TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 326.386 | Formula: C20H22O4
H donors: 0 H acceptors: 1 LogP: 4.54 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COC1=Cc2c3cc(OC)c(cc3c(cc2C(C1=O)(C)C)OC)C
InChi: 1S/C20H22O4/c1-11-7-14-12(8-16(11)22-4)13-9-18(24-6)19(21)20(2,3)15(13)10-17(14)23-5/h7-10H,1-6H3
InChiKey: SVSYTLDPFSIEJY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Leishmania amazonensis	Arginase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium vivax	arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium yoelii	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium falciparum	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania donovani	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania infantum	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	Arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus granulosus	3'partial\|arginase 2 mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Candida albicans	likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania major	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Schistosoma japonicum	ko:K01476 arginase [EC3.5.3.1], putative	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus multilocularis	arginase 2, mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania mexicana	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Candida albicans	likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus multilocularis		Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania braziliensis	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium knowlesi	arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus granulosus	arginase 2 mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium yoelii	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium berghei	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Schistosoma mansoni	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128245	All targets in OG5_128245
Entamoeba histolytica	Arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	Arginase/agmatinase family protein similar to S. pombe SPAC11D3.09	Arginase	329 aa	303 aa	24.8 %
Candida albicans	Arginase/agmatinase family protein similar to S. pombe SPAC11D3.09	Arginase	329 aa	303 aa	24.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	DNA repair protein REV1, putative	0.0032	0.0039	0.0156
Echinococcus granulosus	dna polymerase kappa	0.0133	0.1459	0.1223
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Trypanosoma brucei	unspecified product	0.0126	0.1352	0.2931
Loa Loa (eye worm)	histone methyltransferase	0.007	0.0575	0.0191
Trypanosoma cruzi	DNA polymerase eta, putative	0.0061	0.0452	0.0922
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.005	0.0288	0.0028
Plasmodium vivax	arginase, putative	0.0207	0.2488	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0133	0.1459	0.317
Loa Loa (eye worm)	MH2 domain-containing protein	0.0375	0.4839	0.7977
Toxoplasma gondii	hypothetical protein	0.0057	0.0388	0.0707
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0164	0.1891	0.1582
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0102	0.1028	0.0993
Loa Loa (eye worm)	hypothetical protein	0.035	0.4488	0.7336
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.005	0.0288	0.0028
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0049	0.0286	0.0552
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0288	0.0028
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0084	0.0773	0.3107
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.005	0.0288	0.0028
Echinococcus granulosus	cpg binding protein	0.0231	0.2831	0.2633
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0062	0.0462	0.0198
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0102	0.1028	0.363
Trypanosoma brucei	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Onchocerca volvulus		0.0516	0.6815	1
Echinococcus multilocularis	arginase 2, mitochondrial	0.0207	0.2488	0.2202
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.005	0.0288	0.0028
Mycobacterium ulcerans	DNA polymerase IV	0.0133	0.1459	0.6609
Echinococcus multilocularis	survival motor neuron protein 1	0.0234	0.2867	0.2595
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.011	0.1135	0.4217
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.005	0.0288	0.0028
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.005	0.0288	0.0028
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0167	0.1925	0.4209
Schistosoma mansoni	phosphatidylinositol-4-phosphate 5-kinase type II	0.035	0.4488	0.4466
Plasmodium falciparum	arginase	0.0207	0.2488	1
Echinococcus granulosus	3'partial\|arginase 2 mitochondrial	0.0207	0.2488	0.228
Trypanosoma brucei	agmatinase, putative	0.0075	0.0647	0.1357
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0057	0.0388	0.0022
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0084	0.0773	0.0422
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0034	0.0066	0.0027
Brugia malayi	ImpB/MucB/SamB family protein	0.0132	0.1441	0.2075
Schistosoma mansoni	cpg binding protein	0.0219	0.2657	0.2628
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0467	0.6124	0.6109
Echinococcus granulosus	histone acetyltransferase KAT2B	0.016	0.1826	0.16
Plasmodium vivax	SET domain protein, putative	0.0069	0.0562	0.226
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0069	0.0562	0.0525
Brugia malayi	CXXC zinc finger family protein	0.0219	0.2657	0.4213
Echinococcus granulosus	peptidase Clp S14 family	0.0055	0.0367	0.01
