Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | heat shock protein | 0.0034 | 0.2209 | 0.2895 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0632 | 0.1458 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.4333 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0632 | 0.0632 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0632 | 0.0632 |
Trichomonas vaginalis | heat shock protein, putative | 0.0021 | 0.0762 | 0.1759 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0038 | 0.2729 | 0.2729 |
Plasmodium falciparum | heat shock protein 90 | 0.0034 | 0.2209 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0632 | 0.1458 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0027 | 0.1447 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0044 | 0.3367 | 0.3367 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.2729 | 0.3577 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0375 | 0.0375 |
Trypanosoma brucei | heat shock protein, putative | 0.0034 | 0.2209 | 0.5097 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0632 | 0.1458 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0034 | 0.2209 | 0.5097 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0375 | 0.0865 |
Echinococcus multilocularis | heat shock protein | 0.0034 | 0.2209 | 0.2209 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0034 | 0.2209 | 0.5097 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.4333 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0375 | 0.0865 |
Trypanosoma brucei | small ubiquitin-related modifier | 0.0032 | 0.1999 | 0.4612 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0034 | 0.2209 | 0.426 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2812 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2812 | 1 |
Echinococcus granulosus | heat shock protein | 0.0034 | 0.2209 | 0.2209 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0034 | 0.2209 | 0.5097 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.002 | 0.0675 | 0.1559 |
Schistosoma mansoni | jumonji domain containing protein | 0.0082 | 0.763 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0034 | 0.2209 | 0.5097 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0044 | 0.3367 | 0.3367 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0053 | 0.4333 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0053 | 0.4333 | 0.4333 |
Toxoplasma gondii | small ubiquitin family modifier, putative | 0.0032 | 0.1999 | 0.4612 |
Brugia malayi | Ubiquitin-like protein SMT3 | 0.0032 | 0.1999 | 0.1999 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0053 | 0.4333 | 0.4333 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0053 | 0.4333 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.0021 | 0.0762 | 0.1759 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0.1988 | 0.4588 |
Trypanosoma brucei | heat shock protein, putative | 0.0034 | 0.2209 | 0.5097 |
Echinococcus multilocularis | heat shock protein 90 | 0.0034 | 0.2209 | 0.2209 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0632 | 0.0828 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0034 | 0.2209 | 0.385 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0038 | 0.2729 | 0.2729 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.2729 | 0.4756 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0032 | 0.1999 | 0.4612 |
Trypanosoma brucei | heat shock protein, putative | 0.0034 | 0.2209 | 0.5097 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.4504 | 0.785 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0632 | 0.2398 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0032 | 0.1988 | 0.1988 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0034 | 0.2209 | 0.5097 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0053 | 0.4333 | 0.7552 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0027 | 0.1447 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0632 | 0.1458 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.2812 | 0.2812 |
Trypanosoma brucei | heat shock protein, putative | 0.0034 | 0.2209 | 0.5097 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0632 | 0.1458 |
Plasmodium vivax | hypothetical protein, conserved | 0.0032 | 0.1988 | 0.9001 |
Plasmodium vivax | small ubiquitin-related modifier, putative | 0.0032 | 0.1999 | 0.9049 |
Brugia malayi | jmjC domain containing protein | 0.0038 | 0.2729 | 0.2729 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0053 | 0.4333 | 0.4333 |
Trypanosoma brucei | heat shock protein, putative | 0.0034 | 0.2209 | 0.5097 |
Giardia lamblia | PHD finger protein 15 | 0.0032 | 0.1988 | 0.3664 |
Echinococcus multilocularis | heat shock protein 90 | 0.0027 | 0.1447 | 0.1447 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0632 | 0.1458 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0053 | 0.4333 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0034 | 0.2209 | 0.5097 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0375 | 0.0865 |
Plasmodium falciparum | endoplasmin, putative | 0.0021 | 0.0762 | 0.345 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0053 | 0.4333 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Brugia malayi | Endoplasmin precursor | 0.0034 | 0.2209 | 0.2209 |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.0032 | 0.1999 | 0.1999 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0632 | 0.2247 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0.0375 | 0.0865 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0034 | 0.2209 | 0.5097 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.4333 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0065 | 0.5738 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0053 | 0.4333 | 0.4333 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.4333 | 0.568 |
Trichomonas vaginalis | heat shock protein, putative | 0.0027 | 0.1447 | 0.3339 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0032 | 0.1999 | 0.4612 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0375 | 0.0653 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0053 | 0.4333 | 0.4333 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0032 | 0.1988 | 0.1988 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0032 | 0.1988 | 0.3465 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0053 | 0.4333 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0027 | 0.1447 | 0.3339 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0632 | 0.2861 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1988 | 0.2606 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2812 | 1 |
