Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0172 | 0.5631 | 0.778 |
Onchocerca volvulus | 0.0099 | 0.1613 | 0.5 | |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 0.6584 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0189 | 0.6584 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0172 | 0.5631 | 0.85 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.5631 | 0.778 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0074 | 0.0229 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.5631 | 0.778 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.4304 | 0.6412 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0112 | 0.2291 | 0.3244 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0189 | 0.6584 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0189 | 0.6584 | 1 |
Leishmania major | 0.0189 | 0.6584 | 0.5 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0172 | 0.5631 | 0.85 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0189 | 0.6584 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0189 | 0.6584 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 0.6584 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0189 | 0.6584 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0112 | 0.2291 | 0.3244 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.4304 | 0.6412 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0189 | 0.6584 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0112 | 0.2291 | 0.3244 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0112 | 0.2291 | 0.3244 |
Toxoplasma gondii | melibiase subfamily protein | 0.0112 | 0.2291 | 0.3479 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 100 uM | Inhibition of FBPase in mouse liver | ChEMBL. | 19969452 |
IC50 (binding) | = 3.5 uM | Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrate | ChEMBL. | 19969452 |
IC50 (binding) | = 6.4 uM | Inhibition of FBPase in human liver | ChEMBL. | 19969452 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.