Detailed information for compound 110122

Basic information

Technical information
  • TDR Targets ID: 110122
  • Name: 3-cyclopenten-1-yl-6,7-dimethoxyquinoline
  • MW: 255.312 | Formula: C16H17NO2
  • H donors: 0 H acceptors: 1 LogP: 3.31 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2ncc(cc2cc1OC)C1=CCCC1
  • InChi: 1S/C16H17NO2/c1-18-15-8-12-7-13(11-5-3-4-6-11)10-17-14(12)9-16(15)19-2/h5,7-10H,3-4,6H2,1-2H3
  • InChiKey: DVMMSUYWABLYCR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-cyclopenten-1-yl-6,7-dimethoxy-quinoline
  • 3-(1-cyclopentenyl)-6,7-dimethoxyquinoline
  • 3-(1-cyclopentenyl)-6,7-dimethoxy-quinoline

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens platelet-derived growth factor receptor, alpha polypeptide Starlite/ChEMBL References
Homo sapiens platelet-derived growth factor receptor, beta polypeptide References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0023 0.0074
Echinococcus granulosus histone acetyltransferase KAT2B 0.0333 0.5258 1
Loa Loa (eye worm) CBP-B 0.0171 0.2581 0.4684
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0728 0.3286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0599 0.0588
Onchocerca volvulus 0.0051 0.0599 0.1234
Echinococcus granulosus GPCR family 2 0.0018 0.0056 0.0106
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0016 0.0023 0.0011
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0045 0.049 0.048
Loa Loa (eye worm) ctsf protein 0.0051 0.0599 0.1086
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.2869 0.5186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0599 0.0588
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0144 0.2131 0.982
Plasmodium falciparum cysteine proteinase falcipain 3 0.0051 0.0599 0.3059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0599 0.0588
Loa Loa (eye worm) hypothetical protein 0.0108 0.1531 0.2777
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0429 0.6841 0.6838
Toxoplasma gondii glyoxalase I, putative 0.0045 0.049 0.2178
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.005 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0599 0.2786
Echinococcus granulosus roundabout 2 0.0023 0.0126 0.024
Brugia malayi 4-hydroxyphenylpyruvate dioxygenase family protein 0.0304 0.4771 0.8654
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0023 0.0042
Echinococcus granulosus cysteine protease 0.0028 0.0222 0.0422
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0023 0.0061
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0011 0.002
Echinococcus multilocularis plexin a4 0.002 0.0088 0.0119
Onchocerca volvulus 0.0051 0.0599 0.1234
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0728 0.0718
Loa Loa (eye worm) hypothetical protein 0.0058 0.0707 0.1283
Loa Loa (eye worm) hypothetical protein 0.0036 0.0342 0.062
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0023 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0599 0.0588
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0599 0.0588
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.005 0.0082
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0222 0.0422
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.005 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0728 0.1321
Schistosoma mansoni plexin 0.0017 0.0037 0.0067
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0445 0.2063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0599 0.2786
Mycobacterium tuberculosis Conserved protein TB27.3 0.0045 0.049 0.1618
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0599 0.1234
Echinococcus granulosus CREB binding protein 0.0163 0.2451 0.4662
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.232 0.2312
Echinococcus granulosus cathepsin l1 0.0051 0.0599 0.1139
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0599 0.3101
Loa Loa (eye worm) hypothetical protein 0.017 0.256 0.4645
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0222 0.1111
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.005 0.0072
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0728 0.1321
Brugia malayi NAD-dependent deacetylase SIRT1 0.0124 0.18 0.3252
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0728 0.3396
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0342 0.1744
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0599 0.1086
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Loa Loa (eye worm) cysteine protease 0.0051 0.0599 0.1086
Schistosoma mansoni thyroid hormone receptor 0.0018 0.005 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0222 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0599 0.0588
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0599 0.1049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0599 0.2786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0621 1 1
Leishmania major cathepsin L-like protease 0.0051 0.0599 0.0588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.005 0.0092
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0599 0.1049
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.005 0.0072
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0124 0.18 0.8441
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0051 0.0599 0.1086
Echinococcus granulosus chromatin regulatory protein sir2 0.0016 0.0023 0.0044
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0728 0.0718
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.005 0.0072
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0011 0.002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.2869 0.5186
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0599 0.1069
Schistosoma mansoni hypothetical protein 0.0039 0.0406 0.0736
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.005 0.0096
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0599 0.0588
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0023 0.0074
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0342 0.062
Mycobacterium leprae conserved hypothetical protein 0.0045 0.049 0.5
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Leishmania major cathepsin L-like protease 0.0051 0.0599 0.0588
