Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.1332 | 0.1257 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0008 | 0.0107 | 0.0107 |
Echinococcus multilocularis | tar DNA binding protein | 0.0142 | 0.3902 | 0.3849 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0645 | 0.1236 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0452 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.1332 | 0.1257 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0645 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0142 | 0.3902 | 0.8717 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.1612 | 0.1612 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0645 | 0.1236 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0421 | 0.6071 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0107 | 0.0546 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0645 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0645 | 1 |
Onchocerca volvulus | 0.0029 | 0.0698 | 1 | |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0.0107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.4461 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0421 | 0.6071 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.0645 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0745 | 0.0665 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0008 | 0.0107 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1332 | 0.1332 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0452 | 0.0793 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0645 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0132 | 0.0058 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0645 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0142 | 0.3902 | 0.3849 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0698 | 0.0698 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.3902 | 0.3902 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0645 | 0.1236 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0645 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.1332 | 0.2813 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0008 | 0.0107 | 0.0546 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0645 | 1 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0008 | 0.0107 | 0.0021 |
Brugia malayi | TAR-binding protein | 0.0142 | 0.3902 | 0.8717 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0008 | 0.0107 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.1332 | 0.1257 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0645 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0645 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0645 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0698 | 0.1359 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0008 | 0.0107 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0645 | 0.1236 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0452 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1332 | 0.2813 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0452 | 0.0793 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.011 | 0.3012 | 0.6673 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0452 | 0.0793 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.1332 | 0.1257 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0452 | 0.6617 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.002 | 0.0452 | 0.6421 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0645 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0452 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0142 | 0.3902 | 0.8717 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0161 | 0.4461 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.3902 | 0.3902 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.3012 | 0.6673 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0008 | 0.0107 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1332 | 0.1332 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0.0107 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0645 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0008 | 0.0107 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0645 | 0.1236 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0645 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0107 | 0.0546 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0008 | 0.0107 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1332 | 0.1332 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1332 | 0.1332 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0421 | 0.6071 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.3012 | 0.3012 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0645 | 0.1236 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0745 | 0.0745 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0161 | 0.4461 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0135 | 0.005 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0745 | 0.0665 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0008 | 0.0107 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0142 | 0.3902 | 0.8717 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.1332 | 0.1257 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.1427 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.1332 | 0.2813 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0142 | 0.3902 | 0.8717 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.3902 | 0.3902 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0008 | 0.0107 | 0.0546 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0645 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0645 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0452 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0452 | 0.0793 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.1332 | 0.1257 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0698 | 0.1359 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0645 | 1 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0008 | 0.0107 | 0.5 |
Brugia malayi | RNA binding protein | 0.0142 | 0.3902 | 0.8717 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0107 | 0.0546 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0008 | 0.0107 | 0.0546 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.1332 | 0.2813 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0135 | 0.0066 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0745 | 0.0745 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.3902 | 0.3902 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.3902 | 0.3902 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0107 | 0.0546 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0008 | 0.0107 | 0.0021 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0645 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0421 | 0.6071 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0135 | 0.005 |
Onchocerca volvulus | 0.0027 | 0.0645 | 0.9095 | |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0008 | 0.0107 | 0.0546 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0008 | 0.0107 | 0.0546 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0161 | 0.4461 | 1 |
Echinococcus multilocularis | geminin | 0.0357 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Antiproliferative activity against human HaCaT cells after 48 hrs by phase contrast microscopy | ChEMBL. | 20452101 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.