TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 215.205 | Formula: C12H9NO3
H donors: 0 H acceptors: 2 LogP: 2.67 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: O=c1ccc2c(o1)nc1c(c2)c(c(o1)C)C
InChi: 1S/C12H9NO3/c1-6-7(2)15-12-9(6)5-8-3-4-10(14)16-11(8)13-12/h3-5H,1-2H3
InChiKey: ONCFOYWAEJKVCO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Brugia malayi	nuclear hormone receptor family member odr-7	0.0024	0.0195	0.0308
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0063	0.0775	0.0591
Schistosoma mansoni	hypothetical protein	0.0064	0.0792	0.061
Schistosoma mansoni	hypothetical protein	0.0139	0.1902	0.1741
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0928	0.1465
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0024	0.0195	0.0193
Schistosoma mansoni	hypothetical protein	0.0404	0.5861	0.5778
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1902	0.3006
Brugia malayi	Nuclear hormone receptor-like 1	0.0027	0.0238	0.0376
Onchocerca volvulus		0.0063	0.0775	0.0826
Echinococcus multilocularis	dnaJ subfamily B	0.0404	0.5861	0.586
Schistosoma mansoni	retinoic acid receptor RXR	0.0051	0.0596	0.0409
Schistosoma mansoni	thyroid hormone receptor	0.0051	0.0596	0.0409
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0051	0.0596	0.0594
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0367	0.0365
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0586	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0596	0.094
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0768	0.0585
Echinococcus granulosus	thyroid hormone receptor alpha	0.0024	0.0195	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0596	0.094
Brugia malayi	nuclear receptor RXR	0.0027	0.0238	0.0376
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0672	0.2076
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0792	0.1251
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0051	0.0596	0.0943
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0024	0.0195	0.0193
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0051	0.0596	0.0943
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0064	0.0792	0.1254
Onchocerca volvulus		0.0073	0.0928	0.1044
Onchocerca volvulus		0.0073	0.0928	0.1044
Echinococcus granulosus	FTZ F1 alpha	0.0051	0.0596	0.0594
Brugia malayi	Nuclear hormone receptor-like 1	0.0027	0.0238	0.0376
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0063	0.0775	0.0591
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0928	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Schistosoma mansoni	microtubule-associated protein tau	0.0682	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.159	0.2514
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0928	0.1465
Brugia malayi	hypothetical protein	0.0036	0.0367	0.058
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0027	0.0238	0.0373
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0051	0.0596	0.0594
Schistosoma mansoni	hypothetical protein	0.0064	0.0792	0.061
Brugia malayi	conserved hypotetical protein	0.0024	0.0195	0.0308
Leishmania major	mitochondrial DNA polymerase beta	0.032	0.4602	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0024	0.0195	0.0193
Brugia malayi	RNA recognition motif domain containing protein	0.0257	0.3664	0.5797
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0027	0.0238	0.0236
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0051	0.0596	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Brugia malayi	hypothetical protein	0.0024	0.0195	0.0308
Onchocerca volvulus		0.0028	0.026	0.0092
Echinococcus granulosus	geminin	0.0354	0.512	0.5119
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0051	0.0596	0.0943
Schistosoma mansoni	tar DNA-binding protein	0.0257	0.3664	0.3539
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0051	0.0596	0.0943
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0051	0.0596	0.094
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0151	0.2092	0.3871
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0928	0.1465
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0063	0.0775	0.0591
Brugia malayi	ecdysone receptor	0.0024	0.0195	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0928	0.1465
Schistosoma mansoni	hypothetical protein	0.0064	0.0792	0.061
Schistosoma mansoni	cpg binding protein	0.003	0.0284	0.0091
Brugia malayi	nuclear receptor NHR-88	0.0051	0.0596	0.0943
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0051	0.0596	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0238	0.0373
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0928	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0596	0.094
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0051	0.0596	0.094
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0024	0.0195	0.0193
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0051	0.0596	0.0571
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0151	0.2092	0.3871
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0586	0.0399
Brugia malayi	photoreceptor-specific nuclear receptor	0.0051	0.0596	0.0943
Brugia malayi	MH2 domain containing protein	0.0118	0.159	0.2516
Brugia malayi	nuclear receptor NHR-88	0.0024	0.0195	0.0308
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0051	0.0596	0.0594
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0024	0.0195	0.0193
Mycobacterium ulcerans	hypothetical protein	0.0168	0.2347	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0596	0.094
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0596	0.094
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Brugia malayi	TAR-binding protein	0.0257	0.3664	0.5797
