Detailed information for compound 1100843

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.414 | Formula: C18H23FN6
  • H donors: 3 H acceptors: 2 LogP: 2.96 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/N=C(/NCCCCc1c[nH]cn1)\NCCCc1ccc(cc1)F
  • InChi: 1S/C18H23FN6/c19-16-8-6-15(7-9-16)4-3-11-23-18(24-13-20)22-10-2-1-5-17-12-21-14-25-17/h6-9,12,14H,1-5,10-11H2,(H,21,25)(H2,22,23,24)
  • InChiKey: TZZDUDPJVPMIAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0138 0.3117
Schistosoma mansoni lipoxygenase 0.0089 0.153 0.6591
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0444 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0128
Echinococcus granulosus heat shock protein 0.0036 0.0444 0.0444
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0084 0.0084
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.0444 1
Schistosoma mansoni endoplasmin 0.0036 0.0444 0.1913
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0084 0.0362
Brugia malayi hypothetical protein 0.0021 0.0131 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0084 0.0128
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0131 0.02
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0296 0.5802 0.5802
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0084 0.0128
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0131 0.0131
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0444 1
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0444 0.2061
Brugia malayi hypothetical protein 0.0332 0.6558 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0042 0.0042
Trypanosoma brucei heat shock protein, putative 0.0036 0.0444 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0131 0.0131
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0084 0.0362
Loa Loa (eye worm) endoplasmin 0.0036 0.0444 0.0677
Trypanosoma brucei Heat shock protein 83, putative 0.0036 0.0444 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0084 0.0128
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Schistosoma mansoni loxhd1 0.0021 0.0131 0.0566
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0131 0.2956
Schistosoma mansoni lipoxygenase 0.0127 0.2321 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0084 0.0128
Plasmodium vivax endoplasmin, putative 0.0036 0.0444 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0128
Echinococcus granulosus dna polymerase eta 0.0022 0.0138 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Trypanosoma brucei unspecified product 0.0022 0.0138 0.3117
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0128
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0084 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Plasmodium falciparum heat shock protein 90 0.0036 0.0444 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0029 0.0291 0.5
Schistosoma mansoni rab6-interacting 0.0021 0.0131 0.0566
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0153 0.345
Schistosoma mansoni heat shock protein 0.0036 0.0444 0.1913
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Treponema pallidum heat shock protein 90 0.0029 0.0291 0.5
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0138 0.0596
Echinococcus multilocularis heat shock protein 0.0036 0.0444 0.0444
Trypanosoma brucei heat shock protein, putative 0.0036 0.0444 1
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0084 0.0084
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0138 0.3872
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.0291 0.0291
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0119 0.2155 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0131 0.02
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0084 0.0084
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0084 0.0084
Schistosoma mansoni rab6-interacting 0.0021 0.0131 0.0566
Echinococcus multilocularis heat shock protein 90 0.0036 0.0444 0.0444
Leishmania major DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0291 0.655
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0131 0.0131
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0042 0.0064
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0042 0.0949
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0084 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0084 0.0128
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0136 0.3058
Loa Loa (eye worm) hypothetical protein 0.0332 0.6558 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0084 0.0084
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0084 0.0362
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0084 0.0084
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0029 0.0291 0.655
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0084 0.0128
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0444 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0084 0.0084
Toxoplasma gondii heat shock protein HSP90 0.0036 0.0444 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0042 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0128
Plasmodium falciparum endoplasmin, putative 0.0022 0.0153 0.345
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0138 0.0211
Trypanosoma brucei heat shock protein, putative 0.0036 0.0444 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0138 0.3117
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0138 0.0138
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0029 0.0291 0.5
Schistosoma mansoni hypothetical protein 0.0021 0.0131 0.0566
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0084 0.0084
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Entamoeba histolytica hypothetical protein 0.0119 0.2155 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0138 0.3872
Brugia malayi ecdysteroid receptor 0.0019 0.0084 0.0128
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0042 0.0182
Giardia lamblia Grp94/Hsp90 0.0029 0.0291 0.4987
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0084 0.0128
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Schistosoma mansoni DNA polymerase eta 0.0022 0.0138 0.0596
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0084 0.0084
Mycobacterium ulcerans heat shock protein 90 0.0029 0.0291 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0042 0.0042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0138 0.0211
Entamoeba histolytica hypothetical protein 0.0119 0.2155 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0138 0.3117
Giardia lamblia Heat shock protein HSP 90-alpha 0.0036 0.0444 1
Schistosoma mansoni endoplasmin 0.0036 0.0444 0.1913
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0042 0.0949
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0042 0.0949
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0138 0.3117
Echinococcus granulosus heat shock protein 90 0.0029 0.0291 0.0291
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0296 0.5802 0.5802
Toxoplasma gondii heat shock protein 90, putative 0.0036 0.0444 1
Brugia malayi Endoplasmin precursor 0.0036 0.0444 0.0677
Echinococcus granulosus heat shock protein 90 0.0036 0.0444 0.0444
Trypanosoma cruzi Heat shock protein 83, putative 0.0036 0.0444 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0084 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0084 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Trypanosoma brucei heat shock protein, putative 0.0036 0.0444 1
Echinococcus multilocularis endoplasmin 0.0029 0.0291 0.0291
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0138 0.3117
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0084 0.0128
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0042 0.0949
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Schistosoma mansoni polycystin 1-related 0.0021 0.0131 0.0566
Entamoeba histolytica hypothetical protein 0.0119 0.2155 1
