TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 381.432 | Formula: C19H23N7O2
H donors: 3 H acceptors: 5 LogP: 2.21 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nc(nc(n1)Nc1ccc(cc1)C)CN1C(=O)NC2(C1=O)CCCCC2
InChi: 1S/C19H23N7O2/c1-12-5-7-13(8-6-12)21-17-23-14(22-16(20)24-17)11-26-15(27)19(25-18(26)28)9-3-2-4-10-19/h5-8H,2-4,9-11H2,1H3,(H,25,28)(H3,20,21,22,23,24)
InChiKey: LYSQKWDUPSIMCD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adenosine A2a receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	follicle stimulating hormone receptor	adenosine A2a receptor	412 aa	336 aa	22.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Serine/threonine protein phosphatase PP1-gamma catalytic subunit	0.0019	0.0013	0.0036
Mycobacterium ulcerans	leucyl-tRNA synthetase	0.0032	0.009	0.1709
Mycobacterium leprae	conserved hypothetical protein	0.0073	0.0351	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0063	0.0291
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.004	0.0144	0.0123
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0026	0.0052	0.0065
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.01	0.0311
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0027	0.0063	0.016
Trypanosoma cruzi	polo-like protein kinase, putative	0.0099	0.0513	0.3443
Mycobacterium ulcerans	aspartyl-tRNA synthetase	0.0026	0.0052	0.0498
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Schistosoma mansoni	hypothetical protein	0.0026	0.0052	0.0065
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.004	0.0144	0.0899
Treponema pallidum	leucyl-tRNA synthetase	0.0032	0.009	0.0484
Onchocerca volvulus		0.0052	0.0216	0.0029
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.004	0.0144	0.2497
Chlamydia trachomatis	aspartate--tRNA(Asp/Asn) ligase	0.0026	0.0052	0.0141
Brugia malayi	replication factor A 73 kDa subunit	0.052	0.3174	1
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0351	0.1124
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0099	0.0513	0.1581
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0351	0.1124
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0037	0.0164
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0021	0.0021	0.0053
Mycobacterium ulcerans	hypothetical protein	0.0073	0.0351	1
Brugia malayi	beta-lactamase family protein	0.0073	0.0351	0.1101
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0021	0.0021	0.0053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0069	0.0178
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0073	0.0351	0.1124
Leishmania major	hypothetical protein, conserved	0.0027	0.0063	0.0342
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0037	0.0127	0.0106
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0021	0.0021	0.0053
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0037	0.0127	0.0132
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.028	0.1659	0.5226
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0351	0.107
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0021	0.0021	0.0053
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.028	0.1659	0.2036
Echinococcus granulosus	cpg binding protein	0.0128	0.0697	0.0841
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0024	0.0044	0.0216
Giardia lamblia	Lysyl-tRNA synthetase	0.0026	0.0052	0.0645
Trypanosoma brucei	polo-like protein kinase	0.0099	0.0513	0.3443
Trypanosoma cruzi	Replication factor A protein 1	0.0249	0.1464	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0027	0.0063	0.016
Brugia malayi	lysyl-tRNA synthetase	0.0026	0.0052	0.016
Echinococcus multilocularis	protein phosphatase 1 catalytic subunit	0.0031	0.0088	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0088	0.0236
Trichomonas vaginalis	helicase, putative	0.0027	0.0063	0.016
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.028	0.1659	0.1642
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0351	0.233
Plasmodium falciparum	methionine--tRNA ligase	0.0032	0.009	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0351	0.107
Schistosoma mansoni	hypothetical protein	0.0033	0.01	0.0124
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Leishmania major	replication Factor A 28 kDa subunit, putative	0.0026	0.0052	0.0272
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0021	0.0021	0.0026
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0138	0.0761	0.0943
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0026	0.0052	0.0065
Trypanosoma brucei	aspartyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0033	0.01	0.0276
