, putative 0.0137161 0.0268797 0.0416866
Plasmodium falciparum endoplasmin, putative 0.011448 0.0165657 0.0120568
Schistosoma mansoni DNA topoisomerase II 0.0721886 0.292779 0.838331
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0475929 0.180932 0.518073
Loa Loa (eye worm) endoplasmin 0.0137161 0.0268797 0.0769661
Trypanosoma cruzi heat shock protein 85, putative 0.0137161 0.0268797 0.0416866
Trypanosoma brucei heat shock protein, putative 0.0137161 0.0268797 0.0416866
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0475929 0.180932 0.2806
Schistosoma mansoni endoplasmin 0.0137161 0.0268797 0.0769661
Trypanosoma cruzi DNA topoisomerase III, putative 0.0162372 0.0383441 0.0594662
Mycobacterium ulcerans DNA gyrase subunit B 0.22771 1 1
Plasmodium falciparum carbonic anhydrase 0.0362977 0.129568 0.125577
Leishmania major DNA topoisomerase III, putative 0.0162372 0.0383441 0.0594662
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0559515 0.218942 0.339548
Mycobacterium ulcerans DNA topoisomerase I 0.0162372 0.0383441 0.0339351
Trypanosoma brucei heat shock protein, putative 0.0137161 0.0268797 0.0416866
Echinococcus multilocularis carbonic anhydrase 0.0362977 0.129568 0.370998
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.00880877 0.00456391 0.0130681
Plasmodium falciparum DNA gyrase subunit A 0.113633 0.481245 0.478867
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 0.18051 0.785363 0.784379
Brugia malayi Endoplasmin precursor 0.0137161 0.0268797 0.0769661
Plasmodium vivax DNA gyrase subunit A, putative 0.113633 0.481245 0.478867
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.113633 0.481245 0.478867
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.00880877 0.00456391 0.00707798
Plasmodium vivax DNA gyrase subunit B, putative 0.22771 1 1
Loa Loa (eye worm) hypothetical protein 0.0399556 0.146202 0.418628
Schistosoma mansoni carbonic anhydrase-related 0.0362977 0.129568 0.370998
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Schistosoma mansoni pyruvate dehydrogenase 0.00880877 0.00456391 0.0130681
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0704105 0.284693 1
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.00880877 0.00456391 0.0155882
Trypanosoma cruzi DNA topoisomerase II, putative 0.0559515 0.218942 0.339548
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.18051 0.785363 1
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Trichomonas vaginalis endoplasmin, putative 0.011448 0.0165657 0.0565808
Trypanosoma brucei heat shock protein, putative 0.0137161 0.0268797 0.0416866
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0162372 0.0383441 0.109793
Loa Loa (eye worm) DNA topoisomerase III 0.0162372 0.0383441 0.109793
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0362977 0.129568 0.370998
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0846047 0.349241 1
Trypanosoma cruzi heat shock protein 85, putative 0.0137161 0.0268797 0.0416866
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Trypanosoma brucei developmentally regulated phosphoprotein 0.00880877 0.00456391 0.00707798
Trypanosoma cruzi heat shock protein 90, putative 0.0110769 0.0148779 0.0230735
Brugia malayi kinase, mitochondrial precursor 0.00880877 0.00456391 0.0130681
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.149601 0.644805 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0162372 0.0383441 0.0595245
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0162372 0.0383441 0.130966
Trichomonas vaginalis heat shock protein, putative 0.0137161 0.0268797 0.0918087
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0846047 0.349241 1
Plasmodium falciparum DNA topoisomerase 3, putative 0.0162372 0.0383441 0.0339351
Plasmodium falciparum DNA topoisomerase 2 0.0721886 0.292779 0.289537
Plasmodium vivax heat shock protein 86, putative 0.0137161 0.0268797 0.0224181
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Entamoeba histolytica DNA topoisomerase III, putative 0.0162372 0.0383441 0.0431155
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0162372 0.0383441 0.109793
Loa Loa (eye worm) TOPoisomerase family member 0.0721886 0.292779 0.838331
Trypanosoma cruzi Heat shock protein 83, putative 0.0137161 0.0268797 0.0416866
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0162372 0.0383441 0.109793
Brugia malayi GRF zinc finger family protein 0.0162372 0.0383441 0.109793
Trypanosoma brucei DNA topoisomerase ii 0.149601 0.644805 1
Loa Loa (eye worm) hypothetical protein 0.0778665 0.318599 0.912262
