Detailed information for compound 1099596

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 201.307 | Formula: C14H19N
  • H donors: 0 H acceptors: 0 LogP: 2.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC=C=CCN([C@@H](c1ccccc1)C)C
  • InChi: 1S/C14H19N/c1-4-5-9-12-15(3)13(2)14-10-7-6-8-11-14/h4,6-11,13H,12H2,1-3H3/t5?,13-/m1/s1
  • InChiKey: GZAVCCSXCPNMJG-VVUQYOEASA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum serine repeat antigen 3 0.0155 0.0515 0.1822
Mycobacterium tuberculosis Probable dehydrogenase 0.0129 0.0418 0.5375
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0148 0.0521
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0021 0.0014
Echinococcus granulosus lamin 0.0031 0.0054 0.0181
Echinococcus multilocularis cysteine protease 0.0762 0.2776 0.2773
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0021 0.0075
Loa Loa (eye worm) latrophilin receptor protein 2 0.0151 0.0501 0.1804
Toxoplasma gondii hypothetical protein 0.0022 0.0021 0.0037
Onchocerca volvulus 0.0031 0.0054 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Schistosoma mansoni cpg binding protein 0.0119 0.0383 0.1374
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0129 0.0418 0.5375
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0068 0.0238
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0012 0.0038
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0017 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0155 0.0515 0.1803
Onchocerca volvulus 0.0119 0.0383 0.1367
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0011 0.0033
Plasmodium falciparum serine repeat antigen 4 0.0155 0.0515 0.1822
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0021 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0401 0.1431 0.5138
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0012 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0053 0.0136 0.0132
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0021 0.0062
Loa Loa (eye worm) ctsf protein 0.0762 0.2776 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0155 0.0515 0.1854
Trypanosoma brucei cysteine peptidase C (CPC) 0.033 0.1166 0.4177
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0163 0.0552
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0075 0.0259
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0022 0.0021 0.0037
Schistosoma mansoni zinc finger protein 0.0022 0.0021 0.0069
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0072 0.0805
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0401 0.1431 0.5154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0151 0.0501 0.1793
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0278 0.0274
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0012 0.0008
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0068 0.0753
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0143 0.0471 0.6082
Echinococcus granulosus cysteine protease 0.0401 0.1431 0.515
Schistosoma mansoni ap endonuclease 0.0021 0.0017 0.0056
Brugia malayi Receptor family ligand binding region containing protein 0.0028 0.0042 0.0151
Brugia malayi nuclear hormone receptor 0.002 0.0012 0.0044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0017 0.0023
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0022 0.0021 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0012 0.0044
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0039 0.0101
Entamoeba histolytica cysteine proteinase, putative 0.0762 0.2776 1
Echinococcus granulosus microtubule associated protein 2 0.0688 0.25 0.9007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0012 0.0038
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0131 0.0434
Giardia lamblia Hypothetical protein 0.0155 0.0515 0.4363
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0043 0.0097 0.0345
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0075
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0017 0.0023
Echinococcus granulosus cathepsin l1 0.0516 0.1859 0.6693
Loa Loa (eye worm) isocitrate dehydrogenase 0.0052 0.0131 0.0471
Giardia lamblia Hypothetical protein 0.0155 0.0515 0.4363
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0022 0.0021 0.0017
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0155 0.0515 0.1849
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Brugia malayi beta-lactamase 0.0035 0.0068 0.0244
Brugia malayi cathepsin L-like precursor 0.0516 0.1859 0.6698
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0022 0.0021 0.0069
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0021 0.0069
Schistosoma mansoni hypothetical protein 0.0741 0.2698 0.972
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0012 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.033 0.1166 0.4177
Echinococcus multilocularis lamin dm0 0.0031 0.0054 0.005
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0052 0.0131 0.0434
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0074 0.0265
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0762 0.2776 0.2773
Brugia malayi MBOAT family protein 0.0022 0.0021 0.0075
Giardia lamblia Encystation-specific protease 0.0155 0.0515 0.4363
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0017 0.042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0012 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0068 0.0206