Entamoeba histolytica	hypothetical protein	0.0023	0.0037	0.0185
Brugia malayi	Asparaginyl-tRNA synthetase, cytoplasmic	0.0026	0.0052	0.016
Schistosoma mansoni	methionine-tRNA synthetase	0.0032	0.009	0.0112
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0026	0.0052	0.0065
Echinococcus multilocularis	leucyl tRNA synthetase	0.0032	0.009	0.007
Brugia malayi	protein ZK524.3	0.0032	0.009	0.028
Plasmodium falciparum	nucleic acid binding protein, putative	0.0026	0.0052	0.011
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0513	0.1581
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.028	0.1659	0.5209
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0028	0.0069	0.0213
Toxoplasma gondii	exonuclease III APE	0.004	0.0144	0.0851
Leishmania major	lysyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0052	0.0216	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0063	0.016
Brugia malayi	methionyl-tRNA synthetase	0.0032	0.009	0.028
Echinococcus granulosus	asparaginyl tRNA synthetase, cytoplasmic	0.0026	0.0052	0.0039
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0138	0.0761	0.0741
Treponema pallidum	aspartyl-tRNA synthetase	0.0026	0.0052	0.0141
Schistosoma mansoni	kinase	0.005	0.0207	0.0256
Echinococcus multilocularis	methionine tRNA synthetase	0.0032	0.009	0.007
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0212	0.1225	0.1497
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0021	0.0021	0.0055
Plasmodium vivax	methionine--tRNA ligase, putative	0.0032	0.009	0.0376
Mycobacterium tuberculosis	Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase)	0.0026	0.0052	0.0056
Echinococcus granulosus	histone acetyltransferase MYST2	0.0059	0.0261	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0197	0.0583
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.004	0.0144	0.3396
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0138	0.0761	0.0919
Echinococcus granulosus	glycyl tRNA synthetase	0.0155	0.0866	0.105
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0466	0.2833	1
Schistosoma mansoni	replication factor A 1 rfa1	0.052	0.3174	0.3934
Chlamydia trachomatis	leucine--tRNA ligase	0.0032	0.009	0.0484
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.003	0.008	0.0074
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0026	0.0052	0.0065
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.009	0.0376
Echinococcus multilocularis	replication protein A 70 kDa DNA binding	0.052	0.3174	0.316
Echinococcus granulosus	serine protein kinase ATM	0.0028	0.0069	0.006
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0351	0.107
Giardia lamblia	Kinase, PLK	0.0099	0.0513	1
Onchocerca volvulus		0.0121	0.0654	0.1699
Chlamydia trachomatis	methionine--tRNA ligase	0.0199	0.1146	1
Schistosoma mansoni	hypothetical protein	0.0138	0.0761	0.0943
Treponema pallidum	asparaginyl-tRNA synthetase	0.0026	0.0052	0.0141
Entamoeba histolytica	asparaginyl-tRNA synthetase, putative	0.0026	0.0052	0.0306
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.0351	0.2202
Entamoeba histolytica	replication factor A, putative	0.005	0.0209	0.1519
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.028	0.1659	0.1642
Echinococcus granulosus	protein phosphatase 1, catalytic subunit, beta isozyme	0.0031	0.0088	0.0083
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0026	0.0052	0.0032
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0073	0.0351	0.1124
Mycobacterium tuberculosis	Probable esterase LipL	0.0073	0.0351	0.1124
Toxoplasma gondii	methionyl-tRNA synthetase	0.0032	0.009	0.0483
Brugia malayi	hypothetical protein	0.0027	0.0063	0.0192
Leishmania major	replication factor A, 51kDa subunit, putative	0.0249	0.1464	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Loa Loa (eye worm)	replication factor A 73 kDa subunit	0.052	0.3174	1
Giardia lamblia	Hypothetical protein	0.0076	0.0371	0.7115
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0144	0.0748
Brugia malayi	mbt repeat family protein	0.0052	0.0216	0.0677
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0026	0.0052	0.0065
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.028	0.1659	0.2036
Trypanosoma brucei	aspartyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Echinococcus multilocularis	lysyl tRNA synthetase	0.0026	0.0052	0.0032
Chlamydia trachomatis	lysine--tRNA ligase	0.0026	0.0052	0.0141
Trypanosoma cruzi	asparaginyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Schistosoma mansoni	hypothetical protein	0.0138	0.0761	0.0943