Brugia malayi hypothetical protein 0.0021 0.0131 0.02
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0084 0.0084
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0444 0.2061
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Brugia malayi hypothetical protein 0.0119 0.2155 0.3286
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0084 0.0128
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0084 0.0128
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0084 0.0084
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0042 0.0949
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0084 0.0362
Loa Loa (eye worm) hypothetical protein 0.0272 0.5319 0.8112
Echinococcus granulosus RUN 0.0021 0.0131 0.0131
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0138 0.3117
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0084 0.0128
Trypanosoma brucei heat shock protein, putative 0.0036 0.0444 1
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0444 1
Leishmania major DNA polymerase eta, putative 0.0022 0.0138 0.3117
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Echinococcus multilocularis heat shock protein 90 0.0029 0.0291 0.0291
Loa Loa (eye worm) heat shock protein 90 0.0036 0.0444 0.0677
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0084 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Trypanosoma brucei heat shock protein, putative 0.0036 0.0444 1
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0084 0.0362
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0029 0.0291 1
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0444 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0127 0.2321 0.2321
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0084 0.0362
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0084 0.0128
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0042 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0084 0.0084
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0138 0.3117
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0128
Onchocerca volvulus 0.0332 0.6558 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0042 0.0949
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0042 0.0949
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0084 0.0362
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0084 0.0362
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0084 0.0084
Schistosoma mansoni heat shock protein 0.0036 0.0444 0.1913
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0131 0.0131
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0138 0.3117
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0084 0.0128
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0291 0.655
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0138 0.0596
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0042 0.0949
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0444 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0084 0.0128
Onchocerca volvulus 0.0021 0.0131 0.02
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Echinococcus multilocularis neuropeptide receptor A26 0.0499 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0138 0.0211
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0084 0.0362
Echinococcus granulosus endoplasmin 0.0029 0.0291 0.0291
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0084 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Echinococcus multilocularis dna polymerase eta 0.0022 0.0138 0.0138
Echinococcus multilocularis neuropeptide s receptor 0.0499 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0211
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0042 0.0042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0138 0.0642
Schistosoma mansoni transcription factor LCR-F1 0.0119 0.2155 0.9286
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0084 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0084 0.0128
Brugia malayi isocitrate dehydrogenase 0.0017 0.0042 0.0064
Echinococcus multilocularis RUN 0.0021 0.0131 0.0131
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0084 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0084 0.0128
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0291 0.655
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0131 0.0131
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Trypanosoma brucei heat shock protein, putative 0.0036 0.0444 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0029 0.0291 0.4987
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0119 0.2155 0.2155
Brugia malayi photoreceptor-specific nuclear receptor 0.0272 0.5319 0.8112
Brugia malayi heat shock protein 90 0.0036 0.0444 0.0677
Plasmodium vivax heat shock protein 86, putative 0.0036 0.0444 1
Onchocerca volvulus 0.0019 0.0084 0.0128
Trypanosoma brucei heat shock protein, putative 0.0036 0.0444 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0131 0.2956
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0084 0.0128
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0153 0.345
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0127 0.2321 0.2321
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0084 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0084 0.0128
Brugia malayi steroid hormone receptor 0.0019 0.0084 0.0128
Brugia malayi nuclear hormone receptor 0.0019 0.0084 0.0128
Loa Loa (eye worm) hypothetical protein 0.0021 0.0131 0.02
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0084 0.0362
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0128
Schistosoma mansoni coup transcription factor 0.0019 0.0084 0.0362
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0084 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0138 0.3117
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0042 0.0949
Brugia malayi Doublecortin family protein 0.0021 0.0131 0.02
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0138 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0084 0.0128
Schistosoma mansoni hypothetical protein 0.0119 0.2155 0.9286
Onchocerca volvulus 0.0021 0.0131 0.02
Echinococcus granulosus dna polymerase kappa 0.0022 0.0138 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0084 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0084 0.0084
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0291 0.655
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0131 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0084 0.0128
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0119 0.2155 0.2155
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0084 0.0128
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0291 0.655
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0138 0.0138
Leishmania major heat shock protein 83-1 0.0036 0.0444 1
Echinococcus granulosus neuropeptide receptor A26 0.0499 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0042 0.0042

Activities

Activity type Activity value Assay description Source Reference
pEC50 (functional) Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay ChEMBL. 19791743
pKb (functional) Antagonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay ChEMBL. 19791743
pKb (functional) = 5.28 Antagonist activity at human histamine H2 receptor expressed in Sf9 cells coexpressing GsalphaS protein by steady-state GTPase assay ChEMBL. 19791743
pKb (functional) = 6.11 Antagonist activity at human histamine H3 receptor expressed in Sf9 cells coexpressing Gialpha-2-Gbeta-1-gamma-2 and RGS4 proteins protein by steady-state GTPase assay ChEMBL. 19791743
pKb (functional) = 6.59 Antagonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay ChEMBL. 19791743

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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