Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0539 | 0.0539 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0074 | 0.1773 | 0.1773 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.6665 | 0.6665 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1744 | 0.1744 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.2781 | 0.4173 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0963 | 0.0963 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.2306 | 0.346 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0271 | 0.0407 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0539 | 0.0539 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.2306 | 0.2306 |
Echinococcus multilocularis | lamin | 0.0054 | 0.1159 | 0.1159 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.1504 | 0.2257 |
Echinococcus multilocularis | geminin | 0.0341 | 1 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0026 | 0.0301 | 0.0301 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.1504 | 0.1504 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0539 | 0.0539 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.2306 | 0.2306 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0301 | 0.0452 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.2781 | 0.4173 |
Echinococcus granulosus | lamin | 0.0054 | 0.1159 | 0.1159 |
Schistosoma mansoni | lamin | 0.0054 | 0.1159 | 0.1159 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.1504 | 0.1504 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0029 | 0.0389 | 0.0584 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0108 | 0.283 | 0.283 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.1504 | 0.2257 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.283 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.2306 | 0.2306 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2306 | 0.2306 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0074 | 0.1773 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0108 | 0.283 | 0.283 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0271 | 0.0407 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0074 | 0.1773 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0963 | 0.0963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1504 | 0.1504 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0539 | 0.0809 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.4087 | 0.6131 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.283 | 0.283 |
Loa Loa (eye worm) | inositol-1 | 0.0074 | 0.1773 | 0.266 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0539 | 0.0809 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0074 | 0.1773 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2781 | 0.4173 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0539 | 0.0539 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.1504 | 0.2257 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0074 | 0.1773 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0074 | 0.1773 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0539 | 0.0539 |
Brugia malayi | hypothetical protein | 0.0232 | 0.6665 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0539 | 0.0539 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.1504 | 0.2257 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0539 | 0.0809 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1504 | 0.1504 |
Schistosoma mansoni | inositol monophosphatase | 0.0074 | 0.1773 | 0.1773 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.1159 | 0.1159 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1744 | 0.2616 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.283 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.2306 | 0.346 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0539 | 0.0539 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0539 | 0.0539 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1504 | 0.1504 |
Onchocerca volvulus | 0.0054 | 0.1159 | 0.0627 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2306 | 0.2306 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0026 | 0.0301 | 0.0301 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0074 | 0.1773 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0074 | 0.1773 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1128 | 0.1693 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.6665 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0539 | 0.0539 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0066 | 0.1535 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0074 | 0.1773 | 1 |
Brugia malayi | RNA binding protein | 0.0065 | 0.1504 | 0.2257 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.0389 | 0.0584 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0066 | 0.1535 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0963 | 0.1444 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.283 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2306 | 0.2306 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0074 | 0.1773 | 0.1773 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.1159 | 0.1159 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1504 | 0.1504 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.1504 | 0.2257 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0539 | 0.0539 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0074 | 0.1773 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1159 | 0.1738 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.283 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0074 | 0.1773 | 0.1773 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0539 | 0.0809 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.1159 | 0.1738 |
Echinococcus multilocularis | musashi | 0.0054 | 0.1159 | 0.1159 |
Brugia malayi | hypothetical protein | 0.0108 | 0.283 | 0.4246 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0074 | 0.1773 | 0.5 |
Brugia malayi | hypothetical protein | 0.0149 | 0.4087 | 0.6131 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.1744 | 0.2616 |
Onchocerca volvulus | 0.0149 | 0.4087 | 1 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.6665 | 0.6665 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0108 | 0.283 | 0.283 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.1159 | 0.1738 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1504 | 0.1504 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.1159 | 0.1159 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.1159 | 0.1738 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.2306 | 0.2306 |
Onchocerca volvulus | 0.0054 | 0.1159 | 0.0627 | |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.1159 | 0.1159 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.2781 | 0.4173 |
Brugia malayi | Inositol-1 | 0.0074 | 0.1773 | 0.266 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.1159 | 0.1738 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | lamin | 0.0054 | 0.1159 | 0.1159 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 68 % | Inhibition of human 17beta-HSD7 expressed in HEK293 cells assessed as inhibition of reduction of [14C]estrone into [14C]estradiol at 0.3 uM after 7 hrs | ChEMBL. | 19772289 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.