Brugia malayi	glycyl-tRNA synthetase	0.0155	0.0866	0.2724
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.028	0.1659	0.2057
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0099	0.0513	0.0493
Schistosoma mansoni	protein phosphatase type 1	0.0031	0.0088	0.0109
Loa Loa (eye worm)	MBCTL1	0.0059	0.0261	0.0786
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0028	0.0069	0.0388
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0513	0.1581
Plasmodium vivax	methionine--tRNA ligase, putative	0.0032	0.009	0.0376
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0197	0.0617
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0513	0.1581
Giardia lamblia	Asparaginyl-tRNA synthetase	0.0026	0.0052	0.0645
Plasmodium vivax	lysine--tRNA ligase, putative	0.0026	0.0052	0.011
Trichomonas vaginalis	bsu-protein phosphatase, putative	0.0031	0.0088	0.0236
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0249	0.1464	0.4592
Schistosoma mansoni	hypothetical protein	0.0177	0.1007	0.1247
Entamoeba histolytica	hypothetical protein	0.0028	0.0069	0.0437
Schistosoma mansoni	ap endonuclease	0.004	0.0144	0.0178
Brugia malayi	putative serine/threonine phosphatase	0.0019	0.0013	0.0036
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0021	0.0021	0.0053
Onchocerca volvulus		0.0073	0.0351	0.0543
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Trypanosoma cruzi	serine/threonine protein phosphatase catalytic subunit, putative	0.0031	0.0088	0.0514
Echinococcus granulosus	serine:threonine protein phosphatase PP1 beta	0.0031	0.0088	0.0083
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Trypanosoma brucei	Replication factor A protein 1	0.0249	0.1464	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Schistosoma mansoni	protein phosphatase type 1	0.0019	0.0013	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0261	0.0786
Schistosoma mansoni	hypothetical protein	0.0177	0.1007	0.1247
Schistosoma mansoni	ap endonuclease	0.004	0.0144	0.0178
Loa Loa (eye worm)	aspartyl-tRNA synthetase	0.0026	0.0052	0.0125
Schistosoma mansoni	hypothetical protein	0.0138	0.0761	0.0943
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0144	0.0413
Echinococcus granulosus	beta LACTamase domain containing family member	0.0073	0.0351	0.0411
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0155	0.0866	0.2698
Schistosoma mansoni	cpg binding protein	0.0128	0.0697	0.0864
Echinococcus granulosus	aspartyl tRNA synthetase cytoplasmic	0.0026	0.0052	0.0039
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0144	0.0413
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 isozyme	0.0031	0.0088	0.0067
Mycobacterium leprae	Probable methionyl-tRNA synthase MetS	0.0032	0.009	0.1709
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.004	0.0144	1
Loa Loa (eye worm)	beta-lactamase	0.0073	0.0351	0.107
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.052	0.3174	1
Echinococcus granulosus	SAM and MBT domain containing protein	0.0052	0.0216	0.0243
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0073	0.0351	0.1101
Plasmodium falciparum	serine/threonine protein phosphatase PP1	0.0031	0.0088	0.0356
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0513	0.1581
Brugia malayi	Serine/threonine protein phosphatase PP1 isozyme 1, putative	0.0019	0.0013	0.0036
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.004	0.0144	0.0899
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0351	0.107
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0037	0.0111
Onchocerca volvulus	Putative replication factor A 73 kDa subunit	0.0466	0.2829	1
Loa Loa (eye worm)	63kd antigen	0.0026	0.0052	0.0125
Trypanosoma brucei	hypothetical protein, conserved	0.0073	0.0351	0.233
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0026	0.0052	0.0065
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0027	0.0063	0.016
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0351	0.0435
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0021	0.0021	0.0053
Loa Loa (eye worm)	phosphatidylinositol 3	0.0021	0.0021	0.0024
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 gamma	0.0031	0.0088	0.0067
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.052	0.3174	1
Schistosoma mansoni	protein phosphatase-1	0.0019	0.0013	0.0016
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0021	0.0021	0.006
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0761	0.2366
Brugia malayi	CXXC zinc finger family protein	0.0121	0.0654	0.2056
Schistosoma mansoni	cpg binding protein	0.0121	0.0654	0.081