Toxoplasma gondii cathepsin B 0.033 0.1166 0.4177
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0022 0.0021 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0155 0.0515 0.1822
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0018 0.0004 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0478 0.1717 0.6184
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0012 0.0038
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0068 0.0064
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0192 0.069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0401 0.1431 0.5138
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0012 0.0031
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0054 0.0194
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0054 0.0194
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Schistosoma mansoni thyroid hormone receptor 0.002 0.0012 0.0038
Schistosoma mansoni metabotropic glutamate receptor 0.0053 0.0136 0.0483
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0075 0.0272
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0068 0.0753
Giardia lamblia Cathepsin B precursor 0.033 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0516 0.1859 0.6698
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0155 0.0515 0.1822
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0155 0.0515 0.1822
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.0515 0.4363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Loa Loa (eye worm) inositol-1 0.004 0.0087 0.0314
Loa Loa (eye worm) hypothetical protein 0.0053 0.0136 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.0515 0.1822
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.0515 0.1854
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0048 0.0045
Brugia malayi cathepsin L precursor 0.0155 0.0515 0.1854
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0163 0.0583
Giardia lamblia Cathepsin L-like protease 0.0155 0.0515 0.4363
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0022 0.0021 0.0062
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Echinococcus granulosus cathepsin l cysteine peptidase 0.0762 0.2776 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0253 0.0881 0.3171
Schistosoma mansoni cpg binding protein 0.0126 0.0408 0.1465
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0054 0.0194
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0194
Brugia malayi Hhat protein 0.0022 0.0021 0.0075
Trichomonas vaginalis esterase, putative 0.0035 0.0068 0.0206
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Entamoeba histolytica cysteine proteinase, putative 0.0401 0.1431 0.5126
Loa Loa (eye worm) hypothetical protein 0.0246 0.0855 0.3078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0516 0.1859 0.6685
Echinococcus granulosus cathepsin L cysteine proteinase 0.0762 0.2776 1
Brugia malayi Isocitrate dehydrogenase 0.0052 0.0131 0.0471
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.072 0.262 0.9437
Plasmodium vivax unspecified product 0.0401 0.1431 0.5138
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0012 0.0044
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Brugia malayi glutathione reductase 0.0056 0.0148 0.0534
Onchocerca volvulus 0.0035 0.0068 0.0231
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0148 0.0534
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0155 0.0515 0.1854
Trypanosoma cruzi GUP1, putative 0.0022 0.0021 0.0037
Brugia malayi hypothetical protein 0.0019 0.0008 0.0028
Giardia lamblia Cathepsin B precursor 0.0155 0.0515 0.4363
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0087 0.0302
Brugia malayi ecdysteroid receptor 0.002 0.0012 0.0044
Schistosoma mansoni sterol O-acyltransferase 1 0.0228 0.0788 0.2836
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Brugia malayi fibroinase precursor 0.0155 0.0515 0.1854
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0192 0.0188
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0155 0.0515 0.1822
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0068 0.0206
Giardia lamblia Cathepsin B precursor 0.033 0.1166 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0068 0.0244
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0131 0.0127
Trypanosoma cruzi cysteine peptidase, putative 0.0762 0.2776 1
Treponema pallidum alginate O-acetylation protein (algI) 0.0022 0.0021 1
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0046 0.0129
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Mycobacterium tuberculosis Conserved protein 0.0035 0.0068 0.0753
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0022 0.0021 0.0069
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0048 0.0161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0278 0.0274
Brugia malayi Thioredoxin reductase 0.0056 0.0148 0.0534
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0131 0.0127
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0028 0.0042 0.0151
Loa Loa (eye worm) hypothetical protein 0.0516 0.1859 0.6698
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0011 0.0025
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0068 0.0753