Echinococcus granulosus	cpg binding protein	0.003	0.0284	0.0282
Echinococcus multilocularis	nuclear receptor nhr 48	0.0024	0.0195	0.0193
Echinococcus multilocularis	GPCR, family 2	0.0064	0.0792	0.0791
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0027	0.0238	0.0044
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0073	0.0928	0.1467
Schistosoma mansoni	thyroid hormone receptor	0.0051	0.0596	0.0409
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0051	0.0596	0.0594
Loa Loa (eye worm)	DR-78	0.0024	0.0195	0.0306
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0203	0.2857	0.452
Entamoeba histolytica	hypothetical protein	0.0036	0.0367	0.5
Entamoeba histolytica	hypothetical protein	0.0036	0.0367	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0027	0.0238	0.0044
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.032	0.4602	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0468	0.6807	1
Brugia malayi	ecdysteroid receptor	0.0051	0.0596	0.0943
Schistosoma mansoni	cpg binding protein	0.003	0.0284	0.0091
Onchocerca volvulus		0.0147	0.2031	0.2616
Schistosoma mansoni	hypothetical protein	0.0354	0.512	0.5023
Brugia malayi	hypothetical protein	0.0027	0.0238	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0596	0.094
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0051	0.0596	0.0594
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0928	0.1028
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.032	0.4602	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0051	0.0596	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0147	0.2031	0.3212
Onchocerca volvulus		0.0051	0.0596	0.0571
Brugia malayi	nuclear hormone receptor	0.0024	0.0195	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0928	0.1465
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0055	0.0653	0.0358
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.0928	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0063	0.0775	0.5255
Brugia malayi	hypothetical protein	0.0147	0.2031	0.3213
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0073	0.0928	0.0926
Brugia malayi	nuclear receptor NHR-67	0.0024	0.0195	0.0308
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0064	0.0792	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0238	0.0373
Trichomonas vaginalis	set domain proteins, putative	0.0495	0.7216	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Echinococcus granulosus	GPCR family 2	0.0064	0.0792	0.0791
Mycobacterium leprae	Probable lipase LipE	0.0073	0.0928	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0051	0.0596	0.0943
Schistosoma mansoni	tar DNA-binding protein	0.0257	0.3664	0.3539
Brugia malayi	orphan nuclear receptor NR2E1	0.0024	0.0195	0.0308
Onchocerca volvulus	Bile acid receptor homolog	0.0051	0.0596	0.0571
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0064	0.0792	0.1251
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0051	0.0596	0.0594
Trypanosoma brucei	hypothetical protein, conserved	0.0073	0.0928	0.1028
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0051	0.0596	0.0594
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0051	0.0596	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0063	0.0775	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0203	0.2857	0.4519
Brugia malayi	Nuclear hormone receptor E75	0.0024	0.0195	0.0308
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0195	0.0193
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0151	0.2092	0.3169
Brugia malayi	nuclear hormone receptor	0.0051	0.0596	0.0943
Brugia malayi	CXXC zinc finger family protein	0.0028	0.026	0.0411
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0024	0.0195	0.0306
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0051	0.0596	0.0409
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.006	0.0731	0.073
Schistosoma mansoni	hypothetical protein	0.0064	0.0792	0.061
Brugia malayi	RNA binding protein	0.0257	0.3664	0.5797
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0435	0.6321	1
Toxoplasma gondii	ABC1 family protein	0.0073	0.0928	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.159	0.2514
Schistosoma mansoni	coup transcription factor	0.0051	0.0596	0.0409
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0051	0.0596	0.0594
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0027	0.0238	0.0236
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.032	0.4602	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0063	0.0775	0.0773
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0586	0.0927
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0051	0.0596	0.0943
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0051	0.0596	0.0594
Brugia malayi	nuclear receptor RXR	0.0024	0.0195	0.0308
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0063	0.0775	0.0591
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0051	0.0596	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0238	0.0373
Schistosoma mansoni	tar DNA-binding protein	0.0257	0.3664	0.3539
Echinococcus granulosus	ecdysone induced protein 78C	0.0051	0.0596	0.0594
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0024	0.0195	0.0306
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0051	0.0596	0.0594
Brugia malayi	latrophilin 2 splice variant baaae	0.0139	0.1902	0.3008
Brugia malayi	hypothetical protein	0.0027	0.0238	0.0376
Brugia malayi	beta-lactamase family protein	0.0073	0.0928	0.1467
Brugia malayi	tailless protein	0.0024	0.0195	0.0308
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0051	0.0596	0.0409
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0064	0.0792	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0586	0.0585
Onchocerca volvulus		0.0073	0.0928	0.1044