Plasmodium falciparum	lysine--tRNA ligase	0.0026	0.0052	0.011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Echinococcus granulosus	dnaJ subfamily B	0.1296	0.8068	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0099	0.0513	0.0611
Trypanosoma brucei	asparaginyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Entamoeba histolytica	hypothetical protein	0.0026	0.0052	0.0306
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0513	0.1581
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0351	0.107
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.0216	0.0268
Onchocerca volvulus		0.0073	0.0351	0.0543
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0028	0.0069	0.0388
Leishmania major	lysyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0063	0.0157
Schistosoma mansoni	protein phosphatase-1	0.0031	0.0088	0.0109
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0774	0.4772	0.4761
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Loa Loa (eye worm)	histone methyltransferase	0.0037	0.0127	0.036
Mycobacterium ulcerans	lipase LipD	0.0073	0.0351	1
Toxoplasma gondii	replication factor-a protein 1 (rpa1) subfamily protein	0.0249	0.1464	1
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0026	0.0052	0.0032
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.003	0.008	0.0099
Leishmania major	aspartyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Plasmodium vivax	serine/threonine protein phosphatase PP1, putative	0.0031	0.0088	0.0356
Plasmodium falciparum	methionine--tRNA ligase, putative	0.0032	0.009	0.0376
Wolbachia endosymbiont of Brugia malayi	leucyl-tRNA synthetase	0.0032	0.009	0.5032
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.028	0.1659	0.2057
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0495	0.3012	0.9488
Loa Loa (eye worm)	BRCA2 repeat family protein	0.0105	0.0554	0.171
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0027	0.0063	0.016
Plasmodium vivax	replication protein A1, large subunit, putative	0.0249	0.1464	1
Schistosoma mansoni	glycyl-tRNA synthetase	0.0155	0.0866	0.1073
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.0216	0.0268
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0021	0.0021	0.0053
Brugia malayi	serine/threonine-protein kinase plk-2	0.0099	0.0513	0.1611
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0021	0.0021	0.0053
Plasmodium falciparum	asparagine--tRNA ligase	0.0026	0.0052	0.011
Echinococcus granulosus	lysyl tRNA synthetase	0.0026	0.0052	0.0039
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	0.0032	0.009	0.0192
Wolbachia endosymbiont of Brugia malayi	aspartyl-tRNA synthetase	0.0026	0.0052	0.1467
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0063	0.016
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0021	0.0021	0.0053
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0026	0.0052	0.0065
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1146	0.3585
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0063	0.016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0052	0.0125
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0021	0.0021	0.0053
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0073	0.0351	0.1124
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.004	0.0144	0.0899
Onchocerca volvulus		0.0082	0.0411	0.077
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0351	0.107
Treponema pallidum	exodeoxyribonuclease (exoA)	0.004	0.0144	0.0962
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0021	0.0021	0.006
Loa Loa (eye worm)	multisynthetase complex auxiliary component p43	0.0167	0.0946	0.2953
Loa Loa (eye worm)	apoptosis regulator protein	0.0138	0.0761	0.2366
Toxoplasma gondii	tRNA ligases class I (M) protein	0.0032	0.009	0.0483
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0063	0.0342
Plasmodium falciparum	replication protein A1, large subunit	0.0249	0.1464	1
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0513	0.1581
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0059	0.0261	0.0324
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0351	0.107
Brugia malayi	Aspartyl-tRNA synthetase	0.0026	0.0052	0.016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Mycobacterium ulcerans	beta-lactamase	0.0073	0.0351	1
Brugia malayi	Serine/threonine protein phosphatase PP1-alpha catalytic subunit	0.0019	0.0013	0.0036
Leishmania major	methionyl-tRNA synthetase, putative	0.0032	0.009	0.0534
