Detailed information for compound 1101445

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 405.47 | Formula: C22H19N3O3S
  • H donors: 1 H acceptors: 4 LogP: 3.2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H]1CC[C@]2(CC1)OC(=O)c1c2cncc1)Nc1csc(n1)c1ccccc1
  • InChi: 1S/C22H19N3O3S/c26-19(24-18-13-29-20(25-18)15-4-2-1-3-5-15)14-6-9-22(10-7-14)17-12-23-11-8-16(17)21(27)28-22/h1-5,8,11-14H,6-7,9-10H2,(H,24,26)/t14-,22-
  • InChiKey: OYYWUJLGWLCFON-CAJLXGCNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide Y receptor Y5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.1397 0.2699
Mycobacterium tuberculosis Conserved protein 0.0035 0.0715 0.1022
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.1086 0.1086
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.072 0.1618
Onchocerca volvulus 0.0035 0.0715 0.2749
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.072 0.1618
Loa Loa (eye worm) hypothetical protein 0.0035 0.0697 0.0697
Schistosoma mansoni ran 0.0022 0.0268 0.0268
Leishmania major hypothetical protein, conserved 0.0035 0.0715 0.0715
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0315 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0268 0.1921
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.0025 0.0365 0.0365
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0715 0.0715
Schistosoma mansoni ap endonuclease 0.0056 0.1397 0.1397
Echinococcus multilocularis Niemann Pick C1 protein 0.013 0.3851 0.3851
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0365 0.2615
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1049 0.1049
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0715 0.1022
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.076 0.076
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.4828 0.4828
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0697 0.4991
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.076 0.076
Brugia malayi CHE-14 protein 0.013 0.3851 0.3851
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0715 0.1022
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.1397 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0715 0.512
Schistosoma mansoni importin beta-1 0.0029 0.0527 0.0527
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0268 0.0268
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1086 0.1086
Loa Loa (eye worm) inositol-1 0.0037 0.076 0.076
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.076 0.5441
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.1397 0.1397
Mycobacterium ulcerans hypothetical protein 0.0046 0.1086 0.1086
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0527 0.3769
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0635 0.0906
Loa Loa (eye worm) hypothetical protein 0.0046 0.1086 0.1086
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.7003 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.1397 0.1397
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.1086 0.7772
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1049 0.1049
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1086 0.1086
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0365 0.0365
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.072 0.072
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.072 0.072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.1397 0.1397
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0635 0.0906
Echinococcus granulosus Protein patched homolog 1 0.013 0.3851 0.3851
Schistosoma mansoni inositol monophosphatase 0.0037 0.076 0.076
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0268 0.0268
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0715 0.0715
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.1086 0.1551
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0715 0.0715
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0365 0.2615
Echinococcus multilocularis protein patched 0.013 0.3851 0.3851
Loa Loa (eye worm) hypothetical protein 0.0035 0.0715 0.0715
Schistosoma mansoni alpha-glucosidase 0.0137 0.4093 0.4093
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.072 0.1618
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0268 0.1921
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1049 0.1049
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.076 0.076
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0715 0.0715
Brugia malayi Inositol-1 0.0037 0.076 0.076
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0715 0.0715
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.1086 0.7772
Mycobacterium ulcerans lipase LipD 0.0035 0.0715 0.0715
Echinococcus granulosus sterol regulatory element binding protein 0.013 0.3851 0.3851
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0365 0.0365
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.1086 1
Echinococcus multilocularis protein dispatched 1 0.013 0.3851 0.3851
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0046 0.1086 0.1086
Schistosoma mansoni alpha-glucosidase 0.0137 0.4093 0.4093
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.999 0.999
Schistosoma mansoni hypothetical protein 0.0315 0.999 0.999
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.076 0.076
Schistosoma mansoni inositol monophosphatase 0.0037 0.076 0.076
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0268 0.1921
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0342 0.0767
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0715 0.0715
Loa Loa (eye worm) hypothetical protein 0.0035 0.0715 0.0715
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.1397 1
Entamoeba histolytica Ran family GTPase 0.0022 0.0268 0.1921
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0268 0.0268
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.072 0.1618
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.072 0.072
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1086 0.1086
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.013 0.3851 0.3851
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0715 0.1022
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0715 0.0715
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1086 0.1086
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0715 0.1022
Schistosoma mansoni ran 0.0022 0.0268 0.0268
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.072 0.5154
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0342 0.0767
Trypanosoma brucei glucosidase, putative 0.0035 0.072 0.072
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0715 0.1607
Brugia malayi beta-lactamase family protein 0.0035 0.0715 0.0715
Brugia malayi beta-lactamase 0.0035 0.0715 0.0715
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0342 0.0767
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0715 0.1607
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0268 0.0268
Plasmodium vivax importin-beta 2, putative 0.0029 0.0527 0.3769
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0148 0.4452 1
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0315 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1049 0.1049
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0342 0.0342
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1086 0.1086
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0715 0.1607
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.076 0.076
Loa Loa (eye worm) hypothetical protein 0.0035 0.0697 0.0697
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0715 0.0715
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.072 0.1618
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.1397 0.1397
Schistosoma mansoni hypothetical protein 0.0164 0.4978 0.4978
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.1397 0.5
Echinococcus multilocularis sterol regulatory element binding protein 0.013 0.3851 0.3851
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.1086 0.7772