Echinococcus granulosus FTZ F1 alpha 0.002 0.0012 0.0031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0068 0.0238
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0143 0.0471 1
Leishmania major glycerol uptake protein, putative 0.0022 0.0021 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0012 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Loa Loa (eye worm) hhat protein 0.0022 0.0021 0.0075
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0012 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.0762 0.2776 1
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0022 0.0021 0.0017
Entamoeba histolytica cysteine proteinase, putative 0.0401 0.1431 0.5126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0401 0.1431 0.5138
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0052 0.0131 0.0434
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0087 0.0277
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0013
Plasmodium vivax glutathione reductase, putative 0.0056 0.0148 0.0497
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0163 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0163 0.016
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0022 0.0021 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0012 0.0044
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0192 0.069
Echinococcus multilocularis cysteine protease 0.0762 0.2776 0.2773
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0762 0.2776 1
Brugia malayi hypothetical protein 0.0175 0.0588 0.212
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Plasmodium falciparum serine repeat antigen 8 0.0155 0.0515 0.1822
Leishmania major glycerol uptake protein, putative 0.0022 0.0021 0.0037
Schistosoma mansoni hypothetical protein 0.0151 0.0501 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0075 0.0072
Onchocerca volvulus 0.0762 0.2776 1
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0007
Echinococcus granulosus tar DNA binding protein 0.0068 0.0192 0.0678
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0131 0.0434
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0022 0.0021 0.0062
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0068 0.0753
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Schistosoma mansoni hypothetical protein 0.0151 0.0501 0.1799
Brugia malayi nuclear receptor NHR-88 0.002 0.0012 0.0044
Onchocerca volvulus 0.0762 0.2776 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0052 0.0131 0.0127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0478 0.1717 0.6184
Loa Loa (eye worm) hypothetical protein 0.0246 0.0855 0.3078
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.0515 0.1849
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0087 0.0277
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0068 0.0753
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0278 0.0995
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.0515 0.1849
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0762 0.2776 1
Onchocerca volvulus 0.002 0.0012 0.0031
Loa Loa (eye worm) fibroinase 0.0762 0.2776 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0516 0.1859 0.6698
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0021 0.0062
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0021 0.0017
Leishmania major hypothetical protein, conserved 0.0035 0.0068 0.0206
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.0515 0.4363
Trypanosoma cruzi cysteine peptidase, putative 0.0762 0.2776 1
Trichomonas vaginalis transmembrane protein nessy, putative 0.0022 0.0021 0.0037
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0155 0.0515 0.1822
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0037
Echinococcus granulosus dnaJ subfamily B 0.0408 0.1457 0.5242
Loa Loa (eye worm) beta-lactamase 0.0035 0.0068 0.0244
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0072 0.0098
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Trypanosoma cruzi cruzipain precursor, putative 0.0762 0.2776 1
Brugia malayi diacylglycerol acyltransferase 0.0022 0.0021 0.0075
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0087 0.5021
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0087 0.0277
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.0515 0.4363
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0012 0.0031
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0017 0.6298
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0039 0.0101
Giardia lamblia Cathepsin B precursor 0.0155 0.0515 0.4363
Onchocerca volvulus 0.0031 0.0054 0.0181
Schistosoma mansoni cpg binding protein 0.0126 0.0408 0.1465
Trypanosoma cruzi cysteine proteinase, putative 0.0401 0.1431 0.5138
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Onchocerca volvulus Cathepsin F homolog 0.0762 0.2776 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0155 0.0515 0.1822
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0012 0.0008
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0087 0.0254
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0087 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0155 0.0515 0.1854
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0143 0.0471 0.6082
Brugia malayi cathepsin F-like cysteine proteinase 0.0246 0.0855 0.3078