Echinococcus granulosus	protein phosphatase 1 catalytic subunit	0.0031	0.0088	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0063	0.016
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0099	0.0513	0.116
Toxoplasma gondii	serine/threonine phosophatase PP1	0.0031	0.0088	0.0464
Schistosoma mansoni	protein phosphatase-1	0.0031	0.0088	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0063	0.016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Brugia malayi	mbt repeat family protein	0.0052	0.0216	0.0677
Brugia malayi	exodeoxyribonuclease III family protein	0.004	0.0144	0.0447
Schistosoma mansoni	serine/threonine protein kinase	0.0099	0.0513	0.0635
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0063	0.0342
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0099	0.0513	0.3443
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.0411	0.0484
Brugia malayi	beta-lactamase family protein	0.0073	0.0351	0.1101
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0351	0.107
Leishmania major	aspartyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Trypanosoma cruzi	polo-like protein kinase, putative	0.0099	0.0513	0.3443
Plasmodium falciparum	aspartate--tRNA ligase	0.0026	0.0052	0.011
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0052	0.0272
Plasmodium vivax	asparagine--tRNA ligase, putative	0.0026	0.0052	0.011
Echinococcus granulosus	geminin	0.0177	0.1007	0.1225
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0155	0.0866	0.2698
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0063	0.016
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.003	0.008	0.006
Leishmania major	hypothetical protein, conserved	0.0073	0.0351	0.233
Brugia malayi	Serine/threonine protein phosphatase PP1-beta catalytic subunit	0.0031	0.0088	0.0271
Brugia malayi	Serine/threonine protein phosphatase F56C9.1 in chromosomeIII	0.0031	0.0088	0.0271
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0229	0.1337	0.9116
Trichomonas vaginalis	serine/threonine protein phosphatase, putative	0.0031	0.0088	0.0236
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0063	0.0342
Schistosoma mansoni	hypothetical protein	0.0322	0.1922	0.2382
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Schistosoma mansoni	leucyl-tRNA synthetase	0.0032	0.009	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0032	0.009	0.0245
Schistosoma mansoni	methionine-tRNA synthetase	0.0199	0.1146	0.1421
Brugia malayi	BRCA2 repeat family protein	0.0105	0.0554	0.174
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0063	0.016
Brugia malayi	beta-lactamase	0.0073	0.0351	0.1101
Trichomonas vaginalis	aspartyl/lysyl-tRNA synthetase, putative	0.0026	0.0052	0.0125
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Brugia malayi	methionyl-tRNA synthetase	0.0199	0.1146	0.3608
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0059	0.0261	0.0241
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0351	0.107
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0027	0.0063	0.016
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0052	0.0216	0.0029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Echinococcus multilocularis	aspartyl tRNA synthetase, cytoplasmic	0.0026	0.0052	0.0032
Brugia malayi	F/Y-rich N-terminus family protein	0.0037	0.0124	0.0385
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0021	0.0021	0.006
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0052	0.0065
Toxoplasma gondii	aspartate-tRNA ligase	0.0026	0.0052	0.022
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0031	0.0088	0.0236
Mycobacterium ulcerans	esterase/lipase LipP	0.0073	0.0351	1
Giardia lamblia	Aspartyl-tRNA synthetase	0.0026	0.0052	0.0645
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0021	0.0021	0.0053
Schistosoma mansoni	apoptosis regulator bax	0.0138	0.0761	0.0943
Loa Loa (eye worm)	methionyl-tRNA synthetase	0.0032	0.009	0.0245
Entamoeba histolytica	hypothetical protein	0.0026	0.0052	0.0306
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0155	0.0866	0.2724
Onchocerca volvulus		0.0073	0.0351	0.0543
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Echinococcus multilocularis	asparaginyl tRNA synthetase	0.0026	0.0052	0.0032
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0144	0.0748
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0138	0.0761	0.2393
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.028	0.1659	0.2057
Toxoplasma gondii	ABC1 family protein	0.0073	0.0351	0.2289
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0351	0.1124
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0052	0.0498
