TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 451.555 | Formula: C28H44Cl2
H donors: 0 H acceptors: 0 LogP: 11.84 Rotable bonds: 15
Rule of 5 violations (Lipinski): 1
SMILES: C/C(=C\CC/C=C(/CC/C=C(/CCC=C(Cl)Cl)\C)\C)/CC/C=C(/CCC=C(C)C)\C
InChi: 1S/C28H44Cl2/c1-23(2)13-9-16-26(5)19-10-17-24(3)14-7-8-15-25(4)18-11-20-27(6)21-12-22-28(29)30/h13-15,19-20,22H,7-12,16-18,21H2,1-6H3/b24-14+,25-15+,26-19+,27-20+
InChiKey: YYOSSLZXIRXIMB-OGDZRKEVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0535	0.1681
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0177	0.0177
Leishmania major	cathepsin L-like protease	0.0073	0.0576	0.1287
Loa Loa (eye worm)	TYRA-2 protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Schistosoma mansoni	adenoreceptor	0.004	0.0177	0.0555
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0177	0.0177
Onchocerca volvulus	Neuropeptide F receptor homolog	0.004	0.0177	1
Echinococcus multilocularis	serotonin receptor	0.004	0.0177	0.0177
Echinococcus granulosus	biogenic amine 5HT receptor	0.004	0.0177	0.0555
Brugia malayi	GnHR receptor homolog	0.004	0.0177	0.0395
Echinococcus granulosus	7tm_1 domain containing protein	0.004	0.0177	0.0555
Loa Loa (eye worm)	glutamate receptor	0.0039	0.0165	0.0369
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Brugia malayi	Receptor family ligand binding region containing protein	0.0025	0.000001218	0.0000027202
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.004	0.0177	0.0555
Schistosoma mansoni	biogenic amine (5HT) receptor	0.004	0.0177	0.0555
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0122	0.1174	0.3685
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Schistosoma mansoni	biogenic amine receptor	0.004	0.0177	0.0555
Toxoplasma gondii	cathepsin B	0.0097	0.087	1
Schistosoma mansoni	opsin-like receptor	0.004	0.0177	0.0555
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0177	0.0177
Loa Loa (eye worm)	cathepsin B	0.0097	0.087	0.1942
Brugia malayi	Dopamine receptor	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0097	0.087	0.0752
Echinococcus granulosus	cathepsin b	0.0287	0.3185	1
Onchocerca volvulus		0.004	0.0177	1
Schistosoma mansoni	hypothetical protein	0.004	0.0177	0.0555
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.0177	0.0395
Giardia lamblia	Cathepsin B precursor	0.0097	0.087	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus granulosus	g protein coupled receptor	0.004	0.0177	0.0555
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.004	0.0177	0.0555
Brugia malayi	RNA recognition motif domain containing protein	0.0069	0.0535	0.1196
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0025	0	0.5
Onchocerca volvulus		0.004	0.0177	1
Loa Loa (eye worm)	hypothetical protein	0.0287	0.3185	0.7114
Schistosoma mansoni	amine GPCR	0.004	0.0177	0.0555
Brugia malayi	larval opioid receptor	0.004	0.0177	0.0395
Loa Loa (eye worm)	melatonin receptor type 1A	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0025	0.000001218	0.0000027202
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0393	0.4478	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.004	0.0177	0.0555
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0177	0.0177
Brugia malayi	follicle stimulating hormone receptor	0.004	0.0177	0.0395
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.004	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Brugia malayi	neuropeptide F receptor	0.004	0.0177	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0177	0.0555
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0069	0.0535	0.1196
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0393	0.4478	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Leishmania major	cathepsin L-like protease	0.0073	0.0576	0.1287
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0145	0.0325
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.0177	0.0555
Echinococcus granulosus	g protein coupled receptor	0.004	0.0177	0.0555
Echinococcus multilocularis	neuropeptide receptor	0.004	0.0177	0.0177
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Onchocerca volvulus		0.004	0.0177	1
Brugia malayi	putative neuropeptide receptor	0.004	0.0177	0.0395
Echinococcus multilocularis	tar DNA binding protein	0.0069	0.0535	0.0535
Brugia malayi	RE15519p	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0083	0.07	0.07
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.004	0.0177	0.0177
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0356	0.0794
Echinococcus multilocularis	neuropeptide receptor	0.004	0.0177	0.0177
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0025	0.000001218	0.0000027202
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0177	0.0555
Brugia malayi	G-protein coupled receptor	0.004	0.0177	0.0395
Schistosoma mansoni	amine GPCR	0.004	0.0177	0.0555
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.004	0.0177	0.0555
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0177	0.0177