Entamoeba histolytica cysteine proteinase 2 0.0401 0.1431 0.5126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0012 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.0515 0.1822
Trypanosoma cruzi cruzipain precursor, putative 0.0246 0.0855 0.3052
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0021 0.0075
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0028 0.0042 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0155 0.0515 0.1822
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.0515 0.1822
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0155 0.0515 0.1803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Loa Loa (eye worm) hypothetical protein 0.0246 0.0855 0.3078
Entamoeba histolytica cysteine proteinase, putative 0.0401 0.1431 0.5126
Schistosoma mansoni intermediate filament proteins 0.0031 0.0054 0.0189
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0012 0.0031
Leishmania major hypothetical protein, conserved 0.0022 0.0021 0.0037
Schistosoma mansoni cathepsin C 0.0155 0.0515 0.1849
Plasmodium vivax serine-repeat antigen (SERA) 0.0155 0.0515 0.1822
Echinococcus multilocularis cathepsin L cysteine protease 0.0762 0.2776 0.2773
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0155 0.0515 0.1822
Brugia malayi cathepsin Z-like cysteine proteinase 0.0155 0.0515 0.1854
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.0515 0.1854
Plasmodium vivax vivapain-2 0.0762 0.2776 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0131 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0012 0.0044
Leishmania major glycerol uptake protein, putative 0.0022 0.0021 0.0037
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.033 0.1166 0.4177
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0012 0.0031
Schistosoma mansoni hypothetical protein 0.0151 0.0501 0.1799
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0762 0.2776 1
Echinococcus granulosus geminin 0.0741 0.2698 0.9719
Plasmodium vivax vivapain-1 0.0401 0.1431 0.5138
Echinococcus multilocularis geminin 0.0741 0.2698 0.2695
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0012 0.0008
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0087 0.0277
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0155 0.0515 0.1822
Onchocerca volvulus 0.0175 0.0588 0.211
Echinococcus multilocularis cathepsin L cysteine protease 0.0762 0.2776 0.2773
Echinococcus granulosus cathepsin l1 0.0762 0.2776 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.0515 0.1822
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.033 0.1166 0.4177
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0052 0.0131 0.0434
Entamoeba histolytica cysteine proteinase, putative 0.0516 0.1859 0.6677
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.0515 0.1849
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0017 0.0062
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0129 0.0418 0.5375
Echinococcus granulosus cathepsin L 0.0401 0.1431 0.515
Brugia malayi beta-lactamase family protein 0.0035 0.0068 0.0244
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0012 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0762 0.2776 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0278 0.0988
Plasmodium falciparum serine repeat antigen 1 0.0155 0.0515 0.1822
Mycobacterium tuberculosis Conserved protein 0.0035 0.0068 0.0753
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0685
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0017 0.0023
Echinococcus multilocularis cathepsin L 0.0155 0.0515 0.0511
Echinococcus granulosus cathepsin L 0.0155 0.0515 0.1843
Onchocerca volvulus 0.0035 0.0068 0.0231
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0148 0.0497
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0012 0.0044
Toxoplasma gondii histone lysine methyltransferase SET1 0.0226 0.0781 0.2784
Leishmania major trypanothione reductase 0.0056 0.0148 0.0497
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Toxoplasma gondii thioredoxin reductase 0.0056 0.0148 0.0497
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0163 1
Giardia lamblia Cathepsin B precursor 0.0155 0.0515 0.4363
Brugia malayi intermediate filament protein 0.0031 0.0054 0.0194
Plasmodium falciparum serine repeat antigen 9 0.0155 0.0515 0.1822
Brugia malayi Inositol-1 0.004 0.0087 0.0314
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0155 0.0515 0.1854
Onchocerca volvulus 0.0762 0.2776 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0129 0.0418 0.5375
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Giardia lamblia Cysteine protease 0.0155 0.0515 0.4363
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0068 0.3736
Brugia malayi Metabotropic glutamate receptor precursor. 0.0028 0.0042 0.0151
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0155 0.0515 0.1822
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0148 0.1816
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0011 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0012 0.0031
Onchocerca volvulus 0.0762 0.2776 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0021 0.0017
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0278 0.0995
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.0515 0.1849
Plasmodium falciparum cysteine proteinase falcipain 1 0.0401 0.1431 0.5138