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1988	0.2772
Trypanosoma brucei	unspecified product	0.0071	0.0583	0.1214
Trypanosoma brucei	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Leishmania major	DNA polymerase kappa, putative	0.011	0.1135	0.2446
Plasmodium falciparum	histone acetyltransferase GCN5	0.0044	0.0213	0.0856
Brugia malayi	Probable ClpP-like protease	0.0084	0.0773	0.09
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0048	0.0269	0.0491
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0352	0.4519	1
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0288	0.0028
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0057	0.0388	0.0122
Mycobacterium ulcerans	DNA polymerase IV	0.0133	0.1459	0.6609
Onchocerca volvulus	Huntingtin homolog	0.0132	0.1441	0.18
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0069	0.0562	0.0525
Trypanosoma cruzi	agmatinase, putative	0.0075	0.0647	0.1357
Onchocerca volvulus		0.0171	0.1988	0.2635
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.005	0.0288	0.0028
Schistosoma mansoni	phosphatidylinositol-4-phosphate 5-kinase type II	0.035	0.4488	0.4466
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0069	0.0562	0.0525
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0061	0.0452	0.0824
Leishmania major	arginase	0.0207	0.2488	0.5466
Brugia malayi	Pre-SET motif family protein	0.0454	0.5947	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0167	0.1925	0.4209
Giardia lamblia	DINP protein human, muc B family	0.011	0.1135	1
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0288	0.0028
Echinococcus granulosus	histone lysine methyltransferase setb	0.0069	0.0562	0.0301
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0084	0.0773	0.3416
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0288	0.0028
Schistosoma mansoni	microtubule-associated protein tau	0.0744	1	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.006	0.0438	0.089
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0057	0.0388	0.0022
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0352	0.4519	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.047	0.0963
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0421	0.5486	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0133	0.1459	0.1818
Onchocerca volvulus	Huntingtin homolog	0.0132	0.1441	0.18
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0048	0.0269	0.1082
Echinococcus multilocularis	dna polymerase kappa	0.0133	0.1459	0.1134
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0102	0.1028	0.0686
Trypanosoma cruzi	arginase, putative	0.0075	0.0647	0.1357
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1441	0.1773
Brugia malayi	Pip kinase protein 2	0.035	0.4488	0.7434
Loa Loa (eye worm)	hypothetical protein	0.0234	0.2867	0.4376
Brugia malayi	hypothetical protein	0.0132	0.1441	0.2075
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0069	0.0562	0.0203
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0084	0.0773	0.5
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0773	0.0553
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0055	0.0367	0.4744
Trypanosoma brucei	DNA polymerase kappa, putative	0.011	0.1135	0.2446
Brugia malayi	hypothetical protein	0.0171	0.1988	0.3038
Trypanosoma cruzi	DNA polymerase eta, putative	0.0132	0.1441	0.313
Entamoeba histolytica	Arginase, putative	0.0207	0.2488	1
Schistosoma mansoni	arginase	0.0207	0.2488	0.2458
Onchocerca volvulus		0.035	0.4488	0.6449
Schistosoma mansoni	peptidase Clp (S14 family)	0.0084	0.0773	0.0737
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0185	0.2188	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.069	0.1453
Echinococcus multilocularis	phosphatidylinositol 5 phosphate 4 kinase type 2	0.035	0.4488	0.4278
Loa Loa (eye worm)	transcription factor SMAD2	0.0375	0.4839	0.7977
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0084	0.0773	0.1409
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0039	0.0146	0.0266
Echinococcus granulosus	phosphatidylinositol 5 phosphate 4 kinase type 2	0.035	0.4488	0.4335
Trichomonas vaginalis	set domain proteins, putative	0.0516	0.6815	1
Brugia malayi	hypothetical protein	0.0234	0.2867	0.4583
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0057	0.0388	0.0122
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0288	0.0028
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0454	0.5947	1
Echinococcus granulosus	survival motor neuron protein 1	0.0234	0.2867	0.2669
Trypanosoma brucei	DNA polymerase eta, putative	0.0132	0.1441	0.313
Schistosoma mansoni	hypothetical protein	0.0048	0.0261	0.0223
Trypanosoma brucei	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Onchocerca volvulus		0.0069	0.0562	0.0459
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0084	0.0773	0.3416
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1441	0.1773
Schistosoma mansoni	cpg binding protein	0.0231	0.2831	0.2803
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.007	0.0575	0.0216
Trypanosoma brucei	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0069	0.0562	0.1025
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0288	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0288	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0288	0.0028
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0261	0.0223
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0102	0.1028	0.3582
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0084	0.0773	0.5