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0257	0.151	0.1871
Echinococcus multilocularis	serine protein kinase ATM	0.0028	0.0069	0.0049
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0351	0.0435
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 gamma	0.0031	0.0088	0.0067
Echinococcus granulosus	serine:threonine protein phosphatase PP1 gamma	0.0031	0.0088	0.0083
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0351	0.233
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0026	0.0052	0.0125
Trypanosoma cruzi	replication Factor A 28 kDa subunit, putative	0.0026	0.0052	0.0272
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.0411	0.0391
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.004	0.0144	0.0413
Echinococcus granulosus	asparaginyl tRNA synthetase cytoplasmic	0.0026	0.0052	0.0039
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0021	0.0021	0.0026
Giardia lamblia	Methionyl-tRNA synthetase	0.0032	0.009	0.1419
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0197	0.0617
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0121	0.0654	0.2028
Treponema pallidum	methionyl-tRNA synthetase	0.0199	0.1146	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.004	0.0144	0.0153
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	0.0032	0.009	0.0534
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 beta	0.0031	0.0088	0.0067
Schistosoma mansoni	protein phosphatase type 1	0.0031	0.0088	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0044	0.0099
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0059	0.0261	0.0241
Loa Loa (eye worm)	hypothetical protein	0.005	0.0209	0.062
Trypanosoma brucei	protein phosphatase 1, putative	0.0031	0.0088	0.0514
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0027	0.0063	0.016
Echinococcus granulosus	methionine tRNA synthetase	0.0032	0.009	0.0087
Toxoplasma gondii	hypothetical protein	0.0055	0.0235	0.1487
Entamoeba histolytica	aspartyl-tRNA synthetase, putative	0.0026	0.0052	0.0306
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0021	0.0021	0.0053
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0063	0.0181
Leishmania major	leucyl-tRNA synthetase, putative	0.0032	0.009	0.0534
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.003	0.008	0.006
Echinococcus granulosus	mixed lineage leukemia protein mll	0.003	0.008	0.0074
Echinococcus granulosus	replication protein A 70 kDa DNA binding	0.052	0.3174	0.3918
Mycobacterium leprae	Probable lipase LipE	0.0073	0.0351	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.004	0.0144	0.0899
Mycobacterium tuberculosis	Probable lipase LipD	0.0073	0.0351	0.1124
Mycobacterium tuberculosis	Probable hydrolase	0.0073	0.0351	0.1124
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0073	0.0351	0.107
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0063	0.016
Mycobacterium tuberculosis	Probable lipase LipE	0.0073	0.0351	0.1124
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0059	0.0261	0.0819
Plasmodium falciparum	asparagine--tRNA ligase	0.0026	0.0052	0.011
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0026	0.0052	0.0498
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0037	0.0164
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0099	0.0513	0.3875
Mycobacterium leprae	PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE)	0.0026	0.0052	0.0498
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0021	0.0021	0.0053
Trichomonas vaginalis	bsu-protein phosphatase, putative	0.0031	0.0088	0.0236
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0027	0.0063	0.016
Entamoeba histolytica	replication factor A protein 1, putative	0.0224	0.1302	1
Giardia lamblia	Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit	0.0031	0.0088	0.1361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0197	0.0583
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0027	0.0063	0.016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0021	0.0021	0.006
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0513	0.1581
Trypanosoma cruzi	target of rapamycin kinase 3	0.0021	0.0021	0.0053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Echinococcus granulosus	serine:threonine protein phosphatase PP1 gamma	0.0031	0.0088	0.0083
Echinococcus multilocularis	cpg binding protein	0.0128	0.0697	0.0678
Echinococcus multilocularis	dnaJ subfamily B	0.1296	0.8068	0.8064
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0063	0.0181
Trypanosoma brucei	methionyl-tRNA synthetase, putative	0.0032	0.009	0.0534