Plasmodium vivax unspecified product 0.0155 0.0515 0.1822
Loa Loa (eye worm) hypothetical protein 0.0762 0.2776 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0012 0.0044
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0021 0.0037
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0087 0.0277
Echinococcus granulosus cathepsin b 0.072 0.262 0.9436
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0017 0.0837
Loa Loa (eye worm) hypothetical protein 0.0175 0.0588 0.212
Toxoplasma gondii cathepsin CPC1 0.0155 0.0515 0.1822
Brugia malayi Latrophilin receptor protein 2 0.0151 0.0501 0.1804
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0206 0.0705 0.254
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0052 0.0131 0.0434
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0021 0.0014
Plasmodium falciparum serine repeat antigen 5 0.0155 0.0515 0.1822
Schistosoma mansoni cathepsin F (C01 family) 0.0516 0.1859 0.6696
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0068 0.0206
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0516 0.1859 0.6685
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0017 0.0023
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0401 0.1431 0.5154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0516 0.1859 0.6685
Mycobacterium tuberculosis Probable reductase 0.0129 0.0418 0.5375
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0278 0.0995
Loa Loa (eye worm) CXXC zinc finger family protein 0.0119 0.0383 0.1378
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Echinococcus granulosus cathepsin b 0.072 0.262 0.9436
Onchocerca volvulus Cathepsin L homolog 0.0762 0.2776 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0155 0.0515 0.1822
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0069
Toxoplasma gondii ABC1 family protein 0.0035 0.0068 0.0206
Schistosoma mansoni cathepsin F (C01 family) 0.0762 0.2776 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Plasmodium falciparum glutathione reductase 0.0056 0.0148 0.0497
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0762 0.2776 0.2773
Leishmania major cysteine peptidase A (CPA) 0.0762 0.2776 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0478 0.1717 0.6184
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.25 0.9007
Brugia malayi latrophilin 2 splice variant baaae 0.0327 0.1154 0.4157
Onchocerca volvulus 0.0762 0.2776 1
Trypanosoma cruzi GUP1, putative 0.0022 0.0021 0.0037
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0129 0.0418 0.8673
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0068 0.3736
Leishmania major hypothetical protein, conserved 0.0029 0.0046 0.0129
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0685
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.0515 0.1822
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0022 0.0021 0.0037
Loa Loa (eye worm) cysteine protease 0.0762 0.2776 1
Plasmodium falciparum serine repeat antigen 6 0.0155 0.0515 0.1822
Schistosoma mansoni cathepsin s 0.0246 0.0855 0.3074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0278 0.1
Loa Loa (eye worm) glutathione reductase 0.0056 0.0148 0.0534
Giardia lamblia Cathepsin L-like protease 0.0155 0.0515 0.4363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0048 0.0161
Brugia malayi cathepsin B-like cysteine proteinase 0.072 0.262 0.9437
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0046 0.0129
Loa Loa (eye worm) hypothetical protein 0.072 0.262 0.9437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0052 0.0131 0.0127
Trypanosoma cruzi cysteine peptidase, putative 0.0762 0.2776 1
Entamoeba histolytica cysteine proteinase, putative 0.0401 0.1431 0.5126
Onchocerca volvulus 0.0762 0.2776 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0046 0.0129
Schistosoma mansoni thyroid hormone receptor 0.002 0.0012 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0151 0.0501 0.1793
Brugia malayi beta-lactamase family protein 0.0035 0.0068 0.0244
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0068 0.0206
Schistosoma mansoni lamin 0.0031 0.0054 0.0189
Mycobacterium tuberculosis Probable oxidoreductase 0.0143 0.0471 0.6082
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.072 0.262 0.9437
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0012 0.0031
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.1457 0.1454
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0021 0.0069
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0017 0.0023
Leishmania major glycerol uptake protein, putative 0.0022 0.0021 0.0037
Schistosoma mansoni nuclear hormone receptor 0.002 0.0012 0.0038
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0012 0.0038
Brugia malayi MBOAT family protein 0.0022 0.0021 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0401 0.1431 0.5138
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0048 0.0168
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0401 0.1431 0.5138
Toxoplasma gondii cathepsin CPL 0.0762 0.2776 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Mycobacterium ulcerans hypothetical protein 0.0035 0.0068 0.3736
Schistosoma mansoni hypothetical protein 0.0408 0.1457 0.5245
Loa Loa (eye worm) hypothetical protein 0.0478 0.1717 0.6184
