TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 352.225 | Formula: C14H11BrFN3S
H donors: 2 H acceptors: 0 LogP: 3.87 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(=S)N/N=C(/c1cccc(c1)Br)\c1cccc(c1)F
InChi: 1S/C14H11BrFN3S/c15-11-5-1-3-9(7-11)13(18-19-14(17)20)10-4-2-6-12(16)8-10/h1-8H,(H3,17,19,20)/b18-13-
InChiKey: YAQIEHVEDVVNKL-AQTBWJFISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0277	0.0554
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0262	0.0262
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.5006	0.5006
Brugia malayi	Importin beta-1 subunit	0.0031	0.0656	0.0692
Brugia malayi	Bromodomain containing protein	0.0041	0.0973	0.1026
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0401	0.2591
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0277	0.0554
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0684	0.0721
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0407	0.2627
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0684	0.0721
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0684	0.0721
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.0684	0.0684
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.004	0.0924	0.536
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0684	0.0721
Echinococcus granulosus	cathepsin b	0.0171	0.5006	0.5006
Brugia malayi	PHD-finger family protein	0.0029	0.0583	0.0615
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0284	0.0284
Loa Loa (eye worm)	cathepsin B	0.006	0.1548	0.1548
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0656	0.0656
Trypanosoma cruzi	ISWI complex protein	0.0016	0.0203	0.0405
Echinococcus multilocularis	snurportin 1	0.0331	1	1
Brugia malayi	hypothetical protein	0.0027	0.0535	0.0563
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0684	0.1367
Echinococcus granulosus	cysteine protease	0.0019	0.0277	0.0277
Brugia malayi	cathepsin B-like cysteine proteinase	0.0171	0.5006	0.5276
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0684	0.7405
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.004	0.0924	0.1846
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0684	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0975	0.0975
Entamoeba histolytica	hypothetical protein	0.0025	0.0473	0.5125
Leishmania major	cysteine peptidase A (CPA)	0.0032	0.0684	0.3578
Schistosoma mansoni	hypothetical protein	0.0012	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0315	0.9488	0.9488
Loa Loa (eye worm)	ctsf protein	0.0032	0.0684	0.0684
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0473	0.2012
Schistosoma mansoni	ap endonuclease	0.004	0.0924	0.0924
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.004	0.0924	0.5
Leishmania major	cathepsin L-like protease	0.0032	0.0684	0.3578
Plasmodium vivax	vivapain-2	0.0032	0.0684	0.7405
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0656	0.337
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0473	0.3058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0535	0.5786
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.004	0.0924	0.0924
Loa Loa (eye worm)	fibroinase	0.0032	0.0684	0.0684
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0924	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0407	0.2627
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0262	0.0262
Plasmodium vivax	vivapain-3	0.0019	0.0277	0.3002
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.1548	0.3093
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.0684	0.0684
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0407	0.0407
Echinococcus granulosus	histone lysine methyltransferase setb	0.0019	0.0284	0.0284
Plasmodium vivax	unspecified product	0.0019	0.0277	0.3002
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0535	0.311
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0407	0.0429
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0473	0.0946
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0473	0.3058
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2059	0.2059
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0009	0.0009
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.0684	0.0684
Schistosoma mansoni	hypothetical protein	0.0022	0.0381	0.0381
Schistosoma mansoni	importin beta-1	0.0031	0.0656	0.0656
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0019	0.0284	0.0284
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0009	0.0009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Brugia malayi	F/Y-rich N-terminus family protein	0.0012	0.0069	0.0072
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0684	0.3578
Onchocerca volvulus		0.0032	0.0684	0.951
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0684	0.7405
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.0684	0.4419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0535	0.0535
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0684	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1177	0.1177
Treponema pallidum	exodeoxyribonuclease (exoA)	0.004	0.0924	0.5
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0065	0.1719	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0401	0.4342
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Echinococcus multilocularis	cathepsin b	0.0171	0.5006	0.5006
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0407	0.0429
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.0684	0.1367
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0504	0.0504
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0684	0.3578
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.1873	0.1873
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	0.5006	0.5006
Giardia lamblia	Cathepsin B precursor	0.006	0.1548	1
Schistosoma mansoni	cpg binding protein	0.0037	0.0842	0.0842
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Schistosoma mansoni	bromodomain containing protein	0.007	0.1868	0.1868
Leishmania major	cathepsin L-like protease	0.0032	0.0684	0.3578
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0684	0.7405
Echinococcus granulosus	cathepsin b	0.0171	0.5006	0.5006
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.004	0.0924	0.5
