Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.0019 | 0.1072 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.1002 | 0.1002 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.1072 | 0.1072 |
Brugia malayi | hypothetical protein | 0.0074 | 0.7942 | 0.7942 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.1072 | 0.1072 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.1072 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0.1072 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.1002 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.1002 | 0.1002 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.7942 | 0.7942 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.1002 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 1 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.1002 | 0.1002 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.7942 | 0.7942 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.7942 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.001 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.1002 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.1002 | 0.9348 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.1002 | 0.1002 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.7942 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.1072 | 0.1072 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.1072 | 0.1072 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0.1072 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1002 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0048 | 0.4671 | 0.4671 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.7942 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.1002 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.1002 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1002 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.1002 | 0.9348 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0019 | 0.1072 | 0.1072 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.1002 | 0.1002 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.7942 | 0.7942 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.1002 | 0.9348 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.7942 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.1072 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.1002 | 0.9348 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.1002 | 0.1002 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.1002 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0048 | 0.4671 | 0.4671 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.1002 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.7942 | 0.7942 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.1002 | 0.9348 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 45 % | Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in HeLa cells at 1 uM | ChEMBL. | 19682912 |
Ki (binding) | = 6.28 | Displacement of [3H]DPCPX form adenosine A1 receptor in rat cortex membrane | ChEMBL. | 19682912 |
Ki (binding) | = 6.83 | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HeLa cells by microplate beta scintillation counting | ChEMBL. | 19682912 |
Ki (binding) | = 7.49 | Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells | ChEMBL. | 19682912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.