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.00880877 0.00456391 0.0155882
Brugia malayi DNA topoisomerase III beta-1 0.0162372 0.0383441 0.109793
Plasmodium falciparum DNA gyrase subunit B 0.22771 1 1
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0162372 0.0383441 0.130966
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0162372 0.0383441 0.109793
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.113633 0.481245 0.839966
Toxoplasma gondii heat shock protein HSP90 0.0137161 0.0268797 0.0393229
Leishmania major carbonic anhydrase-like protein 0.0475929 0.180932 0.2806
Echinococcus granulosus carbonic anhydrase 0.0362977 0.129568 0.370998
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0846047 0.349241 1
Trypanosoma cruzi heat shock protein 85, putative 0.0137161 0.0268797 0.0416866
Treponema pallidum DNA topoisomerase I (topA) 0.0162372 0.0383441 0.0339351
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.00880877 0.00456391 0.0155882
Schistosoma mansoni heat shock protein 0.0137161 0.0268797 0.0769661
Leishmania major DNA topoisomerase III, putative 0.0162372 0.0383441 0.0594662
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Chlamydia trachomatis DNA topoisomerase I 0.0162372 0.0383441 0.0339351
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.00880877 0.00456391 0.0155882
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0475929 0.180932 0.518073
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0475929 0.180932 0.518073
Loa Loa (eye worm) hypothetical protein 0.0399556 0.146202 0.418628
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Toxoplasma gondii DNA topoisomerase family protein 0.0162372 0.0383441 0.0595245
Chlamydia trachomatis DNA gyrase subunit A 0.0142177 0.0291606 0.0247095
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.113633 0.481245 0.478867
Chlamydia trachomatis DNA gyrase subunit A 0.113633 0.481245 0.478867
Trypanosoma brucei heat shock protein, putative 0.0137161 0.0268797 0.0416866
Leishmania major hypothetical protein, conserved 0.00880877 0.00456391 0.00707798
Trypanosoma cruzi DNA topoisomerase III, putative 0.0162372 0.0383441 0.0594662
Plasmodium vivax DNA topoisomerase II, putative 0.0721886 0.292779 0.289537
Loa Loa (eye worm) hypothetical protein 0.00880877 0.00456391 0.0130681
Trypanosoma brucei Heat shock protein 83, putative 0.0137161 0.0268797 0.0416866
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0704105 0.284693 1
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 0.18051 0.785363 1
Trichomonas vaginalis sensor histidine kinase, putative 0.00880877 0.00456391 0.0155882
Loa Loa (eye worm) heat shock protein 90 0.0137161 0.0268797 0.0769661
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.133605 0.572065 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0362977 0.129568 0.370998
Trypanosoma brucei DNA topoisomerase III, putative 0.0162372 0.0383441 0.0594662
Giardia lamblia DNA topoisomerase III 0.0162372 0.0383441 0.151724
Trypanosoma cruzi heat shock protein 90, putative 0.0137161 0.0268797 0.0416866
Echinococcus multilocularis carbonic anhydrase 0.0362977 0.129568 0.370998
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbC 0.18051 0.785363 0.784379
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0721886 0.292779 0.838331
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0475929 0.180932 0.2806
Echinococcus granulosus carbonic anhydrase II 0.0475929 0.180932 0.518073
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.00880877 0.00456391 0.00707798
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.149601 0.644805 1
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.22771 1 1
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0559515 0.218942 0.339548
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0721886 0.292779 0.838331
Giardia lamblia Pms1-like protein 0.00880877 0.00456391 0.018059
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0362977 0.129568 0.370998
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Echinococcus granulosus heat shock protein 90 0.0137161 0.0268797 0.0769661
Trypanosoma cruzi DNA topoisomerase II, putative 0.0559515 0.218942 0.339548
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.22771 1 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.00880877 0.00456391 0.0130681
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.18051 0.785363 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0137161 0.0268797 0.106361
Echinococcus multilocularis rho GTPase activating protein 20 0.0162372 0.0383441 0.109793
Trypanosoma brucei heat shock protein 90, putative 0.0137161 0.0268797 0.0416866