Plasmodium vivax	vivapain-2	0.0032	0.0684	0.7405
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0407	0.4403
Onchocerca volvulus		0.0032	0.0684	0.951
Schistosoma mansoni	hypothetical protein	0.0016	0.0203	0.0203
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0684	0.0721
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0684	0.3578
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0277	0.3002
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0684	0.4419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0684	0.3578
Echinococcus multilocularis	muscleblind protein 1	0.0315	0.9488	0.9488
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.0684	0.7405
Onchocerca volvulus		0.0032	0.0684	0.951
Schistosoma mansoni	ran	0.0023	0.0401	0.0401
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0277	0.0277
Schistosoma mansoni	hypothetical protein	0.0331	1	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1055	0.1055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Echinococcus granulosus	cpg binding protein	0.0037	0.0842	0.0842
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.004	0.0924	1
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.0684	0.4419
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0684	0.0721
Trichomonas vaginalis	ran, putative	0.0023	0.0401	0.2591
Echinococcus granulosus	zinc finger protein	0.0023	0.0405	0.0405
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.0684	0.0684
Leishmania major	hypothetical protein, conserved	0.0027	0.0535	0.2466
Leishmania major	cathepsin L-like protease	0.0032	0.0684	0.3578
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.0684	0.0684
Brugia malayi	hypothetical protein	0.0018	0.0235	0.0248
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0535	0.1068
Leishmania major	cathepsin L-like protease	0.0032	0.0684	0.3578
Giardia lamblia	Cathepsin B precursor	0.006	0.1548	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.004	0.0924	0.0924
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.0684	0.0684
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0924	1
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0401	0.4342
Leishmania major	cathepsin L-like protease	0.0032	0.0684	0.3578
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0924	0.5968
Echinococcus granulosus	cathepsin l1	0.0032	0.0684	0.0684
Echinococcus granulosus	muscleblind protein	0.0315	0.9488	0.9488
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	0.5006	1
Brugia malayi	exodeoxyribonuclease III family protein	0.004	0.0924	0.0974
Entamoeba histolytica	Ran family GTPase	0.0023	0.0401	0.4342
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0684	0.0684
Schistosoma mansoni	zinc finger protein	0.0016	0.0203	0.0203
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0282	0.0282
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.004	0.0924	0.536
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0401	0.0801
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0401	0.0401
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0315	0.9488	0.9488
Brugia malayi	Bromodomain containing protein	0.0083	0.2261	0.2383
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.0684	0.0684
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0535	0.5786
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0277	0.0554
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0684	0.1367
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0684	0.0684
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0684	0.3578
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0019	0.0277	0.0554
Echinococcus multilocularis	cathepsin b	0.0171	0.5006	0.5006
Onchocerca volvulus		0.0033	0.0719	1
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0277	0.3002
Schistosoma mansoni	cpg binding protein	0.0033	0.0719	0.0719
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0684	0.4419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0684	0.4419
Onchocerca volvulus		0.0032	0.0684	0.951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.004	0.0924	0.0924
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0684	0.4419
Trypanosoma cruzi	cysteine protease, putative	0.0019	0.0277	0.0554
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0535	0.1068
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.0684	0.7405
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0262	0.0262
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0381	0.0381
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.0894	0.0894
Echinococcus multilocularis	muscleblind protein	0.0315	0.9488	0.9488
Echinococcus granulosus	cathepsin L	0.0019	0.0277	0.0277
Leishmania major	cathepsin L-like protease	0.0032	0.0684	0.3578
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0656	0.0656
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0277	0.1791
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0684	0.4419
Onchocerca volvulus		0.0032	0.0684	0.951
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0504	0.0504
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0277	0.0554
Brugia malayi	Muscleblind-like protein	0.0315	0.9488	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0535	0.5786
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0407	0.0407
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.004	0.0924	0.5968
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0401	0.0801
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.0684	0.951
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.0894	0.0894
Entamoeba histolytica	cysteine proteinase 2	0.0019	0.0277	0.3002
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.1548	1
Echinococcus multilocularis	zinc finger protein	0.0023	0.0405	0.0405
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0504	0.0504
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0719	0.0719
Leishmania major	cathepsin L-like protease	0.0032	0.0684	0.3578
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0277	0.3002
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0656	0.3817
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0656	0.0656
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0069	0.0069