Trypanosoma cruzi cysteine proteinase, putative 0.0401 0.1431 0.5138
Giardia lamblia Cathepsin B precursor 0.0155 0.0515 0.4363
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Onchocerca volvulus 0.0022 0.0021 0.0062
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Brugia malayi Papain family cysteine protease containing protein 0.0762 0.2776 1
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0022 0.0021 0.0062
Leishmania major glycerol uptake protein, putative 0.0022 0.0021 0.0037
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0012 0.0031
Echinococcus granulosus lamin dm0 0.0031 0.0054 0.0181
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0012 0.0008
Schistosoma mansoni ap endonuclease 0.0021 0.0017 0.0056
Brugia malayi MBOAT family protein 0.0022 0.0021 0.0075
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0012 0.0044
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0021 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0052 0.0131 0.0458
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0087 0.0277
Brugia malayi TAR-binding protein 0.0068 0.0192 0.069
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0401 0.1431 0.5154
Loa Loa (eye worm) hypothetical protein 0.0516 0.1859 0.6698
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0068 0.0231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.0515 0.1822
Entamoeba histolytica cysteine proteinase, putative 0.0762 0.2776 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0151 0.0501 0.0497
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0155 0.0515 0.1822
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0187
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0021 0.0037
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0012 0.0044
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0163 0.0583
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0246 0.0855 0.3078
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0012 0.0008
Loa Loa (eye worm) RNA binding protein 0.0068 0.0192 0.069
Giardia lamblia Cathepsin B precursor 0.0155 0.0515 0.4363
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0022 0.0021 0.0062
Mycobacterium tuberculosis Conserved protein 0.0035 0.0068 0.0753
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0068 0.0753
Brugia malayi Cathepsin L-like precursor 0.0246 0.0855 0.3078
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Echinococcus multilocularis cpg binding protein 0.0126 0.0408 0.0405
Plasmodium vivax unspecified product 0.0246 0.0855 0.3052
Trypanosoma cruzi cysteine peptidase, putative 0.0246 0.0855 0.3052
Schistosoma mansoni inositol monophosphatase 0.004 0.0087 0.0309
Giardia lamblia Cathepsin B precursor 0.033 0.1166 1
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Giardia lamblia Cysteine protease 0.0155 0.0515 0.4363
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0021 0.0069
Echinococcus granulosus cathepsin L cysteine protease 0.0401 0.1431 0.515
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0163 0.0576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0151 0.0501 0.0497
Plasmodium vivax vivapain-2 0.0762 0.2776 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0012 0.0038
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0012 0.0008
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0018 0.0004 0.0013
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0012 0.0008
Echinococcus multilocularis neuropeptide receptor A26 0.0498 0.1791 0.1788
Echinococcus granulosus metabotropic glutamate receptor 5 0.0053 0.0136 0.0476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0021 0.0037
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0087 0.0084
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0155 0.0515 0.1822
Echinococcus granulosus GPCR family 2 0.0151 0.0501 0.1793
Brugia malayi Papain family cysteine protease containing protein 0.0401 0.1431 0.5156
Brugia malayi cathepsin F-like cysteine proteinase 0.0155 0.0515 0.1854
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0155 0.0515 0.4363
Toxoplasma gondii exonuclease III APE 0.0021 0.0017 0.0023
Onchocerca volvulus 0.0035 0.0068 0.0231
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0021 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0046 0.0129
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0068 0.0206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0278 0.0988
Loa Loa (eye worm) hhat protein 0.0022 0.0021 0.0075
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0068 0.0753
Toxoplasma gondii cathepsin CPC2 0.0155 0.0515 0.1822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0155 0.0515 0.1849
Schistosoma mansoni coup transcription factor 0.002 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Brugia malayi RNA binding protein 0.0068 0.0192 0.069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0012 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0206
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0017 0.0056
Brugia malayi MBOAT family protein 0.0022 0.0021 0.0075
Plasmodium falciparum serine repeat antigen 2 0.0155 0.0515 0.1822
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.0515 0.1822
Loa Loa (eye worm) glutamate receptor 0.0043 0.0097 0.0351
Schistosoma mansoni cathepsin S (C01 family) 0.0155 0.0515 0.1849