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0411	0.1258
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0059	0.0261	0.0299
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0037	0.0111
Toxoplasma gondii	FATC domain-containing protein	0.0028	0.0069	0.0337
Trichomonas vaginalis	methionine-tRNA synthetase, putative	0.0032	0.009	0.0245
Echinococcus multilocularis	geminin	0.0177	0.1007	0.0988
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0032	0.009	0.0245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0021	0.0021	0.0053
Toxoplasma gondii	OB-fold nucleic acid binding domain-containing protein	0.0131	0.0716	0.4813
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0073	0.0351	1
Toxoplasma gondii	lysine-tRNA ligase	0.0026	0.0052	0.022
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0052	0.0216	0.0268
Schistosoma mansoni	hypothetical protein	0.1296	0.8068	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0073	0.0351	0.0331
Echinococcus multilocularis	glycyl tRNA synthetase	0.0155	0.0866	0.0847
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	0.0032	0.009	0.5032
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0021	0.0021	0.0055
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0026	0.0052	0.011
Leishmania major	serine/threonine protein phosphatase catalytic subunit, putative	0.0031	0.0088	0.0514
Mycobacterium tuberculosis	Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase)	0.0026	0.0052	0.0056
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0774	0.4772	0.5904
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0052	0.0498
Entamoeba histolytica	methionyl-tRNA synthetase, putative	0.0199	0.1146	0.8789
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0199	0.1146	0.1128
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0198	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0351	0.107
Schistosoma mansoni	cpg binding protein	0.0128	0.0697	0.0864
Mycobacterium ulcerans	methionyl-tRNA synthetase	0.0032	0.009	0.1709
Plasmodium vivax	aspartate--tRNA ligase, putative	0.0026	0.0052	0.011
Plasmodium vivax	asparagine--tRNA ligase, putative	0.0026	0.0052	0.011
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0198	0.0587
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0026	0.0052	0.0065
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.0411	0.0509
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0063	0.016
Echinococcus multilocularis	polycomb protein SCMH1	0.0052	0.0216	0.0196
Trichomonas vaginalis	esterase, putative	0.0073	0.0351	0.107
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.004	0.0144	0.0382
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0052	0.0065
Loa Loa (eye worm)	mbt repeat family protein	0.0052	0.0216	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0351	0.107
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0028	0.0069	0.0086
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0063	0.0181
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Leishmania major	asparaginyl-tRNA synthetase, putative	0.0026	0.0052	0.0272
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.004	0.0144	0.1012
Loa Loa (eye worm)	phosphatidylinositol 3	0.0021	0.0021	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0216	0.0643
Brugia malayi	Serine/threonine protein phosphatase PP1 isozyme 1, putative	0.0019	0.0013	0.0036
Giardia lamblia	Leucyl-tRNA synthetase	0.0032	0.009	0.1419
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0021	0.0024
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0026	0.0052	0.0065
Echinococcus granulosus	polycomb protein SCMH1	0.0052	0.0216	0.0243
Trichomonas vaginalis	bsu-protein phosphatase, putative	0.0031	0.0088	0.0236
Trichomonas vaginalis	protein phosphatase-1, putative	0.0031	0.0088	0.0236
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0212	0.1225	0.1207
Schistosoma mansoni	protein phosphatase-1	0.0019	0.0013	0.0016
Loa Loa (eye worm)	serine/threonine protein phosphatase PP1-beta catalytic subunit	0.0031	0.0088	0.0236
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0199	0.1146	0.1399
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.0411	0.1289

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 93 %	Inhibition of human adenosine 2A receptor at 1 mM	ChEMBL.	20095623
Ki (binding)	= 2.8 uM	Inhibition of human adenosine 2A receptor	ChEMBL.	20095623

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL604728

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1101969