Echinococcus granulosus	dnaJ subfamily B	0.0404	0.5861	0.586
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0928	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0238	0.0373
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0586	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Schistosoma mansoni	tar DNA-binding protein	0.0257	0.3664	0.3539
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0586	0.0585
Echinococcus granulosus	nuclear receptor nhr 48	0.0024	0.0195	0.0193
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0203	0.2857	0.4519
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0051	0.0596	0.0409
Echinococcus multilocularis	ecdysone induced protein 78C	0.0051	0.0596	0.0594
Schistosoma mansoni	nuclear hormone receptor	0.0051	0.0596	0.0409
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0051	0.0596	0.094
Brugia malayi	hypothetical protein	0.0024	0.0195	0.0308
Brugia malayi	beta-lactamase	0.0073	0.0928	0.1467
Loa Loa (eye worm)	beta-lactamase	0.0073	0.0928	0.1465
Loa Loa (eye worm)	steroid hormone receptor	0.0051	0.0596	0.094
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0257	0.3664	0.5796
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0367	0.0175
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0051	0.0596	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0596	0.094
Echinococcus multilocularis	tar DNA binding protein	0.0257	0.3664	0.3663
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0051	0.0596	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0238	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0596	0.094
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0024	0.0195	0.0308
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0051	0.0596	0.0594
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0367	0.0365
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0051	0.0596	0.094
Loa Loa (eye worm)	RNA binding protein	0.0257	0.3664	0.5796
Brugia malayi	Nuclear hormone receptor E75	0.0024	0.0195	0.0308
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0024	0.0195	0.0308
Schistosoma mansoni	cpg binding protein	0.0028	0.026	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Echinococcus multilocularis	microtubule associated protein 2	0.0682	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0051	0.0596	0.0594
Schistosoma mansoni	RAR-like nuclear receptor	0.0051	0.0596	0.0409
Echinococcus multilocularis	cpg binding protein	0.003	0.0284	0.0282
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0073	0.0928	0.1465
Schistosoma mansoni	tar DNA-binding protein	0.0257	0.3664	0.3539
Echinococcus multilocularis	geminin	0.0354	0.512	0.5119
Loa Loa (eye worm)	TAR-binding protein	0.0257	0.3664	0.5796
Onchocerca volvulus	Protein ultraspiracle homolog	0.0051	0.0596	0.0571
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0024	0.0195	0.0193
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0195	0.0193
Brugia malayi	Pre-SET motif family protein	0.0435	0.6321	1
Brugia malayi	beta-lactamase family protein	0.0073	0.0928	0.1467
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0051	0.0596	0.0943
Schistosoma mansoni	hypothetical protein	0.0036	0.0367	0.0175
Mycobacterium leprae	conserved hypothetical protein	0.0073	0.0928	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.026	0.0408
Schistosoma mansoni	hypothetical protein	0.0354	0.512	0.5023
Entamoeba histolytica	hypothetical protein	0.0036	0.0367	0.5
Brugia malayi	Pre-SET motif family protein	0.0063	0.0775	0.1225
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0051	0.0596	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0775	0.1223
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0051	0.0596	0.0409
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0051	0.0596	0.0409
Loa Loa (eye worm)	nuclear hormone receptor	0.0024	0.0195	0.0306
Brugia malayi	Latrophilin receptor protein 2	0.0064	0.0792	0.1254
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0168	0.2347	0.2414
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0051	0.0596	0.094
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0203	0.2857	0.452
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0051	0.0596	0.0943
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0024	0.0195	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0306
Echinococcus granulosus	tar DNA binding protein	0.0257	0.3664	0.3663
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0051	0.0596	0.094
Brugia malayi	steroid hormone receptor	0.0051	0.0596	0.0943
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0051	0.0596	0.0943
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0064	0.0792	0.0791
Echinococcus granulosus	beta LACTamase domain containing family member	0.0073	0.0928	0.0926
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0064	0.0792	0.0791
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0051	0.0596	0.0943
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0586	0.0399
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0586	0.0925
Entamoeba histolytica	hypothetical protein	0.0036	0.0367	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0586	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0928	0.1465
Brugia malayi	Steroid receptor seven-up type 2	0.0051	0.0596	0.0943
Echinococcus multilocularis	FTZ F1 alpha	0.0051	0.0596	0.0594
Onchocerca volvulus		0.0495	0.7216	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0051	0.0596	0.094
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0063	0.0775	0.0773

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1079134

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1103046