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0022 0.0021 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0012 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0401 0.1431 0.5138
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0011 0.0038
Echinococcus multilocularis musashi 0.0031 0.0054 0.005
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Brugia malayi Cathepsin L-like precursor 0.0516 0.1859 0.6698
Brugia malayi hypothetical protein 0.0029 0.0046 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0155 0.0515 0.1822
Trypanosoma cruzi major cysteine proteinase, putative 0.0155 0.0515 0.1822
Onchocerca volvulus Cathepsin L homolog 0.0155 0.0515 0.1843
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0012 0.0044
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0246 0.0855 0.3078
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Echinococcus granulosus sterol O acyltransferase 1 0.0228 0.0788 0.283
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0768 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.0501 0.1804
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0148 0.0145
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0068 0.0244
Schistosoma mansoni cathepsin B (C01 family) 0.0155 0.0515 0.1849
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Mycobacterium ulcerans lipase LipD 0.0035 0.0068 0.3736
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0685
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.0515 0.1822
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0068 0.0206
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0017 0.0023
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0163 0.2016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Brugia malayi metabotropic glutamate receptor type 2 0.0053 0.0136 0.0488
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0012 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0012 0.0044
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0021 0.0014
Toxoplasma gondii preprocathepsin c precursor, putative 0.0155 0.0515 0.1822
Loa Loa (eye worm) cathepsin B 0.033 0.1166 0.4199
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Schistosoma mansoni hypothetical protein 0.0151 0.0501 0.1799
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0155 0.0515 0.1854
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Loa Loa (eye worm) hypothetical protein 0.0228 0.0788 0.284
Echinococcus granulosus neuropeptide receptor A26 0.0498 0.1791 0.6448
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0046 0.0129
Onchocerca volvulus 0.0762 0.2776 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0012 0.0044
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0048 0.0045
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0155 0.0515 0.1849
Brugia malayi isocitrate dehydrogenase 0.0052 0.0131 0.0471
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0037
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0021 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.0515 0.1849
Plasmodium falciparum serine repeat antigen 7 0.0155 0.0515 0.1822
Mycobacterium ulcerans beta-lactamase 0.0035 0.0068 0.3736
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0017 0.0049
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0131 0.0127
Onchocerca volvulus 0.0516 0.1859 0.6693
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0022 0.0021 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0037
Brugia malayi Papain family cysteine protease containing protein 0.0401 0.1431 0.5156
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0022 0.0021 0.0075
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0017 0.0085
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0012 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0068 0.0206
Plasmodium falciparum thioredoxin reductase 0.0056 0.0148 0.0497
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0017 0.0023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0012 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0012 0.0044
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0052 0.0131 0.0465
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Echinococcus multilocularis cathepsin b 0.072 0.262 0.2617
Echinococcus granulosus neuropeptide s receptor 0.0498 0.1791 0.6448
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0087 0.0277
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Echinococcus multilocularis cathepsin L 0.0401 0.1431 0.1428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0012 0.0038
Giardia lamblia Cysteine protease 0.0155 0.0515 0.4363
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0046 0.0129
Giardia lamblia Cysteine protease 0.0155 0.0515 0.4363
Schistosoma mansoni hypothetical protein 0.0741 0.2698 0.972
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0131 0.0434
Echinococcus multilocularis neuropeptide s receptor 0.0498 0.1791 0.1788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Echinococcus multilocularis lamin 0.0031 0.0054 0.005
Entamoeba histolytica cysteine proteinase 1, putative 0.0401 0.1431 0.5126
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0155 0.0515 0.1822