Schistosoma mansoni alpha-glucosidase 0.0162 0.2435 0.4419
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0023 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0599 0.2786
Echinococcus multilocularis cathepsin L 0.0028 0.0222 0.0362
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0599 0.1049
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0011 0.0001
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.0023 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0445 0.2063
Loa Loa (eye worm) sirtuin 4 0.0016 0.0023 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Onchocerca volvulus 0.0109 0.1556 0.3245
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.005 0.0096
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0124 0.18 0.8441
Loa Loa (eye worm) hypothetical protein 0.0018 0.0056 0.0101
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0599 0.3101
Brugia malayi TAZ zinc finger family protein 0.0202 0.3093 0.5603
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0599 0.2786
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.005 0.0096
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.0023 0.0012
Schistosoma mansoni coup transcription factor 0.0018 0.005 0.0092
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0011 0.002
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0011 0.002
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0016 0.0023 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.017 0.256 0.5355
Onchocerca volvulus 0.0051 0.0599 0.1234
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0639 0.2976
Plasmodium vivax vivapain-2 0.0051 0.0599 0.2773
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.005 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0222 0.0211
Mycobacterium ulcerans hypothetical protein 0.0045 0.049 0.1618
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0445 0.229
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0023 0.0074
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0445 0.0789
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0599 0.1234
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0222 0.0211
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0011 0.002
Onchocerca volvulus 0.0051 0.0599 0.1234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0222 0.0211
Trypanosoma brucei cysteine peptidase C (CPC) 0.0054 0.0639 0.0628
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0445 0.0769
Brugia malayi plexin A 0.002 0.0088 0.0141
Echinococcus granulosus CREB binding protein 0.0202 0.3093 0.5882
Echinococcus granulosus FTZ F1 alpha 0.0018 0.005 0.0096
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.005 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Trypanosoma brucei glucosidase, putative 0.0042 0.0445 0.0434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0599 0.0588
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0621 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0445 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.005 0.0092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0056 0.0106
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0349 0.5511 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.002
Mycobacterium ulcerans hypothetical protein 0.0191 0.2913 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0023 0.0042
Entamoeba histolytica acetyltransferase, GNAT family 0.013 0.1906 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0342 0.062
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0222 0.0403
Onchocerca volvulus 0.0051 0.0599 0.1234
Leishmania major cathepsin L-like protease 0.0051 0.0599 0.0588
Trichomonas vaginalis bromodomain-containing protein, putative 0.0144 0.2131 1
Mycobacterium ulcerans hypothetical protein 0.0045 0.049 0.1618
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.005 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0599 0.2786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0021
Loa Loa (eye worm) STAT protein 0.0262 0.4079 0.7402
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0639 0.116
Schistosoma mansoni thyroid hormone receptor 0.0018 0.005 0.0092
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0445 0.2063
Schistosoma mansoni hypothetical protein 0.0018 0.0056 0.0101
Onchocerca volvulus 0.0051 0.0599 0.1234
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0222 0.0403
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0016 0.0023 0.0011
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0728 0.1285
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.005 0.0072
Echinococcus multilocularis cysteine protease 0.0051 0.0599 0.1049
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.049 0.2276
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.005 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.005 0.0072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0342 0.062
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.2869 0.5196
Leishmania major cathepsin L-like protease 0.0051 0.0599 0.0588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.005 0.0092
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0011 0.002
Mycobacterium ulcerans glyoxalase GloA 0.0045 0.049 0.1618
Loa Loa (eye worm) hypothetical protein 0.0145 0.2145 0.3892
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0599 0.2786
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.005 0.0092
Brugia malayi cathepsin L-like precursor 0.0036 0.0342 0.0601
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.005 0.005
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0045 0.049 0.048
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.2131 0.4052
Brugia malayi Cathepsin L-like precursor 0.0051 0.0599 0.1069
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0092
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0445 0.1968
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.005 0.005
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0728 0.3746
Loa Loa (eye worm) acetyltransferase 0.0349 0.5511 1