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0066	0.1749	0.1749
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0684	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0407	0.0407
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.0684	0.7405
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0019	0.0277	0.3002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0684	0.3578
Brugia malayi	RNA, U transporter 1	0.0088	0.2437	0.2568
Onchocerca volvulus		0.0032	0.0684	0.951
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0277	0.0277
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0277	0.3002
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0684	0.1367
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.004	0.0924	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0284	0.0284
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.0684	0.951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0684	0.3578
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.0684	0.951
Echinococcus granulosus	cathepsin L cysteine protease	0.0019	0.0277	0.0277
Echinococcus multilocularis	cpg binding protein	0.0037	0.0842	0.0842
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.004	0.0924	0.1846
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0401	0.0423
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0656	0.337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.1548	0.1548
Plasmodium vivax	vivapain-1	0.0019	0.0277	0.3002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0684	0.3578
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0719	0.0758
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0684	0.3578
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0277	0.0292
Onchocerca volvulus		0.0023	0.0407	0.5655
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0023	0.0407	0.0813
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0262	0.0262
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0401	0.1475
Toxoplasma gondii	cathepsin B	0.006	0.1548	0.9005
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0331	1	1
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0401	0.0401
Schistosoma mansoni	zinc finger protein	0.0023	0.0405	0.0405
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.5006	0.5006
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0473	0.3058
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0069	0.0069
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0277	0.0277
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0277	0.0554
Plasmodium falciparum	importin beta, putative	0.0031	0.0656	0.7102
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0407	0.0429
Echinococcus granulosus	cathepsin l1	0.0023	0.0407	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0171	0.5006	0.5006
Toxoplasma gondii	cathepsin CPL	0.0032	0.0684	0.3979
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0277	0.1791
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0924	0.5968
Toxoplasma gondii	exonuclease III APE	0.004	0.0924	0.5374
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0684	0.0721
Echinococcus multilocularis	cathepsin L	0.0019	0.0277	0.0277
Trypanosoma cruzi	ISWI complex protein	0.0016	0.0203	0.0405
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0407	0.0407
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0656	0.7102
Giardia lamblia	Cathepsin B precursor	0.006	0.1548	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.1548	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.5006	0.5006
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Echinococcus multilocularis	cysteine protease	0.0032	0.0684	0.0684
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0535	0.2466
Leishmania major	GTP-binding protein, putative	0.0023	0.0401	0.1475
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0684	0.4419
Schistosoma mansoni	cpg binding protein	0.0037	0.0842	0.0842
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.0684	0.0684
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0401	0.0401
Onchocerca volvulus		0.0032	0.0684	0.951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0684	0.3578
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0401	0.2333
Schistosoma mansoni	ap endonuclease	0.004	0.0924	0.0924
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0684	0.4419
Entamoeba histolytica	cysteine proteinase 1, putative	0.0019	0.0277	0.3002
Leishmania major	cathepsin L-like protease	0.0032	0.0684	0.3578
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.1548	1
Echinococcus multilocularis	cysteine protease	0.0032	0.0684	0.0684
Schistosoma mansoni	ran	0.0023	0.0401	0.0401
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0684	0.1367
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0277	0.0292
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0684	0.3578
Brugia malayi	cathepsin L-like precursor	0.0023	0.0407	0.0429
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0009	0.0009
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0284	0.0284
Loa Loa (eye worm)	cysteine protease	0.0032	0.0684	0.0684
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0277	0.3002
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0066	0.1749	0.1749
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0684	0.4419

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 43.2 %	Inhibition of human DU145 cells migration at 20 uM after 24 hrs by Matrigel assay relative to control	ChEMBL.	20089402
Activity (functional)	= 70.5 %	Inhibition of human DU145 cells invasion at 20 uM after 24 hrs by Matrigel assay relative to control	ChEMBL.	20089402
GI50 (functional)	= 17.7 uM	Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay	ChEMBL.	20089402
GI50 (functional)	= 26.3 uM	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	ChEMBL.	20089402
GI50 (functional)	= 29.9 uM	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	ChEMBL.	20089402
IC50 (binding)	= 250 nM	Inhibition of human liver cathepsin L	ChEMBL.	20089402
IC50 (binding)	> 10000 nM	Inhibition of human liver cathepsin B	ChEMBL.	20089402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL605998

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1099856