Leishmania major	DNA polymerase eta, putative	0.0061	0.0452	0.0922
Trichomonas vaginalis	helicase, putative	0.005	0.0288	0.0028
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0049	0.0286	0.0552
Mycobacterium ulcerans	hypothetical protein	0.0185	0.2188	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.069	0.1453
Trypanosoma brucei	unspecified product	0.0071	0.0583	0.1214
Onchocerca volvulus		0.0219	0.2657	0.3655
Trypanosoma brucei	DNA polymerase IV, putative	0.0126	0.1352	0.2931
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0084	0.0773	1
Echinococcus granulosus	dna polymerase eta	0.0132	0.1441	0.1204
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0102	0.1028	0.0993
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0084	0.0773	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.047	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1441	0.1773
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.2488	0.3389
Echinococcus multilocularis	microtubule associated protein 2	0.0744	1	1
Leishmania major	mitochondrial DNA polymerase beta	0.0352	0.4519	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Echinococcus multilocularis	cpg binding protein	0.0231	0.2831	0.2558
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0084	0.0773	0.1409
Echinococcus multilocularis		0.0207	0.2488	0.2202
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0048	0.0269	0.0491
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0069	0.0562	0.0203
Leishmania major	agmatinase-like protein	0.0075	0.0647	0.1357
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0057	0.0388	0.035
Trypanosoma cruzi	agmatinase, putative	0.0075	0.0647	0.1357
Echinococcus granulosus	arginase 2 mitochondrial	0.0207	0.2488	0.228
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Schistosoma mansoni	cpg binding protein	0.0231	0.2831	0.2803
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0288	0.0028
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0102	0.1028	0.1018
Brugia malayi	acetyltransferase, GNAT family protein	0.0164	0.1891	0.2866
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0084	0.0773	0.3107
Trypanosoma brucei	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Trypanosoma brucei	DNA polymerase IV, putative	0.0133	0.1459	0.317
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0352	0.4519	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Giardia lamblia	Histone acetyltransferase GCN5	0.0044	0.0213	0.1588
Plasmodium falciparum	DNA repair protein REV1, putative	0.0032	0.0039	0.0156
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0167	0.1925	0.4209
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0133	0.1459	0.1818
Echinococcus multilocularis	dna polymerase eta	0.0132	0.1441	0.1115
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.011	0.1135	0.2446
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0084	0.0773	1
Trypanosoma cruzi	arginase, putative	0.0075	0.0647	0.1357
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0084	0.0773	0.0518
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0164	0.1891	0.1859
Leishmania major	DNA polymerase eta, putative	0.0132	0.1441	0.313
Schistosoma mansoni	DNA polymerase eta	0.0132	0.1441	0.1408
Trichomonas vaginalis	Arginase, putative	0.0207	0.2488	0.3389
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0219	0.2657	0.3993
Brugia malayi	ImpB/MucB/SamB family protein	0.0102	0.1028	0.1348
Brugia malayi	Pre-SET motif family protein	0.0069	0.0562	0.0529
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.007	0.0575	0.0314
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0102	0.1028	0.078
Loa Loa (eye worm)	pip kinase 2	0.035	0.4488	0.7336
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0032	0.0039	0.0071
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.005	0.0288	0.0028
Brugia malayi	F/Y-rich N-terminus family protein	0.0069	0.0562	0.053
Loa Loa (eye worm)	acetyltransferase	0.0164	0.1891	0.2594
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0069	0.0562	0.0525
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0049	0.0286	0.0552
Trypanosoma brucei	DNA polymerase kappa, putative	0.0078	0.069	0.1453
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.2488	0.3389
Trypanosoma brucei	DNA polymerase kappa, putative	0.0133	0.1459	0.317
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0562	0.0168
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0049	0.0286	0.0552
Brugia malayi	polk-prov protein	0.0063	0.047	0.0367
Brugia malayi	MH2 domain containing protein	0.0375	0.4839	0.8051

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 5 ug ml-1	Cytotoxicity against human NCI-H187 cells by SRB assay	ChEMBL.	19778068
IC50 (functional)	> 5 ug ml-1	Cytotoxicity against human KB cells by SRB assay	ChEMBL.	19778068
IC50 (functional)	> 5 ug ml-1	Cytotoxicity against human MCF7 cells by SRB assay	ChEMBL.	19778068
IC50 (functional)	> 20 ug ml-1	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 assessed as [G-3H]hypoxanthine uptake after 24 hrs by scintillation counting	ChEMBL.	19778068
IC50 (binding)	= 16.6 uM	Inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substrate incubated for 10 mins prior to substrate addition measured after 10 mins by colorimetry	ChEMBL.	24521209

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	19778068

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1078766

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1099750