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.0576	0.1287
Echinococcus granulosus	cathepsin b	0.0287	0.3185	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.004	0.0177	0.0395
Echinococcus granulosus	alpha 1A adrenergic receptor	0.004	0.0177	0.0555
Echinococcus granulosus	orexin receptor type 2	0.004	0.0177	0.0555
Echinococcus multilocularis	dro:myosuppressin receptor	0.004	0.0177	0.0177
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0177	0.0177
Echinococcus granulosus	serotonin receptor	0.004	0.0177	0.0555
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.087	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0177	0.0555
Leishmania major	C-8 sterol isomerase-like protein	0.0393	0.4478	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.004	0.0177	0.0395
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0287	0.3185	0.7114
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0177	0.0177
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0177	0.0555
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0177	0.0177
Onchocerca volvulus		0.004	0.0177	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0356	0.0794
Onchocerca volvulus		0.004	0.0177	1
Onchocerca volvulus		0.004	0.0177	1
Echinococcus multilocularis	allatostatin A receptor	0.004	0.0177	0.0177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0177	0.0555
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.0177	0.0177
Echinococcus multilocularis	cathepsin b	0.0287	0.3185	0.3185
Echinococcus granulosus	neuropeptide receptor	0.004	0.0177	0.0555
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.004	0.0177	0.0555
Echinococcus multilocularis	neuropeptide FF receptor 2	0.004	0.0177	0.0177
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0576	0.1287
Schistosoma mansoni	histamine h1 receptor	0.004	0.0177	0.0555
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0576	0.1287
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0122	0.1174	0.1174
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.0177	0.0395
Onchocerca volvulus		0.004	0.0177	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0177	0.0177
Schistosoma mansoni	neuropeptide receptor	0.004	0.0177	0.0555
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.004	0.0177	0.0177
Echinococcus granulosus	tar DNA binding protein	0.0069	0.0535	0.1681
Loa Loa (eye worm)	TAR-binding protein	0.0069	0.0535	0.1196
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.004	0.0177	0.0555
Onchocerca volvulus		0.004	0.0177	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.0177	0.0555
Schistosoma mansoni	metabotropic glutamate receptor	0.0083	0.07	0.2198
Onchocerca volvulus		0.004	0.0177	1
Echinococcus granulosus	G protein coupled receptor 139	0.004	0.0177	0.0555
Brugia malayi	hypothetical protein	0.004	0.0177	0.0395
Echinococcus granulosus	neuropeptide receptor A26	0.004	0.0177	0.0555
Onchocerca volvulus		0.004	0.0177	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0059	0.0409	0.0913
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.004	0.0177	0.0177
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0067	0.0508	0.1135
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0177	0.0555
Schistosoma mansoni	growth hormone secretagogue receptor	0.004	0.0177	0.0555
Schistosoma mansoni	neuropeptide f receptor 76f	0.004	0.0177	0.0555
Echinococcus multilocularis	somatostatin receptor	0.004	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0177	0.0555
Echinococcus granulosus	peptide allatostatin:somatostatin	0.004	0.0177	0.0555
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0177	0.0555
Brugia malayi	hypothetical protein	0.004	0.0177	0.0395
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.0177	0.0555
Loa Loa (eye worm)	glutamate receptor	0.0099	0.0896	0.2
Schistosoma mansoni	opsin-like receptor	0.004	0.0177	0.0555
Echinococcus granulosus	neuropeptide FF receptor 2	0.004	0.0177	0.0555
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.0177	0.0177
Echinococcus multilocularis	neuropeptide s receptor	0.004	0.0177	0.0177
Brugia malayi	G-protein coupled receptor	0.004	0.0177	0.0395
Echinococcus granulosus	7TM GPCR rhodopsin	0.004	0.0177	0.0555
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.0177	0.0177
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0535	0.1681
Schistosoma mansoni	neuropeptide receptor	0.004	0.0177	0.0555
Brugia malayi	Tachykinin-like peptides receptor 99D	0.004	0.0177	0.0395
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus multilocularis	neuropeptide receptor A26	0.004	0.0177	0.0177
Echinococcus granulosus	neuropeptide s receptor	0.004	0.0177	0.0555
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.0177	0.0177
Schistosoma mansoni	hypothetical protein	0.004	0.0177	0.0555
Brugia malayi	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	RNA binding protein	0.0069	0.0535	0.1196
Onchocerca volvulus		0.004	0.0177	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0097	0.087	0.1942