Brugia malayi MAP kinase sur-1 0.0059 0.0728 0.1304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Echinococcus multilocularis CREB binding protein 0.0017 0.0029 0.001
Mycobacterium ulcerans biphenyl-2,3-diol 1,2-dioxygenase 0.0045 0.049 0.1618
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.005 0.0096
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0128 0.186 0.1851
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0124 0.18 0.8441
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.005 0.0092
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0145 0.2145 0.3892
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0036 0.0342 0.0331
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0707 0.1266
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0728 0.0718
Brugia malayi Cathepsin L-like precursor 0.0036 0.0342 0.0601
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0728 0.0718
Schistosoma mansoni hypothetical protein 0.0018 0.0056 0.0101
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0222 0.0403
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0445 0.229
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0429 0.6841 0.6838
Loa Loa (eye worm) hypothetical protein 0.0045 0.049 0.089
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0067
Echinococcus granulosus CREB binding protein 0.0017 0.0029 0.0054
Loa Loa (eye worm) plexin A 0.002 0.0088 0.016
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0144 0.2131 0.982
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0023 0.0074
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0092
Plasmodium vivax vivapain-1 0.0028 0.0222 0.0995
Echinococcus multilocularis CREB binding protein 0.017 0.2567 0.4635
Onchocerca volvulus 0.0051 0.0599 0.1234
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.005 0.0096
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.005 0.005
Schistosoma mansoni nephrin 0.0019 0.0066 0.012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0406 0.0736
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0016 0.0023 0.0044
Trypanosoma brucei protein kinase, putative 0.0059 0.0728 0.0718
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.005 0.0092
Echinococcus granulosus cathepsin l cysteine peptidase 0.0051 0.0599 0.1139
Loa Loa (eye worm) hypothetical protein 0.0051 0.0599 0.1086
Leishmania major cathepsin L-like protease 0.0051 0.0599 0.0588
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0011 0.002
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0023 0.0022
Schistosoma mansoni chromatin regulatory protein sir2 0.0124 0.18 0.3265
Echinococcus granulosus neuroglian 0.0019 0.0066 0.0125
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0445 0.0808
Schistosoma mansoni nuclear hormone receptor 0.0018 0.005 0.0092
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0599 0.1049
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.0023 0.0012
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0222 0.0383
Brugia malayi steroid hormone receptor 0.0018 0.005 0.0072
Leishmania major glyoxalase I,trypanothione-dependent glyoxalase I 0.0045 0.049 0.048
Schistosoma mansoni alpha-glucosidase 0.0162 0.2435 0.4419
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0707 0.1266
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.005 0.0096
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0445 0.2063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Echinococcus multilocularis cathepsin b 0.0145 0.2145 0.3866
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0445 0.0434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0599 0.0588
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.002
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0728 0.1385
Giardia lamblia Cathepsin B precursor 0.0054 0.0639 0.3273
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.005 0.0082
Echinococcus multilocularis CREB binding protein 0.0017 0.0029 0.001
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0599 0.0588
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0059 0.0087
Echinococcus granulosus twitchin 0.0019 0.0075 0.0142
Schistosoma mansoni alpha glucosidase 0.0042 0.0445 0.0808
Giardia lamblia Cathepsin B precursor 0.0054 0.0639 0.3273
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0023 0.0022
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.2869 0.5456
Brugia malayi Cathepsin L-like precursor 0.0051 0.0599 0.1069
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0144 0.2131 1
Onchocerca volvulus Lactoylglutathione lyase homolog 0.0045 0.049 0.1006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.005 0.0072
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0728 0.0718
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0445 0.0847
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0092
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0222 0.0211
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0092
Leishmania major cathepsin L-like protease 0.0051 0.0599 0.0588
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0342 0.0601
Brugia malayi Cathepsin L-like precursor 0.0036 0.0342 0.0601
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0016 0.0023 0.0012
Leishmania major cathepsin L-like protease 0.0051 0.0599 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.005 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0445 0.0435
Brugia malayi ecdysteroid receptor 0.017 0.256 0.4634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0599 0.0588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0599 0.2786
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.005 0.0092
Trypanosoma brucei SIR2-like protein 4, putative 0.0016 0.0023 0.0011
Schistosoma mansoni 4-hydroxyphenylpyruvate dioxygenase 0.0045 0.049 0.089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.005 0.0096
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.005 0.005
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Mycobacterium ulcerans hypothetical protein 0.0045 0.049 0.1618
Echinococcus granulosus cathepsin b 0.0145 0.2145 0.4079
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0599 0.1086