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.1397 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.1397 0.1397
Loa Loa (eye worm) hypothetical protein 0.0035 0.0715 0.0715
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.072 0.072
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0268 0.0268
Echinococcus multilocularis snurportin 1 0.0315 0.999 0.999
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.4828 0.4828
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0633 0.0904
Toxoplasma gondii ABC1 family protein 0.0035 0.0715 0.512
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0148 0.4452 1
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0315 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.4828 0.4828
Loa Loa (eye worm) hypothetical protein 0.0035 0.0715 0.0715
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0527 0.0527
Entamoeba histolytica hypothetical protein 0.0024 0.0342 0.2445
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0715 0.0715
Leishmania major GTP-binding protein, putative 0.0022 0.0268 0.0268
Echinococcus granulosus geminin 0.0164 0.4978 0.4978
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0527 0.0527
Onchocerca volvulus 0.0035 0.0715 0.2749
Mycobacterium ulcerans beta-lactamase 0.0035 0.0715 0.0715
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0315 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1086 0.1086
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.1086 0.1086
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0715 0.1607
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.076 0.076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.1086 0.1551
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1086 0.1086
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0148 0.4452 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0697 0.0996
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.0035 0.0697 0.0697
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1086 0.1086
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.4828 0.4828
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.1086 0.1086
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.1086 0.1086
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.072 0.1618
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.1397 0.1995
Loa Loa (eye worm) hypothetical protein 0.0035 0.0697 0.0697
Mycobacterium leprae Probable lipase LipE 0.0035 0.0715 0.6587
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0715 0.1022
Mycobacterium ulcerans hypothetical protein 0.0035 0.0715 0.0715
Loa Loa (eye worm) hypothetical protein 0.013 0.3851 0.3851
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0715 0.0715
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.4828 0.4828
Loa Loa (eye worm) hypothetical protein 0.0035 0.0697 0.0697
Mycobacterium tuberculosis Conserved protein 0.0035 0.0715 0.1022
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.072 0.5154
Loa Loa (eye worm) hypothetical protein 0.0315 1 1
Brugia malayi hypothetical protein 0.0025 0.0365 0.0365
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0715 0.6587
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0315 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.1397 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1049 0.1049
Brugia malayi beta-lactamase family protein 0.0035 0.0715 0.0715
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0365 0.2615
Echinococcus granulosus Niemann Pick C1 protein 0.013 0.3851 0.3851
Trichomonas vaginalis ran, putative 0.0022 0.0268 0.0603
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0697 0.5
Brugia malayi hypothetical protein 0.0016 0.0076 0.0076
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.1397 0.3139
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1049 0.1049
Toxoplasma gondii exonuclease III APE 0.0056 0.1397 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0268 0.0268
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0635 0.0906
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0715 0.1607
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0315 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.072 0.5154
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.076 0.1708
Trichomonas vaginalis esterase, putative 0.0035 0.0715 0.1607
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.1397 0.1397
Brugia malayi Importin beta-1 subunit 0.0029 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0035 0.0715 0.0715
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0635 0.0906
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.1086 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.076 0.076
Echinococcus granulosus snurportin 1 0.0315 0.999 0.999
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.1397 0.3139
Schistosoma mansoni niemann-pick C1 (NPC1) 0.013 0.3851 0.3851
Leishmania major importin beta-1 subunit, putative 0.0024 0.0342 0.0342
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0715 0.1022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0697 0.0697
Plasmodium falciparum importin beta, putative 0.0029 0.0527 0.3769
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0315 1 1
Trichomonas vaginalis conserved hypothetical protein 0.013 0.3851 0.8651
Onchocerca volvulus 0.0046 0.1086 0.4173
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0148 0.4452 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.072 0.072
Leishmania major hypothetical protein, conserved 0.0025 0.0365 0.0365
Schistosoma mansoni ap endonuclease 0.0056 0.1397 0.1397
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.072 0.1618
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.076 0.1708
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0697 0.4991
Brugia malayi RNA, U transporter 1 0.0084 0.233 0.233
Echinococcus multilocularis geminin 0.0164 0.4978 0.4978
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.076 0.5441
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.1397 0.1397
Schistosoma mansoni alpha glucosidase 0.0035 0.072 0.072
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0315 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.072 0.1618
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0715 0.1022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0715 0.0715
Schistosoma mansoni hypothetical protein 0.0164 0.4978 0.4978
Schistosoma mansoni patched 1 0.013 0.3851 0.3851
Onchocerca volvulus 0.0035 0.0715 0.2749
Loa Loa (eye worm) beta-lactamase 0.0035 0.0715 0.0715
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0715 0.0715
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1086 0.1086
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.076 0.1708
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0268 0.0268
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0365 0.2615
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1086 0.1086
Echinococcus granulosus importin subunit beta 1 0.0029 0.0527 0.0527
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1049 0.1049
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0527 0.0527
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0633 0.5831
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.1397 0.1397
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.072 0.072
Mycobacterium tuberculosis Conserved protein 0.0035 0.0715 0.1022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0527 0.0527
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.072 0.1618
Onchocerca volvulus 0.0092 0.2602 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.1397 0.1397

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.2 nM Displacement of [125I]PYY from human recombinant Y5 receptor ChEMBL. 19720539

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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