Echinococcus granulosus	somatostatin receptor	0.004	0.0177	0.0555
Onchocerca volvulus		0.004	0.0177	1
Echinococcus multilocularis	G protein coupled receptor 139	0.004	0.0177	0.0177
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0393	0.4478	1
Brugia malayi	hypothetical protein	0.004	0.0177	0.0395
Giardia lamblia	Cathepsin B precursor	0.0097	0.087	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.0177	0.0555
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.0177	0.0555
Brugia malayi	neuropeptide F receptor	0.004	0.0177	0.0395
Brugia malayi	sulfakinin receptor protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Onchocerca volvulus		0.004	0.0177	1
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0	0.5
Brugia malayi	TAR-binding protein	0.0069	0.0535	0.1196
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0287	0.3185	1
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.0177	0.0555
Echinococcus multilocularis	serotonin receptor	0.004	0.0177	0.0177
Echinococcus granulosus	tachykinin peptides receptor 99D	0.004	0.0177	0.0555
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0177	0.0555
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.0177	0.0555
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.004	0.0177	0.0555
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.004	0.0177	0.0555
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.004	0.0177	0.0177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0177	0.0555
Schistosoma mansoni	hypothetical protein	0.0037	0.0145	0.0457
Schistosoma mansoni	alpha-1 adrenergic receptor	0.004	0.0177	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1174	0.2622
Schistosoma mansoni	biogenic amine (5HT) receptor	0.004	0.0177	0.0555
Echinococcus granulosus	hypothetical protein	0.004	0.0177	0.0555
Echinococcus granulosus	dro:myosuppressin receptor	0.004	0.0177	0.0555
Plasmodium vivax	vivapain-2	0.0025	0	0.5
Brugia malayi	ORL1-like opioid receptor	0.004	0.0177	0.0395
Echinococcus granulosus	sex peptide receptor	0.004	0.0177	0.0555
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.004	0.0177	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0356	0.0794
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0177	0.0177
Brugia malayi	putative neuropeptide receptor NPR1	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Brugia malayi	Serotonin receptor	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Onchocerca volvulus		0.004	0.0177	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0177	0.0555
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.004	0.0177	0.0177
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0287	0.3185	1
Giardia lamblia	Cathepsin B precursor	0.0097	0.087	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0177	0.0555
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0177	0.0555
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0177	0.0177
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.009	0.0782	0.1747
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.004	0.0177	0.0177
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0083	0.07	0.2198
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.004	0.0177	0.0395
Echinococcus granulosus	g protein coupled receptor	0.004	0.0177	0.0555
Brugia malayi	hypothetical protein	0.004	0.0177	0.0395
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0535	0.1681
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.0177	0.0395
Brugia malayi	Serotonin receptor	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.004	0.0177	0.0395
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.087	0.273
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Onchocerca volvulus		0.004	0.0177	1
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.0177	0.0555
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0177	0.0555
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0177	0.0555
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0177	0.0177
Schistosoma mansoni	opsin-like receptor	0.004	0.0177	0.0555
Brugia malayi	Melatonin receptor type 1A	0.004	0.0177	0.0395
Schistosoma mansoni	amine GPCR	0.004	0.0177	0.0555
Echinococcus multilocularis	sex peptide receptor	0.004	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.004	0.0177	0.0555
Schistosoma mansoni	neuropeptide receptor	0.004	0.0177	0.0555
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0535	0.1681
Brugia malayi	cathepsin B-like cysteine proteinase	0.0287	0.3185	0.7114
Echinococcus multilocularis	cathepsin b	0.0287	0.3185	0.3185
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0535	0.1681
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.004	0.0177	0.0177
Echinococcus multilocularis	g-protein coupled receptor	0.004	0.0177	0.0177
Schistosoma mansoni	amine GPCR	0.004	0.0177	0.0555
Brugia malayi	hypothetical protein	0.004	0.0177	0.0395
Onchocerca volvulus		0.004	0.0177	1
Schistosoma mansoni	hypothetical protein	0.004	0.0177	0.0555
