Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1499 | 0.355 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0256 | 0.0256 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0256 | 0.0256 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0889 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.147 | 0.147 |
Brugia malayi | hypothetical protein | 0.011 | 0.4223 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1499 | 0.1499 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1499 | 0.355 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1499 | 0.1499 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0256 | 0.0256 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0239 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0256 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.147 | 0.147 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0889 | 0.2105 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.147 | 0.147 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.147 | 0.147 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0805 | 0.0805 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.147 | 0.147 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0256 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0256 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0256 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0256 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.147 | 0.147 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0256 | 0.0256 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0889 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0889 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0889 | 0.0889 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0805 | 0.0805 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.147 | 0.348 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0889 | 0.0889 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0256 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0239 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.147 | 0.147 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0256 | 0.0256 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0256 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0805 | 0.1907 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0256 | 0.0606 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0889 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0256 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0256 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0256 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0889 | 0.0889 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.147 | 0.147 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0256 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0256 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0889 | 0.0889 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0256 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 11303 after 24 hrs by NCCLS M7-A6 broth dilution method | ChEMBL. | 21641699 |
MIC (functional) | > 200 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 after 24 hrs by NCCLS M38-P broth dilution method | ChEMBL. | 21641699 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.