Echinococcus granulosus | endoplasmin | 0.0027 | 0.1447 | 0.1447 |
Echinococcus granulosus | heat shock protein 90 | 0.0027 | 0.1447 | 0.1447 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.2812 | 0.2812 |
Schistosoma mansoni | endoplasmin | 0.0034 | 0.2209 | 0.2895 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.0375 | 0.0375 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0027 | 0.1447 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0034 | 0.2209 | 0.7854 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0632 | 0.2861 |
Schistosoma mansoni | ubiquitin-like protein sumo/smt3-related | 0.0032 | 0.1999 | 0.262 |
Giardia lamblia | Grp94/Hsp90 | 0.0027 | 0.1447 | 0.2201 |
Trichomonas vaginalis | heat shock protein, putative | 0.0027 | 0.1447 | 0.3339 |
Brugia malayi | heat shock protein 90 | 0.0034 | 0.2209 | 0.2209 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0053 | 0.4333 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0034 | 0.2209 | 0.5097 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0032 | 0.1988 | 0.2606 |
Trypanosoma brucei | protein kinase, putative | 0.0053 | 0.4333 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.2812 | 0.2812 |
Plasmodium vivax | heat shock protein 86, putative | 0.0034 | 0.2209 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0034 | 0.2209 | 0.7854 |
Plasmodium falciparum | small ubiquitin-related modifier | 0.0032 | 0.1999 | 0.9049 |
Schistosoma mansoni | heat shock protein | 0.0034 | 0.2209 | 0.2895 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.2729 | 0.3577 |
Echinococcus multilocularis | Small ubiquitin modifier 2 | 0.0032 | 0.1999 | 0.1999 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.4333 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0027 | 0.1447 | 0.3339 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0375 | 0.0375 |
Echinococcus granulosus | heat shock protein 90 | 0.0034 | 0.2209 | 0.2209 |
Schistosoma mansoni | endoplasmin | 0.0034 | 0.2209 | 0.2895 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0.1988 | 0.4588 |
Onchocerca volvulus | Alhambra homolog | 0.0032 | 0.1988 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0375 | 0.0865 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0104 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0375 | 0.0375 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0375 | 0.0375 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.0375 | 0.0491 |
Loa Loa (eye worm) | SMO-1 protein | 0.0032 | 0.1999 | 0.3483 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Trypanosoma brucei | heat shock protein, putative | 0.0034 | 0.2209 | 0.5097 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0375 | 0.0375 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0034 | 0.2209 | 0.5097 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.1999 | 0.4612 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Entamoeba histolytica | ubiquitin like protein | 0.0032 | 0.1999 | 0.7107 |
Plasmodium falciparum | phd finger protein, putative | 0.0032 | 0.1988 | 0.9001 |
Echinococcus multilocularis | peregrin | 0.0032 | 0.1988 | 0.1988 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0017 | 0.0375 | 0.1698 |
Echinococcus granulosus | peregrin | 0.0032 | 0.1988 | 0.1988 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0632 | 0.0632 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0027 | 0.1447 | 0.1447 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2812 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0027 | 0.1447 | 0.3339 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0027 | 0.1447 | 1 |
Plasmodium vivax | endoplasmin, putative | 0.0034 | 0.2209 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0104 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Echinococcus multilocularis | endoplasmin | 0.0027 | 0.1447 | 0.1447 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.4333 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0.0375 | 0.0865 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0034 | 0.2209 | 0.5097 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0632 | 0.0828 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.4333 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0034 | 0.2209 | 0.5097 |
Loa Loa (eye worm) | endoplasmin | 0.0034 | 0.2209 | 0.385 |
Treponema pallidum | heat shock protein 90 | 0.0027 | 0.1447 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0034 | 0.2209 | 0.5097 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Giardia lamblia | Sentrin | 0.0032 | 0.1999 | 0.3693 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2812 | 0.3686 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0027 | 0.1447 | 0.3339 |
Leishmania major | small ubiquitin protein, putative | 0.0032 | 0.1999 | 0.4612 |
Leishmania major | heat shock protein 83-1 | 0.0034 | 0.2209 | 0.5097 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0027 | 0.1447 | 0.2201 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0.0375 | 0.1698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1988 | 0.3465 |
Trichomonas vaginalis | heat shock protein, putative | 0.0034 | 0.2209 | 0.5097 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0375 | 0.0865 |
Brugia malayi | PHD-finger family protein | 0.0032 | 0.1988 | 0.1988 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0053 | 0.4333 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0632 | 0.1458 |
Brugia malayi | Bromodomain containing protein | 0.0032 | 0.1988 | 0.1988 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0632 | 0.1101 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.2812 | 0.3686 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 80.5 uM | Cytotoxicity against human MT4 cells after 4 days by MTT assay | ChEMBL. | 21824782 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.