Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0034 | 0.4422 | 0.4414 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0458 | 0.0444 |
Mycobacterium tuberculosis | Probable aminopeptidase PepC | 0.0072 | 1 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.8453 | 0.8453 |
Mycobacterium leprae | PROBABLE AMINOPEPTIDASE PEPC | 0.0072 | 1 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.3722 | 0.3722 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0458 | 0.0444 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0458 | 0.0444 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0458 | 0.0444 |
Echinococcus multilocularis | aspartyl aminopeptidase | 0.0072 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0034 | 0.4422 | 0.4414 |
Trypanosoma cruzi | aspartyl aminopeptidase, putative | 0.0072 | 1 | 0.5 |
Plasmodium falciparum | M18 aspartyl aminopeptidase | 0.0072 | 1 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0808 | 0.0272 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0458 | 0.0444 |
Leishmania major | aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 | 0.0072 | 1 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.3722 | 0.5 | |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0808 | 0.0272 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.4422 | 0.4414 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0458 | 0.0444 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0458 | 0.0444 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0458 | 0.0444 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.3963 | 0.3611 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0034 | 0.4422 | 0.4414 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.3963 | 0.3963 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.4422 | 0.4414 |
Loa Loa (eye worm) | aspartyl aminopeptidase | 0.0072 | 1 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.7497 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0458 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.3722 | 0.3171 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0458 | 0.0444 |
Plasmodium vivax | M18 aspartyl aminopeptidase, putative | 0.0072 | 1 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0458 | 0.0444 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.3722 | 0.3183 |
Echinococcus granulosus | aspartyl aminopeptidase | 0.0072 | 1 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0072 | 1 | 1 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0072 | 1 | 1 |
Entamoeba histolytica | aspartyl aminopeptidase, putative | 0.0072 | 1 | 1 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0072 | 1 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0458 | 0.0444 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0072 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0458 | 0.0444 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.055 | 0.055 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0458 | 0.0444 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.3963 | 0.3611 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0072 | 1 | 0.5 |
Schistosoma mansoni | aspartyl aminopeptidase (M18 family) | 0.0072 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.4422 | 0.4414 |
Trypanosoma cruzi | metallo-peptidase, Clan MH, Family M20 | 0.0072 | 1 | 0.5 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0072 | 1 | 1 |
Schistosoma mansoni | aspartyl aminopeptidase (M18 family) | 0.0072 | 1 | 1 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0034 | 0.4422 | 0.4414 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0458 | 0.0444 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0458 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0458 | 0.0444 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.3963 | 0.3963 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0107 | 0.0107 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0458 | 0.0444 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.87 uM | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent method | ChEMBL. | 19715321 |
Inhibition (functional) | = 56.18 % | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 1 uM after 24 hrs by Griess reagent method | ChEMBL. | 19715321 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 19715321 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.