Loa Loa (eye worm) fibroinase 0.0051 0.0599 0.1086
Loa Loa (eye worm) 4-hydroxyphenylpyruvate dioxygenase 0.0304 0.4771 0.8656
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0429 0.6841 0.6838
Schistosoma mansoni CREB-binding protein 2 0.0202 0.3093 0.5612
Entamoeba histolytica cysteine protease, putative 0.0051 0.0599 0.3101
Onchocerca volvulus Cathepsin F homolog 0.0051 0.0599 0.1234
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.0023 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0342 0.1576
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0128 0.186 0.1851
Echinococcus multilocularis cysteine protease 0.0051 0.0599 0.1049
Plasmodium vivax vivapain-3 0.0028 0.0222 0.0995
Brugia malayi STAT protein, DNA binding domain containing protein 0.0262 0.4079 0.7396
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Brugia malayi cathepsin B-like cysteine proteinase 0.0145 0.2145 0.388
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.005 0.0072
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0124 0.18 0.8441
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0445 0.2063
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Brugia malayi Cathepsin L-like precursor 0.0051 0.0599 0.1069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.005 0.005
Plasmodium falciparum histone acetyltransferase GCN5 0.013 0.1906 1
Brugia malayi Plexin repeat family protein 0.0017 0.0037 0.0047
Giardia lamblia Cathepsin B precursor 0.0054 0.0639 0.3273
Plasmodium vivax unspecified product 0.0028 0.0222 0.0995
Mycobacterium tuberculosis Conserved protein 0.0045 0.049 0.1618
Loa Loa (eye worm) cathepsin B 0.0054 0.0639 0.116
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0728 0.1385
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0124 0.18 0.3422
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0222 0.1111
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.005 0.0072
Schistosoma mansoni cathepsin s 0.0016 0.0011 0.002
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0056 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0222 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0599 0.2786
Mycobacterium tuberculosis Cadmium inducible protein CadI 0.0045 0.049 0.1618
Schistosoma mansoni hypothetical protein 0.0018 0.0056 0.0101
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0092
Echinococcus multilocularis roundabout 2 0.0023 0.0126 0.0188
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0128 0.186 0.1851
Mycobacterium ulcerans hypothetical protein 0.0045 0.049 0.1618
Plasmodium vivax NAD-dependent deacetylase, putative 0.0016 0.0023 0.0056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.005 0.0092
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0023 0.0022
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0599 0.1086
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0445 0.2063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Brugia malayi Cathepsin L-like precursor 0.0051 0.0599 0.1069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0145 0.2145 0.3892
Brugia malayi Cathepsin L-like precursor 0.0051 0.0599 0.1069
Loa Loa (eye worm) hypothetical protein 0.0023 0.0126 0.0229
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.049 0.1618
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0126 0.0229
Echinococcus granulosus cathepsin l1 0.0036 0.0342 0.065
Toxoplasma gondii cathepsin CPL 0.0051 0.0599 0.2683
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.005 0.0092
Echinococcus granulosus CREB binding protein 0.0017 0.0029 0.0054
Onchocerca volvulus 0.0018 0.005 0.0082
Plasmodium vivax vivapain-2 0.0051 0.0599 0.2773
Brugia malayi lactoylglutathione lyase 0.0045 0.049 0.0872
Echinococcus granulosus cathepsin b 0.0145 0.2145 0.4079
Toxoplasma gondii hypothetical protein 0.0146 0.2169 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.005 0.005
Echinococcus multilocularis GPCR, family 2 0.0018 0.0056 0.006
Plasmodium falciparum glyoxalase I 0.0045 0.049 0.2483
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0222 0.0211
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0051 0.0599 0.3059
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0023 0.0042
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0016 0.0023 0.0044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.005 0.0092
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.005 0.005
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0023 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0023 0.0056
Brugia malayi nuclear hormone receptor 0.0018 0.005 0.0072
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0023 0.0074
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0728 0.0718
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.049 0.2276
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0128 0.186 0.185
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0621 1 1
Toxoplasma gondii glyoxalase family protein 0.0045 0.049 0.2178
Mycobacterium ulcerans glyoxalase GloA 0.0045 0.049 0.1618
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0599 0.2786
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0599 0.0588
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0124 0.18 0.9436
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.005 0.0092
Echinococcus multilocularis cathepsin b 0.0145 0.2145 0.3866
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0056 0.0081
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0728 0.3396
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0056 0.006
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0222 0.1111
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.005 0.0072
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0202 0.3093 0.5612
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0445 0.2063
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.2869 0.5206
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0056 0.0106
Plasmodium falciparum glyoxalase I 0.0045 0.049 0.2483
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0056 0.006