Brugia malayi Cathepsin L-like precursor 0.0516 0.1859 0.6698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0278 0.1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Trypanosoma brucei trypanothione reductase 0.0056 0.0148 0.0497
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0021 0.0017
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0155 0.0515 0.1822
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.25 0.2498
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.072 0.262 0.9437
Brugia malayi MBOAT family protein 0.0022 0.0021 0.0075
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0131 0.0434
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.0515 0.1854
Echinococcus multilocularis cathepsin b 0.072 0.262 0.2617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Entamoeba histolytica hypothetical protein 0.0155 0.0515 0.1803
Loa Loa (eye worm) glutamate receptor 0.0028 0.0042 0.0151
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0762 0.2776 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0762 0.2776 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0155 0.0515 0.1849
Entamoeba histolytica hypothetical protein 0.0022 0.0021 0.0014
Brugia malayi CXXC zinc finger family protein 0.0119 0.0383 0.1378
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0155 0.0515 0.1822
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0685
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0163 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.0515 0.1822
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0148 0.0497
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Brugia malayi steroid hormone receptor 0.002 0.0012 0.0044
Schistosoma mansoni cathepsin F (C01 family) 0.0762 0.2776 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0685
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0155 0.0515 0.1822
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0012 0.0038
Schistosoma mansoni inositol monophosphatase 0.004 0.0087 0.0309
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0012 0.0008
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0012 0.0044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.033 0.1166 0.4196
Echinococcus granulosus cpg binding protein 0.0126 0.0408 0.1459
Onchocerca volvulus Cathepsin L homolog 0.0762 0.2776 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.072 0.262 0.9437
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Trichomonas vaginalis porcupine, putative 0.0022 0.0021 0.0037
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0046 0.0129
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0052 0.0131 0.1585
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0163 0.0552
Trichomonas vaginalis helicase, putative 0.0027 0.0039 0.0101
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0129 0.0418 0.5375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0012 0.0044
Schistosoma mansoni hypothetical protein 0.0327 0.1154 0.4153
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0087 0.0277
Entamoeba histolytica vacuolar protein sorting 26 0.0022 0.0021 0.0014
Echinococcus granulosus intermediate filament protein 0.0031 0.0054 0.0181
Schistosoma mansoni lamin 0.0031 0.0054 0.0189
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.072 0.262 0.9435
Echinococcus multilocularis sterol O acyltransferase 1 0.0228 0.0788 0.0785
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0011 0.0007
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0021 0.0075
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0022 0.0021 0.0017
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0022 0.0021 0.0069
Echinococcus multilocularis GPCR, family 2 0.0151 0.0501 0.0497
Loa Loa (eye worm) hypothetical protein 0.0327 0.1154 0.4157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Entamoeba histolytica cysteine protease, putative 0.0762 0.2776 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0762 0.2776 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0012 0.0044
Onchocerca volvulus 0.0155 0.0515 0.1843
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0155 0.0515 0.1822
Trypanosoma cruzi cysteine protease, putative 0.0401 0.1431 0.5138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0167
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0151 0.0501 0.1804
Plasmodium vivax vivapain-3 0.0401 0.1431 0.5138
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0012 0.0031
Brugia malayi cathepsin L-like cysteine proteinase 0.0155 0.0515 0.1854
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0022 0.0021 0.0075
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0192 0.069

Activities

Activity type Activity value Assay description Source Reference
k2 (binding) = 0.44 min-1 Kinetic parameter for the time dependent inhibition of Bovine liver Monoamine Oxidase B at 25 degrees C (pH= 7.4). ChEMBL. 3397993
k2 (binding) = 0.61 min-1 Kinetic parameter for the time dependent inhibition of Bovine liver Monoamine Oxidase B at 25 degrees C (pH= 7.4). ChEMBL. 3397993
Ki (binding) = 0.73 mM In vitro inhibition of bovine monoamine oxidase B. ChEMBL. 3397993
Ki (binding) = 1.8 mM In vitro inhibition of bovine monoamine oxidase B. ChEMBL. 3397993

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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