Echinococcus multilocularis	orexin receptor type 2	0.004	0.0177	0.0177
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0393	0.4478	1
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0099	0.0896	0.2
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0177	0.0555
Schistosoma mansoni	hypothetical protein	0.004	0.0177	0.0555
Brugia malayi	G protein-coupled receptor	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Schistosoma mansoni	biogenic amine receptor	0.004	0.0177	0.0555
Plasmodium vivax	vivapain-2	0.0025	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0177	0.0555
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0177	0.0555
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0356	0.0794
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.004	0.0177	0.0555
Brugia malayi	AKH receptor	0.004	0.0177	0.0395
Brugia malayi	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0025	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Brugia malayi	G protein-coupled receptor F59B2.13	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0201	0.2138	0.4774
Brugia malayi	hypothetical protein	0.004	0.0177	0.0395
Echinococcus multilocularis	fmrfamide receptor	0.004	0.0177	0.0177
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0287	0.3185	1
Brugia malayi	hypothetical protein	0.004	0.0177	0.0395
Schistosoma mansoni	metabotropic glutamate receptor	0.0048	0.0278	0.0874
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.0177	0.0555
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.004	0.0177	0.0555
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.0177	0.0177
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus granulosus	g-protein coupled receptor	0.004	0.0177	0.0555
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0177	0.0555
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus granulosus	neuropeptide receptor	0.004	0.0177	0.0555
Brugia malayi	RNA binding protein	0.0069	0.0535	0.1196
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.004	0.0177	0.0395
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0287	0.3185	1
Echinococcus granulosus	fmrfamide receptor	0.004	0.0177	0.0555
Schistosoma mansoni	amine GPCR	0.004	0.0177	0.0555
Echinococcus multilocularis	fmrfamide receptor	0.004	0.0177	0.0177
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0177	0.0555
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.004	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Brugia malayi	hypothetical protein	0.004	0.0177	0.0395
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0576	0.1287
Schistosoma mansoni	neuropeptide receptor	0.004	0.0177	0.0555
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.004	0.0177	0.0555
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0177	0.0177
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.0177	0.0555
Echinococcus multilocularis	G-protein coupled receptor, putative	0.004	0.0177	0.0177
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0177	0.0555
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0025	0.000001218	0.0000027202
Onchocerca volvulus		0.004	0.0177	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.004	0.0177	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0177	0.0555
Schistosoma mansoni	biogenic amine receptor	0.004	0.0177	0.0555
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.004	0.0177	0.0555
Brugia malayi	Dopamine receptor protein 1	0.004	0.0177	0.0395
Leishmania major	cathepsin L-like protease	0.0073	0.0576	0.1287
Brugia malayi	metabotropic glutamate receptor type 2	0.0048	0.0278	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0325
Echinococcus granulosus	allatostatin A receptor	0.004	0.0177	0.0555
Brugia malayi	Dopamine receptor protein 2	0.004	0.0177	0.0395
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0113	0.1061	0.333
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.0177	0.0395
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.004	0.0177	0.0395
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.004	0.0177	0.0395
Schistosoma mansoni	myosin xvIII	0.004	0.0177	0.0555
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0097	0.087	0.1942
Loa Loa (eye worm)	hypothetical protein	0.004	0.0177	0.0395

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	uM	Inhibitory activity against Oxidosqualene-lanosterol cyclase in pig liver; NI-No inhibitory effect at 400 microM	ChEMBL.	2769687
IC50 (binding)	uM	Inhibitory activity against Squalene Epoxidase in pig liver; NI-No inhibitory effect at 400 microM	ChEMBL.	2769687
IC50 (binding)	NI 0 uM	Inhibitory activity against Squalene Epoxidase in pig liver; NI-No inhibitory effect at 400 microM	ChEMBL.	2769687
IC50 (binding)	NI 0 uM	Inhibitory activity against Oxidosqualene-lanosterol cyclase in pig liver; NI-No inhibitory effect at 400 microM	ChEMBL.	2769687

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL422947

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 109995