Schistosoma mansoni hypothetical protein 0.0018 0.0056 0.0101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.005 0.0072
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Mycobacterium ulcerans hypothetical protein 0.0045 0.049 0.1618
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.005 0.0072
Mycobacterium tuberculosis Conserved protein 0.0045 0.049 0.1618
Brugia malayi nuclear receptor NHR-88 0.0018 0.005 0.0072
Onchocerca volvulus 0.0036 0.0342 0.0694
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0406 0.0717
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0599 0.0588
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.005 0.0072
Echinococcus granulosus cathepsin L cysteine proteinase 0.0051 0.0599 0.1139
Onchocerca volvulus 0.0017 0.0037 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0599 0.0588
Onchocerca volvulus Putative protein 0.0304 0.4771 1
Toxoplasma gondii cathepsin B 0.0054 0.0639 0.2871
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Entamoeba histolytica cysteine proteinase 2 0.0028 0.0222 0.1111
Mycobacterium tuberculosis Conserved hypothetical protein 0.0191 0.2913 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0016 0.0023 0.0012
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0023 0.0042
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.005 0.0092
Entamoeba histolytica cysteine proteinase 1, putative 0.0028 0.0222 0.1111
Echinococcus multilocularis neuroglian 0.0019 0.0066 0.0078
Loa Loa (eye worm) hypothetical protein 0.0124 0.18 0.3265
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0145 0.2145 0.3892
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0016 0.0023 0.0061
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.005 0.0092
Plasmodium vivax glyoxalase I, putative 0.0045 0.049 0.2262
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0445 0.2063
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0056 0.0101
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.005 0.005
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0124 0.18 0.3237
Schistosoma mansoni gynecophoral canal protein 0.0045 0.049 0.089
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0145 0.2145 0.3892
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0728 0.3396
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0707 0.1283
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0145 0.2145 0.2136
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0349 0.5511 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0222 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0342 0.1576
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0092
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0023 0.0042
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0011 0.002
Entamoeba histolytica cysteine protease, putative 0.0028 0.0222 0.1111
Loa Loa (eye worm) hypothetical protein 0.0048 0.054 0.098
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.005 0.0092
Leishmania major cathepsin L-like protease 0.0051 0.0599 0.0588
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0599 0.0588
Brugia malayi acetyltransferase, GNAT family protein 0.0349 0.5511 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.005 0.0092
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0728 0.0718
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0222 0.0383
Brugia malayi Cathepsin L-like precursor 0.0051 0.0599 0.1069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Echinococcus granulosus cathepsin L 0.0028 0.0222 0.0422
Leishmania major silent information regulator 2, putative 0.0016 0.0023 0.0011
Echinococcus multilocularis CREB binding protein 0.0017 0.0029 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0222 0.1111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Plasmodium vivax glyoxalase I, putative 0.0045 0.049 0.2262
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0054 0.0639 0.0628
Echinococcus granulosus plexin a4 0.002 0.0088 0.0168
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0051 0.0599 0.3059
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0054 0.0639 0.0629
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.005 0.0092
Mycobacterium ulcerans hypothetical protein 0.0045 0.049 0.1618
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0599 0.2786
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0018 0.0059 0.0107
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0728 0.1285
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0023 0.0042
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0222 0.0211
Leishmania major sir2-family protein-like protein 0.0016 0.0023 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0445 0.2063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0051 0.0599 0.0588
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0016 0.0023 0.0044
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0222 0.1057
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0728 0.3396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0599 0.2786
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0023 0.0042
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.0023 0.0061
Leishmania major cysteine peptidase A (CPA) 0.0051 0.0599 0.0588
Giardia lamblia Histone acetyltransferase GCN5 0.013 0.1906 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0144 0.2131 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0011 0.002

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.04 uM Inhibition of human PDGF receptor phosphorylation; 0.02-0.04 ChEMBL. 8035419
IC50 (binding) = 0.04 uM Inhibition of human PDGF receptor phosphorylation; 0.02-0.04 ChEMBL. 8035419
IC50 (binding) > 20 uM Concentration required to inhibit phosphorylation of isolated human epidermal growth factor tyrosine kinase receptor by 50% ChEMBL. 8035419
IC50 (binding) > 20 uM Concentration required to inhibit phosphorylation of isolated human epidermal growth factor tyrosine kinase receptor by 50% ChEMBL. 8035419

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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