Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.0964 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.0964 | 0.1555 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0056 | 0.1225 | 0.1976 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0888 | 0.1317 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0192 | 0.6202 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.0964 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0888 | 0.1317 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0888 | 0.0888 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 0.6742 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0123 | 0.3668 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0888 | 0.0888 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.0964 | 0.1555 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0192 | 0.6202 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0123 | 0.3668 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0123 | 0.3668 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0123 | 0.3668 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0049 | 0.098 | 0.1453 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.011 | 0.322 | 0.8342 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.011 | 0.322 | 0.8342 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0056 | 0.1225 | 0.1976 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0049 | 0.098 | 0.1579 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0049 | 0.098 | 0.1579 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0888 | 0.1432 |
Brugia malayi | glutathione reductase | 0.0048 | 0.0964 | 0.143 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.011 | 0.322 | 0.8342 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.0964 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.0964 | 0.143 |
Brugia malayi | ecdysteroid receptor | 0.0207 | 0.6742 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0049 | 0.098 | 0.1579 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.011 | 0.322 | 0.8342 |
Loa Loa (eye worm) | MBCTL1 | 0.0056 | 0.1225 | 0.1818 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.098 | 0.1453 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.0964 | 0.143 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0888 | 0.0888 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0888 | 0.1432 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.098 | 0.098 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0056 | 0.1225 | 0.1818 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0056 | 0.1225 | 0.1225 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1225 | 0.1818 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.098 | 0.1453 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0888 | 0.1432 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.098 | 0.1453 |
Leishmania major | trypanothione reductase | 0.0048 | 0.0964 | 0.5 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0049 | 0.098 | 0.098 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0888 | 0.1432 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.0964 | 0.5 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0056 | 0.1225 | 0.1976 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.0964 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.6742 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.011 | 0.322 | 0.8342 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.098 | 0.098 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0049 | 0.098 | 0.1579 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.011 | 0.322 | 0.8342 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0049 | 0.098 | 0.1453 |
Onchocerca volvulus | 0.0049 | 0.098 | 0.1453 | |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.0964 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.0964 | 0.5 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0056 | 0.1225 | 0.1976 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.0964 | 0.143 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 30 nM | Agonist activity at human recombinant LXR-LBD by Gal4beta transactivation assay | ChEMBL. | 19932617 |
Efficacy (functional) | = 85 % | Agonist activity at human recombinant LXR-LBD by Gal4beta transactivation assay relative to T0901317 | ChEMBL. | 19932617 |
IC50 (binding) | = 1.2 nM | Displacement of [3H]T0901317 from human recombinant LXRalpha-LBD | ChEMBL. | 19932617 |
IC50 (binding) | = 3.3 nM | Displacement of [3H]T0901317 from human recombinant LXRbeta-LBD | ChEMBL. | 19932617 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.