Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.4692 | 0.4648 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0165 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0165 | 0.0083 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0201 | 0.012 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0165 | 0.0731 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0259 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0165 | 0.5 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0083 | 0.0366 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0165 | 0.0731 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1394 | 0.6176 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.1467 | 0.1324 |
Onchocerca volvulus | 0.0053 | 0.1467 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1197 | 0.1124 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0068 | 0.2089 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1085 | 0.1011 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0259 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0165 | 0.0083 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.0111 | 0.0029 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0165 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0341 | 0.151 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0165 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.0971 | 0.0896 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0165 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0251 | 0.017 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0165 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1394 | 0.1323 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0165 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1287 | 0.1214 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.1467 | 0.6497 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0083 | 0.0366 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0165 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0165 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.1082 | 0.0932 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0165 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0165 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0452 | 0.0292 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.1467 | 0.6497 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0341 | 0.026 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0165 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1394 | 0.1323 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1394 | 0.1323 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0201 | 0.0891 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.4692 | 0.4603 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.2608 | 0.2546 |
Brugia malayi | Bromodomain containing protein | 0.0085 | 0.2809 | 0.2688 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.4692 | 0.4648 |
Schistosoma mansoni | bromodomain containing protein | 0.0072 | 0.2257 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0165 | 0.0083 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0341 | 0.026 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0068 | 0.2089 | 0.2023 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0165 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0083 | 0.0366 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0165 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1394 | 0.1323 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1394 | 0.125 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1394 | 0.6176 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0083 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1394 | 0.6176 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0165 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0201 | 0.012 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0251 | 0.1112 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.0971 | 0.0896 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1394 | 0.1323 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.7 ug ml-1 | Cytotoxicity against human SKOV3 cells | ChEMBL. | 11170665 |
ED50 (functional) | = 2.4 ug ml-1 | Cytotoxicity against human SK-MEL-2 cells | ChEMBL. | 11170665 |
ED50 (functional) | = 7.5 ug ml-1 | Cytotoxicity against human HCT15 cells | ChEMBL. | 11170665 |
ED50 (functional) | > 10 ug ml-1 | Cytotoxicity against human A549 cells | ChEMBL. | 11170665 |
ED50 (functional) | > 10 ug ml-1 | Cytotoxicity against human XF498 cells | ChEMBL. | 11170665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.