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0721886 0.292779 0.838331
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0475929 0.180932 0.518073
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Plasmodium vivax endoplasmin, putative 0.0137161 0.0268797 0.0224181
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.00880877 0.00456391 0.0155882
Echinococcus multilocularis heat shock protein 90 0.0137161 0.0268797 0.0769661
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0362977 0.129568 0.370998
Echinococcus granulosus carbonic anhydrase 0.0362977 0.129568 0.370998
Brugia malayi heat shock protein 90 0.0137161 0.0268797 0.0769661
Chlamydia trachomatis DNA gyrase subunit B 0.150298 0.647975 0.646361
Leishmania major developmentally regulated phosphoprotein-like protein 0.00880877 0.00456391 0.00707798
Plasmodium falciparum heat shock protein 90 0.0137161 0.0268797 0.0224181
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Echinococcus multilocularis carbonic anhydrase 0.0362977 0.129568 0.370998
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0162372 0.0383441 0.0594662
Echinococcus granulosus heat shock protein 0.0137161 0.0268797 0.0769661
Trypanosoma brucei DNA topoisomerase IA, putative 0.0162372 0.0383441 0.0594662
Leishmania major DNA topoisomerase 1A 0.0162372 0.0383441 0.0594662
Echinococcus multilocularis carbonic anhydrase II 0.0475929 0.180932 0.518073
Loa Loa (eye worm) hypothetical protein 0.0362977 0.129568 0.370998
Trypanosoma brucei heat shock protein 90, putative 0.0137161 0.0268797 0.0416866
Trypanosoma brucei heat shock protein, putative 0.0137161 0.0268797 0.0416866
Entamoeba histolytica DNA topoisomerase III, putative 0.0162372 0.0383441 0.0431155
Loa Loa (eye worm) hypothetical protein 0.0167788 0.040807 0.116845
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0846047 0.349241 1
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Trypanosoma brucei DNA topoisomerase III, putative 0.0162372 0.0383441 0.0594662
Entamoeba histolytica DNA topoisomerase II, putative 0.0721886 0.292779 1
Schistosoma mansoni hypothetical protein 0.0362977 0.129568 0.370998
Trichomonas vaginalis receptor histidine kinase, putative 0.00880877 0.00456391 0.0155882
Giardia lamblia DNA topoisomerase II 0.0633799 0.252722 1
Leishmania major DNA topoisomerase ii 0.0559515 0.218942 0.339548
Schistosoma mansoni endoplasmin 0.0137161 0.0268797 0.0769661
Echinococcus multilocularis heat shock protein 0.0137161 0.0268797 0.0769661
Trypanosoma cruzi DNA topoisomerase III, putative 0.0162372 0.0383441 0.0594662
Schistosoma mansoni carbonic anhydrase-related 0.0362977 0.129568 0.370998
Loa Loa (eye worm) hypothetical protein 0.0167788 0.040807 0.116845
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0721886 0.292779 0.838331
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0475929 0.180932 0.518073
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0162372 0.0383441 0.0594662
Loa Loa (eye worm) hypothetical protein 0.0362977 0.129568 0.370998
Toxoplasma gondii hypothetical protein 0.0362977 0.129568 0.220271
Toxoplasma gondii DNA topoisomerase 2, putative 0.0721886 0.292779 0.507868
Trypanosoma brucei carbonic anhydrase-like protein 0.0475929 0.180932 0.2806
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbA 0.18051 0.785363 0.784379
Brugia malayi Probable DNA topoisomerase II 0.0721886 0.292779 0.838331
Chlamydia trachomatis DNA gyrase subunit B 0.22771 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0362977 0.129568 0.370998
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.00880877 0.00456391 0.00707798
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0704105 0.284693 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0362977 0.129568 0.370998
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.18051 0.785363 0.784379
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Plasmodium vivax DNA topoisomerase 3, putative 0.0162372 0.0383441 0.0339351
Mycobacterium ulcerans DNA gyrase subunit A 0.113633 0.481245 0.478867
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866
Trichomonas vaginalis heat shock protein, putative 0.011448 0.0165657 0.0565808
Leishmania major heat shock protein 83-1 0.0137161 0.0268797 0.0416866

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 = 51.73 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 0.643 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 0.777 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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