Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.1335 | 0.1335 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0136 | 0.0136 |
Plasmodium vivax | hypothetical protein, conserved | 0.0169 | 0.1108 | 0.1108 |
Trichomonas vaginalis | glycoside hydrolase, putative | 0.03 | 0.2066 | 0.4405 |
Echinococcus multilocularis | muscleblind protein | 0.0464 | 0.3265 | 0.3265 |
Loa Loa (eye worm) | thymidylate synthase | 0.1384 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0236 | 0.0236 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0426 | 0.5337 |
Brugia malayi | RNA binding protein | 0.026 | 0.177 | 0.177 |
Trichomonas vaginalis | beta-mannosidase, putative | 0.0061 | 0.0316 | 0.0673 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1384 | 1 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0136 | 0.0136 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0136 | 0.0136 |
Echinococcus granulosus | muscleblind protein | 0.0464 | 0.3265 | 0.3265 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0136 | 0.0136 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.1174 | 0.1174 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0136 | 0.0136 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.0426 | 0.0426 |
Mycobacterium ulcerans | thymidylate synthase | 0.1384 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.3265 | 0.3265 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0169 | 0.1108 | 0.1108 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0136 | 0.0136 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0236 | 0.0236 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0658 | 0.4689 | 0.4689 |
Loa Loa (eye worm) | hypothetical protein | 0.1285 | 0.928 | 0.928 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | glycosyl hydrolase family 2 | 0.0066 | 0.0353 | 0.0353 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0188 | 0.1245 | 0.2654 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0426 | 0.0426 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0136 | 0.0136 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0136 | 0.0289 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0136 | 0.0136 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0236 | 0.0236 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0136 | 0.0136 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0136 | 0.0136 |
Echinococcus multilocularis | beta galactosidase | 0.0169 | 0.1108 | 0.1108 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0426 | 0.5337 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0136 | 0.0136 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0136 | 0.0136 |
Onchocerca volvulus | 0.0036 | 0.0136 | 0.0136 | |
Loa Loa (eye worm) | RNA binding protein | 0.026 | 0.177 | 0.177 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0242 | 0.1643 | 0.1643 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0136 | 0.0136 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0236 | 0.0236 |
Onchocerca volvulus | 0.1384 | 1 | 1 | |
Brugia malayi | N-terminal motif family protein | 0.02 | 0.1335 | 0.1335 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1384 | 1 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0136 | 0.0136 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0136 | 0.0136 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0426 | 0.0426 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.1568 | 0.1568 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0136 | 0.0136 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0236 | 0.0236 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0136 | 0.0136 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.02 | 0.1335 | 0.1335 |
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | 0.0066 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1108 | 0.1108 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1384 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0.0136 | 0.0136 | |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0136 | 0.0136 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.177 | 0.177 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0136 | 0.0136 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0136 | 0.0136 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0136 | 0.0289 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0426 | 0.5337 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0136 | 0.0136 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0136 | 0.0136 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0236 | 0.0236 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.0426 | 0.0426 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.026 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0136 | 0.0136 |
Echinococcus granulosus | thymidylate synthase | 0.1384 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0242 | 0.1643 | 0.1643 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1384 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0658 | 0.4689 | 0.4689 |
Brugia malayi | TAR-binding protein | 0.026 | 0.177 | 0.177 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | beta-glucuronidase | 0.0061 | 0.0316 | 0.0316 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1384 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0018 | 0 | 0.5 |
Brugia malayi | Beta-glucuronidase precursor | 0.0061 | 0.0316 | 0.0316 |
Entamoeba histolytica | beta-galactosidase, putative | 0.0127 | 0.0799 | 1 |
Onchocerca volvulus | 0.0036 | 0.0136 | 0.0136 | |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0136 | 0.0136 |
Brugia malayi | hypothetical protein | 0.0658 | 0.4689 | 0.4689 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0242 | 0.1643 | 0.1643 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0236 | 0.0236 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1384 | 1 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0136 | 0.0136 |
Schistosoma mansoni | beta-galactosidase | 0.0169 | 0.1108 | 0.1108 |
Echinococcus granulosus | beta galactosidase | 0.0169 | 0.1108 | 0.1108 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1384 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0236 | 0.0236 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0136 | 0.0136 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1384 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.177 | 0.177 |
Brugia malayi | Muscleblind-like protein | 0.0464 | 0.3265 | 0.3265 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0464 | 0.3265 | 0.3265 |
Loa Loa (eye worm) | TAR-binding protein | 0.026 | 0.177 | 0.177 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0136 | 0.0136 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0136 | 0.0136 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.3265 | 0.3265 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0136 | 0.0136 |
Brugia malayi | RNA recognition motif domain containing protein | 0.026 | 0.177 | 0.177 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.177 | 0.177 |
Giardia lamblia | Aldose reductase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0658 | 0.4689 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.026 | 0.177 | 0.177 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0136 | 0.0136 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1384 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0136 | 0.0289 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0136 | 0.0289 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.0188 | 0.1245 | 0.2654 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0136 | 0.0136 |
Echinococcus granulosus | tar DNA binding protein | 0.026 | 0.177 | 0.177 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0136 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0136 | 0.0136 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.177 | 0.177 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0136 | 0.0136 |
Brugia malayi | manba-prov protein | 0.0061 | 0.0316 | 0.0316 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.0426 | 0.0426 |
Schistosoma mansoni | beta-mannosidase | 0.0061 | 0.0316 | 0.0316 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0426 | 0.5337 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0136 | 0.0289 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0136 | 0.0136 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC90 (functional) | = 8 ug ml-1 | Antibacterial activity against Escherichia coli NCIM 2574 after 24 hrs by NCCLS method | ChEMBL. | 21664730 |
MIC90 (functional) | = 16 ug ml-1 | Antifungal activity against Cryptococcus neoformans isolate NCL2 after 72 hrs by broth dilution method | ChEMBL. | 21664730 |
MIC90 (functional) | = 32 ug ml-1 | Antifungal activity against Candida albicans isolate NCL1 after 48 hrs by broth dilution method | ChEMBL. | 21664730 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.